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Effects of Chronic Oxitocin administration on Body Weight and Food Intake in PCOS Rats

The effects of chronic oxytocin administration on body weight and food intake in DHT-induced PCOS model rats

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Pages 55-60 | Received 10 Jan 2019, Accepted 19 May 2019, Published online: 21 Jun 2019

References

  • Lauritsen MP, Bentzen JG, Pinborg A, et al. The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Mullerian hormone. Hum Reprod. 2014;29:791–801.
  • Rosenfield RL, Ehrmann DA. The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocr Rev. 2016;37:467–520.
  • Ding T, Hardiman PJ, Petersen I, et al. The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta- analysis. Oncotarget. 2017;8:96351–96358.
  • Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.
  • Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005;352:1223–1236.
  • Moran LJ, Misso ML, Wild RA, et al. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2010;16:347–363.
  • Brower MA, Hai Y, Jones MR, et al. Bidirectional mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome. Hum Reprod. 2019;34:127–136.
  • Ladson G, Dodson WC, Sweet SD, et al. The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study. Fertil Steril. 2011;95:1059–1066.
  • Bates GW, Legro RS. Longterm management of polycystic ovarian syndrome (PCOS)). Mol Cell Endocrinol. 2013;373:91–97.
  • Foster GD, Wyatt HR, Hill JO, et al. Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med. 2010;153:147–157.
  • Altirriba J, Poher AL, Rohner-Jeanrenaud F. Chronic oxytocin administration as a treatment against impaired leptin signaling or leptin resistance in obesity. Front Endocrinol (Lausanne). 2015;6:119.
  • Maejima Y, Iwasaki Y, Yamahara Y, et al. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging. 2011;3:1169–1177.
  • Maejima Y, Rita RS, Santoso P, et al. Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology. 2015;101:35–44.
  • Maejima Y, Aoyama M, Sakamoto K, et al. Impact of sex, fat distribution and initial body weight on oxytocin's body weight regulation. Sci Rep. 2017;7:8599
  • Maejima Y, Yokota S, Nishimori K, et al. The anorexigenic neural pathways of oxytocin and their clinical implication. Neuroendocrinology. 2018;107:91–104.
  • Zhang G, Bai H, Zhang H, et al. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 2011;69:523–535.
  • Zhang G, Cai D. Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. Am J Physiol Endocrinol Metab. 2011;301:E1004–E1012.
  • Roberts ZS, Wolden-Hanson T, Matsen ME, et al. Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol. 2017;313:R357–R371.
  • Arletti R, Benelli A, Bertolini A. Oxytocin inhibits food and fluid intake in rats. Physiol Behav.. 1990;48:825–830.
  • Blevins JE, Thompson BW, Anekonda VT, et al. Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization. Am J Physiol Regul Integr Comp Physiol. 2016;310:R640–R658.
  • Deblon N, Veyrat-Durebex C, Bourgoin L, et al. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One. 2011;6:e25565
  • Morton GJ, Thatcher BS, Reidelberger RD, et al. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2012;302:E134–E144.
  • Olson BR, Drutarosky MD, Chow MS, et al. Oxytocin and an oxytocin agonist administered centrally de- crease food intake in rats. Peptides. 1991;12:113–118.
  • Ong ZY, Alhadeff AL, Grill HJ. Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastro- intestinal satiation signal processing. Am J Physiol Regul Integr Comp Physiol. 2015;308:R800–R806.
  • Maejima Y, Sakuma K, Santoso P, et al. Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Lett. 2014;588:4404–4412.
  • Blevins JE, Graham JL, Morton GJ, et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2015;308:R431–R438.
  • Lawson EA, Marengi DA, DeSanti RL, et al. Oxytocin reduces caloric intake in men. Obesity (Silver Spring). 2015;23:950–956.
  • Thienel M, Fritsche A, Heinrichs M, et al. Oxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men. Int J Obes (Lond). 2016;40:707–1714.
  • Altirriba J, Poher AL, Caillon A, et al. Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes. Endocrinology. 2014;155:4189–4201.
  • Eckertova M, Ondrejcakova M, Krskova K, et al. Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis. Br J Pharmacol. 2011;162:452–463.
  • Gajdosechova L, Krskova K, Segarra AB, et al. Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue. J Endocrinol. 2014;220:333–343.
  • Yi KJ, So KH, Hata Y, et al. The regulation of oxytocin receptor gene expression during adipogenesis. J Neuroendocrinol. 2015;27:335–342.
  • Iwasaki Y, Maejima Y, Suyama S, et al. Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity. Am J Physiol Regul Integr Comp Physiol. 2015;308:R360–369.
  • Kublaoui BM, Gemelli T, Tolson KP, et al. Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Endocrinology. 2008;22:1723–1743.
  • Maejima Y, Sedbazar U, Suyama S, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab. 2009;10:355–365.
  • Plante E, Menaouar A, Bogdan A, et al. Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db/db mice. Endocrinology. 2015;156:1416–1428.
  • Walters KA, Allan CM, Handelsman DJ. Rodent models for human polycystic ovary syndrome. Biol Reprod. 2012;86:149.
  • Iwasa T, Matsuzaki T, Yano K, et al. Prenatal undernutrition affects the phenotypes of PCOS model rats. J Endocrinol. 2018;239:137–151.
  • Iwasa T, Matsuzaki T, Yano K, et al. Effects of chronic testosterone administration on the degree of preference for a high-fat diet and body weight in gonadal-intact and ovariectomized female rats. Behav Brain Res. 2018;349:102–108.
  • Iwasa T, Matsuzaki T, Yano K, et al. The effects of ovariectomy and lifelong high-fat diet consumption on body weight, appetite, and lifespan in female rats. Horm Behav. 2018;97:25–30.
  • Balazova L, Krskova K, Suski M, et al. Metabolic effects of subchronic peripheral oxytocin administration in lean and obese zucker rats. J Physiol Pharmacol. 2016;67:531–541.
  • Camerino C. Low sympathetic tone and obese phenotype in oxytocin-deficient mice. Obesity (Silver Spring). 2009;17:980–984.
  • Takayanagi Y, Kasahara Y, Onaka T, et al. Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport. 2008;19:951–955.
  • Balen AH, Morley LC, Misso M, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22:687–708.
  • Huber-Buchholz MM, Carey DGP, Norman RJ. Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone. J Clin Endocrinl Metab. 1999;84:1470–1474.
  • Zhang H, Wu C, Chen Q, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One. 2013;8:e61477.
  • Iwasa T, Matsuzaki T, Mayila Y, et al. Oxytocin treatment reduced food intake and body fat ameliorated obesity in ovariectomized female rats. Neuropeptides. 2019;75:49–57.

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