Advanced search
Publication Cover
Ocular Immunology and Inflammation Volume 29, 2021 - Issue 1
Submit an article Journal homepage
323
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Sustained Remission with Tocilizumab in Refractory Relapsing Polychondritis with Ocular Involvement: A Case Series

Rebecca Farhata Ophthalmology Department, Rothschild Foundation Hospital, Paris, France;b Ophthalmology Department, Cochin Hospital, Paris, FranceORCID Iconhttps://orcid.org/0000-0001-9380-9201
, M.DORCID Icon,
Gaël Clavelc Internal Medicine Department, Rothschild Foundation Hospital, Paris, France
, M.D,
Delphine Villeneuvec Internal Medicine Department, Rothschild Foundation Hospital, Paris, France
, M.D,
Youssef Abdelmassiha Ophthalmology Department, Rothschild Foundation Hospital, Paris, FranceORCID Iconhttps://orcid.org/0000-0001-9887-0992
, M.DORCID Icon,
Marwan Sahyouna Ophthalmology Department, Rothschild Foundation Hospital, Paris, FranceORCID Iconhttps://orcid.org/0000-0002-5012-9473
, M.DORCID Icon,
Eric Gabisona Ophthalmology Department, Rothschild Foundation Hospital, Paris, FranceORCID Iconhttps://orcid.org/0000-0001-9457-3245
, M.DORCID Icon,
Thomas Senéc Internal Medicine Department, Rothschild Foundation Hospital, Paris, FranceORCID Iconhttps://orcid.org/0000-0002-3162-2537
, M.DORCID Icon,
Isabelle Cochereaua Ophthalmology Department, Rothschild Foundation Hospital, Paris, France
, M.D &
Cherif Titaha Ophthalmology Department, Rothschild Foundation Hospital, Paris, FranceCorrespondence[email protected]
, M.D show all
Pages 9-13 | Received 01 Mar 2020, Accepted 28 Apr 2020, Published online: 09 Jul 2020

References

  • McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore). 1976;55(3):193–215. doi:10.1097/00005792-197605000-00001.
  • Rapini RP, Warner NB. Relapsing polychondritis. Clin Dermatol. 2006;24(6):482–485. doi:10.1016/j.clindermatol.2006.07.018.
  • Michet CJ, McKenna CH, Luthra HS, O’Fallon WM. Relapsing polychondritis: survival and predictive role of early disease manifestations. Ann Intern Med. 1986;104(1):74–78. doi:10.7326/0003-4819-104-1-74.
  • Clavel G, Gabison E, Semerano L. Corneal and scleral involvement in inflammatory rheumatic disease: rheumatologists and ophthalmologists exchanging views. Joint Bone Spine. 2019;86(6):699–705. doi:10.1016/j.jbspin.2019.01.014.
  • Sharma A, Gnanapandithan K, Sharma K, Sharma S. Relapsing polychondritis: a review. Clin Rheumatol. 2013;32(11):1575–1583. doi:10.1007/s10067-013-2328-x.
  • Leroux G, Costedoat-Chalumeau N, Brihaye B, et al. Treatment of relapsing polychondritis with rituximab: a retrospective study of nine patients. Arthritis Rheum. 2009;61(5):577–582.doi:10.1002/art.24366.
  • Lahmer T, Treiber M, von Werder A, et al. Relapsing polychondritis: an autoimmune disease with many faces. Autoimmun Rev. 2010;9(8):540–546.doi:10.1016/j.autrev.2010.02.016.
  • Zeuner M, Straub RH, Rauh G, Albert ED, Schölmerich J, Lang B. Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J Rheumatol. 1997;24:96–101.
  • Stael R, Smith V, Wittoek R, Creytens D, Mielants H. Sustained response to tocilizumab in a patient with relapsing polychondritis with aortic involvement: a case based review. Clin Rheumatol. 2015;34(1):189–193. doi:10.1007/s10067-014-2670-7.
  • Kemta Lekpa F, Kraus VB, Chevalier X. Biologics in relapsing polychondritis: a literature review. Semin Arthritis Rheum. 2012;41(5):712–719. doi:10.1016/j.semarthrit.2011.08.006.
  • Kawai M, Hagihara K, Hirano T, et al. Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis. Rheumatol Oxf Engl. 2009;48(3):318–319. doi:10.1093/rheumatology/ken468
  • Narshi CB, Allard SA. Sustained response to tocilizumab, anti-IL-6 antibody, following anti-TNF-α failure in a patient with relapsing polychondritis complicated by aortitis. Rheumatol Oxf Engl. 2012;51(5):952–953. doi:10.1093/rheumatology/ker451.
  • Wallace ZS, Stone JH. Refractory relapsing polychondritis treated with serial success with interleukin 6 receptor blockade. J Rheumatol. 2013;40(1):100–101. doi:10.3899/jrheum.120381.
  • Weber E, Gaultier J-B, Paul S, Guichard I, Monard E, Cathébras P. [Sustained response with tocilizumab in a case of refractory relapsing polychondritis]. Rev Med Interne. 2014;35(3):196–198. doi:10.1016/j.revmed.2013.02.019.
  • Shimizu H, Nishioka H. Successful treatment with tocilizumab for refractory scleritis associated with relapsing polychondritis. Scand J Rheumatol. 2017;46(5):418–419. doi:10.1080/03009742.2016.1275774.
  • Motozawa N, Nakamura T, Takagi S, et al. Unique circumferential peripheral keratitis in relapsing polychondritis: A case report. Medicine (Baltimore). 2017;96(41):e7951.doi:10.1097/MD.0000000000007951.
  • Tanaka R, Kaburaki T, Nakahara H, Komae K. Ocular inflammation associated with relapsing polychondritis in Japanese patients: a review of 11 patients. Int Ophthalmol. 2019;39(11):2649–2659. doi:10.1007/s10792-019-01114-8.
  • Wendling D, Godfrin-Valnet M, Prati C. Treatment of relapsing polychondritis with tocilizumab. J Rheumatol. 2013;40(7):1232. doi:10.3899/jrheum.130371.
  • Silpa-Archa S, Oray M, Preble JM, Foster CS. Outcome of tocilizumab treatment in refractory ocular inflammatory diseases. Acta Ophthalmol (Copenh). 2016;94(6):e400–e406. doi:10.1111/aos.13015.
  • Arnaud L, Mathian A, Haroche J, Gorochov G, Amoura Z. Pathogenesis of relapsing polychondritis: a 2013 update. Autoimmun Rev. 2014;13(2):90–95. doi:10.1016/j.autrev.2013.07.005.
  • Stabler T, Piette J-C, Chevalier X, Marini-Portugal A, Kraus VB. Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum. 2004;50(11):3663–3667. doi:10.1002/art.20613.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.