Immune Response Genes in Uveitis

REFERENCES

• Janeway C A, Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20: 197–216
   PubMed Web of Science ®Google Scholar
• Sohn J H, Kaplan H J, Suk H J, et al. Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. Invest Ophthalmol Vis Sci 2000; 41: 3492–3502
   PubMed Web of Science ®Google Scholar
• Sohn J H, Kaplan H J, Suk H J, et al. Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59. Invest Ophthalmol Vis Sci 2000; 41: 4195–4202
   PubMed Web of Science ®Google Scholar
• Jha P, Bora P S, Bora N S. The role of complement system in ocular diseases including uveitis and macular degeneration. Mol Immunol 2007; 44: 3901–3908
   PubMed Web of Science ®Google Scholar
• Taurog J D, Richardson J A, Croft J T, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994; 180: 2359–2364
   PubMed Web of Science ®Google Scholar
• Wakefield D, Montanaro A, McCluskey P. Acute anterior uveitis and HLA-B27. Surv Ophthalmol 1991; 36: 223–232
   PubMed Web of Science ®Google Scholar
• Rosenbaum J T, Rosenzweig H L, Smith J R, et al. Uveitis secondary to bacterial products. Ophthalmic Res 2008; 40: 165–168
   PubMed Web of Science ®Google Scholar
• Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21: 335–376
   PubMed Web of Science ®Google Scholar
• Chang J H, McCluskey P J, Wakefield D. Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. Br J Ophthalmol 2006; 90: 103–108
   PubMed Web of Science ®Google Scholar
• Dabbagh K, Lewis D B. Toll-like receptors and T-helper-1/T-helper-2 responses. Curr Opin Infect Dis 2003; 16: 199–204
   PubMedGoogle Scholar
• Fearon D T, Locksley R M. The instructive role of innate immunity in the acquired immune response. Science 1996; 272: 50–53
   PubMed Web of Science ®Google Scholar
• Medzhitov R, Preston-Hurlburt P, Janeway C A, Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394–397
   PubMed Web of Science ®Google Scholar
• Brito B E, Zamora D O, Bonnah R A, et al. Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells. Exp Eye Res 2004; 79: 203–208
   PubMed Web of Science ®Google Scholar
• Chang J H, Hampartzoumian T, Everett B, et al. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Invest Ophthalmol Vis Sci 2007; 48: 1711–1717
   PubMedGoogle Scholar
• Chang J H, McCluskey P, Wakefield D. Expression of toll-like receptor 4 and its associated lipopolysaccharide receptor complex by resident antigen-presenting cells in the human uvea. Invest Ophthalmol Vis Sci 2004; 45: 1871–1878
   PubMed Web of Science ®Google Scholar
• Fujimoto C, Shi G, Gery I. Microbial products trigger autoimmune ocular inflammation. Ophthalmic Res 2008; 40: 193–199
   PubMed Web of Science ®Google Scholar
• Inohara N, Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 2003; 3: 371–382
   PubMed Web of Science ®Google Scholar
• Watanabe T, Kitani A, Murray P J, et al. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 2004; 5: 800–808
   PubMed Web of Science ®Google Scholar
• Strober W, Murray P J, Kitani A, et al. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 2006; 6: 9–20
   PubMed Web of Science ®Google Scholar
• Netea M G, Ferwerda G, de Jong D J, et al. Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J Immunol 2005; 174: 6518–6523
   PubMed Web of Science ®Google Scholar
• Miceli-Richard C, Lesage S, Rybojad M, et al. CARD15 mutations in Blau syndrome. Nat Genet 2001; 29: 19–20
   PubMed Web of Science ®Google Scholar
• Davey M P, Martin T M, Planck S R, et al. Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Microvasc Res 2006; 71: 103–107
   PubMedGoogle Scholar
• Rosenzweig H L, Martin T M, Jann M M, et al. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci 2008; 49: 1518–1524
   PubMed Web of Science ®Google Scholar
• Rosenzweig H L, Galster K T, Planck S R, et al. NOD1 is expressed in the eye and functionally contributes to IL-1beta dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci 2009; 50: 1746–1753
   PubMed Web of Science ®Google Scholar
• Brewerton D A, Caffrey M, Nicholls A, et al. Letter: Acute anterior uveitis and HL-A 27. Lancet 1974; 1: 464
   PubMedGoogle Scholar
• Schwimmbeck P L, Yu D T, Oldstone M B. Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome: molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease. J Exp Med 1987; 166: 173–181
   PubMed Web of Science ®Google Scholar
• Linssen A, Rothova A, Valkenburg H A, et al. The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. Invest Ophthalmol Vis Sci 1991; 32: 2568–2578
   PubMed Web of Science ®Google Scholar
• Davey M P, Rosenbaum J T. The human leukocyte antigen complex and chronic ocular inflammatory disorders. Am J Ophthalmol 2000; 129: 235–243
   PubMed Web of Science ®Google Scholar
• Levinson R D. Immunogenetics of ocular inflammatory disease. Tissue Antigens 2007; 69: 105–112
   PubMed Web of Science ®Google Scholar
• Yabuki K, Inoko H, Ohno S. HLA testing in patients with uveitis. Int Ophthalmol Clin 2000; 40: 19–35
   PubMedGoogle Scholar
• Shah K H, Levinson R D, Yu F, et al. Birdshot chorioretinopathy. Surv Ophthalmol 2005; 50: 519–541
   PubMed Web of Science ®Google Scholar
• Chang J H, McCluskey P J, Wakefield D. Acute anterior uveitis and HLA-B27. Surv Ophthalmol 2005; 50: 364–388
   PubMed Web of Science ®Google Scholar
• Byrom N A, Brown J J, Davies D L, et al. T and B lymphocytes in patients with acute anterior uveitis and ankylosing spondylitis, and in their household contacts. Lancet 1979; 2: 601–603
   PubMedGoogle Scholar
• Hou S, Yang P, Du L, et al. SUMO4 gene polymorphisms in Chinese Han patients with Behcet's disease. Clin Immunol 2008; 129: 170–175
   PubMed Web of Science ®Google Scholar
• Al-Mutawa S A, Hegab S M. Behcet's disease. Clin Exp Med 2004; 4: 103–131
   PubMed Web of Science ®Google Scholar
• Mizuki N, Ota M, Yabuki K, et al. Localization of the pathogenic gene of Behcet's disease by microsatellite analysis of three different populations. Invest Ophthalmol Vis Sci 2000; 41: 3702–3708
   PubMed Web of Science ®Google Scholar
• Islam S M, Numaga J, Fujino Y, et al. HLA class II genes in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci 1994; 35: 3890–3896
   PubMed Web of Science ®Google Scholar
• Alaez C, del Pilar Mora M, Arellanes L, et al. Strong association of HLA class II sequences in Mexicans with Vogt-Koyanagi-Harada's disease. Hum Immunol 1999; 60: 875–882
   PubMedGoogle Scholar
• Oruc S, Duffy B F, Mohanakumar T, et al. The association of HLA class II with pars planitis. Am J Ophthalmol 2001; 131: 657–659
   PubMed Web of Science ®Google Scholar
• Raja S C, Jabs D A, Dunn J P, et al. Pars planitis: clinical features and class II HLA associations. Ophthalmology 1999; 106: 594–599
   PubMed Web of Science ®Google Scholar
• Kilmartin D J, Wilson D, Liversidge J, et al. Immunogenetics and clinical phenotype of sympathetic ophthalmia in British and Irish patients. Br J Ophthalmol 2001; 85: 281–286
   PubMed Web of Science ®Google Scholar
• Levinson R D, Park M S, Rikkers S M, et al. Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. Invest Ophthalmol Vis Sci 2003; 44: 653–657
   PubMed Web of Science ®Google Scholar
• Du L, Yang P, Hou S, et al. Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome. Clin Immunol 2008; 127: 43–48
   PubMedGoogle Scholar
• Ueda H, Howson J M, Esposito L, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423: 506–511
   PubMed Web of Science ®Google Scholar
• Bye L, Modi N, Stanford M R, et al. CTLA-4 polymorphisms are not associated with ocular inflammatory disease. Tissue Antigens 2008; 72: 49–53
   PubMedGoogle Scholar
• Verity D H, Wallace G R, Vaughan R W, et al. HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behcet's disease. Tissue Antigens 1999; 54: 264–272
   PubMed Web of Science ®Google Scholar
• Lee E B, Kim J Y, Lee Y J, et al. TNF and TNF receptor polymorphisms in Korean Behcet's disease patients. Hum Immunol 2003; 64: 614–620
   PubMed Web of Science ®Google Scholar
• Duymaz-Tozkir J, Gul A, Uyar F A, et al. Tumour necrosis factor-alpha gene promoter region -308 and -376 G– > A polymorphisms in Behcet's disease. Clin Exp Rheumatol 2003; 21: S15–S18
   PubMed Web of Science ®Google Scholar
• Ahmad T, Wallace G R, James T, et al. Mapping the HLA association in Behcet's disease: a role for tumor necrosis factor polymorphisms?. Arthritis Rheum 2003; 48: 807–813
   PubMed Web of Science ®Google Scholar
• Espinosa G, Arostegui J I, Plaza S, et al. Behcet's disease and hereditary periodic fever syndromes: casual association or causal relationship?. Clin Exp Rheumatol 2005; 23: S64–S66
   PubMed Web of Science ®Google Scholar
• Akman A, Sallakci N, Coskun M, et al. TNF-alpha gene 1031 T/C polymorphism in Turkish patients with Behcet's disease. Br J Dermatol 2006; 155: 350–356
   PubMed Web of Science ®Google Scholar
• Park K, Kim N, Nam J, et al. Association of TNFA promoter region haplotype in Behcet's Disease. J Korean Med Sci 2006; 21: 596–601
   PubMedGoogle Scholar
• Kamoun M, Chelbi H, Houman M H, et al. Tumor necrosis factor gene polymorphisms in Tunisian patients with Behcet's disease. Hum Immunol 2007; 68: 201–205
   PubMed Web of Science ®Google Scholar
• Seki N, Yamaguchi K, Yamada A, et al. Polymorphism of the 5'-flanking region of the tumor necrosis factor (TNF)-alpha gene and susceptibility to human T-cell lymphotropic virus type I (HTLV-I) uveitis. J Infect Dis 1999; 180: 880–883
   PubMedGoogle Scholar
• Kuo N W, Lympany P A, Menezo V, et al. TNF-857T, a genetic risk marker for acute anterior uveitis. Invest Ophthalmol Vis Sci 2005; 46: 1565–1571
   PubMed Web of Science ®Google Scholar
• McGarry F, Walker R, Sturrock R, et al. The -308.1 polymorphism in the promoter region of the tumor necrosis factor gene is associated with ankylosing spondylitis independent of HLA-B27. J Rheumatol 1999; 26: 1110–1116
   PubMed Web of Science ®Google Scholar
• Gonzalez S, Torre-Alonso J C, Martinez-Borra J, et al. TNF-238A promoter polymorphism contributes to susceptibility to ankylosing spondylitis in HLA-B27 negative patients. J Rheumatol 2001; 28: 1288–1293
   PubMed Web of Science ®Google Scholar
• Mizuki N, Ota M, Kimura M, et al. Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behcet disease. Proc Natl Acad Sci U S A 1997; 94: 1298–1303
   PubMed Web of Science ®Google Scholar
• Goto K, Ota M, Ando H, et al. MICA gene polymorphisms and HLA-B27 subtypes in Japanese patients with HLA-B27-associated acute anterior uveitis. Invest Ophthalmol Vis Sci 1998; 39: 634–637
   PubMedGoogle Scholar
• Ota M, Mizuki N, Katsuyama Y, et al. The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping. Am J Hum Genet 1999; 64: 1406–1410
   PubMedGoogle Scholar
• Wallace G R, Verity D H, Delamaine L J, et al. MIC-A allele profiles and HLA class I associations in Behcet's disease. Immunogenetics 1999; 49: 613–617
   PubMed Web of Science ®Google Scholar
• Karasneh J, Hajeer A H, Barrett J, et al. Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behcet's disease. Rheumatology (Oxford) 2003; 42: 860–864
   PubMed Web of Science ®Google Scholar
• Akman A, Ekinci N C, Kacaroglu H, et al. Relationship between periodontal findings and specific polymorphisms of interleukin-1alpha and -1beta in Turkish patients with Behcet's disease. Arch Dermatol Res 2008; 300: 19–26
   PubMed Web of Science ®Google Scholar
• Cordeiro C A, Moreira P R, Costa G C, et al. Interleukin-1 gene polymorphisms and toxoplasmic retinochoroiditis. Mol Vis 2008; 14: 1845–1849
   PubMed Web of Science ®Google Scholar
• Menezo V, Bond S K, Towler H M, et al. Cytokine gene polymorphisms involved in chronicity and complications of anterior uveitis. Cytokine 2006; 35: 200–206
   PubMed Web of Science ®Google Scholar
• Chen Y, Vaughan R W, Kondeatis E, et al. Chemokine gene polymorphisms associate with gender in patients with uveitis. Tissue Antigens 2004; 63: 41–45
   PubMedGoogle Scholar
• Wegscheider B J, Weger M, Renner W, et al. Role of the CCL2/MCP-1 -2518A > G gene polymorphism in HLA-B27 associated uveitis. Mol Vis 2005; 11: 896–900
   PubMedGoogle Scholar
• Yeo T K, Ahad M A, Kuo N W, et al. Chemokine gene polymorphisms in idiopathic anterior uveitis. Cytokine 2006; 35: 29–35
   PubMedGoogle Scholar
• Ahad M A, Missotten T, Abdallah A, et al. Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis. Mol Vis 2007; 13: 388–396
   PubMedGoogle Scholar
• Lee E B, Kim J Y, Zhao J, et al. Haplotype association of IL-8 gene with Behcet's disease. Tissue Antigens 2007; 69: 128–132
   PubMedGoogle Scholar
• Inanc N, Mumcu G, Birtas E, et al. Serum mannose-binding lectin levels are decreased in Behcet's disease and associated with disease severity. J Rheumatol 2005; 32: 287–291
   PubMed Web of Science ®Google Scholar
• Park K S, Min K, Nam J H, et al. Association of HYPA haplotype in the mannose-binding lectin gene-2 with Behcet's disease. Tissue Antigens 2005; 65: 260–265
   PubMedGoogle Scholar
• Li K, Zhao M, Hou S, et al. Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations. Mol Vis 2008; 14: 2136–2142
   PubMed Web of Science ®Google Scholar