Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer

References

• Ardito, C. M., B. M. Gruner, K. K. Takeuchi, C. Lubeseder-Martellato, N. Teichmann, P. K. Mazur, K. E. Delgiorno, et al. 2012. “EGF Receptor is Required for KRAS-Induced Pancreatic Tumorigenesis.” Cancer Cell 22 (3): 304–317. https://doi.org/10.1016/j.ccr.2012.07.024
   PubMed Web of Science ®Google Scholar
• Arnold, D., B. Lueza, J. Y. Douillard, M. Peeters, H. J. Lenz, A. Venook, V. Heinemann, et al. 2017. “Prognostic and Predictive Value of Primary Tumor Side in Patients with RAS Wild-Type Metastatic Colorectal Cancer Treated with Chemotherapy and EGFR Directed Antibodies in Six Randomized Trials.” Annals of Oncology 28 (8): 1713–1729. https://doi.org/10.1093/annonc/mdx175
   PubMed Web of Science ®Google Scholar
• Asif, P. J., C. Longobardi, M. Hahne, and J. P. Medema. 2021. “The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis.” Cancers 13 (18): 4720. https://doi.org/10.3390/cancers13184720
   PubMed Web of Science ®Google Scholar
• Behrenbruch, Corina, Momeneh Foroutan, Phoebe Lind, Jai Smith, Mélodie Grandin, Benjamin Cooper, Carolyn Shembrey, et al. 2021. “Targeting of TP53-Independent Cell Cycle Checkpoints Overcomes FOLFOX Resistance in Metastatic Colorectal Cancer.” bioRxiv:2021.02.04.429849. https://doi.org/10.1101/2021.02.04.429849
   Google Scholar
• Berg, K. C. G., P. W. Eide, I. A. Eilertsen, B. Johannessen, J. Bruun, S. A. Danielsen, M. Bjornslett, et al. 2017. “Multi-Omics of 34 Colorectal Cancer Cell Lines–A Resource for Biomedical Studies.” Molecular Cancer 16 (1): 116. https://doi.org/10.1186/s12943-017-0691-y
   PubMedGoogle Scholar
• Betge, J., N. I. Schneider, L. Harbaum, M. J. Pollheimer, R. A. Lindtner, P. Kornprat, M. P. Ebert, and C. Langner. 2016. “MUC1, MUC2, MUC5AC, and MUC6 in Colorectal Cancer: Expression Profiles and Clinical Significance.” Virchows Archiv 469 (3): 255–265. https://doi.org/10.1007/s00428-016-1970-5
   PubMed Web of Science ®Google Scholar
• Carpinteri, S., S. Sampurno, M. P. Bernardi, M. Germann, J. Malaterre, A. Heriot, B. A. Chambers, S. E. Mutsaers, A. C. Lynch, and R. G. Ramsay. 2015. “Peritoneal Tumorigenesis and Inflammation Are Ameliorated by Humidified-Warm Carbon Dioxide Insufflation in the Mouse.” Annals of Surgical Oncology 22 (Suppl 3): S1540–S7. https://doi.org/10.1245/s10434-015-4508-1
   PubMedGoogle Scholar
• Castle, J. C., M. Loewer, S. Boegel, J. de Graaf, C. Bender, A. D. Tadmor, V. Boisguerin, et al. 2014. “Immunomic, Genomic and Transcriptomic Characterization of CT26 Colorectal Carcinoma.” BMC Genomics 15 (1): 190. https://doi.org/10.1186/1471-2164-15-190
   PubMedGoogle Scholar
• Cattaneo, C. M., K. K. Dijkstra, L. F. Fanchi, S. Kelderman, S. Kaing, N. van Rooij, S. van den Brink, T. N. Schumacher, and E. E. Voest. 2020. “Tumor organoid-T-Cell Coculture Systems.” Nature Protocols 15 (1): 15–39. https://doi.org/10.1038/s41596-019-0232-9
   PubMed Web of Science ®Google Scholar
• Ceelen, W., R. G. Ramsay, V. Narasimhan, A. G. Heriot, and O. De Wever. 2020. “Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases.” Trends in Cancer 6 (3): 236–246. https://doi.org/10.1016/j.trecan.2019.12.008
   PubMed Web of Science ®Google Scholar
• Cheasley, D., L. Pereira, S. Lightowler, E. Vincan, J. Malaterre, and R. G. Ramsay. 2011. “Myb Controls Intestinal Stem Cell Genes and Self-Renewal.” Stem Cells 29 (12): 2042–2050. https://doi.org/10.1002/stem.761
   PubMed Web of Science ®Google Scholar
• Cheasley, D., L. Pereira, S. Sampurno, O. Sieber, R. Jorissen, H. Xu, M. Germann, Y. Yuqian, R. G. Ramsay, and J. Malaterre. 2015. “Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.” Molecular Cancer Research 13 (8): 1185–1196. https://doi.org/10.1158/1541-7786.MCR-15-0014
   PubMed Web of Science ®Google Scholar
• Chen, B., C. R. Scurrah, E. T. McKinley, A. J. Simmons, M. A. Ramirez-Solano, X. Zhu, N. O. Markham, et al. 2021. “Differential Pre-Malignant Programs and Microenvironment Chart Distinct Paths to Malignancy in Human Colorectal Polyps.” Cell 184 (26): 6262–6280.e26. https://doi.org/10.1016/j.cell.2021.11.031
   PubMed Web of Science ®Google Scholar
• Chen, W., B. J. Swanson, and W. L. Frankel. 2017. “Molecular Genetics of Microsatellite-Unstable Colorectal Cancer for Pathologists.” Diagnostic Pathology 12 (1): 24. https://doi.org/10.1186/s13000-017-0613-8
   PubMedGoogle Scholar
• Cortes-Guiral, D., M. Hubner, M. Alyami, A. Bhatt, W. Ceelen, O. Glehen, F. Lordick, et al. 2021. “Primary and Metastatic Peritoneal Surface Malignancies.” Nature Reviews. Disease Primers 7 (1): 91. https://doi.org/10.1038/s41572-021-00326-6
   PubMed Web of Science ®Google Scholar
• Cremolini, C., C. Antoniotti, S. Lonardi, F. Bergamo, E. Cortesi, G. Tomasello, R. Moretto, et al. 2018. “Primary Tumor Sidedness and Benefit from FOLFOXIRI plus Bevacizumab as Initial Therapy for Metastatic Colorectal Cancer. Retrospective Analysis of the TRIBE Trial by GONO.” Annals of Oncology 29 (7): 1528–1534. https://doi.org/10.1093/annonc/mdy140
   PubMed Web of Science ®Google Scholar
• Dakowicz, D., M. Zajkowska, and B. Mroczko. 2022. “Relationship between VEGF Family Members, Their Receptors and Cell Death in the Neoplastic Transformation of Colorectal Cancer.” International Journal of Molecular Sciences 23 (6): 3375. https://doi.org/10.3390/ijms23063375
   PubMed Web of Science ®Google Scholar
• Derynck, R., Y. Zhang, and X. H. Feng. 1998. “Smads: transcriptional Activators of TGF-Beta Responses.” Cell 95 (6): 737–740. https://doi.org/10.1016/s0092-8674(00)81696-7
   PubMed Web of Science ®Google Scholar
• Dignass, A. U., and A. Sturm. 2001. “Peptide Growth Factors in the Intestine.” European Journal of Gastroenterology & Hepatology 13 (7): 763–770. https://doi.org/10.1097/00042737-200107000-00002
   PubMed Web of Science ®Google Scholar
• Drost, J., R. H. van Jaarsveld, B. Ponsioen, C. Zimberlin, R. van Boxtel, A. Buijs, N. Sachs, et al. 2015. “Sequential Cancer Mutations in Cultured Human Intestinal Stem Cells.” Nature 521 (7550): 43–47. https://doi.org/10.1038/nature14415
   PubMed Web of Science ®Google Scholar
• Efremova, M., D. Rieder, V. Klepsch, P. Charoentong, F. Finotello, H. Hackl, N. Hermann-Kleiter, et al. 2018. “Targeting Immune Checkpoints Potentiates Immunoediting and Changes the Dynamics of Tumor Evolution.” Nature Communications 9 (1): 32. https://doi.org/10.1038/s41467-017-02424-0
   PubMedGoogle Scholar
• Fearon, E. R., and B. Vogelstein. 1990. “A Genetic Model for Colorectal Tumorigenesis.” Cell 61 (5): 759–767. https://doi.org/10.1016/0092-8674(90)90186-i
   PubMed Web of Science ®Google Scholar
• Flood, M., V. Narasimhan, K. Wilson, W. M. Lim, R. Ramsay, M. Michael, and A. Heriot. 2022. “Organoids as a Robust Preclinical Model for Precision Medicine in Colorectal Cancer: A Systematic Review.” Annals of Surgical Oncology 29 (1): 47–59. https://doi.org/10.1245/s10434-021-10829-x
   PubMed Web of Science ®Google Scholar
• Fre, S., S. K. Pallavi, M. Huyghe, M. Lae, K. P. Janssen, S. Robine, S. Artavanis-Tsakonas, and D. Louvard. 2009. “Notch and Wnt Signals Cooperatively Control Cell Proliferation and Tumorigenesis in the Intestine.” Proceedings of the National Academy of Sciences of the United States of America 106 (15): 6309–6314. https://doi.org/10.1073/pnas.0900427106
   PubMed Web of Science ®Google Scholar
• Fuhr, L., R. El-Athman, R. Scrima, O. Cela, A. Carbone, H. Knoop, Y. Li, et al. 2018. “The Circadian Clock Regulates Metabolic Phenotype Rewiring via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.” EBio Medicine 33: 105–121. https://doi.org/10.1016/j.ebiom.2018.07.002
   PubMed Web of Science ®Google Scholar
• Fujii, M., and T. Sato. 2017. “Defining the Role of Lgr5(+) Stem Cells in Colorectal Cancer: From Basic Research to Clinical Applications.” Genome Medicine 9 (1): 66. https://doi.org/10.1186/s13073-017-0460-y
   PubMedGoogle Scholar
• Fujii, M., M. Shimokawa, S. Date, A. Takano, M. Matano, K. Nanki, Y. Ohta, et al. 2016. “A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.” Cell Stem Cell 18 (6): 827–838. https://doi.org/10.1016/j.stem.2016.04.003
   PubMed Web of Science ®Google Scholar
• Gagos, S., V. L. Hopwood, D. Iliopoulos, A. Kostakis, P. Karayannakos, H. Yatzides, G. D. Skalkeas, and S. Pathak. 1995. “Chromosomal Markers Associated with Metastasis in Two Colon Cancer Cell Lines Established from the Same Patient.” Anticancer Res.15 (2): 369–378.
   PubMed Web of Science ®Google Scholar
• Ganesh, K., C. Wu, K. P. O’Rourke, B. C. Szeglin, Y. Zheng, C. G. Sauve, M. Adileh, et al. 2019. “A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation.” Nature Medicine 25 (10): 1607–1614. https://doi.org/10.1038/s41591-019-0584-2
   PubMed Web of Science ®Google Scholar
• Germann, M., H. Xu, J. Malaterre, S. Sampurno, M. Huyghe, D. Cheasley, S. Fre, and R. G. Ramsay. 2014. “Tripartite Interactions between Wnt Signaling, Notch and Myb for Stem/Progenitor Cell Functions during Intestinal Tumorigenesis.” Stem Cell Research 13 (3 Pt A): 355–366. https://doi.org/10.1016/j.scr.2014.08.002
   PubMed Web of Science ®Google Scholar
• Go, Y. H., W. H. Choi, W. J. Bae, S. I. Jung, C. H. Cho, S. A. Lee, J. S. Park, et al. 2022. “Modeling Pancreatic Cancer with Patient-Derived Organoids Integrating Cancer-Associated Fibroblasts.” Cancers 14 (9): 2077. https://doi.org/10.3390/cancers14092077
   PubMed Web of Science ®Google Scholar
• Greenlee, J. D., and M. R. King. 2022. “A Syngeneic MC38 Orthotopic Mouse Model of Colorectal Cancer Metastasis.” Biology Methods & Protocols 7 (1): bpac024. https://doi.org/10.1093/biomethods/bpac024
   PubMedGoogle Scholar
• Guinney, J., R. Dienstmann, X. Wang, A. de Reynies, A. Schlicker, C. Soneson, L. Marisa, et al. 2015. “The Consensus Molecular Subtypes of Colorectal Cancer.” Nature Medicine 21 (11): 1350–1356. https://doi.org/10.1038/nm.3967
   PubMed Web of Science ®Google Scholar
• Hadadi, E., W. Taylor, X. M. Li, Y. Aslan, M. Villote, J. Riviere, G. Duvallet, et al. 2020. “Chronic Circadian Disruption Modulates Breast Cancer Stemness and Immune Microenvironment to Drive Metastasis in Mice.” Nature Communications 11 (1): 3193. https://doi.org/10.1038/s41467-020-16890-6
   PubMed Web of Science ®Google Scholar
• Hayashi, Y., M. Tsujii, T. Kodama, T. Akasaka, J. Kondo, H. Hikita, T. Inoue, et al. 2016. “p53 Functional Deficiency in Human Colon Cancer Cells Promotes Fibroblast-Mediated Angiogenesis and Tumor Growth.” Carcinogenesis 37 (10): 972–984. https://doi.org/10.1093/carcin/bgw085
   PubMed Web of Science ®Google Scholar
• Hirokawa, Y., J. Clarke, M. Palmieri, T. Tan, D. Mouradov, S. Li, C. Lin, et al. 2021. “Low-Viscosity Matrix Suspension Culture Enables Scalable Analysis of Patient-Derived Organoids and Tumoroids from the Large Intestine.” Communications Biology 4 (1): 1067. https://doi.org/10.1038/s42003-021-02607-y
   PubMed Web of Science ®Google Scholar
• Huang, B., M. Huang, and Q. Li. 2019. “Cancer-Associated Fibroblasts Promote Angiogenesis of Hepatocellular Carcinoma by VEGF-Mediated EZH2/VASH1 Pathway.” Technology in Cancer Research & Treatment 18: 1533033819879905. https://doi.org/10.1177/1533033819879905
   Web of Science ®Google Scholar
• Huang, J. J., and G. C. Blobe. 2016. “Dichotomous Roles of TGF-Beta in Human Cancer.” Biochemical Society Transactions 44 (5): 1441–1454. https://doi.org/10.1042/BST20160065
   PubMedGoogle Scholar
• Iacopetta, B. 2002. “Are There Two Sides to Colorectal Cancer?” International Journal of Cancer 101 (5): 403–408. https://doi.org/10.1002/ijc.10635
   PubMed Web of Science ®Google Scholar
• Jass, J. R. 1983. “Relation between Metaplastic Polyp and Carcinoma of the Colorectum.” Lancet 1 (8314-5): 28–30. https://doi.org/10.1016/s0140-6736(83)91564-7
   PubMed Web of Science ®Google Scholar
• Jenkins, R. W., A. R. Aref, P. H. Lizotte, E. Ivanova, S. Stinson, C. W. Zhou, M. Bowden, et al. 2018. “Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.” Cancer Discovery 8 (2): 196–215. https://doi.org/10.1158/2159-8290.CD-17-0833
   PubMed Web of Science ®Google Scholar
• Joanito, I., P. Wirapati, N. Zhao, Z. Nawaz, G. Yeo, F. Lee, C. L. P. Eng, et al. 2022. “Single-Cell and Bulk Transcriptome Sequencing Identifies Two Epithelial Tumor Cell States and Refines the Consensus Molecular Classification of Colorectal Cancer.” Nature Genetics 54 (7): 963–975. https://doi.org/10.1038/s41588-022-01100-4
   PubMed Web of Science ®Google Scholar
• Katoh, M. 2016. “FGFR Inhibitors: Effects on Cancer Cells, Tumor Microenvironment and Whole-Body Homeostasis (Review).” International Journal of Molecular Medicine 38 (1): 3–15. https://doi.org/10.3892/ijmm.2016.2620
   PubMed Web of Science ®Google Scholar
• Khaliq, A. M., C. Erdogan, Z. Kurt, S. S. Turgut, M. W. Grunvald, T. Rand, S. Khare, et al. 2022. “Refining Colorectal Cancer Classification and Clinical Stratification through a Single-Cell Atlas.” Genome Biology 23 (1): 113. https://doi.org/10.1186/s13059-022-02677-z
   PubMed Web of Science ®Google Scholar
• Kim, K. A., M. Kakitani, J. Zhao, T. Oshima, T. Tang, M. Binnerts, Y. Liu, et al. 2005. “Mitogenic Influence of Human R-spondin1 on the Intestinal Epithelium.” Science 309 (5738): 1256–1259. https://doi.org/10.1126/science.1112521
   PubMed Web of Science ®Google Scholar
• Kong, J. C., M. Flood, R. G. Ramsay, S. K. Warrier, and A. Heriot. 2021. “Shifting the Treatment Paradigm for Patients with Deficient Mismatch Repair Colon Cancer: Is There a Role for Immunotherapy?” ANZ Journal of Surgery 91 (5): 778–780. https://doi.org/10.1111/ans.16485
   PubMed Web of Science ®Google Scholar
• Kong, J. C. H., G. R. Guerra, R. M. Millen, S. Roth, H. Xu, P. J. Neeson, P. K. Darcy, et al. 2018. “Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer.” JCO Precision Oncology 2: 1–15. https://doi.org/10.1200/PO.18.00075
   PubMed Web of Science ®Google Scholar
• Lannagan, T. R. M., Y. K. Lee, T. Wang, J. Roper, M. L. Bettington, L. Fennell, L. Vrbanac, et al. 2019. “Genetic Editing of Colonic Organoids Provides a Molecularly Distinct and Orthotopic Preclinical Model of Serrated Carcinogenesis.” Gut 68 (4): 684–692. https://doi.org/10.1136/gutjnl-2017-315920
   PubMed Web of Science ®Google Scholar
• Li, C., D. Zuo, L. Yin, Y. Lin, C. Li, T. Liu, and L. Wang. 2018. “Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.” Gastroenterology Research and Practice 2018: 6986870. https://doi.org/10.1155/2018/6986870
   PubMed Web of Science ®Google Scholar
• Li, H., E. T. Courtois, D. Sengupta, Y. Tan, K. H. Chen, J. J. L. Goh, S. L. Kong, et al. 2017. “Reference Component Analysis of Single-Cell Transcriptomes Elucidates Cellular Heterogeneity in Human Colorectal Tumors.” Nature Genetics 49 (5): 708–718. https://doi.org/10.1038/ng.3818
   PubMed Web of Science ®Google Scholar
• Lim, J. T. C., L. G. Kwang, N. C. W. Ho, C. C. M. Toh, N. S. H. Too, L. Hooi, T. Benoukraf, et al. 2022. “Hepatocellular Carcinoma Organoid co-Cultures Mimic Angiocrine Crosstalk to Generate Inflammatory Tumor Microenvironment.” Biomaterials 284: 121527. https://doi.org/10.1016/j.biomaterials.2022.121527
   PubMed Web of Science ®Google Scholar
• Linnekamp, J. F., S. R. V. Hooff, P. R. Prasetyanti, R. Kandimalla, J. Y. Buikhuisen, E. Fessler, P. Ramesh, et al. 2018. “Consensus Molecular Subtypes of Colorectal Cancer Are Recapitulated in in Vitro and in Vivo Models.” Cell Death and Differentiation 25 (3): 616–633. https://doi.org/10.1038/s41418-017-0011-5
   PubMed Web of Science ®Google Scholar
• Loree, J. M., and S. Kopetz. 2017. “Recent Developments in the Treatment of Metastatic Colorectal Cancer.” Therapeutic Advances in Medical Oncology 9 (8): 551–564. https://doi.org/10.1177/1758834017714997
   PubMed Web of Science ®Google Scholar
• Loree, J. M., A. A. L. Pereira, M. Lam, A. N. Willauer, K. Raghav, A. Dasari, V. K. Morris, et al. 2018. “Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes.” Clinical Cancer Research 24 (5): 1062–1072. https://doi.org/10.1158/1078-0432.CCR-17-2484
   PubMed Web of Science ®Google Scholar
• Malaterre, J., M. Carpinelli, M. Ernst, W. Alexander, M. Cooke, S. Sutton, S. Dworkin, et al. 2007. “c-Myb is Required for Progenitor Cell Homeostasis in Colonic Crypts.” Proceedings of the National Academy of Sciences of the United States of America 104 (10): 3829–3834. https://doi.org/10.1073/pnas.0610055104
   PubMed Web of Science ®Google Scholar
• Malaterre, J., L. Pereira, T. Putoczki, R. Millen, S. Paquet-Fifield, M. Germann, J. Liu, et al. 2016. “Intestinal-Specific Activatable Myb Initiates Colon Tumorigenesis in Mice.” Oncogene 35 (19): 2475–2484. https://doi.org/10.1038/onc.2015.305
   PubMed Web of Science ®Google Scholar
• Marshall, L. J., M. Triunfol, and T. Seidle. 2020. “Patient-Derived Xenograft vs. Organoids: A Preliminary Analysis of Cancer Research Output, Funding and Human Health Impact in 2014–2019.” Animals 10 (10): 1923. https://doi.org/10.3390/ani10101923
   Web of Science ®Google Scholar
• Martin, S. Z., D. C. Wagner, N. Horner, D. Horst, H. Lang, K. E. Tagscherer, and W. Roth. 2019. “Ex Vivo Tissue Slice Culture System to Measure Drug-Response Rates of Hepatic Metastatic Colorectal Cancer.” BMC Cancer 19 (1): 1030. https://doi.org/10.1186/s12885-019-6270-4
   PubMed Web of Science ®Google Scholar
• Michie, J., P. A. Beavis, A. J. Freeman, S. J. Vervoort, K. M. Ramsbottom, V. Narasimhan, E. J. Lelliott, et al. 2019. “Antagonism of IAPs Enhances CAR T-Cell Efficacy.” Cancer Immunology Research 7 (2): 183–192. https://doi.org/10.1158/2326-6066.CIR-18-0428
   PubMed Web of Science ®Google Scholar
• Moore, S. R., J. Pruszka, J. Vallance, E. Aihara, T. Matsuura, M. H. Montrose, N. F. Shroyer, and C. I. Hong. 2014. “Robust Circadian Rhythms in Organoid Cultures from PERIOD2::LUCIFERASE Mouse Small Intestine.” Disease Models & Mechanisms 7 (9): 1123–1130. https://doi.org/10.1242/dmm.014399
   PubMed Web of Science ®Google Scholar
• Narasimhan, V., J. A. Wright, M. Churchill, T. Wang, R. Rosati, T. R. M. Lannagan, L. Vrbanac, et al. 2020. “Medium-Throughput Drug Screening of Patient-Derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy.” Clinical Cancer Research 26 (14): 3662–3670. https://doi.org/10.1158/1078-0432.CCR-20-0073
   PubMed Web of Science ®Google Scholar
• Nusse, R., and H. Clevers. 2017. “Wnt/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.” Cell 169 (6): 985–999. https://doi.org/10.1016/j.cell.2017.05.016
   PubMed Web of Science ®Google Scholar
• Ooft, S. N., F. Weeber, K. K. Dijkstra, C. M. McLean, S. Kaing, E. van Werkhoven, L. Schipper, et al. 2019. “Patient-Derived Organoids Can Predict Response to Chemotherapy in Metastatic Colorectal Cancer Patients.” Science Translational Medicine 11 (513): . ay2574 https://doi.org/10.1126/scitranslmed.aay2574.
   Web of Science ®Google Scholar
• Pellino, G., O. Warren, S. Mills, S. Rasheed, P. P. Tekkis, and C. Kontovounisios. 2018. “Comparison of Western and Asian Guidelines concerning the Management of Colon Cancer.” Diseases of the Colon and Rectum 61 (2): 250–259. https://doi.org/10.1097/DCR.0000000000001012
   PubMed Web of Science ®Google Scholar
• Riggins, G. J., K. W. Kinzler, B. Vogelstein, and S. Thiagalingam. 1997. “Frequency of Smad Gene Mutations in Human Cancers.” Cancer Res 57 (13): 2578–2580.
   PubMed Web of Science ®Google Scholar
• Rosselot, A. E., M. Park, M. Kim, T. Matsu-Ura, G. Wu, D. E. Flores, K. R. Subramanian, et al. 2022. “Ontogeny and Function of the Circadian Clock in Intestinal Organoids.” The EMBO Journal 41 (2): e106973. https://doi.org/10.15252/embj.2020106973
   PubMed Web of Science ®Google Scholar
• Sato, T., and H. Clevers. 2015. “SnapShot: Growing Organoids from Stem Cells.” Cell 161 (7): 1700–17e1. https://doi.org/10.1016/j.cell.2015.06.028
   PubMed Web of Science ®Google Scholar
• Sato, T., D. E. Stange, M. Ferrante, R. G. Vries, J. H. Van Es, S. Van den Brink, W. J. Van Houdt, et al. 2011. “Long-Term Expansion of Epithelial Organoids from Human Colon, Adenoma, Adenocarcinoma, and Barrett’s Epithelium.” Gastroenterology 141 (5): 1762–1772. https://doi.org/10.1053/j.gastro.2011.07.050
   PubMed Web of Science ®Google Scholar
• Sato, T., J. H. van Es, H. J. Snippert, D. E. Stange, R. G. Vries, M. van den Born, N. Barker, N. F. Shroyer, M. van de Wetering, and H. Clevers. 2011. “Paneth Cells Constitute the Niche for Lgr5 Stem Cells in Intestinal Crypts.” Nature 469 (7330): 415–418. https://doi.org/10.1038/nature09637
   PubMed Web of Science ®Google Scholar
• Schuth, Sebastian, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad, and Oliver Strobel. 2022. “Patient-Specific Modeling of Stroma-Mediated Chemoresistance of Pancreatic Cancer Using a Three-Dimensional Organoid-Fibroblast co-Culture System.” Journal of Experimental & Clinical Cancer Research 41 (1): 312. https://doi.org/10.1186/s13046-022-02519-7
   PubMed Web of Science ®Google Scholar
• Shembrey, Carolyn, Jai Smith, Mélodie Grandin, Nathalia Williams, Hyun-Jung Cho, Christina Mølck, Corina Behrenbruch, et al. 2022. “Longitudinal Monitoring of Intra-Tumoral Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumor Models.” Cancers 14 (3): 581. https://doi.org/10.3390/cancers14030581
   PubMed Web of Science ®Google Scholar
• Stintzing, S., P. Wirapati, H. J. Lenz, D. Neureiter, L. Fischer von Weikersthal, T. Decker, A. Kiani, et al. 2019. “Consensus Molecular Subgroups (CMS) of Colorectal Cancer (CRC) and First-Line Efficacy of FOLFIRI plus Cetuximab or Bevacizumab in the FIRE3 (AIO KRK-0306) Trial.” Annals of Oncology 30 (11): 1796–1803. https://doi.org/10.1093/annonc/mdz387
   PubMed Web of Science ®Google Scholar
• Stokes, K., M. Nunes, C. Trombley, Defl Flores, G. Wu, Z. Taleb, A. Alkhateeb, et al. 2021. “The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation.” Cellular and Molecular Gastroenterology and Hepatology 12 (5): 1847–1872 e0. https://doi.org/10.1016/j.jcmgh.2021.08.001
   PubMed Web of Science ®Google Scholar
• Sulli, G., M. T. Y. Lam, and S. Panda. 2019. “Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment.” Trends in Cancer 5 (8): 475–494. https://doi.org/10.1016/j.trecan.2019.07.002
   PubMed Web of Science ®Google Scholar
• Sveen, A., J. Bruun, P. W. Eide, I. A. Eilertsen, L. Ramirez, A. Murumagi, M. Arjama, et al. 2018. “Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies.” Clinical Cancer Research 24 (4): 794–806. https://doi.org/10.1158/1078-0432.CCR-17-1234
   PubMed Web of Science ®Google Scholar
• Tan, T., Y. Hirokawa, J. Clarke, A. Sakthianandeswaren, and O. M. Sieber. 2022. “Low-Viscosity Matrix Suspension Culture for Human Colorectal Epithelial Organoids and Tumoroids.” Bio-protocol 12 (8): e4394. https://doi.org/10.21769/BioProtoc.4394
   PubMed Web of Science ®Google Scholar
• Trumpi, K., I. Ubink, A. Trinh, M. Djafarihamedani, J. M. Jongen, K. M. Govaert, S. G. Elias, et al. 2017. “Neoadjuvant Chemotherapy Affects Molecular Classification of Colorectal Tumors.” Oncogenesis 6 (7): e357. https://doi.org/10.1038/oncsis.2017.48
   PubMedGoogle Scholar
• Ubink, I., W. J. van Eden, P. Snaebjornsson, N. F. M. Kok, J. van Kuik, W. M. U. van Grevenstein, M. M. Lacle, et al. 2018. “Histopathological and Molecular Classification of Colorectal Cancer and Corresponding Peritoneal Metastases.” The British Journal of Surgery 105 (2): e204–e11. https://doi.org/10.1002/bjs.10788
   PubMed Web of Science ®Google Scholar
• van de Wetering, M., H. E. Francies, J. M. Francis, G. Bounova, F. Iorio, A. Pronk, W. van Houdt, et al. 2015. “Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients.” Cell 161 (4): 933–945. https://doi.org/10.1016/j.cell.2015.03.053
   PubMed Web of Science ®Google Scholar
• Varga, J., A. Nicolas, V. Petrocelli, M. Pesic, A. Mahmoud, B. E. Michels, E. Etlioglu, et al. 2020. “AKT-Dependent NOTCH3 Activation Drives Tumor Progression in a Model of Mesenchymal Colorectal Cancer.” Journal of Experimental Medicine 217 (10): . 0191515 https://doi.org/10.1084/jem.20191515.
   Web of Science ®Google Scholar
• Varinelli, Luca, Marcello Guaglio, Silvia Brich, Susanna Zanutto, Antonino Belfiore, Federica Zanardi, Fabio Iannelli, et al. 2021. “Decellularized Normal and Tumor Scaffolds for Cancer Organoid Cultures as a Model of Colorectal Peritoneal Metastases.” bioRxiv:2021.07.15.452437. https://doi.org/10.1101/2021.07.15.452437
   Google Scholar
• Vincan, E., P. K. Darcy, C. A. Farrelly, M. C. Faux, T. Brabletz, and R. G. Ramsay. 2007. “Frizzled-7 Dictates Three-Dimensional Organization of Colorectal Cancer Cell Carcinoids.” Oncogene 26 (16): 2340–2352. https://doi.org/10.1038/sj.onc.1210026
   PubMed Web of Science ®Google Scholar
• Wang, F., J. Long, L. Li, Z. B. Zhao, F. Wei, Y. Yao, W. J. Qiu, et al. 2020. “Mutations in the Notch Signaling Pathway Are Associated with Enhanced anti-Tumor Immunity in Colorectal Cancer.” Journal of Cellular and Molecular Medicine 24 (20): 12176–12187. https://doi.org/10.1111/jcmm.15867
   PubMed Web of Science ®Google Scholar
• Wang, J., Z. Xu, Z. Wang, G. Du, and L. Lun. 2021. “TGF-Beta Signaling in Cancer Radiotherapy.” Cytokine 148: 155709. https://doi.org/10.1016/j.cyto.2021.155709
   PubMed Web of Science ®Google Scholar
• Wang, X., Y. Yamamoto, L. H. Wilson, T. Zhang, B. E. Howitt, M. A. Farrow, F. Kern, et al. 2015. “Cloning and Variation of Ground State Intestinal Stem Cells.” Nature 522 (7555): 173–178. https://doi.org/10.1038/nature14484
   PubMed Web of Science ®Google Scholar
• Weeber, F., S. N. Ooft, K. K. Dijkstra, and E. E. Voest. 2017. “Tumor Organoids as a Pre-Clinical Cancer Model for Drug Discovery.” Cell Chemical Biology 24 (9): 1092–1100. https://doi.org/10.1016/j.chembiol.2017.06.012
   PubMed Web of Science ®Google Scholar
• Weng, A. P., A. A. Ferrando, W. Lee, J. P. Th Morris, L. B. Silverman, C. Sanchez-Irizarry, S. C. Blacklow, A. T. Look, and J. C. Aster. 2004. “Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia.” Science 306 (5694): 269–271. https://doi.org/10.1126/science.1102160
   PubMed Web of Science ®Google Scholar
• Whitehead, R. H., K. Demmler, S. P. Rockman, and N. K. Watson. 1999. “Clonogenic Growth of Epithelial Cells from Normal Colonic Mucosa from Both Mice and Humans.” Gastroenterology 117 (4): 858–865. https://doi.org/10.1016/s0016-5085(99)70344-6
   PubMed Web of Science ®Google Scholar
• Xu, H., Y. Yan, S. Deb, D. Rangasamy, M. Germann, J. Malaterre, N. C. Eder, et al. 2014. “Cohesin Rad21 Mediates Loss of Heterozygosity and is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors.” Cell Reports 9 (5): 1781–1797. https://doi.org/10.1016/j.celrep.2014.10.059
   PubMed Web of Science ®Google Scholar
• Yamamoto, T., K. Kawada, Y. Itatani, S. Inamoto, R. Okamura, M. Iwamoto, E. Miyamoto, et al. 2017. “Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis.” Clinical Cancer Research 23 (3): 833–844. https://doi.org/10.1158/1078-0432.CCR-16-0520
   PubMed Web of Science ®Google Scholar
• You, Y. N., K. M. Hardiman, A. Bafford, V. Poylin, T. D. Francone, K. Davis, I. M. Paquette, et al. 2020. “The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer.” Diseases of the Colon and Rectum 63 (9): 1191–1222. https://doi.org/10.1097/DCR.0000000000001762
   PubMed Web of Science ®Google Scholar
• Zhang, J., B. Chen, H. Li, Y. Wang, X. Liu, K. Y. Wong, W. N. Chan, et al. 2022. “Cancer-Associated Fibroblasts Potentiate Colorectal Cancer Progression by Crosstalk of the IGF2-IGF1R and Hippo-YAP1 Signaling Pathways.” The Journal of Pathology, 2022, 033 doi: 10.1002/path.6033.
   Google Scholar
• Zhong, W., J. S. Myers, F. Wang, K. Wang, J. Lucas, E. Rosfjord, J. Lucas, et al. 2020. “Comparison of the Molecular and Cellular Phenotypes of Common Mouse Syngeneic Models with Human Tumors.” BMC Genomics 21 (1): 2. https://doi.org/10.1186/s12864-019-6344-3
   PubMed Web of Science ®Google Scholar
• Zorbas, M., C. Sicurella, I. Bertoncello, D. Venter, S. Ellis, M. L. Mucenski, and R. G. Ramsay. 1999. “c-Myb is Critical for Murine Colon Development.” Oncogene 18 (42): 5821–5830. https://doi.org/10.1038/sj.onc.1202971
   PubMed Web of Science ®Google Scholar