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Gynecological Endocrinology Volume 35, 2019 - Issue 5
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EFFECTS OF BASEDOXIFENE/CONJUGATED ESTROGENS IN PREMENOPAUSAL WOMEN

Effects of bazedoxifene/conjugated estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study

Valerie A. FloresDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Cheryl LeoneThe John B. Pierce Laboratory, Yale School of Medicine, New Haven, CT, USAView further author information
,
Hugh S. TaylorDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA; Correspondence[email protected]
View further author information
&
Nina S. StachenfeldDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA; ;The John B. Pierce Laboratory, Yale School of Medicine, New Haven, CT, USAView further author information
Pages 390-394 | Received 09 Jun 2018, Accepted 12 Dec 2018, Published online: 22 Jan 2019

References

  • Taylor HS, Ohleth K. Using bazedoxifene plus conjugated estrogens for treating postmenopausal women: a comprehensive review. Menopause. 2012;19:479–485.
  • Lobo RA, Pinkerton JV, Gass ML, et al. Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile. Fertil Steril. 2009;92:1025–1038.
  • Santen RJ, Kagan R, Altomare CJ, et al. Current and evolving approaches to individualizing estrogen receptor-based therapy for menopausal women. J Clin Endocrinol Metab. 2014;99:733–747.
  • Pinkerton JV, Harvey JA, Pan K, et al. Breast effects of bazedoxifene-conjugated estrogens: a randomized controlled trial. Obstet Gynecol. 2013;121:959–968.
  • Taylor HS. Designing the ideal selective estrogen receptor modulator-an achievable goal? Menopause. 2009;16:609–615.
  • Kulak J Jr, Ferriani RA, Komm BS, et al. Tissue selective estrogen complexes (TSECs) differentially modulate markers of proliferation and differentiation in endometrial cells. Reprod Sci. 2013;20:129–137.
  • Kulak J Jr, Fischer C, Komm B, et al. Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model. Endocrinology. 2011;152:3226–3232.
  • Naqvi H, Sakr S, Presti T, et al. Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model. Biol Reprod. 2014;90:121.
  • Ethun KF, Wood CE, Cline JM, et al. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013;20:777–784.
  • Flores VA, Taylor HS. The effect of menopausal hormone therapies on breast cancer: avoiding the risk. Endocrinol Metab Clin North Am. 2015;44:587–602.
  • Pinkerton JV, Utian WH, Constantine GD, et al. Relief of vasomotor symptoms with the tissue-selective estrogen complex containing bazedoxifene/conjugated estrogens: a randomized, controlled trial. Menopause. 2009;16:1116–1124.
  • Pinkerton JV, Pickar JH, Racketa J, et al. Bazedoxifene/conjugated estrogens for menopausal symptom treatment and osteoporosis prevention. Climacteric. 2012;15:411–418.
  • Pinkerton JV, Harvey JA, Pan K, et al. Breast effects of bazedoxifene-conjugated estrogens: a randomized controlled trial. Obstet Gynecol. 2013;121:959–968.
  • Pinkerton JV, Archer DF, Utian WH, et al. Bazedoxifene effects on the reproductive tract in postmenopausal women at risk for osteoporosis. Menopause. 2009;16:1102–1108.
  • Pinkerton JV, Harvey JA, Lindsay R, et al. Effects of bazedoxifene/conjugated estrogens on the endometrium and bone: a randomized trial. J Clin Endocrinol Metab. 2014;99:E189–E198.
  • Archer DF, Lewis V, Carr BR, et al. Bazedoxifene/conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal women. Fertil Steril. 2009;92:1039–1044.
  • Mirkin S, Archer DF, Taylor HS, et al. Differential effects of menopausal therapies on the endometrium. Menopause. 2014;21:899–908.
  • Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362:2389–2398.
  • Attar E, Tokunaga H, Imir G, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009;94:623–631.
  • Bulun SE, Gurates B, Fang Z, et al. Mechanisms of excessive estrogen formation in endometriosis. J Reprod Immunol. 2002;55:21–33.
  • Bulun SE. Endometriosis. N Engl J Med. 2009;360:268–279.
  • Stovall DW, Utian WH, Gass ML, et al. The effects of combined raloxifene and oral estrogen on vasomotor symptoms and endometrial safety. Menopause. 2007;14:510–517.
  • Davis SR, OʼNeill SM, Eden J, et al. Transition from estrogen therapy to raloxifene in postmenopausal women: effects on treatment satisfaction and the endometrium-a pilot study. Menopause. 2004;11:167–175.
  • Stratton P, Sinaii N, Segars J, et al. Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial. Obstet Gynecol. 2008;111:88–96.

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