Advanced search
Publication Cover
Somatosensory & Motor Research Volume 16, 1999 - Issue 1
Submit an article Journal homepage
4
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Deafferentation-induced regulation of AMPA receptors in the spinal cord of the adult rat

MAUREEN E. HELGREN Physical Therapy Department, Quinnipiac College, Hamden, CT 06518
,
KERRY ARSENAULT Physical Therapy Department, Quinnipiac College, Hamden, CT 06518
,
SHANTA E. KAPADIA Physical Therapy Department, Quinnipiac College, Hamden, CT 06518
&
CAROLE C. LaMOTTE Department of Neurosurger y, Yale University School of Medicine, New Haven, CT 06520, USA
Pages 39-48 | Published online: 10 Jul 2009

  • ABBADIE, C., and J.M. BESSON (1993) C-fos expression in rat lumbar spinal cord following peripheral stimulation in adjuvant-induced arthritic and normal rats. Brain Res 607: 195-204.
  • ABBADIE, C., J.L. BROWN, P.W. MANYTH, and A.I. BASBAUM (1996) Spinal cord substance P receptor immunoreactivty increases in both inflammatory and nerve injury models of persistent pain. Neurosci 70: 201-209.
  • BOXALL, S.J., S.W.N. THOMPSON, A. DRAY, A.H. DICKENSON, and L. URBAN (1996) Metabotropic glutamate receptor activation contributes to nociceptive reflex activity in the rat spinal cord in vitro. Neurosci 74: 13-20.
  • CHOI, D.W. (1992) Excitotoxic cell death. J Neurobiol 23: 1261-1276.
  • COGGESHALL, R.E. (1994) A possible relation between neuropathic pain and central sensory sprouting following peripheral nerve lesions. In Peripheral Neurons in Nociception: Physiopharmacological Aspects J. M. Besson, G.Guilbaud, H. Ollat eds, pp 201-208, John Libbey Eurotext, Paris.
  • COLLINGRIDGE, G.L., and W. SINGER (1990) Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol Sci 11: 290-296.
  • EL-BOHY, A., and C.C. LAMOTTE (1993) Deafferentationinduced changes in neuropeptides of the adult rat dorsal horn following pronase injection of the sciatic nerve. J Camp Neural 336: 545-q554.
  • EVANS, R.H., and J.C. WATKINS (1978) Specific antagonism of excitant amino acids in the isolated spinal cord of the neonatal rat. Bur J Pharmacol 50: 123-129.
  • FURUYAMA, T., H. KIYAMA, K. SATO, H. TAB PARK, H. MAENO, H. TAKAGI, and M. TOHYAMA (1993) Region specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Mol Brain Res 18: 141-151.
  • GOLDBERGER, M.E. (1988) Spared root deafferentation of a cat's hindlimb: hierachial regulations of pathways mediating recovery of motor behavior. Exp Brain Res 73(2): 329-342.
  • HARRIS, J.A., M. CORSI, M. QUARTAROLI, R. ARBAN, and M. BENTIVOGLIO (1996) Upregulation of spinal glutamate receptors in chronic pain. Neurosci 74: 7-12.
  • HELGREN, H.E., K. ARSENAULT, S. KAPADIA, and C. LAMOTTE (1999) Deafferentation-induced regulation of AMDA receptors in the spinal cord of adult rat. Somatosens. Mot. Res. 16: 41-50.
  • HIMES, B.T., and A. TESSLER (1989) Death of some dorsal root ganglion neurons and plasticity of others following sciatic nerve section in adult and neonatal rats. J Comp Neural 284: 215-30.
  • HOLLMAN, M., and S. HEINEMANN (1994) Cloned glutamate receptors. Annu Rev Neurosci 17: 31-108.
  • HUME, R.I., R. DINGLEDINE, and S.F. HEINEMANN (1991) Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253: 1028-1031.
  • KADOTANI, H., T. HIRANO, M. MASUGI, K. NAKAMURA, K. NAKAO, M. KATSUKI, and S. NAKANISHI (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci 16: 7859-7867.
  • KAI-KAI, M.A., and R. HOWE (1991) Glutamate immunoreactivity in the trigeminal and dorsal room ganglia and intraspinal neurons and fibers in the dorsal horn of the rat. Histochem J 23: 171-179.
  • KAWAGOE, R., K. ONODERA, and A. TAKEUCHI (1986) The release of endogenous glutamate from the newborn rat spinal cord induced by dorsal root stimulation and substance P. Biomed Res 7: 253-259.
  • LAMOTTE, C.C. (1994) Deafferentation-induced alterations in the adult rat dorsal horn. In Peripheral Neurons in Nociception: Physio-pharmacological Aspects J.M. Besson, G. Guilbaud and H. Ollat (Eds), pp. 209-214, John Libby Eurotext, Paris.
  • LAMOTTE, C.C., and S.E. KAPADIA (1993) Deafferentation-induced terminal field expansion of myelinated saphenous afferents in the adult rat dorsal horn and the nucleus gracilis following pronase injection of the sciatic nerve. J Comp Neural 330: 83-94.
  • LAMOTTE, C.C., S.E. KAPADIA, and C.M. KOCOL (1989) Deafferentation-induced expansion of saphenous terminal field labeling in the adult rat dorsal horn following pronase injection of the sciatic nerve. J Comp Neural 288: 311-325.
  • MANNION, R.J., T.P. DOUBELL, R.E. COGGESHALL, and C.J. WOOLF (1996) Collateral sprouting of uninjured primary afferent A-fibers into the superficial dorsal horn of the adult rat spinal cord after topical capsaicin treatment to the sciatic nerve. J Neurosci 16: 5189-5195.
  • MAO, J., D.D. PRICE, R.L. HAYES, J. Lu, and DJ. MAYER (1992) Differential role of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res 598: 271-278.
  • McMAHON, S.B., and R. KETT-WHITE (1991) Sprouting of primary sensory neurones in the adult central nervous system. J Camp Neural 304: 307-315.
  • MELLER, S.T., C.L. DYKSTRA, and G.F. GEBHART (1993) Acute mechanical hyperalgesia is produced by coactivation of AMPA and met ab o tropic glutamate receptors. Neuroreport 4: 879-882.
  • MUNGLANI, R., S.M. HARRISON, G.D. SMITH, C. BOUNTRA, P.J. BIRCH, P.J. ELLIOT, and S.P. HUNT (1996) Neuropeptide changes persist in spinal cord despite resolving hyperalgesia in a rat model of mononeuropathy. Brain Res 743: 102-108.
  • MURRAY, M., and M.E. GOLDBERGER (1986) Replacement of synaptic terminals in laminae II and Clarke's nucleus after unilateral lumbosacral dorsal rhizotomy in adult cats. J Neurosci 6: 3205-3217.
  • PEKHLETSKI, R., R. GERLAI, L. OVERSTREET, X. HUNANG, N. AGOPYAN, N.T. SLATER, W. ABRAMOW-NEWERLY, J.C. RODER, D.R. HAMPSON (1996) Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J Neurosci 16: 6364-6373.
  • PETRALIA, R.S., N.YOKOTANI, and R.J. WENTHOLD (1996) Light and electron microscope distribution of the NMDA receptor subunit NMDARl in the rat nervous system using a selective anti-peptide antibody. J Neurosci 14: 667-696.
  • PIN, J.P., and R. DUVOISIN (1995) The metabotropic glutamate receptors: structure and functions. Neuropharm 31: 1-26.
  • SCHNEIDER, S.P. and E.R. PERL (1985) Selective excitation of neurons in the mammalian spinal cord by aspartate and glutamate in vitro: correlation with location and excitatory input. Brain Res 360: 339-343.
  • SUGIMOTO, T, M. FUNAHASHI, C. XIAO, A. ADACHI, and H. ICHIKAWA (1997) Exaggerated C-fiber activation prevents peripheral nerve injury-induced hyperinducibility of c-Fos in partially deafferented spinal dorsal horn. Neurosci Res 27: 161-167.
  • TACHIBANA, M., R.J. WENTHOLD, H. MORIOKA, and R. PETRALIA, (1994) Light and electron microscopic immunocytochemical localization of AMPA-selective glutamate receptors in the rat spinal cord. J Comp Neural 344: 431-454.
  • TESSLER, A., B.T. HIMES, N.R. KRIEGER, M. MURRAY, and M.E. GOLDBERGER (1985) Sciatic nerve transaction produces death of a dorsal root ganglion cells and reversible loss of substance P in spinal cord. Brain Res 332: 209-218.
  • URBAN, L., S.W.N. THOMPSON, and A. DRAY (1994) Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters. TINS 17: 432-438.
  • VILLAR, M.J., Z. WIESENPELD-HALLIN, X.J. Xu, E. THEODORSSON, P. EMSON, and T. HOKPELT (1991) Further studies on galanin-, substance P-, and CGRP-like immunoreactivities in primary sensory neurons and spinal cord: effects of dorsal rhizotomies and sciatic nerve lesions. Exp Neural 112: 29-39.
  • VITA, G., C.K., HAUN, E.F. HAWKIN, and W.K. ENGEL (1990) Effects of experimental spinal cord transaction on substance P receptors: A quantitative autoradiographie study. Neuropeptides 17: 147-153.
  • WANAKA, A., Y. SHIOTANI, H. KIYAMA, T. MATSUYAMA, T. KAMADA, S. SHIOSAKA, and M. TOHYAMA (1987) Glutamate-like immunoreactive structures in primary sensory neurons in the rat detected by a specific antiserum against glutamate. Exp Brain Res 65: 691-694.
  • WESTLUND, K.N., D.L. MCNEILL, and R.E. COGGESHALL (1989) Glutamate immunoreactivity in rat dorsal root axons. Neurosci Lett 96: 13-17.
  • WOLFE, C.J., P. SHROTLAND, and R.E. COGGESHALL (1992) Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 355: 75-78.
  • WOOLF, C.F. (1992) Excitability changes in central neurons following peripheral damage: the role of central sensitization in the pathogenesis of pain. In Hyperalgesia and Allodynia, Willis, W.D., ed., pp. 221-224, Raven Press, New York.
  • YOSHIMURA, M. and S. NISHI (1992) Excitatory amino acid receptors involved in primary afferent-evoked polysnaptic EPSPs of substantia gelatinosa neurons in the adult rat spinal cord slice. Neurosci Lett 143: 131-134.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.