A comprehensive review on lipid nanocarrier systems for cancer treatment: fabrication, future prospects and clinical trials

References

• Abd El-Alim, S.H., et al., 2019. Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: in vitro and in vivo evaluation. International journal of pharmaceutics, 563, 293–303.
   PubMed Web of Science ®Google Scholar
• Abdelbaky, S.B., et al., 2021. Cancer immunotherapy from biology to nanomedicine. Journal of controlled release, 336 (March), 410–432.
   PubMedGoogle Scholar
• Abdelkader, H., Alani, A.W.G., and Alany, R.G., 2014. Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations. Drug Delivery, 21 (2), 87–100.
   PubMed Web of Science ®Google Scholar
• Abdelmoneem, M.A., et al., 2019. Dual-targeted lactoferrin shell-oily core nanocapsules for synergistic targeted/herbal therapy of hepatocellular carcinoma. ACS applied materials & interfaces, 11 (30), 26731–26744.
   PubMed Web of Science ®Google Scholar
• Abdel-Salam, F.S., et al., 2017. Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. Journal of liposome research, 27 (1), 41–55.
   PubMed Web of Science ®Google Scholar
• Abd-Rabou, A.A., Bharali, D.J., and Mousa, S.A., 2020. Viramidine-loaded galactosylated nanoparticles induce hepatic cancer cell apoptosis and inhibit angiogenesis. Applied biochemistry and biotechnology, 190 (1), 305–324.
   PubMed Web of Science ®Google Scholar
• Aboul-Einien, M.H., et al., 2020. Ascorbic acid derivative-loaded modified aspasomes: formulation, in vitro, ex vivo and clinical evaluation for melasma treatment. Journal of liposome research, 30 (1), 54–67.
   PubMed Web of Science ®Google Scholar
• Abu-Azzam, O., and Nasr, M., 2020. In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis. Pharmaceutical Development and Technology, 25 (8), 930–935.
   PubMed Web of Science ®Google Scholar
• Adel, I.M., et al., 2021. Design and characterization of spray-dried proliposomes for the pulmonary delivery of curcumin. International journal of nanomedicine, 16, 2667–2687.
   PubMed Web of Science ®Google Scholar
• Agrawal, U., et al., 2015. Tailored polymer–lipid hybrid nanoparticles for the delivery of drug conjugate: dual strategy for brain targeting. Colloids and Surfaces. B, Biointerfaces, 126, 414–425.
   PubMed Web of Science ®Google Scholar
• Ahad, A., et al., 2018. Formulation and characterization of Phospholipon 90 G and tween 80 based transfersomes for transdermal delivery of eprosartan mesylate. Pharmaceutical development and technology, 23 (8), 787–793.
   PubMed Web of Science ®Google Scholar
• Ahmed, S., and Rai, K.R., 2003. Interferon in the treatment of hairy-cell leukemia. Best practice & research clinical haematology, 16 (1), 69–81.
   PubMed Web of Science ®Google Scholar
• Ainbinder, D., and Touitou, E., 2005. Testosterone ethosomes for enhanced transdermal delivery. Drug delivery, 12 (5), 297–303.
   PubMed Web of Science ®Google Scholar
• Alberti, L., et al., 2003. RET and NTRK1 proto-oncogenes in human diseases. Journal of cellular physiology, 195 (2), 168–186.
   PubMed Web of Science ®Google Scholar
• Aldalaen, S., Nasr, M., and El-Gogary, R.I., 2020. Angiogenesis and collagen promoting nutraceutical-loaded nanovesicles for wound healing. Journal of drug delivery science and technology, 56, 101548.
   Web of Science ®Google Scholar
• Aldawsari, H.M., and Singh, S., 2020. Rapid microwave-assisted cisplatin-loaded solid lipid nanoparticles : synthesis, characterization and anticancer study. Nanomaterials, 10 (3), 510.
   Web of Science ®Google Scholar
• Alexander, J.S., et al., 2010. Gastrointestinal lymphatics in health and disease. Pathophysiology, 17 (4), 315–335.
   PubMedGoogle Scholar
• Al-Karaki, R., et al., 2020. Preparation, characterization and cytotoxic activity of new oleuropein microemulsion against HCT-116 colon cancer cells. Pharmaceutical chemistry journal, 53 (12), 1118–1121.
   Web of Science ®Google Scholar
• Allen, T.M., and Martin, F.J., 2004. Advantages of liposomal delivery systems for anthracyclines. Seminars in oncology, 31 (6 Suppl 13), 5–15.
   PubMed Web of Science ®Google Scholar
• Al-mahallawi, A.M., Khowessah, O.M., and Shoukri, R.A., 2017. Enhanced non invasive trans-tympanic delivery of ciprofloxacin through encapsulation into nano-spanlastic vesicles: fabrication, in-vitro characterization, and comparative ex-vivo permeation studies. International Journal of pharmaceutics, 522 (1–2), 157–164.
   PubMed Web of Science ®Google Scholar
• Alves, G., et al., 2021. Mitoxantrone-loaded lipid nanoparticles for breast cancer therapy – quality-by-design approach and efficacy assessment in 2D and 3D in vitro cancer models. International journal of pharmaceutics, 607 (June), 0378–5173.
   Google Scholar
• Alwan, L.M., et al., 2014. Comparison of acute toxicity and mortality after two different dosing regimens of high-dose interleukin-2 for patients with metastatic melanoma. Targeted oncology, 9 (1), 63–71.
   PubMed Web of Science ®Google Scholar
• Ambekar, R.S., Choudhary, M., and Kandasubramanian, B., 2020. Recent advances in dendrimer-based nanoplatform for cancer treatment: a review. European polymer journal, 126, 109546.
   Web of Science ®Google Scholar
• Amer, S.S., et al., 2020. Cosm-nutraceutical nanovesicles for acne treatment: Physicochemical characterization and exploratory clinical experimentation. International journal of pharmaceutics, 577, 119092.
   PubMed Web of Science ®Google Scholar
• Arastu-Kapur, S., et al., 2011. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clinical Cancer Research, 17 (9), 2734–2743.
   PubMed Web of Science ®Google Scholar
• Arduino, I., et al., 2021. Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by microfluidic technique. Acta biomaterialia, 121, 566–578.
   PubMed Web of Science ®Google Scholar
• Arora, N., Gupta, A., and Singh, P.P., 2017. Biological agents in gastrointestinal cancers: adverse effects and their management. Journal of gastrointestinal oncology, 8 (3), 485–498.
   PubMed Web of Science ®Google Scholar
• Asatsuma-Okumura, T., Ito, T., and Handa, H., 2020. Molecular mechanisms of the teratogenic effects of thalidomide. Pharmaceuticals, 13 (5), 95.
   Web of Science ®Google Scholar
• Ashraf, O., et al., 2018. In vitro stabilization and in vivo improvement of ocular pharmacokinetics of the multi-therapeutic agent baicalin: delineating the most suitable vesicular systems. International journal of pharmaceutics, 539 (1–2), 83–94.
   PubMed Web of Science ®Google Scholar
• Attama, A.A., Momoh, M.A., and Builders, P.F., 2012. Chapter 5-lipid nanoparticulate drug delivery systems: a revolution in dosage form design and development. Recent advances in novel drug carrier systems, 5, 107–140.
   Google Scholar
• Badawi, A.A., et al., 2009. Preparation and evaluation of microemulsion systems containing salicylic acid. AAPS PharmSciTech, 10 (4), 1081–1084.
   PubMed Web of Science ®Google Scholar
• Baek, J., Na, Y., and Cho, C., 2018. Sustained cytotoxicity of wogonin on breast cancer cells by encapsulation in solid lipid nanoparticles. Nanomaterials, 8 (3), 159.
   Web of Science ®Google Scholar
• Baguley, B.C., 2010. Multiple drug resistance mechanisms in cancer. Molecular biotechnology, 46 (3), 308–316.
   PubMed Web of Science ®Google Scholar
• Baig, B., et al., 2019. Current status of nanomaterial-based treatment for hepatocellular carcinoma. Biomedecine & Pharmacotherapie [Biomedicine & Pharmacotherapy], 116, 108852.
   PubMed Web of Science ®Google Scholar
• Baillie, A.J., et al., 1985. The preparation and properties of niosomes—non-ionic surfactant vesicles. The journal of pharmacy and pharmacology, 37 (12), 863–868.
   PubMed Web of Science ®Google Scholar
• Banerjee, I., et al., 2016. Paclitaxel-loaded solid lipid nanoparticles modified with Tyr-3-octreotide for enhanced anti-angiogenic and anti-glioma therapy. Acta biomaterialia, 38, 69–81.
   PubMed Web of Science ®Google Scholar
• Bangham, A.D., Standish, M.M., and Watkins, J.C., 1965. Diffusion of univalent ions across the lamellae of swollen phospholipids. Journal of molecular biology, 13 (1), 238–252.
   PubMed Web of Science ®Google Scholar
• Basha, S.K., et al., 2021. Solid lipid nanoparticles for oral drug delivery. Materials today: proceedings, 36, 313–324.
   Google Scholar
• Baskar, R., et al., 2012. Cancer and radiation therapy: current advances and future directions. International journal of medical sciences, 9 (3), 193–199.
   PubMed Web of Science ®Google Scholar
• Battaglia, L., et al., 2014. Solid lipid nanoparticles for potential doxorubicin delivery in glioblastoma treatment: preliminary in vitro studies. Journal of pharmaceutical sciences, 103 (7), 2157–2165.
   PubMed Web of Science ®Google Scholar
• Battaglia, L., and Gallarate, M., 2012. Lipid nanoparticles: State of the art, new preparation methods and challenges in drug delivery. Expert opinion on drug delivery, 9 (5), 497–508.
   PubMed Web of Science ®Google Scholar
• Behranvand, N., et al., 2022. Chemotherapy: a double-edged sword in cancer treatment. Cancer immunology, immunotherapy, 71 (3), 507–526.
   PubMed Web of Science ®Google Scholar
• Ben-Sasson, S.Z., et al., 2009. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proceedings of the National Academy of Sciences of the United States of America, 106 (17), 7119–7124.
   PubMed Web of Science ®Google Scholar
• Bertsimas, D., et al., 2016. An analytics approach to designing combination chemotherapy regimens for cancer. Management science, 62 (5), 1511–1531.
   Web of Science ®Google Scholar
• Bidros, D.S., Liu, J.K., and Vogelbaum, M.A., 2010. Future of convection-enhanced delivery in the treatment of brain tumors. Future oncology, 6 (1), 117–125.
   PubMed Web of Science ®Google Scholar
• Blick, S.K.A., and Scott, L.J., 2007. Cetuximab. Drugs, 67 (17), 2585–2607.
   PubMedGoogle Scholar
• Bobo, R.H., et al., 1994. Convection-enhanced delivery of macromolecules in the brain. Proceedings of the National Academy of Sciences of the United States of America, 91 (6), 2076–2080.
   PubMed Web of Science ®Google Scholar
• Boonme, P., et al., 2013. Influence of lipids on the properties of solid lipid nanoparticles from microemulsion technique. European journal of lipid science and technology, 115 (7), 820–824.
   Web of Science ®Google Scholar
• Boulikas, T., and Vougiouka, M., 2003. Cisplatin and platinum drugs at the molecular level. Oncology reports, 10 (6), 1663–1682.
   PubMed Web of Science ®Google Scholar
• Bseiso, E.A., et al., 2016. Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis. Drug delivery, 23 (8), 2813–2819.
   PubMed Web of Science ®Google Scholar
• Carneiro, B.A., and El-Deiry, W.S., 2020. Targeting apoptosis in cancer therapy. Nature reviews-clinical oncology, 17 (7), 395–417.
   PubMed Web of Science ®Google Scholar
• Carrick, S., et al., 2009. Single agent versus combination chemotherapy for metastatic breast. Cochrane database of systematic reviews, 2021 (5), 1465–1858.
   Google Scholar
• Chan, H.-K., and Kwok, P.C.L., 2011. Production methods for nanodrug particles using the bottom-up approach. Advanced drug delivery reviews, 63 (6), 406–416.
   PubMed Web of Science ®Google Scholar
• Chana, J., Forbes, B., and Jones, S.A., 2015. Triggered-release nanocapsules for drug delivery to the lungs. Nanomedicine, 11 (1), 89–97.
   PubMed Web of Science ®Google Scholar
• Charles, O., James, C.D., and Park, J.W., 2013. Convection-enhanced delivery of targeted quantum dot – immunoliposome hybrid nanoparticles to intracranial brain tumor models. Nanomedicine, 8 (12), 1913–1925.
   PubMed Web of Science ®Google Scholar
• Chauhan, D.S., et al., 2021. Nanotechnology synergized immunoengineering for cancer. European journal of pharmaceutics and biopharmaceutics, 163 (December 2020), 72–101.
   PubMedGoogle Scholar
• Chen, J., et al., 2016. Natural terpenes as penetration enhancers for transdermal drug delivery. Molecules, 21 (12), 1709.
   PubMed Web of Science ®Google Scholar
• Chen, S., et al., 2019. Recent advances in non-ionic surfactant vesicles (niosomes): fabrication, characterization, pharmaceutical and cosmetic applications. European journal of pharmaceutics and biopharmaceutics 144, 18–39.
   PubMed Web of Science ®Google Scholar
• Cheng, Y., et al., 2018. Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma. International journal of pharmaceutics, 545 (1–2), 261–273.
   PubMed Web of Science ®Google Scholar
• Chen, L., Liu, S., and Tao, Y., 2020. Regulating tumor suppressor genes: post-translational modifications. Signal transduction and targeted therapy, 5 (1), 90.
   PubMed Web of Science ®Google Scholar
• Chirio, D., et al., 2014. Positive-charged solid lipid nanoparticles as paclitaxel drug delivery system in glioblastoma treatment. European journal of pharmaceutics and biopharmaceutics, 88 (3), 746–758.
   PubMed Web of Science ®Google Scholar
• Choi, E.-H., et al., 2020. Maintenance of genome integrity and active homologous recombination in embryonic stem cells. Experimental & molecular medicine, 52 (8), 1220–1229.
   PubMed Web of Science ®Google Scholar
• Clawson, C., et al., 2011. Synthesis and characterization of lipid-polymer hybrid nanoparticles with ph-triggered poly(ethylene glycol) shedding. Langmuir, 27 (17), 10556–10561.
   PubMed Web of Science ®Google Scholar
• Cohen, S.M., et al., 2001. Cisplatin: from DNA damage to cancer chemotherapy. Progress in nucleic acid research and molecular biology. Academic Press, (67), 93–130.
   Google Scholar
• Constantinescu, S.N., et al., 1994. Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex. Proceedings of the National Academy of Sciences of the United States of America, 91 (20), 9602–9606.
   PubMed Web of Science ®Google Scholar
• Corrales, L., et al., 2015. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell reports, 11 (7), 1018–1030.
   PubMed Web of Science ®Google Scholar
• Cox, M.A., Harrington, L.E., and Zajac, A.J., 2011. Cytokines and the inception of CD8 T cell responses. Trends in Immunology, 32 (4), 180–186.
   PubMed Web of Science ®Google Scholar
• Crane, E., and List, A., 2005. Immunomodulatory drugs. Cancer investigation, 23 (7), 625–634.
   PubMed Web of Science ®Google Scholar
• Crown, J., and O’Leary, M., 2000. The taxanes: an update. The Lancet, 355 (9210), 1176–1178.
   PubMed Web of Science ®Google Scholar
• Cuya, S.M., Bjornsti, M.A., and van Waardenburg, R.C.A.M., 2017. DNA topoisomerase-targeting chemotherapeutics: what’s new? Cancer chemotherapy and pharmacology, 80 (1), 1–14.
   PubMed Web of Science ®Google Scholar
• Dahan, A., and Hoffman, A., 2008. Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs. Journal of controlled release, 129 (1), 1–10.
   PubMed Web of Science ®Google Scholar
• Dallavalle, S., et al., 2020. Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors. Drug resistance updates, 50, 100682.
   PubMed Web of Science ®Google Scholar
• de Souza Guedes, L., et al., 2021. An overview on topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles. Antioxidants, 10 (7), 1034.
   Web of Science ®Google Scholar
• Demaria, S., Golden, E.B., and Formenti, S.C., 2015. Role of local radiation therapy in cancer immunotherapy. JAMA oncology, 1 (9), 1325–1332.
   PubMed Web of Science ®Google Scholar
• DeSantis, C.E., et al., 2014. Cancer treatment and survivorship statistics. A cancer journal for clinicians, 64 (4), 252–271.
   PubMed Web of Science ®Google Scholar
• Dickens, E., and Ahmed, S., 2018. Principles of cancer treatment by chemotherapy. Surgery, 36 (3), 134–138.
   Google Scholar
• Digklia, A., and Wagner, A.D., 2016. Advanced gastric cancer: current treatment landscape and future perspectives. World journal of gastroenterology, 22 (8), 2403–2414.
   PubMed Web of Science ®Google Scholar
• Dimitroulis, D., et al., 2017. From diagnosis to treatment of hepatocellular carcinoma: an epidemic problem for both developed and developing world. World journal of gastroenterology, 23 (29), 5282.
   PubMed Web of Science ®Google Scholar
• Ding, L., et al., 2021. Pulmonary siRNA delivery for lung disease: review of recent progress and challenges. Journal of controlled release, 330, 977–991.
   PubMed Web of Science ®Google Scholar
• Ding, Y., et al., 2018. Lipid-drug-conjugate (LDC) solid lipid nanoparticles (SLN) for the delivery of nicotine to the oral cavity – optimization of nicotine loading efficiency. European Journal of Pharmaceutics and Biopharmaceutics, 128, 10–17.
   PubMed Web of Science ®Google Scholar
• Doktorovova, S., Shegokar, R., and Souto, E. B., 2017. Chapter 30 – role of excipients in formulation development and biocompatibility of lipid nanoparticles (SLNs/NLCs). In: D. Ficai and A.M.B.T.N Grumezescu, eds. Micro and nano technologies, Nanostructures for Novel Therapy, Elsevier, 811–843.
   Google Scholar
• Dos Santos, M., et al., 2020. Minibeam radiation therapy: a micro- and nano-dosimetry Monte Carlo study. Medical Physics, 47 (3), 1379–1390.
   PubMed Web of Science ®Google Scholar
• Dowell, J.E., and Palmer, B.F., 2010. Small cell lung cancer: are we making progress? The American journal of the medical sciences, 339 (1), 68–76.
   PubMed Web of Science ®Google Scholar
• Dragicevic-Curic, N., et al., 2008. Temoporfin-loaded invasomes: development, characterization and in vitro skin penetration studies. Journal of controlled release, 127 (1), 59–69.
   PubMed Web of Science ®Google Scholar
• Duan, Y., et al., 2020. A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems. RSC advances, 10 (45), 26777–26791.
   PubMed Web of Science ®Google Scholar
• Duan, W., and Liu, Y., 2018. Targeted and synergistic therapy for hepatocellular carcinoma: Monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib. Drug design, development and therapy, 12, 2149–2161.
   PubMed Web of Science ®Google Scholar
• Dudhipala, N., et al., 2020. Effect of lipid and edge activator concentration on development of aceclofenac-loaded transfersomes gel for transdermal application: in vitro and ex vivo skin permeation. Drug development and industrial pharmacy, 46 (8), 1334–1344.
   PubMed Web of Science ®Google Scholar
• Eble, J.A., and Niland, S., 2019. The extracellular matrix in tumor progression and metastasis. Clinical & experimental metastasis, 36 (3), 171–198.
   PubMed Web of Science ®Google Scholar
• El Hoffy, N.M., et al., 2021. Glaucoma: management and future perspectives for nanotechnology-based treatment modalities. European journal of pharmaceutical sciences, 158, (July 2020), 105648.
   PubMedGoogle Scholar
• Elder, K., et al., 2021. Endocrine therapy for cancer. Surgery, 39 (4), 208–214.
   Google Scholar
• ElKasabgy, N.A., Elsayed, I., and Elshafeey, A.H., 2014. Design of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: in-vitro and in-vivo characterization. International journal of pharmaceutics, 472 (1–2), 369–379.
   PubMed Web of Science ®Google Scholar
• El-Kayal, M., et al., 2019. Colloidal (-)-epigallocatechin-3-gallate vesicular systems for prevention and treatment of skin cancer: a comprehensive experimental study with preclinical investigation. European Journal of Pharmaceutical Sciences, 137, 104972.
   PubMed Web of Science ®Google Scholar
• Ellis, L.M., 2006. Mechanisms of action of bevacizumab as a component of therapy for metastatic colorectal cancer. Seminars in oncology, 33 (5 Suppl 10), S1–S7.
   PubMed Web of Science ®Google Scholar
• ElMeshad, A.N., and Mohsen, A.M., 2016. Enhanced corneal permeation and antimycotic activity of itraconazole against Candida albicans via a novel nanosystem vesicle. Drug delivery, 23 (7), 2115–2123.
   PubMed Web of Science ®Google Scholar
• Elmowafy, E., et al., 2019. Novel antipsoriatic fluidized spanlastic nanovesicles: in vitro physicochemical characterization, ex vivo cutaneous retention and exploratory clinical therapeutic efficacy. International journal of pharmaceutics, 568 (April), 118556.
   PubMedGoogle Scholar
• El-Nabarawi, M.A., et al., 2018. Dapsone-loaded invasomes as a potential treatment of acne: preparation, characterization, and in vivo skin deposition assay. AAPS Pharmscitech, 19 (5), 2174–2184.
   PubMed Web of Science ®Google Scholar
• Elsayed, I., et al., 2019. Tripling the bioavailability of rosuvastatin calcium through development and optimization of an in-situ forming nanovesicular system. Pharmaceutics, 11 (6), 275.
   PubMed Web of Science ®Google Scholar
• El‐Serag, H. B., 2020. Epidemiology of hepatocellular carcinoma. In: I.M. Arias, H.J. Alter, J.L. Boyer, D.E. Cohen, D.A. Shafritz, S.S. Thorgeirsson, and A.W. Wolkoff, eds. The liver. Wiley, 758–772.
   Google Scholar
• El-Sherbiny, I.M., et al., 2017. Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases. Nanomedicine, 12 (4), 387–402.
   PubMed Web of Science ®Google Scholar
• El-Subbagh, H. I., and Al-Badr, A. A., 2009. Cytarabine. In: H. G. Brittain ed., Profiles of drug substances, excipients and related methodology. 34th edn., Academic Press, (34), 37–113.
   Google Scholar
• Eskiler, G., et al., 2018. Solid lipid nanoparticles: Reversal of tamoxifen resistance in breast cancer. European journal of pharmaceutical sciences 120 (March), 73–88.
   PubMedGoogle Scholar
• Esposito, E., et al., 2003. Lipid-based supramolecular systems for topical application: a preformulatory study. AAPS pharmsci, 5 (4), 62–76.
   Google Scholar
• Fan, X., et al., 2021. Synergistic combination therapy of lung cancer using lipid-layered cisplatin and oridonin co-encapsulated nanoparticles. Biomedecine & Pharmacotherapie [Biomedicine & pharmacotherapy], 141, 111830.
   PubMed Web of Science ®Google Scholar
• Fang, C.-L., et al., 2013. Nanostructured lipid carriers (NLCs) for drug delivery and targeting. Recent patents on nanotechnology, 7 (1), 41–55.
   PubMed Web of Science ®Google Scholar
• Fauvel, M., et al., 2012. Aerosolized liposomal amphotericin B: prediction of lung deposition, in vitro uptake and cytotoxicity. International journal of pharmaceutics, 436 (1–2), 106–110.
   PubMed Web of Science ®Google Scholar
• Fawzi Kabil, M., Nasr, M., and El-Sherbiny, I.M., 2021. Conventional and hybrid nanoparticulate systems for the treatment of hepatocellular carcinoma: an updated review. European journal of pharmaceutics and biopharmaceutics, 167, 9–37.
   PubMed Web of Science ®Google Scholar
• Feeney, O.M., et al., 2016. 50years of oral lipid-based formulations: provenance, progress and future perspectives. Advanced drug delivery reviews, 101, 167–194.
   PubMed Web of Science ®Google Scholar
• Flak, D.K., et al., 2020. At101-loaded cubosomes as an alternative for improved glioblastoma therapy. International journal of nanomedicine, 15, 7415–7431.
   PubMed Web of Science ®Google Scholar
• Fu, D., Calvo, J.A., and Samson, L.D., 2012. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nature reviews-cancer, 12 (2), 104–120.
   PubMed Web of Science ®Google Scholar
• Gao, J., et al., 2015. Liposome encapsulated of temozolomide for the treatment of glioma tumor: preparation, characterization and evaluation. Drug discoveries & therapeutics, 9 (3), 205–212.
   PubMed Web of Science ®Google Scholar
• Garanti, T., et al., 2016. Anti-glioma activity and the mechanism of cellular uptake of Asiatic acid-loaded solid lipid nanoparticles. International journal of pharmaceutics, 500 (1–2), 305–315.
   PubMed Web of Science ®Google Scholar
• Garanti, T., Alhnan, M.A., and Wan, K.W., 2020. RGD-decorated solid lipid nanoparticles enhance tumor targeting, penetration and anticancer effect of Asiatic acid. Nanomedicine, 15 (16), 1567–1583.
   PubMed Web of Science ®Google Scholar
• Gill, K.K., Nazzal, S., and Kaddoumi, A., 2011. Paclitaxel loaded PEG5000-DSPE micelles as pulmonary delivery platform: formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 79 (2), 276–284.
   PubMed Web of Science ®Google Scholar
• Giuliano, M., et al., 2019. Endocrine treatment versus chemotherapy in postmenopausal women with hormone receptor-positive, HER2-negative, metastatic breast cancer: a systematic review and network meta-analysis. The Lancet-Oncology, 20 (10), 1360–1369.
   PubMed Web of Science ®Google Scholar
• Goel, G., and Sun, W., 2015. Advances in the management of gastrointestinal cancers—an upcoming role of immune checkpoint blockade. Journal of hematology & oncology, 8 (1), 86.
   PubMedGoogle Scholar
• Green, D.W., and Drebin, J.A., 2001. 37 – Cancer genetics. In: W.W. Souba and D. W. B. T.-S. R. Wilmore, eds. Surgical Research. San Diego: Academic Press, 445–456.
   Google Scholar
• Griggs, J., and Zinkewich-Peotti, K., 2009. The state of the art: immune-mediated mechanisms of monoclonal antibodies in cancer therapy. British journal of cancer, 101 (11), 1807–1812.
   PubMed Web of Science ®Google Scholar
• Grillone, A., et al., 2019. Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment. Nanomedicine, 14 (6), 727–752.
   PubMed Web of Science ®Google Scholar
• Guinan, M., et al., 2020. Recent advances in the chemical synthesis and evaluation of anticancer nucleoside analogues. Molecules, 25 (9), 2050.
   PubMed Web of Science ®Google Scholar
• Gulati, M., et al., 1998. Lipophilic drug derivatives in liposomes. International journal of pharmaceutics, 165 (2), 129–168.
   Web of Science ®Google Scholar
• Gulla, S., et al., 2021. Titanium dioxide nanotubes conjugated with quercetin function as an effective anticancer agent by inducing apoptosis in melanoma cells. Journal of nanostructure in chemistry, 11 (4), 721–734.
   Web of Science ®Google Scholar
• Gupta, T., et al., 2020. Enhancing bioavailability and stability of curcumin using solid lipid nanoparticles (CLEN): a covenant for its effectiveness. Frontiers in bioengineering and biotechnology, 8, (October), 1–14.
   PubMedGoogle Scholar
• Hallan, S.S., et al., 2020. Design and characterization of ethosomes for transdermal delivery of caffeic acid. Pharmaceutics, 12 (8), 740.
   PubMed Web of Science ®Google Scholar
• Hassan, D.H., et al., 2018. Formulation and characterization of carvedilol leciplex for glaucoma treatment: in-vitro, ex-vivo and in-vivo study. Pharmaceutics, 10 (4), 197.
   PubMed Web of Science ®Google Scholar
• Hatem, S., et al., 2018. Melatonin vitamin C-based nanovesicles for treatment of androgenic alopecia: design, characterization and clinical appraisal. European journal of pharmaceutical sciences, 122, 246–253.
   PubMed Web of Science ®Google Scholar
• Hatem, S., et al., 2020. Background and different treatment modalities for melasma : conventional and nanotechnology-based approaches. Journal of drug delivery science and technology, 60 (August), 101984.
   Google Scholar
• He, C., Liu, D., and Lin, W., 2015. Self-assembled core–shell nanoparticles for combined chemotherapy and photodynamic therapy of resistant head and neck cancers. ACS nano, 9 (1), 991–1003.
   PubMed Web of Science ®Google Scholar
• Henson, J.W., et al., 1994. The retinoblastoma gene is involved in malignant progression of astrocytomas. Annals of neurology, 36 (5), 714–721.
   PubMed Web of Science ®Google Scholar
• Heurtault, B., et al., 2002. A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharmaceutical research, 19 (6), 875–880.
   PubMed Web of Science ®Google Scholar
• Heurtault, B., et al., 2003. Interfacial stability of lipid nanocapsules. Colloids and surfaces B: biointerfaces, 30 (3), 225–235.
   Web of Science ®Google Scholar
• Hidai, C., et al., 2018. Nonviral gene therapy for cancer: a review. Diseases, 6 (3), 57.
   PubMedGoogle Scholar
• Ho, D. H. W., and Freireich, E. J., 1975. Clinical pharmacology of arabinosylcytosine. In: A.C. Sartorelli and D.G. Johns, eds., Antineoplastic and immunosuppressive agents. Berlin, Heidelberg: Springer, (38/2), 257–271.
   Google Scholar
• Howell, A., Downey, S., and Anderson, E., 1996. New endocrine therapies for breast cancer. European journal of cancer, 32 (4), 576–588.
   Google Scholar
• Hsieh, C.W., et al., 2012. Preparing glabridin-in-water nanoemulsions by high pressure homogenization with response surface methodology. Journal of oleo science, 61 (9), 483–489.
   PubMed Web of Science ®Google Scholar
• Hu, X., et al., 2022. Cytotoxicity of aptamer-conjugated chitosan encapsulated mycogenic gold nanoparticles in human lung cancer cells. Journal of nanostructure in chemistry, 12 (4), 641–653.
   Web of Science ®Google Scholar
• Hu, L.D., Jia, Y., and Ding, W., 2010. Preparation and characterization of solid lipid nanoparticles loaded with epirubicin for pulmonary delivery. Pharmazie, 65 (8), 585–587.
   PubMed Web of Science ®Google Scholar
• Hureaux, J., et al., 2009. Lipid nanocapsules: Ready-to-use nanovectors for the aerosol delivery of paclitaxel. European Journal of Pharmaceutics and Biopharmaceutics, 73 (2), 239–246.
   PubMed Web of Science ®Google Scholar
• Huse, J.T., and Holland, E.C., 2010. Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nature reviews-cancer, 10 (5), 319–331.
   PubMed Web of Science ®Google Scholar
• Hwang, J.P., et al., 2019. Oncologic implications of chronic hepatitis C virus infection. Journal of oncology practice, 15 (12), 629–637.
   PubMed Web of Science ®Google Scholar
• Hyder, T., et al., 2021. Approaching neoadjuvant therapy in the management of early-stage breast cancer. Breast Cancer, 13, 199–211.
   PubMed Web of Science ®Google Scholar
• Ibrahim, A., et al., 2022. Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation. Expert opinion on drug delivery, 19 (11), 1549–1560.
   PubMed Web of Science ®Google Scholar
• Indoria, S., Singh, V., and Hsieh, M.-F., 2020. Recent advances in theranostic polymeric nanoparticles for cancer treatment: a review. International journal of pharmaceutics, 582, 119314.
   PubMed Web of Science ®Google Scholar
• Irby, D., Du, C., and Li, F., 2017. Lipid-drug conjugate for enhancing drug delivery. Molecular pharmaceutics, 14 (5), 1325–1338.
   PubMed Web of Science ®Google Scholar
• Ismael, G.F.V., et al., 2008. Novel cytotoxic drugs: old challenges, new solutions. Cancer treatment reviews, 34 (1), 81–91.
   PubMed Web of Science ®Google Scholar
• Ismail, A., Nasr, M., and Sammour, O., 2020. Nanoemulsion as a feasible and biocompatible carrier for ocular delivery of travoprost: improved pharmacokinetic/pharmacodynamic properties. International journal of pharmaceutics, 583, 119402.
   PubMed Web of Science ®Google Scholar
• Jacob, S., Nair, A.B., and Shah, J., 2020. Emerging role of nanosuspensions in drug delivery systems. Biomaterials research, 24 (1), 1–16.
   PubMedGoogle Scholar
• Jadhav, S.M., et al., 2012. Novel vesicular system: an overview. Journal of applied pharmaceutical science, 2 (1), 193–202.
   Google Scholar
• Janga, K.Y., et al., 2012. Bioavailability enhancement of zaleplon via proliposomes: role of surface charge. European journal of pharmaceutics and biopharmaceutics, 80 (2), 347–357.
   PubMed Web of Science ®Google Scholar
• Jenning, V., Lippacher, A., and Gohla, S.H., 2002. Medium scale production of solid lipid nanoparticles (SLN) by high pressure homogenization. Journal of microencapsulation, 19 (1), 1–10.
   PubMed Web of Science ®Google Scholar
• Jeon, D., et al., 2019. Preparation and evaluation of celecoxib-loaded proliposomes with high lipid content. European journal of pharmaceutics and biopharmaceutics, 141, 139–148.
   PubMed Web of Science ®Google Scholar
• Jian, Y., et al., 2020. A gastric cancer peptide GX1-modified nano-lipid carriers encapsulating paclitaxel: design and evaluation of anti-tumor activity. Drug design, development and therapy, 14, 2355–2370.
   PubMed Web of Science ®Google Scholar
• Jiang, H., et al., 2016. Co-delivery of etoposide and curcumin by lipid nanoparticulate drug delivery system for the treatment of gastric tumors delivery system for the treatment of gastric tumors. Drug delivery, 23 (9), 3665–3673.
   PubMed Web of Science ®Google Scholar
• Jiao, Q., et al., 2018. Advances in studies of tyrosine kinase inhibitors and their acquired resistance. Molecular CANCER, 17 (1), 36.
   PubMedGoogle Scholar
• Jin, J., et al., 2011. In vivo specific delivery of c-Met siRNA to glioblastoma using cationic solid lipid nanoparticles. Bioconjugate chemistry, 22 (12), 2568–2572.
   PubMed Web of Science ®Google Scholar
• Jin, M., et al., 2013. In vivo study of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice. Drug delivery, 20 (3–4), 127–133.
   PubMed Web of Science ®Google Scholar
• Johnsen, K.B., et al., 2017. Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma. Scientific reports, 7 (1), 1–13.
   PubMedGoogle Scholar
• Jonasch, E., and Haluska, F.G., 2001. Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities. The oncologist, 6 (1), 34–55.
   PubMed Web of Science ®Google Scholar
• Jordan, M.A., Thrower, D., and Wilson, L., 1991. Mechanism of inhibition of cell proliferation by vinca alkaloids. Cancer research, 51 (8), 2212–2222.
   PubMed Web of Science ®Google Scholar
• Jørgensen, N., G., Persson, and T.V. F.H., et al., 2019. The tolerogenic function of regulatory T cells in pregnancy and cancer. Frontiers in immunology, 10, 911.
   PubMed Web of Science ®Google Scholar
• Jyoti, K., et al., 2015. Inhalable nanostructured lipid particles of 9-bromo-noscapine, a tubulin-binding cytotoxic agent: in vitro and in vivo studies. Journal of colloid and interface science, 445, 219–230.
   PubMed Web of Science ®Google Scholar
• Kabil, M.F., Mahmoud, M.Y., et al., 2022. Switching indication of PEGylated lipid nanocapsules-loaded with rolapitant and deferasirox against breast cancer: enhanced in-vitro and in-vivo cytotoxicity. Life sciences, 305, 120731.
   PubMed Web of Science ®Google Scholar
• Kabil, M.F., Nasr, M., et al., 2022. New repurposed rolapitant in nanovesicular systems for lung cancer treatment: development, in-vitro assessment and in-vivo biodistribution study. European journal of pharmaceutical sciences, 171, 106119.
   PubMed Web of Science ®Google Scholar
• Kadiyala, P., et al., 2019. High-density lipoprotein-mimicking nanodiscs for chemo-immunotherapy against glioblastoma multiforme. ACS Nano. 3 (2), 1365-1384.
   Google Scholar
• Kakkar, S., and Kaur, I.P., 2011. Spanlastics—a novel nanovesicular carrier system for ocular delivery. International journal of pharmaceutics, 413 (1–2), 202–210.
   PubMed Web of Science ®Google Scholar
• Kapoor, B., et al., 2018. Prodrugs, phospholipids and vesicular delivery – an effective triumvirate of pharmacosomes. Advances in colloid and interface science, 253, 35–65.
   PubMed Web of Science ®Google Scholar
• Karami, Z., and Hamidi, M., 2016. Cubosomes: remarkable drug delivery potential. Drug discovery today., 21 (5), 789–801.
   PubMed Web of Science ®Google Scholar
• Katze, M.G., He, Y., and Gale, M., 2002. Viruses and interferon: a fight for supremacy. Nature reviews-immunology, 2 (9), 675–687.
   PubMed Web of Science ®Google Scholar
• Kawar, D., and Abdelkader, H., 2019. Hyaluronic acid gel-core liposomes (hyaluosomes) enhance skin permeation of ketoprofen. Pharmaceutical development and technology, 24 (8), 947–953.
   PubMed Web of Science ®Google Scholar
• Keating, G.M., 2014. Bevacizumab: a review of its use in advanced cancer. Drugs, 74 (16), 1891–1925.
   PubMed Web of Science ®Google Scholar
• Khan, I., et al., 2018. Proliposome powders for the generation of liposomes: the influence of carbohydrate carrier and separation conditions on crystallinity and entrapment of a model antiasthma steroid. AAPS Pharmscitech, 19 (1), 262–274.
   PubMed Web of Science ®Google Scholar
• Kim, S.S., et al., 2015. Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma. cancer letters, 369 (1), 250–258.
   PubMed Web of Science ®Google Scholar
• Kimiz-Gebologlu, I., Gulce-Iz, S., and Biray-Avci, C., 2018. Monoclonal antibodies in cancer immunotherapy. Molecular biology reports, 45 (6), 2935–2940.
   PubMed Web of Science ®Google Scholar
• Kim, A., and Walz, W., 2021. Nanotherapy for brain tumor drug delivery. Neuromethods, XII, 280.
   Google Scholar
• Kirchner, G.I., et al., 1998. Pharmacokinetics of recombinant human interleukin-2 in advanced renal cell carcinoma patients following subcutaneous application. British journal of clinical pharmacology, 46 (1), 5–10.
   PubMed Web of Science ®Google Scholar
• Kirpotin, D.B., et al., 2006. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer research, 66 (13), 6732–6740.
   PubMed Web of Science ®Google Scholar
• Kisselev, A.F., and Goldberg, A.L., 2001. Proteasome inhibitors: from research tools to drug candidates. Chemistry & biology, 8 (8), 739–758.
   PubMed Web of Science ®Google Scholar
• Kondo, N., et al., 2010. DNA damage induced by alkylating agents and repair pathways. Journal of nucleic acids, 2010, 543531.
   PubMedGoogle Scholar
• Krauze, M.T., et al., 2005. Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. Journal of neurosurgery, 103 (5), 923–929.
   PubMed Web of Science ®Google Scholar
• Küçüktürkmen, B., and Bozkır, A., 2018. Development and characterization of cationic solid lipid nanoparticles for co-delivery of pemetrexed and miR-21 antisense oligonucleotide to glioblastoma cells. Drug development and industrial pharmacy, 44 (2), 306–315.
   PubMed Web of Science ®Google Scholar
• Kumar, G.P., and Rajeshwarrao, P., 2011. Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta pharmaceutica sinica B, 1 (4), 208–219.
   Web of Science ®Google Scholar
• Kuo, Y.C., and Cheng, S.J., 2016. Brain targeted delivery of carmustine using solid lipid nanoparticles modified with tamoxifen and lactoferrin for antitumor proliferation. International journal of pharmaceutics, 499 (1–2), 10–19.
   PubMed Web of Science ®Google Scholar
• Kuo, Y.C., and Hsu, C.C., 2017. Anti-melanotransferrin and apolipoprotein E on doxorubicin-loaded cationic solid lipid nanoparticles for pharmacotherapy of glioblastoma multiforme. Journal of the Taiwan Institute of Chemical Engineers, 77, 10–20.
   Web of Science ®Google Scholar
• Kuo, Y.C., and Lee, C.H., 2015. Inhibition against growth of glioblastoma multiforme in vitro using etoposide-loaded solid lipid nanoparticles with p-aminophenyl-α-D-manno-pyranoside and folic acid. Journal of pharmaceutical sciences, 104 (5), 1804–1814.
   PubMed Web of Science ®Google Scholar
• Kuo, Y.C., and Lee, I.H., 2016. Delivery of doxorubicin to glioblastoma multiforme in vitro using solid lipid nanoparticles with surface aprotinin and melanotransferrin antibody for enhanced chemotherapy. Journal of the Taiwan Institute of Chemical Engineers, 61, 32–45.
   Web of Science ®Google Scholar
• Kuo, Y.C., and Liang, C.T., 2011. Inhibition of human brain malignant glioblastoma cells using carmustine-loaded catanionic solid lipid nanoparticles with surface anti-epithelial growth factor receptor. Biomaterials, 32 (12), 3340–3350.
   PubMed Web of Science ®Google Scholar
• Labrie, F., 2011. Blockade of testicular and adrenal androgens in prostate cancer treatment. Nature reviews-urology, 8 (2), 73–85.
   PubMed Web of Science ®Google Scholar
• Lam, F.C., et al., 2018. Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nature communications, 9 (1), 1991.
   Google Scholar
• Lee, S., et al., 2011. Cytokines in cancer immunotherapy. Cancers, 3 (4), 3856–3893.
   PubMedGoogle Scholar
• Lefebvre, G., et al., 2017. Spontaneous nano-emulsification: Process optimization and modeling for the prediction of the nanoemulsion’s size and polydispersity. International journal of pharmaceutics, 534 (1–2), 220–228.
   PubMed Web of Science ®Google Scholar
• Lemjabbar-Alaoui, H., et al., 2015. Lung cancer: biology and treatment options. Biochimica et biophysica acta - reviews on cancer, 1856 (2), 189–210.
   PubMed Web of Science ®Google Scholar
• LePage, G. A., 1977. Purine antagonists. In: F.F. Becker, ed. Chemotherapy. Springer, 5, 309–326.
   Google Scholar
• Li, T., et al., 2017. miR-542-3p appended sorafenib/all- trans retinoic acid (ATRA) -loaded lipid nanoparticles to enhance the anticancer efficacy in gastric cancers. Pharmaceutical research, 34 (12), 2710–2719.
   PubMed Web of Science ®Google Scholar
• Li, T., et al., 2018. Tumor angiogenesis and anti-angiogenic gene therapy for cancer. Oncology letters, 16 (1), 687–702.
   PubMed Web of Science ®Google Scholar
• Li, W., et al., 2016. Overcoming ABC transporter-mediated multidrug resistance: molecular mechanisms and novel therapeutic drug strategies. Drug resistance updates, 27, 14–29.
   PubMed Web of Science ®Google Scholar
• Li, Y., et al., 2017. Tumor-specific multiple stimuli-activated dendrimeric nanoassemblies with metabolic blockade surmount chemotherapy resistance. ACS nano, 11 (1), 416–429.
   PubMed Web of Science ®Google Scholar
• Lim, J.K.M., and Leprivier, G., 2019. The impact of oncogenic RAS on redox balance and implications for cancer development. Cell death & disease, 10 (12), 1–9.
   Google Scholar
• Lin, K., et al., 2022. The breast cancer protooncogenes HER2, BRCA1 and BRCA2 and their regulation by the iNOS/NOS2 Axis. Antioxidants, 11 (6), 1195.
   Web of Science ®Google Scholar
• Lin, X., et al., 2022. Genetic association of ERCC6 rs2228526 polymorphism with the risk of cancer: evidence from a meta-analysis. BioMed research international, 2022, 1–10.
   Web of Science ®Google Scholar
• Liu, C., et al., 2017. A dual-mediated liposomal drug delivery system targeting the brain: Rational construction, integrity evaluation across the blood–brain barrier, and the transporting mechanism to glioma cells. International journal of nanomedicine, 12, 2407–2425.
   PubMed Web of Science ®Google Scholar
• Liu, J., et al., 2016. MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell. International journal of nanomedicine, 11, 6713–6725.
   PubMed Web of Science ®Google Scholar
• Liu, J., et al., 2018. Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement. Nano today, 21, 55–73.
   Web of Science ®Google Scholar
• Liu, Y., et al., 2020. Formulation of nanoparticles using mixing-induced nanoprecipitation for drug delivery. Industrial & engineering chemistry research, 59 (9), 4134–4149.
   Web of Science ®Google Scholar
• Liu, G.X., Fang, G.Q., and Xu, W., 2014. Dual targeting biomimetic liposomes for paclitaxel/DNA combination cancer treatment. International journal of molecular sciences, 15 (9), 15287–15303.
   PubMed Web of Science ®Google Scholar
• Lollo, G., et al., 2015. Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma. international journal of pharmaceutics, 495 (2), 972–980.
   PubMed Web of Science ®Google Scholar
• Lowell, G.H., et al., 1997. Proteosomes, emulsomes, and cholera Toxin B improve nasal immunogenicity of human immunodeficiency virus gp160 in mice: induction of serum, intestinal, vaginal, and lung IgA and IgG. The journal of infectious diseases, 175 (2), 292–301.
   PubMed Web of Science ®Google Scholar
• Luiz, M.T., et al., 2021. Docetaxel-loaded folate-modified TPGS-transfersomes for glioblastoma multiforme treatment. Materials science & engineering. C, materials for biological applications, 124, 112033.
   PubMed Web of Science ®Google Scholar
• Ma, L., et al., 2018. Co-delivery of paclitaxel and tanespimycin in lipid nanoparticles enhanced anti-gastric-tumor effect in vitro and in vivo. Artificial cells, nanomedicine, and biotechnology, 46 (sup2), 904–911.
   PubMed Web of Science ®Google Scholar
• Madan, J., et al., 2013. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine, 9 (4), 492–503.
   PubMed Web of Science ®Google Scholar
• Maeki, M., et al., 2018. Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems. Advanced drug delivery reviews, 128, 84–100.
   PubMed Web of Science ®Google Scholar
• Mahindroo, N., et al., 2006. Antitubulin agents for the treatment of cancer – a medicinal chemistry update. Expert opinion on therapeutic patents, 16 (5), 647–691.
   Web of Science ®Google Scholar
• Mainelis, G., et al., 2013. Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice. Journal of aerosol medicine and pulmonary drug delivery, 26 (6), 345–354.
   PubMed Web of Science ®Google Scholar
• Maishi, N., and Hida, K., 2017. Tumor endothelial cells accelerate tumor metastasis. Cancer science, 108 (10), 1921–1926.
   PubMed Web of Science ®Google Scholar
• Maley, F., 1977. Pyrimidine antagonists. In: F.F. Becker, ed., Chemotherapy. Springer, 5, 327–361.
   Google Scholar
• Manasanch, E.E., and Orlowski, R.Z., 2017. Proteasome inhibitors in cancer therapy. Nature reviews-clinical oncology, 14 (7), 417–433.
   PubMed Web of Science ®Google Scholar
• Manconi, M., et al., 2011. Penetration enhancer containing vesicles as carriers for dermal delivery of tretinoin. International journal of pharmaceutics, 412 (1–2), 37–46.
   PubMed Web of Science ®Google Scholar
• Manconi, M., et al., 2012. Penetration enhancer-containing vesicles: composition dependence of structural features and skin penetration ability. European journal of pharmaceutics and biopharmaceutics, 82 (2), 352–359.
   PubMed Web of Science ®Google Scholar
• Manosroi, A., et al., 2003. Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol. Colloids and surfaces B, 30 (1–2), 129–138.
   Web of Science ®Google Scholar
• Mao, S., et al., 2003. Preparation of solid lipid nanoparticles by microemulsion technique. Yao Xue Xue Bao [Acta Pharmaceutica Sinica], 38 (8), 624–626.
   PubMedGoogle Scholar
• Marshall, J.C., Charbonney, E., and Gonzalez, P.D., 2008. The immune system in critical illness. Clinics in chest medicine, 29 (4), 605–616, vii.
   PubMed Web of Science ®Google Scholar
• Martinelli, E., et al., 2009. Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy. Clinical and experimental immunology, 158 (1), 1–9.
   PubMed Web of Science ®Google Scholar
• Master, A.M., et al., 2010. Development of a respirable, sustained release microcarrier for 5-fluorouracil i: in vitro assessment of liposomes, microspheres, and lipid coated nanoparticles. Journal of pharmaceutical sciences, 99 (5), 2386–2398.
   PubMed Web of Science ®Google Scholar
• McGlynn, K.A., Petrick, J.L., and El-Serag, H.B., 2021. Epidemiology of hepatocellular carcinoma. Hepatology, 73 (S1), 4–13.
   PubMedGoogle Scholar
• McGrogan, B.T., et al., 2008. Taxanes, microtubules and chemoresistant breast cancer. Biochimica et Biophysica Acta, 1785 (2), 96–132.
   PubMed Web of Science ®Google Scholar
• Meenach, S.A., Anderson, K.W., et al., 2013. Characterization and aerosol dispersion performance of advanced spray-dried chemotherapeutic PEGylated phospholipid particles for dry powder inhalation delivery in lung cancer. European journal of pharmaceutical sciences, 49 (4), 699–711.
   PubMed Web of Science ®Google Scholar
• Meenach, S.A., Vogt, F.G., et al., 2013. Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) microparticles and nanoparticles f. International journal of nanomedicine, 8, 275–293.
   PubMed Web of Science ®Google Scholar
• Mendes, M., et al., 2018. Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma. European Journal of Pharmaceutical Sciences, 17 (2017), 255–269.
   Google Scholar
• Mishra, D.K., Shandilya, R., and Mishra, P.K., 2018. Lipid based nanocarriers: a translational perspective. Nanomedicine, 14 (7), 2023–2050.
   PubMed Web of Science ®Google Scholar
• Moghaddam, F.A., et al., 2022. Effect of thymoquinone-loaded lipid–polymer nanoparticles as an oral delivery system on anticancer efficiency of doxorubicin. Journal of nanostructure in chemistry, 12 (1), 33–44.
   Web of Science ®Google Scholar
• Moghddam, S.R.M., et al., 2016. Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis. Materials science & engineering. C, materials for biological applications, 69, 789–797.
   PubMed Web of Science ®Google Scholar
• Moudi, M., et al., 2013. Vinca alkaloids. International journal of preventive medicine, 4 (11), 1231–1235.
   PubMedGoogle Scholar
• Moura, R.P., et al., 2020. Lipid nanocapsules to enhance drug bioavailability to the central nervous system. Journal of Controlled Release, 322, (February), 390–400.
   PubMedGoogle Scholar
• Müller, R.H., Mäder, K., and Gohla, S., 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. European journal of pharmaceutics and biopharmaceutics, 50 (1), 161–177.
   PubMed Web of Science ®Google Scholar
• Müller, R.H., Radtke, M., and Wissing, S.A., 2002. Nanostructured lipid matrices for improved microencapsulation of drugs. International journal of pharmaceutics, 242 (1–2), 121–128.
   PubMed Web of Science ®Google Scholar
• Müller, R.H., Radtke, M., and Wissing, S.A., 2002. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Advanced drug delivery reviews, 54, S131–S155.
   PubMed Web of Science ®Google Scholar
• Mura, S., et al., 2009. Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil. International journal of pharmaceutics, 380 (1–2), 72–79.
   PubMed Web of Science ®Google Scholar
• Najafi, F., 2020. Thermodynamic studies of carbon nanotube interaction with gemcitabine anticancer drug: DFT calculations. Journal of nanostructure in chemistry, 10 (3), 227–242.
   Web of Science ®Google Scholar
• Nasr, A.M., et al., 2020. Quality by design for the development and analysis of enhanced in-situ forming vesicles for the improvement of the bioavailability of fexofenadine HCL in vitro and in vivo. Pharmaceutics, 12 (5), 409.
   PubMed Web of Science ®Google Scholar
• Nasr, M., 2016. Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery. Drug delivery, 23 (4), 1444–1452.
   PubMed Web of Science ®Google Scholar
• Nasr, M., et al., 2008. Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. Journal of microencapsulation, 25 (7), 499–512.
   PubMed Web of Science ®Google Scholar
• Nasr, M., and Abdel-Hamid, S., 2016. Optimizing the dermal accumulation of a tazarotene microemulsion using skin deposition modeling. Drug development and industrial pharmacy, 42 (4), 636–643.
   PubMed Web of Science ®Google Scholar
• Nasri, S., et al., 2020. Thymoquinone-loaded ethosome with breast cancer potential: optimization, in vitro and biological assessment. Journal of nanostructure in chemistry, 10 (1), 19–31.
   Web of Science ®Google Scholar
• Nasr, M., Taha, I., and Hathout, R.M., 2013. Suitability of liposomal carriers for systemic delivery of risedronate using the pulmonary route. Drug delivery, 20 (8), 311–318.
   PubMed Web of Science ®Google Scholar
• Nasr, M., and Wahdan, S.A., 2019. Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration. Life sciences, 226 (March), 117–129.
   PubMedGoogle Scholar
• Nayek, S., et al., 2021. Development of novel S PC-3 gefitinib lipid nanoparticles for effective drug delivery in breast cancer. Tissue distribution studies and cell cytotoxicity analysis. Journal of drug delivery science and technology, 61, 102073.
   Web of Science ®Google Scholar
• Nishikawa, K., et al., 2018. The clinical impact of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: analyses of pooled data from two phase II randomized clinical trials (HANGESHA-G and HANGESHA-C). Journal of cancer, 9 (10), 1725–1730.
   PubMed Web of Science ®Google Scholar
• O'Driscoll, C.M., and Griffin, B.T., 2008. Biopharmaceutical challenges associated with drugs with low aqueous solubility—the potential impact of lipid-based formulations. Advanced drug delivery reviews, 60 (6), 617–624.
   PubMed Web of Science ®Google Scholar
• Olbrich, C., et al., 2002. Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate. Journal of drug targeting, 10 (5), 387–396.
   PubMed Web of Science ®Google Scholar
• Orlando, L., et al., 2010. Molecularly targeted endocrine therapies for breast cancer. Cancer treatment reviews, 36, S67–S71.
   PubMed Web of Science ®Google Scholar
• Ostuni, E., et al., 2001. A survey of structure − property relationships of surfaces that resist the adsorption of protein. Langmuir, 17 (18), 5605–5620.
   Web of Science ®Google Scholar
• Paiva-Santos, A.C., et al., 2021. Ethosomes as nanocarriers for the development of skin delivery formulations. Pharmaceutical research, 38 (6), 947–970.
   PubMed Web of Science ®Google Scholar
• Pakpayat, N., et al., 2009. Formulation of ascorbic acid microemulsions with alkyl polyglycosides. European journal of pharmaceutics and biopharmaceutics, 72 (2), 444–452.
   PubMed Web of Science ®Google Scholar
• Pandita, A., and Sharma, P., 2013. Pharmacosomes: an emerging novel vesicular drug delivery system for poorly soluble synthetic and herbal drugs. ISRN pharmaceutics, 2013 (3), 1–10.
   Google Scholar
• Pang, X., et al., 2019. Functionalized docetaxel-loaded lipid-based- nanosuspensions to enhance antitumor efficacy in vivo. International journal of nanomedicine, 14, 2543–2555.
   PubMed Web of Science ®Google Scholar
• Paolillo, M., Boselli, C., and Schinelli, S., 2018. Glioblastoma under siege: an overview of current therapeutic strategies. Brain Sciences, 8 (1), 15.
   PubMed Web of Science ®Google Scholar
• Paolino, D., et al., 2005. Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. Journal of controlled release, 106 (1–2), 99–110.
   PubMed Web of Science ®Google Scholar
• Paranjpe, M., et al., 2014. Nanoparticle-mediated pulmonary drug delivery: a review. International journal of molecular sciences, 15 (4), 5852–5873.
   PubMed Web of Science ®Google Scholar
• Pardoll, D.M., 2012. The blockade of immune checkpoints in cancer immunotherapy. Nature reviews-cancer, 12 (4), 252–264.
   PubMed Web of Science ®Google Scholar
• Parikh, S., and Hyman, D., 2007. Hepatocellular cancer: a guide for the internist. The American journal of medicine, 120 (3), 194–202.
   PubMed Web of Science ®Google Scholar
• Parvathaneni, V., et al., 2020. Systematic development and optimization of inhalable pirfenidone liposomes for non-small cell lung cancer treatment. Pharmaceutics, 12 (3), 206.
   PubMed Web of Science ®Google Scholar
• Pasha, N., and Turner, N.C., 2021. Understanding and overcoming tumor heterogeneity in metastatic breast cancer treatment. Nature cancer, 2 (7), 680–692.
   PubMedGoogle Scholar
• Patlolla, R.R., et al., 2010. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. Journal of controlled release, 144 (2), 233–241.
   PubMed Web of Science ®Google Scholar
• Paul, M.K., and Mukhopadhyay, A.K., 2004. Tyrosine kinase – role and significance in cancer. International journal of medical sciences, 1 (2), 01–115.
   PubMedGoogle Scholar
• Pavelić, Z., et al., 2005. Development and in vitro evaluation of a liposomal vaginal delivery system for acyclovir. Journal of Controlled Release, 106 (1–2), 34–43.
   PubMed Web of Science ®Google Scholar
• Perz, J.F., et al., 2006. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. Journal of Hepatology, 45 (4), 529–538.
   PubMed Web of Science ®Google Scholar
• Petering, H.G., 1952. Folic acid antagonists. Physiological reviews, 32 (2), 197–213.
   PubMed Web of Science ®Google Scholar
• Pietenpol, J.A., and Stewart, Z.A., 2002. Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology, 181-182, 475–481.
   PubMed Web of Science ®Google Scholar
• Pisco, A.O., et al., 2014. Reduced intracellular drug accumulation in drug-resistant leukemia cells is not only solely due to MDR-mediated efflux but also to decreased uptake. Frontiers in oncology, 4, 306.
   PubMedGoogle Scholar
• Pommier, Y., 2013. Drugging topoisomerases: lessons and challenges. ACS chemical biology, 8 (1), 82–95.
   PubMed Web of Science ®Google Scholar
• Pons, M., Foradada, M., and Estelrich, J., 1993. Liposomes obtained by the ethanol injection method. International journal of pharmaceutics, 95 (1–3), 51–56.
   Web of Science ®Google Scholar
• Porter, C.J.H., Trevaskis, N.L., and Charman, W.N., 2007. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nature reviews-drug discovery, 6 (3), 231–248.
   PubMed Web of Science ®Google Scholar
• Pouton, C.W., 2000. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and “self-microemulsifying” drug delivery systems. European journal of pharmaceutical sciences, 11, S93–S98.
   PubMed Web of Science ®Google Scholar
• Pouton, C.W., 2006. Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. European journal of pharmaceutical sciences, 29 (3–4), 278–287.
   PubMed Web of Science ®Google Scholar
• Pouton, C.W., and Porter, C.J.H., 2008. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Advanced drug delivery reviews, 60 (6), 625–637.
   PubMed Web of Science ®Google Scholar
• Puglia, C., and Bonina, F., 2012. Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals. Expert opinion on drug delivery, 9 (4), 429–441.
   PubMed Web of Science ®Google Scholar
• Qian, Y., et al., 2014. Enhanced cytotoxic activity of cetuximab in EGFR-positive lung cancer by conjugating with gold nanoparticles. Scientific reports, 4 (1), 7490.
   PubMedGoogle Scholar
• Quach, H., et al., 2010. Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma. Leukemia, 24 (1), 22–32.
   PubMed Web of Science ®Google Scholar
• Radomska-Soukharev, A., 2007. Stability of lipid excipients in solid lipid nanoparticles. Advanced drug delivery reviews, 59 (6), 411–418.
   PubMed Web of Science ®Google Scholar
• Rai, P., et al., 2010. Development and applications of photo-triggered theranostic agents. Advanced drug delivery reviews, 62 (11), 1094–1124.
   PubMed Web of Science ®Google Scholar
• Ramez, S.A., et al., 2018. Novel methotrexate soft nanocarrier/fractional erbium YAG laser combination for clinical treatment of plaque psoriasis. Artificial cells, nanomedicine, and biotechnology, 46 (sup1), 996–1002.
   PubMed Web of Science ®Google Scholar
• Ravula, V., et al., 2021. Arginine-tocopherol bioconjugated lipid vesicles for selective pTRAIL delivery and subsequent apoptosis induction in glioblastoma cells. Materials science & engineering. C, materials for biological applications, 126, 112189.
   PubMed Web of Science ®Google Scholar
• Rawal, S., and Patel, M.M., 2019. Threatening cancer with nanoparticle aided combination oncotherapy. Journal of controlled release, 301, 76–109.
   PubMed Web of Science ®Google Scholar
• Rehman, M., et al., 2017. Enhanced blood brain barrier permeability and glioblastoma cell targeting via thermoresponsive lipid nanoparticles. Nanoscale, 9 (40), 15434–15440.
   PubMed Web of Science ®Google Scholar
• Rogers, L.M., Veeramani, S., and Weiner, G.J., 2014. Complement in monoclonal antibody therapy of cancer. Immunologic research, 59 (1–3), 203–210.
   PubMed Web of Science ®Google Scholar
• Roma-Rodrigues, C., et al., 2020. Gene therapy in cancer treatment: why go nano? Pharmaceutics, 12 (3), 233.
   PubMed Web of Science ®Google Scholar
• Rosa, A., et al., 2015. Monoolein-based cubosomes affect lipid profile in HeLa cells. Chemistry and physics of lipids, 191, 96–105.
   PubMed Web of Science ®Google Scholar
• Rosenberg, S.A., 2014. IL-2: the first effective immunotherapy for human cancer. Journal of immunology, 192 (12), 5451–5458.
   PubMed Web of Science ®Google Scholar
• Rubin, P., and Carter, S.K., 1976. Combination radiation therapy and chemotherapy: a logical basis for their clinical use. A cancer journal for clinicians, 26 (5), 274–292.
   PubMedGoogle Scholar
• Safwat, S., et al., 2017. Augmented simvastatin cytotoxicity using optimized lipid nanocapsules: a potential for breast cancer treatment. Journal of liposome research, 27 (1), 1–10.
   PubMed Web of Science ®Google Scholar
• Salama, A., et al., 2019. Spironolactone-loaded leciplexes as potential topical delivery systems for female acne: in vitro appraisal and ex vivo skin permeability studies. Pharmaceutics, 12 (1), 25.
   PubMed Web of Science ®Google Scholar
• Sapra, B., Jain, S., and Tiwary, A.K., 2008. Percutaneous permeation enhancement by terpenes: mechanistic view. The AAPS journal, 10 (1), 120–132.
   PubMed Web of Science ®Google Scholar
• Satapathy, B.S., et al., 2016. Lipid nanocarrier-based transport of docetaxel across the blood brain barrier. RSC advances, 6 (88), 85261–85274.
   Web of Science ®Google Scholar
• Sawant, D., Dandagi, P.M., and Gadad, A.P., 2016. Formulation and evaluation of sparfloxacin emulsomes-loaded thermosensitive in situ gel for ophthalmic delivery. Journal of sol-gel science and technology, 77 (3), 654–665.
   Web of Science ®Google Scholar
• Scagliotti, G.V., and Selvaggi, G., 2006. Antimetabolites and cancer: emerging data with a focus on antifolates. Expert opinion on therapeutic patents, 16 (2), 189–200.
   PubMed Web of Science ®Google Scholar
• Scalia, S., Young, P.M., and Traini, D., 2015. Solid lipid microparticles as an approach to drug delivery. Expert opinion on drug delivery, 12 (4), 583–599.
   PubMed Web of Science ®Google Scholar
• Schirrmacher, V., 2019. From chemotherapy to biological therapy: a review of novel concepts to reduce the side effects of systemic cancer treatment. International journal of oncology, 54 (2), 407–419.
   PubMed Web of Science ®Google Scholar
• Schulenburg, H., Leopold Kurz, C., and Ewbank, J.J., 2004. Evolution of the innate immune system: the worm perspective. Immunological reviews, 198 (1), 36–58.
   PubMedGoogle Scholar
• Scott, A.M., Wolchok, J.D., and Old, L.J., 2012. Antibody therapy of cancer. Nature reviews-cancer, 12 (4), 278–287.
   PubMed Web of Science ®Google Scholar
• Segaert, S., and Van Cutsem, E., 2005. Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. Annals of oncology, 16 (9), 1425–1433.
   PubMed Web of Science ®Google Scholar
• Sekerdag, E., et al., 2017. A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles. Journal of controlled release, 261, 187–198.
   PubMed Web of Science ®Google Scholar
• Sethuraman, V., et al., 2021. In vivo synergistic anti-tumor effect of lumefantrine combined with pH responsive behavior of nano calcium phosphate based lipid nanoparticles on lung cancer. European Journal of Pharmaceutical Sciences, 158, 105657.
   PubMed Web of Science ®Google Scholar
• Shah, R.M., et al., 2014. Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. Journal of colloid and interface science, 428, 286–294.
   PubMed Web of Science ®Google Scholar
• Shah, S.M., et al., 2015. LeciPlex, invasomes, and liposomes: a skin penetration study. International journal of pharmaceutics, 490 (1–2), 391–403.
   PubMed Web of Science ®Google Scholar
• Shah, R.R., and Shah, D.R., 2019. Safety and tolerability of epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in oncology. Drug safety, 42 (2), 181–198.
   PubMed Web of Science ®Google Scholar
• Shaji, J., and Bhatia, V., 2013. Proliposomes: a brief overview of novel delivery system. International journal of pharma and bio sciences, 4 (1), 150–160.
   Google Scholar
• Shaker, D.S., et al., 2019. Nanoemulsion: a review on mechanisms for the transdermal delivery of hydrophobic and hydrophilic drugs. Scientia Pharmaceutica, 87 (3), 17.
   Web of Science ®Google Scholar
• Sharma, P., et al., 2017. Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell, 168 (4), 707–723.
   PubMed Web of Science ®Google Scholar
• Shetab Boushehri, M.A., Dietrich, D., and Lamprecht, A., 2020. Nanotechnology as a platform for the development of injectable parenteral formulations: a comprehensive review of the know-hows and state of the art. Pharmaceutics, 12 (6), 510.
   PubMed Web of Science ®Google Scholar
• Shibu, E.S., et al., 2013. Nanomaterials formulations for photothermal and photodynamic therapy of cancer. Journal of photochemistry and photobiology C, 15, 53–72.
   Google Scholar
• Shih, T., and Lindley, C., 2006. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clinical therapeutics, 28 (11), 1779–1802.
   PubMed Web of Science ®Google Scholar
• Shrestha, H., Bala, R., and Arora, S., 2014. Lipid-based drug delivery systems. Journal of pharmaceutics, 2014, 1–10.
   Google Scholar
• Silva, C.O., et al., 2019. Current trends in cancer nanotheranostics: metallic, polymeric, and lipid-based systems. Pharmaceutics, 11 (1), 22.
   PubMed Web of Science ®Google Scholar
• Singh, V., et al., 2023. Recent development of multi-targeted inhibitors of human topoisomerase II enzyme as potent cancer therapeutics. International journal of biological macromolecules, 226, 473–484.
   PubMed Web of Science ®Google Scholar
• Smith, J.A., 1994. Neutrophils, host defense, and inflammation: a double-edged sword. Journal of leukocyte biology, 56 (6), 672–686.
   PubMed Web of Science ®Google Scholar
• Soehnlein, O., and Lindbom, L., 2010. Phagocyte partnership during the onset and resolution of inflammation. Nature reviews-immunology, 10 (6), 427–439.
   PubMed Web of Science ®Google Scholar
• Song, G., et al., 2017. Emerging nanotechnology and advanced materials for cancer radiation therapy. Advanced materials, 29 (32), 1700996.
   Web of Science ®Google Scholar
• Song, H., et al., 2018. Enhanced permeability of blood-brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle. International journal of nanomedicine, 13, 1869–1879.
   PubMed Web of Science ®Google Scholar
• Stacker, S.A., et al., 2001. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nature medicine, 7 (2), 186–191.
   PubMed Web of Science ®Google Scholar
• Steen, H.C., and Gamero, A.M., 2010. Interferon-lambda as a potential therapeutic agent in cancer treatment. Journal of interferon & cytokine research 30 (8), 597–602.
   PubMed Web of Science ®Google Scholar
• Strickley, R.G., 2004. Solubilizing excipients used in commercially available oral and injectable formulations. Pharmaceutical research, 21 (2), 201–230.
   PubMed Web of Science ®Google Scholar
• Sun, T., et al., 2014. Inhibition of tumor angiogenesis by interferon-γ by suppression of tumor-associated macrophage differentiation. Oncology research, 21 (5), 227–235.
   PubMed Web of Science ®Google Scholar
• Tabasi, H., et al., 2021. Metal–polymer-coordinated complexes as potential nanovehicles for drug delivery. Journal of nanostructure in chemistry, 11 (4), 501–526.
   Web of Science ®Google Scholar
• Talluri, S.V., et al., 2016. Lipid-based nanocarriers for breast cancer treatment – comprehensive review. Drug delivery, 23 (4), 1291–1305.
   PubMed Web of Science ®Google Scholar
• Tammela, T., 2004. Endocrine treatment of prostate cancer. The journal of steroid biochemistry and molecular biology, 92 (4), 287–295.
   PubMed Web of Science ®Google Scholar
• Tang, B., et al., 2015. Co-encapsulation of borneol and paclitaxel by liprosomes improved anti-tumor effect in a xenografted glioma model. RSC advances, 5 (129), 106613–106620.
   Web of Science ®Google Scholar
• Tantisripreecha, C., et al., 2012. Development of delayed-release proliposomes tablets for oral protein drug delivery. Drug development and industrial pharmacy, 38 (6), 718–727.
   PubMed Web of Science ®Google Scholar
• Tao, J., Chow, S.F., and Zheng, Y., 2019. Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles. Acta pharmaceutica sinica. B, 9 (1), 4–18.
   PubMed Web of Science ®Google Scholar
• Taratula, O., et al., 2013. Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA. Journal of controlled release, 171 (3), 349–357.
   PubMed Web of Science ®Google Scholar
• Tavakoli, N., et al., 2021. Milk protein-based nanodelivery systems for the cancer treatment. Journal of Nanostructure in Chemistry, 11 (4), 483–500.
   Web of Science ®Google Scholar
• Teicher, B.A., and Tomaszewski, J.E., 2015. Proteasome inhibitors. Biochemical pharmacology, 96 (1), 1–9.
   PubMed Web of Science ®Google Scholar
• Thevenot, J., et al., 2007. Steric stabilization of lipid/polymer particle assemblies by poly(ethylene glycol)-lipids. Biomacromolecules, 8 (11), 3651–3660.
   PubMed Web of Science ®Google Scholar
• Thorn, C.F., et al., 2011. Doxorubicin pathways. Pharmacogenetics and genomics, 21 (7), 440–446.
   PubMed Web of Science ®Google Scholar
• Torchilin, V.P., 2005. Recent advances with liposomes as pharmaceutical carriers. Nature reviews-drug discovery, 4 (2), 145–160.
   PubMed Web of Science ®Google Scholar
• Tran, N., et al., 2017. Dual-modality NIRF-MRI cubosomes and hexosomes: high throughput formulation and in vivo biodistribution. Materials science & engineering. C, materials for biological applications, 71, 584–593.
   PubMed Web of Science ®Google Scholar
• Tsend-Ayush, A., et al., 2017. Lactobionic acid-conjugated TPGS nanoparticles for enhancing therapeutic efficacy of etoposide against hepatocellular carcinoma. Nanotechnology, 28 (19), 195602.
   PubMed Web of Science ®Google Scholar
• Tunki, L., et al., 2019. Modulating the site-specific oral delivery of sorafenib using sugar-grafted nanoparticles for hepatocellular carcinoma treatment. European journal of pharmaceutical sciences, 137 (April), 104978.
   PubMedGoogle Scholar
• Ucisik, M., Sleytr, U., and Schuster, B., 2015. Emulsomes meet S-layer proteins: an emerging targeted drug delivery system. Current pharmaceutical biotechnology, 16 (4), 392–405.
   PubMed Web of Science ®Google Scholar
• Ulrike, M., et al., 1994. Functional role of type I and type II interferons in antiviral defense. Science, 264 (5167), 1918–1921.
   PubMed Web of Science ®Google Scholar
• Vaidya, J.S., 2021. Principles of cancer treatment by radiotherapy. Surgery, 39 (4), 193–201.
   Google Scholar
• Vance, R.E., Isberg, R.R., and Portnoy, D.A., 2009. Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell host & microbe, 6 (1), 10–21.
   PubMed Web of Science ®Google Scholar
• Varshosaz, J., et al., 2013. Biodistribution of amikacin solid lipid nanoparticles after pulmonary delivery. BioMed research international, 2013, 1–8.
   Web of Science ®Google Scholar
• Varshosaz, J., et al., 2014. Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma. Journal of liposome research, 24 (3), 191–203.
   PubMed Web of Science ®Google Scholar
• Varshosaz, J., et al., 2019. PEGylated trimethylchitosan emulsomes conjugated to octreotide for targeted delivery of sorafenib to hepatocellular carcinoma cells of HepG2. Journal of liposome research, 29 (4), 383–398.
   PubMed Web of Science ®Google Scholar
• Videira, M., Almeida, A.J., and Fabra, N., 2012. Preclinical evaluation of a pulmonary delivered paclitaxel-loaded lipid nanocarrier antitumor effect. Nanomedicine 8 (7), 1208–1215.
   PubMed Web of Science ®Google Scholar
• Vilcek, J., 2003. Novel interferons. Nature immunology, 4 (1), 8–9.
   PubMed Web of Science ®Google Scholar
• Waldman, T., et al., 1997. Cell-cycle arrest versus cell death in cancer therapy. Nature medicine, 3 (9), 1034–1036.
   PubMed Web of Science ®Google Scholar
• Wang, J., et al., 2014. Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria- mediated apoptosis pathway. International journal of nanomedicine, 9, 3987–3998.
   PubMed Web of Science ®Google Scholar
• Wang, L., et al., 2021. Paclitaxel and naringenin-loaded solid lipid nanoparticles surface modified with cyclic peptides with improved tumor targeting ability in glioblastoma multiforme. Biomedecine & Pharmacotherapie [Biomedicine & pharmacotherapy], 138, 111461.
   PubMed Web of Science ®Google Scholar
• Wang, W., et al., 2017. Anticancer effects of resveratrol-loaded solid lipid nanoparticles on human breast cancer cells. Molecules, 22 (11), 1814.
   PubMed Web of Science ®Google Scholar
• Wang, X., et al., 2016. Tunable lipidoid-telodendrimer hybrid nanoparticles for intracellular protein delivery in brain tumor treatment. Small, 12 (31), 4185–4192.
   PubMed Web of Science ®Google Scholar
• Wang, X.-Z., et al., 2020. Interpretation of the development of neoadjuvant therapy for gastric cancer based on the vicissitudes of the NCCN guidelines. World journal of gastrointestinal oncology, 12 (1), 37–53.
   PubMed Web of Science ®Google Scholar
• Wang, Y., et al., 2017. A step-by-step multiple stimuli-responsive nanoplatform for enhancing combined chemo-photodynamic therapy. Advanced materials, 29 (12), 1605357.
   Web of Science ®Google Scholar
• Wang, L., Li, M., and Zhang, N., 2012. Folate-targeted docetaxel-lipid-based-nanosuspensions for active-targeted cancer therapy. International journal of nanomedicine, 7, 3281–3294.
   PubMed Web of Science ®Google Scholar
• Warwick, G.P., 1963. The mechanism of action of alkylating agents. Cancer research, 23 (8 Part 1), 1315 LP–1333.
   PubMed Web of Science ®Google Scholar
• Wei, W., et al., 2020. Journal of nanostructure in chemistry. ACS applied materials & interfaces, 12 (13), 14839–14854.
   PubMedGoogle Scholar
• Wen, Y., et al., 2022. Bimetallic Au–Ag nanocages extended TPP conjugate structure for self-enhancing therapy of tumors. Journal of nanostructure in chemistry, 12 (6), 1105–1117.
   Web of Science ®Google Scholar
• Whalen, K., Finkel, R., and Panavelil, T., 2015. Lippincott illustrated reviews pharmacology, 6th ed. China: Wolters Kluwer.
   Google Scholar
• Wieduwilt, M.J., and Moasser, M.M., 2008. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cellular and molecular life sciences, 65 (10), 1566–1584.
   PubMed Web of Science ®Google Scholar
• Wu, R., et al., 2020. Combination chemotherapy of lung cancer – co-delivery of docetaxel prodrug and cisplatin using aptamer-decorated lipid–polymer hybrid nanoparticles. Drug design, development and therapy, 14, 2249–2261.
   PubMed Web of Science ®Google Scholar
• Xu, W., Bae, E.J., and Lee, M.K., 2018. Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells. International journal of nanomedicine, 13, 7549–7563.
   PubMed Web of Science ®Google Scholar
• Yaghmur, A., and Glatter, O., 2009. Characterization and potential applications of nanostructured aqueous dispersions. Advances in colloid and interface science, 147–148, 333–342.
   PubMed Web of Science ®Google Scholar
• Yanamandra, S., et al., 2014. Proliposomes as a drug delivery system to decrease the hepatic first-pass metabolism: case study using a model drug. European Journal of Pharmaceutical Sciences, 64, 26–36.
   PubMed Web of Science ®Google Scholar
• Yang, Q., et al., 2021. Gene therapy for drug-resistant glioblastoma via lipid-polymer hybrid nanoparticles combined with focused ultrasound. International journal of nanomedicine, 16, 185–199.
   PubMed Web of Science ®Google Scholar
• Yang, S., et al., 2016. In vivo biodistribution, biocompatibility, and efficacy of sorafenib-loaded lipid-based nanosuspensions evaluated experimentally in cancer. International journal of nanomedicine, 11, 2329–2343.
   PubMed Web of Science ®Google Scholar
• Yan-yu, X., et al., 2006. Preparation of silymarin proliposome: a new way to increase oral bioavailability of silymarin in beagle dogs. International journal of pharmaceutics, 319 (1–2), 162–168.
   PubMed Web of Science ®Google Scholar
• Yassemi, A., Kashanian, S., and Zhaleh, H., 2020. Folic acid receptor-targeted solid lipid nanoparticles to enhance cytotoxicity of letrozole through induction of caspase-3 dependent- apoptosis for breast cancer treatment. Pharmaceutical development and technology, 25 (4), 397–407.
   PubMed Web of Science ®Google Scholar
• Yin, L., et al., 2020. Triple-negative breast cancer molecular subtyping and treatment progress. Breast cancer research, 22 (1), 61.
   PubMed Web of Science ®Google Scholar
• Younis, M.A., et al., 2019. A multifunctional lipid-based nanodevice for the highly specific codelivery of sorafenib and midkine siRNA to hepatic cancer cells. Molecular pharmaceutics, 16 (9), 4031–4044.
   PubMed Web of Science ®Google Scholar
• Yu, B., Lee, R.J., and Lee, L.J.B.T.-MiE., 2009. Chapter 7 – microfluidic methods for production of liposomes. Methods in enzymology, 465,129–141.
   PubMed Web of Science ®Google Scholar
• Zak, D.E., and Aderem, A., 2015. Systems integration of innate and adaptive immunity. Vaccine, 33 (40), 5241–5248.
   PubMed Web of Science ®Google Scholar
• Zang, X., et al., 2021. Dual-targeting tumor cells and tumor associated macrophages with lipid coated calcium zoledronate for enhanced lung cancer chemoimmunotherapy. International Journal of pharmaceutics, 594, 120174.
   PubMed Web of Science ®Google Scholar
• Zare, K., Shadmani, N., and Pournamdari, E., 2013. DFT/NBO study of nanotube and calixarene with anti-cancer drug. Journal of nanostructure in chemistry, 3 (1), 1–6.
   Google Scholar
• Zhai, J., et al., 2019. Non-lamellar lyotropic liquid crystalline lipid nanoparticles for the next generation of nanomedicine. ACS nano, 13 (6), 6178–6206.
   PubMed Web of Science ®Google Scholar
• Zhai, Y., and Zhai, G., 2014. Advances in lipid-based colloid systems as drug carrier for topic delivery. Journal of controlled release, 193, 90–99.
   PubMed Web of Science ®Google Scholar
• Zhang, H., 2017. Thin-film hydration followed by extrusion method for liposome preparation. In: G. G. M. D’Souza, ed. Liposomes. New York, NY: Springer New York, 17–22.
   Google Scholar
• Zhang, J., et al., 2018. Lactoferrin- and RGD-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers for gliomatosis cerebri combination therapy. International journal of nanomedicine, 13, 3039–3051.
   PubMed Web of Science ®Google Scholar
• Zhao, X., et al., 2015. Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. European Journal of Pharmaceutics and Biopharmaceutics, 93, 27–36.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., and Huang, L., 2014. Chapter two – lipid nanoparticles for gene delivery. In: L. Huang, D. Liu, and E.B.T.-A. Wagner, eds. Advances in Genetics . Elsevier, 88, 13–36.
   Google Scholar
• Zheng, B., et al., 2015. Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: formulation optimization, characterization, oral bioavailability and tissue distribution in rats. European Journal of Pharmaceutical Sciences, 77, 254–264.
   PubMed Web of Science ®Google Scholar
• Zheng, G., et al., 2019. Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles : synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo. Biomedecine & Pharmacotherapie [Biomedicine & pharmacotherapy], 116 (440), 109006.
   PubMedGoogle Scholar
• Zhong, T., et al., 2016. A self-assembling nanomedicine of conjugated linoleic acid-paclitaxel conjugate (CLA-PTX) with higher drug loading and carrier-free characteristic. Scientific reports, 6 (1), 1–11.
   PubMedGoogle Scholar
• Zhou, Q., et al., 2019. Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy. Nature nanotechnology, 14 (8), 799–809.
   PubMed Web of Science ®Google Scholar
• Zhou, X., et al., 2012. Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma. International journal of nanomedicine, 7, 5465–5474.
   PubMed Web of Science ®Google Scholar
• Zhou, Z., et al., 2017. Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration. Advanced drug delivery reviews, 115, 115–154.
   PubMed Web of Science ®Google Scholar
• Zwain, T., et al., 2021. Tailoring functional nanostructured lipid carriers for glioblastoma treatment with enhanced permeability through in-vitro 3D BBB/BBTB models. Materials science & engineering. C, materials for biological applications, 121, 111774.
   PubMed Web of Science ®Google Scholar