140
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Comparison of the Anti-Inflammatory and Cytotoxic Potential of Different Corticosteroid Eye Drop Preparations

, PhDORCID Icon, , PhD, , MD & , MD, PhD
Pages 839-845 | Received 17 Oct 2018, Accepted 17 Jun 2019, Published online: 06 Sep 2019

References

  • Sheikh A, Hurwitz B, van Schayck CP, McLean S, Nurmatov U. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. 2012;9:CD001211. doi:10.1002/14651858.CD001211.pub3.
  • Kessel L, Tendal B, Jørgensen KJ, et al. Post-cataract prevention of inflammation and macular edema by steroid and nonsteroidal anti-inflammatory eye dropss: a systematic review. Ophthalmology. 2014;121(10):1915–1924. doi:10.1016/j.ophtha.2014.04.035.
  • Bielory L. Ocular allergy guidelines: a practical treatment algorithm. Drugs. 2002;62(11):1611–1634. doi:10.2165/00003495-200262110-00004.
  • Chigbu DI. The management of allergic eye diseases in primary eye care. Cont Lens Anterior Eye. 2009;32(6):260–272. doi:10.1016/j.clae.2009.08.002.
  • Gower EW, Lindsley K, Nanji AA, Leyngold I, McDonnell PJ. Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Cochrane Database Syst Rev. 2013;7:CD006364. doi:10.1002/14651858.CD006364.pub2.
  • McDonald EM, Ram FSF, Patel DV, McGhee CNJ. Topical antibiotics for the management of bacterial keratitis: an evidence-based review of high quality randomised controlled trials. Br J Ophthalmol. 2014;98(11):1470–1477. doi:10.1136/bjophthalmol-2013-304660.
  • McGhee CN. Pharmacokinetics of ophthalmic corticosteroids. Br J Ophthalmol. 1992;76(11):681–684. doi:10.1136/bjo.76.11.681.
  • García E, Mensa J, Martínez JA. [Diffusion and pharmacokinetics of antibiotics in the ocular globus. Therapeutic implications]. Rev Esp Quimioter. 2001;14:331–339.
  • Awan MA, Agarwal PK, Watson DG, McGhee CNJ, Dutton GN. Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance. Br J Ophthalmol. 2009;93(6):708–713. doi:10.1136/bjo.2008.154906.
  • Sherif Z, Pleyer U. Corticosteroids in ophthalmology: past-present-future. Ophthalmologica. 2002;216(5):305–315. doi:10.1159/000066189.
  • Pianini V, Passani A, Rossi GCM, Passani F. Efficacy and safety of netilmycin/dexamethasone preservative-free and tobramycin/dexamethasone-preserved fixed combination in patients after cataract surgery. J Ocul Pharmacol Ther. 2010;26(6):617–621. doi:10.1089/jop.2010.0050.
  • Beringer A, Gouriou Y, Lavocat F, Ovize M, Miossec P. Blockade of store-operated calcium entry reduces IL-17/TNF cytokine-induced inflammatory response in human myoblasts. Front Immunol. 2018;9:3170. doi:10.3389/fimmu.2018.03170.
  • Lapucci A, Pittelli M, Rapizzi E, Felici R, Moroni F, Chiarugi A. Poly(ADP-ribose) Polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription. Mol Pharmacol. 2011;79(6):932–940. doi:10.1124/mol.110.070110.
  • Liang -C-C, Park AY, Guan J-L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2007;2(2):329–333. doi:10.1038/nprot.2007.30.
  • Berridge MV, Tan AS. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch Biochem Biophys. 1993;303(2):474–482. doi:10.1006/abbi.1993.1311.
  • Bessler H, Kagazanov S, Punsky I, Sirota L. Effect of Dexamethasone on IL-10 and IL-12p40 production in newborns and adults. Neonatology. 2001;80(4):262–266. doi:10.1159/000047154.
  • Bourcier T, Forgez P, Borderie V, Scheer S, Rostène W, Laroche L. Regulation of human corneal epithelial cell proliferation and apoptosis by dexamethasone. Invest Ophthalmol Vis Sci. 2000;41:4133–4141.
  • van Meerloo J, Kaspers GJL, Cloos J. Cell sensitivity assays: the MTT assay. Methods Mol Biol. 2011;731:237–245. doi:10.1007/978-1-61779-080-5_20.
  • Dey S, Bishayi B. Effect of iNOS inhibitor LNMMA along with antibiotics Chloramphenicol or Ofloxacin in murine peritoneal macrophages regulates S.aureus infection as well as inflammation: an in vitro study. Microb Pathog. 2017;105:307–320. doi:10.1016/j.micpath.2017.02.031.
  • Kulkarni PS, Bhattacherjee P, Eakins KE, Srinivasan BD. Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. Curr Eye Res. 1981;1:43–47.
  • Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017;17(4):233–247. doi:10.1038/nri.2017.1.
  • Kadmiel M, Janoshazi A, Xu X, Cidlowski JA. Glucocorticoid action in human corneal epithelial cells establishes roles for corticosteroids in wound healing and barrier function of the eye. Exp Eye Res. 2016;152:10–33. doi:10.1016/j.exer.2016.08.020.
  • Surin AM, Sharipov RR, Krasil’nikova IA, et al. Disruption of functional activity of mitochondria during MTT assay of viability of cultured neurons. Biochem Mosc. 2017;82(6):737–749. doi:10.1134/S0006297917060104.
  • Karasawa T, Steyger PS. Intracellular mechanisms of aminoglycoside-induced cytotoxicity. Integr Biol (Camb). 2011;3(9):879–886. doi:10.1039/c1ib00034a.
  • Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. Int J Pharm. 2016;511(1):73–78. doi:10.1016/j.ijpharm.2016.06.135.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.