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Review Article

Common and Rare Ocular Side-effects of the Dexamethasone Implant

, MD, PhD ORCID Icon, , MD & , MD, PhD
Pages 834-840 | Received 11 Dec 2015, Accepted 21 Apr 2016, Published online: 05 Jul 2016

REFERENCES

  • Haller JA, Bandello F, Belfort R Jr, et al. Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology. 2010;117:1134–1146.
  • Boyer DS, Yoon YH, Belfort R Jr, et al. Three-year, randomized, sham controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology. 2014;121:1904–1914.
  • Lowder C, Belfort R Jr, Lightman S, et al. Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol. 2011;129:545–553.
  • Agrawal R, Fernandez-Sanz G, Bala S, et al. Desegmentation of Ozurdex implant in vitreous cavity: report of two cases. Br J Ophthalmol. 2014;98:961–963.
  • Donmez O, Parlak M, Yaman A, et al. Splitting of a Dexamethasone implant (Ozurdex) following the injection. Case Rep Ophthalmol Med. 2013;2013:247949.
  • Chalioulias K, Muqit MM. Vitreoretinal surgery for inadvertent intralenticular Ozurdex implant. Eye (Lond). 2014;28:1523–1524.
  • Chhabra R, Kopsidas K, Mahmood S. Accidental insertion of dexamethasone implant into the crystalline lens – 12 months follow-up. Eye. 2014;28:624–625.
  • Coca-Robinot J, Casco-Silva B, Armada-Maresca F, et al. Accidental injections of dexamethasone intravitreal implant (Ozurdex) into the crystalline lens. Eur J Ophthalmol. 2014;24:633–636.
  • Fasce F, Battaglia Parodi M, Knutsson KA, et al. Accidental injection of dexamethasone intravitreal implant in the crystalline lens. Acta Ophthalmologica. 2014;92:e330–e331.
  • Panjaphongse R, Stewart JM. Risk factors for wound leakage after Ozurdex injection. Ocul Immunol Inflamm. 2015;23:410–411.
  • Khurana RN, Appa SN, McCannel CA, et al. Dexamethasone implant anterior chamber migration: risk factors, complications, and management strategies. Ophthalmology. 2014;121:67–71.
  • Pardo-Lopez D, Frances-Munoz E, Gallego-Pinazo R, et al. Anterior chamber migration of dexamethasone intravitreal implant (Ozurdex®). Graefes Arch Clin Exp Ophthalmol. 2012;250:1703–1704.
  • Vela JI, Crespí J, Andreu D. Repositioning of dexamethasone intravitreal implant (Ozurdex) migrated into the anterior chamber. Int Ophthalmol. 2012;32:583–584.
  • Kishore SA, Schaal S. Management of anterior chamber dislocation of dexamethasone implant. Ocul Immunol Inflamm. 2013;21:90–91.
  • Gillies MC, Lim LL, Campain A, et al. A randomized clinical trial of intravitreal bevacizumab versus intravitreal dexamethasone for diabetic macular edema: the BEVORDEX study. Ophthalmology. 2014;121:2473–2481.
  • Kiddee W, Trope GE, Sheng L, et al. Intraocular pressure monitoring post intravitreal steroids: a systematic review. Surv Ophthalmol. 2013;58:291–310.
  • Capone A, Singer MA, Dodwell DG, et al. Efficacy and safety of two or more dexamethasone intravitreal implant injections for treatment of macular edema related to retinal vein occlusion (Shasta study). Retina. 2014;34:342–351.
  • Ozkok A, Saleh OA, Sigford D, et al. The OMAR Study: comparison of Ozurdex and triamcinolone acetonide for refractory cystoid macular edema in retinal vein occlusion. Retina. 2015;35:1393–1400.
  • Callanan DG, Gupta S, Boyer DS, et al. Dexamethasone intravitreal implant in combination with laser photocoagulation for the treatment of diffuse diabetic macular edema. The PLACID Study Group. Ophthalmology. 2013;120:1843–1851.
  • Kuppermann BD, Goldstein M, Maturi RK, et al. Dexamethasone intravitreal implant as adjunctive therapy to ranibizumab in neovascular age-related macular degeneration: A multicenter randomized controlled trial. Ozurdex® ERIE Study Group. Ophthalmologica. 2015;234:40–54.
  • Ramu J, Yang Y, Menon G, et al. A randomized clinical trial comparing fixed vs pro-re-nata dosing of Ozurdex in refractory diabetic macular oedema (OZDRY study). Eye (Lond). 2015;29:1603–1612.
  • Casati S, Bruni E, Marchini G. Retinal and vitreous hemorrhage after traumatic impact of dexamethasone implant in a vitrectomized eye. Eur J Ophthalmol. 2016;26:e55–e57.
  • Afshar AR, Loh AR, Pongsachareonnont P, et al. Dexamethasone intravitreal implant trapped at the macula in a silicone oil-filled eye. Ophthalmology. 2013;120:2748–2749.
  • Noma H, Funatsu H, Mimura T, et al. Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. Ophthalmology. 2009;116:87–93.
  • Praidou A, Klangas I, Papakonstantinou E, et al. Vitreous and serum levels of platelet-derived growth factor and their correlation in patients with proliferative diabetic retinopathy. Curr Eye Res. 2009;34:152–161.
  • Bakri SJ, Omar AF. Evolution of vitreomacular traction following the use of the dexamethasone intravitreal implant (Ozurdex) in the treatment of macular edema secondary to central retinal vein occlusion. J Ocul Pharmacol Ther. 2012;28:547–549.
  • Panjaphongse R, Stewart JM. Vitreomacular traction after dexamethasone intravitreal implant (Ozurdex) injection: the effect of anomalous posterior vitreous detachment. Retin Cases Brief Rep. 2016;10:55–57.
  • Arikan Yorgun M, Mutlu M, Toklu Y, et al. Suspected bacterial endophthalmitis following sustained-release dexamethasone intravitreal implant: a case report. Korean J Ophthalmol. 2014;28:275–277.
  • Marchino T, Vela JI, Bassaganyas F, et al. Acute-onset endophthalmitis caused by alloiococcus otitidis following a dexamethasone intravitreal implant. Case Rep Ophthalmol. 2013;4:37–41.
  • Esen E, Sizmaz S, Demircan N. Two cases of acute endophthalmitis after intravitreal dexamethasone implant injection. Retin Cases Brief Rep. 2016;10:154–156.
  • Lei S, Lam WC. Efficacy and safety of dexamethasone intravitreal implant for refractory macular edema in children. Can J Ophthalmol. 2015;50:236–241.
  • Sella R, Oray M, Friling R, et al. Dexamethasone intravitreal implant (Ozurdex®) for pediatric uveitis. Graefes Arch Clin Exp Ophthalmol. 2015;253:1777–1782.
  • Tomkins-Netzer O, Talat L, Seguin Greenstein S, et al. Outcome of treating pediatric uveitis with dexamethasone implants. Am J Ophthalmol. 2015;161:110–115.

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