483
Views
3
CrossRef citations to date
0
Altmetric
Research Article

RICINOLEIC ACID, THE ACTIVE INGREDIENT OF CASTOR OIL, INCREASES NITRIC OXIDE SYNTHASE ACTIVITY IN THE RAT ILEUM AND COLON

, , , &
Pages 364-370 | Accepted 20 Jun 1997, Published online: 29 Sep 2008

REFERENCES

  • Beubler E. and Juan H. (1979) Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colon. J. Pharm. Pharmacol. 31: 681–685.
  • Bonaventura J. and Bonaventura C. (1981) In Methods in enzymology edited by Antonini E., Rossi-Bernardi L. and Chiancone E., Vol. 76, pp. 60–61. Academic Press, London.,
  • Bretagne J. F., Vidon N., L'Hirondel C. and Bernier J. J. (1981) Increased cell loss in the human jejunum induced by laxatives (ricinoleic acid, dioctyl sodium sulphosuccinate, magnesium sulphate, bile salts). Gut 22: 264–269.
  • Capasso F., Mascolo N., Autore G. and Romano V. (1986) Laxatives and the production of autacoids by rat colon. J. Pharm. Pharmacol. 38: 627–629.
  • Capasso F., Mascolo N., Izzo A. A., and Gaginella T. (1994) Dissociation of castor oil-induced diarrhoea and intestinal mucosal injury in rat: Effect of NG-L-arginine methyl ester. Br. J. Pharmacol. 113: 1127–1130.
  • Cline W. S., Lorenzsonn V., Benz L., Bass P. and Olsen W. A. (1976) The effects of sodium ricinoleate on small intestinal function and structure. J. Clin. Invest. 58: 380–390.
  • Doyle M. P. and Hoekstra J. W. (1981) Oxidation of nitrogen oxides by boud dioxygen in hemoproteins. J. Inorg. Biochem. 14: 351–355.
  • Feelisch M. and Noack E. A (1987) Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur. J. Pharmacol. 139: 19–30.
  • Gaginella T. S. (1994) Laxative drugs, in Textbook of basic and clinical pharmacology edited by Munson P., Mueller R. and Breese G., pp. 1075–1082. Chapman and Hall, New York.,
  • Gaginella T. S. and Phillips S. F. (1975) Ricinoleic acid: current view of an ancient oil. Dig. Dis. 20: 1171–1175.
  • Gaginella T. S., Haddad A. C., Go V. L. W. and Phillips S. F. (1977a) Cytotoxic action of ricinoleic acid and other intestinal secretagogues on isolated intestinal epithelial cells. J. Pharm. Exp. Therap. 201: 259–266.
  • Gaginella T. S., Chadwick V. S., Debongnie J. C., Lewis J. C. and Phillips S. P. (1977b) Perfusion of rabbit colon with ricinoleic acid: dose related mucosal injury, fluid secretion and increased permeability. Gastroenterology 73: 95–101.
  • Gaginella T. S., Mascolo N., Izzo A. A., Autore G. and Capasso F. (1994) Nitric oxide as a mediator of bisacodyle and phenolphthalein laxative action: induction of nitric oxide synthase. J. Pharm. Exp. Therap. 270: 1239–1245.
  • Gaginella T. S., Phillips S. F., Dozois R. R. and Go V. L. W. (1978) Stimulation of adenylate cyclase in homogenate of isolated intestinal epithelial cells from hamsters. Effects of gastrointestinal hormones, prostaglandins, and deoxycholic and ricinoleic acid. Gastroenterology 74: 11–15.
  • Gaginella T. S., Stewart J. J., Olsen W. A. and Bass P (1975) Actions of ricinoleic acid and structurally related fatty acids on the gastrointestinal tract. II. Effects on water and electrolyte absorption in vitro. J. Pharm. Exp. Therap. 195: 335–361.
  • Gaginella T. S. and Phillips S. F (1976) Ricinoleic acid (castor oil) alters intestinal surface morphology: scanning electron microscopic appearance. Mayo Clin. Proc. 6–12.
  • Hariharan M., Naga S. and Van Noord T. (1993) Systematic approach to the development of plasma amino acid analysis by high-performance liquid chromatography with ultraviolet detection with precolumn derivatization using phenyl isothiocyanate. J. Chromatogr. 621: 15–19.
  • Ignarro L. J., Buga G. M., Wood K. S., Byrns R. E. and Chaudhuri G. (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. 84: 9265–9269.
  • Izzo A. A., Gaginella T. S., Mascolo N. and Capasso F. (1994) Nitric oxide as a mediator of the laxative action of magnesium sulphate. Br. J. Pharmacol. 113: 228–232.
  • Izzo A. A., Mascolo N., Viola P. and Capasso F. (1993) Inhibitors of nitric oxide synthase enhance rat ileum contractions induced by ricinoleic acid in vitro. Eur. J. Pharmacol. 243: 87–90.
  • Kostka D., Jan E., Watson E. G., Steward E. G. and Daniel E. E. (1993) Nitric oxide synthase in the autonomic nervous system of canine ileum. J. Pharm. Exp. Therap. 264: 234–239.
  • Lowry O. H., Rosebrough N. J., Farr A. L. and Randall R. J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265–275.
  • Mascolo N., Izzo A. A. and Capasso F. (1992) Castor oil induced diarrhoea: involvement of nitric oxide in Natural drugs and the digestive tract edited by Capasso F. and Mascolo N., pp. 121–128. EMSI, Rome, Italy.
  • Mascolo N., Izzo A. A., Autore G., Barbato F. and Capasso F. (1994) Nitric oxide and castor oil-induced diarrhea. J. Pharmacol. Exp. Ther. 268: 291–295.
  • Mascolo N., Izzo A. A., Barbato F. and Capasso F. (1993) Inhibitors of nitric oxide synthase prevent castor oil-induced diarrhoea in the rat. Br. J. Pharmacol. 108: 861–864.
  • Moncada S. and Higgs E. A. (1991) Endogenous nitric oxide: Physiology, pathology and clinical relevance. Eur. J. Clin. Inv. 21: 361–374.
  • Nakao S. (1963) The effect of ricinoleic acid and phenolphthalein on creatine phophate levels in the rat intestine in vitro. Biochem. 12: 216–217.
  • Nichols K., Staines W. and Krantis A. (1993) Nitric oxide sinthase distribution in the rat intestine: a histochemical analyses. Gastroenterology 105: 1651–1661.
  • Phillips R. A., Lowe A. H. G., Mitchell T. G. and Neptune E. M. (1965) Cathartics and the sodium pump. Nature 206: 1367–1368.
  • Pinto A., Autore G., Mascolo N., Sorrentino R., Biondi A., Izzo A. A. and Capasso F. (1992) Time course of PAF formation by gastrointestinal tissue in rats after castor oil challenge. J. Pharm. Pharmacol. 44: 224–226.
  • Pinto A., Calignano A., Mascolo N., Autore G. and Capasso F. (1989) Castor oil increases intestinal formation of platelet-activating factor and acid phosphatase release in the rat. Br. J. Pharmacol. 96: 872–874.
  • Racusen L. C. and Binder H. J. (1979) Ricinoleic acid stimulation of active anion secretion in colonic mucosa of the rat. J. Clin. Invest. 63: 743–749.
  • Saunders D. R., Sillery J., Rachmilewitz D., Ruben C. E. and Tytgat G. N. (1977) Effect of bisacodyl on the structure and function of rodent and human intestine. Gastroenterology 72: 849–856.
  • Saunders D. R., Sillery J., Suruwica C. and Tytgat G. N. (1978) Effect of phenolphthalein on the function and structure of rodent and human intestine. Dig. Dis. Sci. 23: 909–913.
  • Simon B. and Kather H. (1980) Interaction of laxatives with enzymes of cyclic AMP metabolism from human colonic mucosa. Eur. J. Clin. Invest. 10: 231–234.
  • Tarnai H. and Gaginella T. S. (1993) Direct evidence for nitric oxide stimulation of electrolyte secretion in the rat colon. Free. Rad. Res. Comms. 19: 229–239.
  • Valette G. and Salvanet R. (1936) Les causes de l'action de l'huile de ricin. Bull. Sci. Pharmacol. 43: 1–11.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.