316
Views
11
CrossRef citations to date
0
Altmetric
Original Article

Successful Treatment of Necrotizing Retinitis with Epstein–Barr Virus-Positive Ocular Fluid by Intravitreal Methotrexate Injection

, , , &
Pages 552-555 | Received 14 May 2018, Accepted 15 Apr 2019, Published online: 03 Jul 2019

References

  • Kim SJ, Barañano DE, Grossniklaus HE, Martin DF. Epstein-Barr infection of the retina: case report and review of the literature. Retin Cases Brief Rep. 2011;5(1):1–5. doi:10.1097/ICB.0b013e3181babf1f.
  • Sugita S, Shimizu N, Watanabe K, et al. Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. Br J Ophthalmol. 2008;92(7):928–932. doi:10.1136/bjo.2007.133967.
  • Schaal S, Kagan A, Wang Y, Chan CC, Kaplan HJ. Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation. JAMA Ophthalmol. 2014;132(7):881–882. doi:10.1001/jamaophthalmol.2014.266.
  • Keorochana N. A case report of Epstein-Barr virus-associated retinal vasculitis: successful treatment using only acyclovir therapy. Int Med Case Rep J. 2016;25(9):213–218. doi:10.2147/IMCRJ.S107089.
  • Matoba AY. Ocular disease associated with Epstein-Barr virus infection. Surv Ophthalmol. 1990;35:145–150.
  • Yamamoto M, Ohga S, Ohnishi Y, Inomata H. Optic disk vasculitis associated with chronic active Epstein-Barr virus infection. Ophthalmologica. 2002;216(3):221–225. doi:10.1159/000059638.
  • Wong KW, D‘Amico DJ, Hedges TR 3rd, Soong HK, Schooley RT, Kenyon KR. Ocular involvement associated with chronic Epstein-Barr virus disease. Arch Ophthalmol. 1987;105:788–792.
  • Ho SF, Fink C, Murray PI. Epstein-Barr Virus DNA quantification: an adjunctive diagnostic marker for AIDS-associated lymphoma. Ocul Immunol Inflamm. 2005;13(6):471–473. doi:10.1080/09273940590951089.
  • Imai A, Takase H, Imadome KI, et al. Development of extranodal NK/T-cell lymphoma nasal type in cerebrum following Epstein-Barr virus-positive uveitis. Intern Med. 2017;56(11):1409–1414. doi:10.2169/internalmedicine.56.7573.
  • Sou R, Ohguro N, Maeda T, Saishin Y, Tano Y. Treatment of primary intraocular lymphoma with intravitreal methotrexate. Jpn J Ophthalmol. 2008;52(3):167–174. doi:10.1007/s10384-008-0519-9.
  • Gershburg E, Pagano JS. Epstein-Barr virus infections: prospects for treatment. J Antimicrob Chemother. 2005;56(2):277–281. doi:10.1093/jac/dki240.
  • Rajagopalan PT, Zhang Z, McCourt L, Dwyer M, Benkovic SJ, Hammes GG. Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proc Natl Acad Sci U S A. 2002;99(21):13481–13486. doi:10.1073/pnas.172501499.
  • Riksen NP, Barrera P, van Den Broek PH, van Riel PL, Smits P, Rongen GA. Methotrexate modulates the kinetics of adenosine in humans in vivo. Ann Rheum Dis. 2006;65(4):465–470. doi:10.1136/ard.2005.048637.
  • Frenkel S, Hendler K, Siegal T, Shalom E, Pe‘Er J. Intravitreal methotrexate for treating vitreoretinal lymphoma: 10 years of experience. Br J Ophthalmol. 2008;92(3):383–388. doi:10.1136/bjo.2007.127928.
  • Julian K, Langner-Wegscheider BJ, Haas A, De Smet MD. Intravitreal methotrexate in the management of presumed tuberculous serpiginous-like choroiditis. Retina. 2013;33(9):1943–1948. doi:10.1097/IAE.0b013e318285cdbe.
  • Birx DL, Redfield RR, Tosato G. Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders. N Engl J Med. 1986;314:874–879. doi:10.1056/NEJM198604033141403.
  • Preiksatis JK, Diaz-Mitoma F, Mirzayans F, Roberts S, Tyrrell DL. Quantitative oropharyngeal EBV shedding in renal and cardiac transplant recipients: relationship to immunosuppressive therapy, serologic responses, and the risk of posttransplant lymphoproliferative disorders. J Infect Dis. 1992;166:986–994.
  • Tosato G, Taga K, Angiolillo AL, Sgadari C. Epstein-Barr virus as an agent of haematological disease. Baillieres Clin Haematol. 1995;8(1):165–199. doi:10.1016/S0950-3536(05)80237-9.
  • Calvo CM, Khan MA, Mehta S, Garg SJ, Dunn JP. Correlation of clinical outcomes with quantitative polymerase chain reaction DNA copy number in patients with acute retinal necrosis. Ocul Immunol Inflamm. 2017;25(2):246–252. doi:10.3109/09273948.2015.1115081.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.