279
Views
48
CrossRef citations to date
0
Altmetric
Research Article

Activation of the Human Complement System by Cholesterol-Rich and PEGylated Liposomes—Modulation of Cholesterol-Rich Liposome-Mediated Complement Activation by Elevated Serum LDL and HDL Levels

, , , , , , , & show all
Pages 167-174 | Received 01 May 2006, Accepted 30 May 2006, Published online: 09 Dec 2008

References

  • Alberts D. S., Garcia D. J. Safety aspects of pegylated liposomal doxorubicin in patients with cancer. Drugs 1997; 54(Suppl.)30–45, [INFOTRIEVE], [CSA]
  • Andresen T. L., Davidsen J., Begtrup M., Mouritsen O. G., Jørgensen K. Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs. J. Med. Chem 2004; 47: 1694–1703, [INFOTRIEVE], [CSA], [CROSSREF]
  • Chanan-Khan A., Szebeni J., Savay S., Liebes L., Rafique N. M., Alving C. R., Muggia F. M. Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions. Annal. Oncology 2003; 14: 1430–1437, [CSA], [CROSSREF]
  • Chonn A., Cullis P. R., Devine D. V. The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. J. Immunol 1991; 146: 4234–4241, [INFOTRIEVE], [CSA]
  • Dezube B. J. Safety assessment: Doxil® (doxorubicin HCl liposome injection) in refractory AIDS-related Kaposi's sarcoma. Doxil Clinical Series. Gardiner-Caldwell SynerMed, Califon, NJ 1996; 1–8
  • Kent K. M., Cleman M. W., Cowley M. J., Forman M. B., Jaffe C. C., Kaplan M., King S. B., Krucoff M. W., Lassar T., Mcauley B., Smith R., Wisdom C., Wohlgelernter D. Reduction of myocardial ischemia during percutaneous coronary angioplasty with oxygenated Fluosol. Am. J. Cardiol 1990; 66: 279–284, [INFOTRIEVE], [CSA], [CROSSREF]
  • Levine S. J., Walsh T. J., Martinez A., Eichacker P. Q., Lopez-Berstein G., Natanson C. Cardiopulmonary toxicity after liposomal amphotericin B infusion. Ann. Intern. Med 1991; 114: 664–666, [INFOTRIEVE], [CSA]
  • Lustig R., McIntosh-Lowe N., Rose C., Haas J., Krasnow S., Spaulding M., Prosnitz L. Phase I/II study of Fluosol-DA and 100% oxygen as an adjuvant to radiation in the treatment of advanced squamous cell tumours of the head and neck. Int. J. Radiat. Oncol. Biol. Phys 1989; 16: 1587–1593, [INFOTRIEVE], [CSA]
  • Lutz H. U., Stammler P., Jelezarova E., Nater M., Spath P. J. High doses of immunoglobulin G attenuate immune aggregate-mediated complement activation by enhancing physiologic cleavage of C3b in C3bn-IgG complexes. Blood 1996; 88: 184–193, [INFOTRIEVE], [CSA]
  • McLoughlin T. M., Fontana J. L., Alving C. R., Mongan P. D., Bünger R. Profound normovolemic hemodilution: hemostatic effects in patients and in a porcine model. Anesth. Analg 1996; 83: 459–465, [INFOTRIEVE], [CSA], [CROSSREF]
  • Moghimi S. M., Andresen T. L., Jørgensen K., Szebeni J. Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production in human serum. 2006, (Submitted)[CSA]
  • Moghimi S. M., Hunter A. C. Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups. Pharm. Res 2001; 18: 1–8, [INFOTRIEVE], [CSA], [CROSSREF]
  • Moghimi S. M., Hunter A. C., Dadswell C. M., Savay S., Alving C. R., Szebeni J. Causative factors behind poloxamer 188 (Pluronic F68, Flocor™)-induced complement activation in human sera. A protective role against poloxamer-mediated complement activation by elevated serum lipoprotein levels. Biochim. Biophys. Acta (Mol. Basis Disease) 2004; 1689: 103–113, [CSA], [CROSSREF]
  • Moghimi S. M., Szebeni J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog. Lipid Res 2003; 42: 463–478, [INFOTRIEVE], [CSA], [CROSSREF]
  • Moore F. D., Jr. Therapeutic regulation of the complement system in acute injury states. Adv. Immunol 1994; 56: 267–299, [INFOTRIEVE], [CSA]
  • Police A. M., Waxman K., Tominaga G. Pulmonary complications after Fluosol administration to patients with life-threatening blood loss. Crit. Care Med 1985; 13: 96–98, [INFOTRIEVE], [CSA]
  • Ringdén O., Andström E., Remberger M., Svahn B. M., Tollemar J. Allergic reactions and other rare side effects of liposomal amphotericin. Lancet 1994; 344: 1156–1157, [CSA]
  • Szebeni J., Baranyi B., Savay S., Bodo M., Morse D. S., Basta M., Stahl G. L., Bunger R., Alving C. R. Liposome-induced pulmonary hypertension in pigs: properties and mechanism of a complement-mediated pseudoallergic reaction. Am. J. Physiol. (Heart Circ. Physiol.) 2000a; 279: H1319–H1328, [CSA]
  • Szebeni J., Baranyi L., Savay S., Lutz H. U., Jelezarova E., Bunger R., Alving C. R. The role of complement activation in hypersensitivity to pegylated liposomal doxorubicin (Doxil®). J. Liposome Res 2000; 10: 469–481, [CSA]
  • Szebeni J., Baranyi L., Savay S., Milosevits J., Bubger R., Laverman P., Metselaar J. M., Storm G., Chanan-Khan A., Liebes L., Muggia F. M., Cohen R., Barenholz Y., Alving C. R. Role of complement activation in hypersensitivity reactions to doxil and HYNICPEG liposomes: experimental and clinical studies. J. Liposome Res 2002; 12: 165–172, [INFOTRIEVE], [CSA], [CROSSREF]
  • Szebeni J., Fontana J. L., Wassef N. M., Mongan P. D., Morse D. S., Dobbins D. E., Stahl G. L., Bünger R., Alving C. R. Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs. A model for pseudoallergic cardiopulmonary reactions to liposomes: role of complement and inhibition by soluble CR1 and anti-C5a antibody. Circulation 1999; 99: 2302–2309, [INFOTRIEVE], [CSA]
  • Tremper K. K., Friedman A. E., Levine E. M., Lapin R., Camarillo D. The preoperative treatment of severely anemic patients with a perfluorochemical oxygen-transport fluid, Fluosol-DA. N. Engl. J. Med 1984; 12: 428–431, [CSA]
  • Vercellotti G. M., Hammerschmidt D. E., Craddock P. R., Jacob H. S. Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroid prophylaxis. Blood 1982; 59: 1299–1304, [INFOTRIEVE], [CSA]
  • Zakharov A. T. S., Ivanov A. S., Echkalov A. P., Berezov A. T., Khalilov E. M., Archakov A. I. Effect of the cholesterol content in liposomes on their interaction with blood-serum lipoproteins. Biochemistry (Moscow) 1994; 59: 525–530, [CSA]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.