OCT Angiography Study of the Macula in Patients with Diabetic Macular Edema Treated with Intravitreal Aflibercept

References

• Klein R, Klein BE, Moss SE, et al. The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol. 1984;102:527–532. doi:https://doi.org/10.1001/archopht.1984.01040030405011.
   PubMed Web of Science ®Google Scholar
• Jia Y, Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology. 2014;121:1435–1444. doi:https://doi.org/10.1016/j.ophtha.2014.01.034.
   PubMed Web of Science ®Google Scholar
• Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015;133:45–50. doi:https://doi.org/10.1001/jamaophthalmol.2014.3616.
   PubMed Web of Science ®Google Scholar
• Salz DA, de Carlo TE, Adhi M, et al. Select features of diabetic retinopathy on swept-source optical coherence tomographic angiography compared with fluorescein angiography and normal eyes. JAMA Ophthalmol. 2016;134:644–650. doi:https://doi.org/10.1001/jamaophthalmol.2016.0600.
   PubMed Web of Science ®Google Scholar
• Takase N, Nozaki M, Kato A, Ozeki H, Yoshida M, Ogura Y. Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography. Retina. 2015;35:2377–2383. doi:https://doi.org/10.1097/IAE.0000000000000849.
   PubMed Web of Science ®Google Scholar
• Ting DSW, Tan GSW, Agrawal R, et al. Optical coherence tomographic angiography in type 2 diabetes and diabetic retinopathy. JAMA Ophthalmol. 2017;135:306–312. doi:https://doi.org/10.1001/jamaophthalmol.2016.5877.
   PubMed Web of Science ®Google Scholar
• Diabetic Retinopathy Clinical Research Network, Elman MJ, Aiello LP, et al., Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2010;117:1064–1077. doi:https://doi.org/10.1016/j.ophtha.2010.02.031.
   PubMed Web of Science ®Google Scholar
• Nguyen QD, Brown DM, Marcus DM, et al. RISE and RIDE Research Group. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology. 2012;119:789–801. doi:https://doi.org/10.1016/j.ophtha.2011.12.039.
   PubMedGoogle Scholar
• Korobelnik JF, Do DV, Schmidt-Erfurth U, et al. Intravitreal aflibercept for diabetic macular edema. Ophthalmology. 2014;121:2247–2254. doi:https://doi.org/10.1016/j.ophtha.2014.05.006.
   PubMed Web of Science ®Google Scholar
• Hou KK, Au A, Kashani AH, et al. Pseudoflow with OCT angiography in eyes with hard exudates and macular drusen. Transl Vis Sci Technol. 2019;8:50. doi:https://doi.org/10.1167/tvst.8.3.50.
   PubMed Web of Science ®Google Scholar
• Ghasemi Falavarjani K, Iafe NA, Hubschman JP, et al. Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-VEGF therapy in eyes with diabetic macular edema and retinal vein occlusion. Invest Ophthalmol Vis Sci. 2017;58:30–34. doi:https://doi.org/10.1167/iovs.16-20579.
   PubMedGoogle Scholar
• Busch C, Wakabayashi T, Sato T, et al. Retinal microvasculature and visual acuity after intravitreal aflibercept in diabetic macular edema: An optical coherence tomography angiography study. Sci Rep. 2019;9:1561. doi:https://doi.org/10.1038/s41598-018-38248-1.
   PubMed Web of Science ®Google Scholar
• Hsieh YT, Alam MN, Le D, et al. OCT angiography biomarkers for predicting visual outcomes after ranibizumab treatment for diabetic macular edema. Ophthalmol Retina. May 7, 2019;pii: S2468-6530(18)30554–2. [ Epub ahead of print]. doi:https://doi.org/10.1016/j.oret.2019.04.027.
   Google Scholar
• Campochiaro PA, Wykoff CC, Shapiro H, et al. Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema. Ophthalmology. 2014;121:1783–1789. doi:https://doi.org/10.1016/j.ophtha.2014.03.021.
   PubMed Web of Science ®Google Scholar
• Terui T, Kondo M, Sugita T, et al. Changes in areas of capillary nonperfusion after intravitreal injection of bevacizumab in eyes with branch retinal vein occlusion. Retina. 2011;31:1068–1074. doi:https://doi.org/10.1097/IAE.0b013e31820c83c2.
   PubMed Web of Science ®Google Scholar
• Campochiaro PA, Bhisitkul RB, Shapiro H, et al. Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion. Ophthalmology. 2013;120:795–802. doi:https://doi.org/10.1016/j.ophtha.2012.09.032.
   PubMed Web of Science ®Google Scholar
• Michaelides M, Fraser-Bell S, Hamilton R, et al. Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1. Retina 2010;30:781–786. doi: https://doi.org/10.1097/iae.0b013e3181d2f145
   PubMed Web of Science ®Google Scholar
• Ghasemi Falavarjani K, Habibi A, Anvari P, et al. Effect of segmentation error correction on optical coherence tomography angiography measurements in healthy subjects and diabetic macular oedema. Br J Ophthalmol. 2019 Apr 29. pii: bjophthalmol-2019-314018. doi:https://doi.org/10.1136/bjophthalmol-2019-314018.
   Google Scholar
• Lee J, Moon BG, Cho AR, et al. Optical coherence tomography angiography of DME and its association with anti-VEGF treatment response. Ophthalmology. 2016;123:2368–2375. doi:https://doi.org/10.1016/j.ophtha.2016.07.010.
   PubMed Web of Science ®Google Scholar
• Mané V, Dupas B, Gaudric A, et al. Correlation between cystoid spaces in chronic macular edema and capillary nonperfusion detected by optical coherence tomography angiography. Retina. 2016;36:S102–S110. doi:https://doi.org/10.1097/IAE.0000000000001289.
   PubMed Web of Science ®Google Scholar
• Choi W, Waheed NK, Moult EM, et al. Ultrahigh speed swept source optical coherence tomography angiography of retinal and choriocapillaris alterations in diabetic patients with and without retinopathy. Retina. 2017;37:11–21. doi:https://doi.org/10.1097/IAE.0000000000001250.
   PubMed Web of Science ®Google Scholar
• Spaide RF. Volume-rendered optical coherence tomography of diabetic retinopathy pilot study. Am J Ophthalmol. 2015;160:1200–1210. doi:https://doi.org/10.1016/j.ajo.2015.09.010.
   PubMed Web of Science ®Google Scholar
• Spaide RF, Fujimoto JG, Waheed NK, et al. Optical coherence tomography angiography. Prog Retin Eye Res. 2018;64:1–55. doi:https://doi.org/10.1016/j.preteyeres.2017.11.003.
   PubMed Web of Science ®Google Scholar
• Papadopoulou DN, Mendrinos E, Mangioris G, et al. Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration. Ophthalmology. 2009;116:1755–1761. doi:https://doi.org/10.1016/j.ophtha.2009.03.017.
   PubMed Web of Science ®Google Scholar
• Soliman W, Vinten M, Sander B, et al. Optical coherence tomography and vessel diameter changes after intravitreal bevacizumab in diabetic macular oedema. Acta Ophthalmol. 2008;86:365–371. doi:https://doi.org/10.1111/j.1600-0420.2007.01057.x.
   PubMed Web of Science ®Google Scholar
• Carpineto P, Mastropasqua R, Marchini G, et al. Reproducibility and repeatability of foveal avascular zone measurements in healthy subjects by optical coherence tomography angiography. Br J Ophthalmol. 2016;100:671–676. doi:https://doi.org/10.1136/bjophthalmol-2015-307330.
   PubMed Web of Science ®Google Scholar
• Pilotto E, Frizziero L, Crepaldi A, et al. Repeatability and reproducibility of foveal avascular zone area measurement on normal eyes by different optical coherence tomography angiography instruments. Ophthalmic Res. 2018;59:206–211. doi:https://doi.org/10.1159/000485463.
   PubMed Web of Science ®Google Scholar
• Lee MW, Kim KM, Lim HB, et al. Repeatability of vessel density measurements using optical coherence tomography angiography in retinal diseases. Br J Ophthalmol. 2018 July 4. PMID 29973363.
   Google Scholar
• Czakó C, Sándor G, Ecsedy M, et al. Intrasession and between-visit variability of retinal vessel density values measured with OCT angiography in diabetic patients. Sci Rep. 2018;8:10598. doi:https://doi.org/10.1038/s41598-018-28994-7.
   PubMed Web of Science ®Google Scholar