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PCOS and Cardiovascular Events

Cardiovascular events among reproductive and menopausal age women with polycystic ovary syndrome: a systematic review and meta-analysis

ORCID Icon, , , &
Pages 12-23 | Received 20 Feb 2019, Accepted 23 Jul 2019, Published online: 06 Aug 2019

References

  • Azziz R. Does the risk of diabetes and heart disease in women with polycystic ovary syndrome lessen with age? Fertil Steril. 2017;108:959–960.
  • Carmina E, Lobo RA. Is there really any increased cardiovascular risk in women with Polycystic Ovary Syndrome? J Women’s Health. 2018;27:1385–1388.
  • Wild RA, Carmina E, Diamanti-Kandarakis E, et al. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab. 2010;95:2038–2049.
  • Apridonidze T, Essah PA, Iuorno MJ, et al. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90:1929–1935.
  • Dokras A, Bochner M, Hollinrake E, et al. Screening women with polycystic ovary syndrome for metabolic syndrome. Obstet Gynecol. 2005;106:131–137.
  • Carmina E, Napoli N, Longo R, et al. Metabolic syndrome in polycystic ovary syndrome (PCOS): lower prevalence in southern Italy than in the USA and the influence of criteria for the diagnosis of PCOS. Eur J Endocrinol. 2006;154:141–145.
  • Berneis K, Rizzo M, Lazzaroni V, et al. Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2007;92:186–189.
  • Wild RA, Rizzo M, Clifton S, et al. Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis. Fertil Steril. 2011;95:1073–1079. e11.
  • Talbott EO, Guzick DS, Sutton-Tyrrell K, et al. Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women. Arterioscler Thromb Vasc Biol. 2000;20:2414–2421.
  • Christian RC, Dumesic DA, Behrenbeck T, et al. Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003;88:2562–2568.
  • Berger JS, Jordan CO, Lloyd-Jones D, et al. Screening for cardiovascular risk in asymptomatic patients. J Am Coll Cardiol. 2010;55:1169–1177.
  • De Groot P, Dekkers O, Romijn J, et al. PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Hum Reprod Update. 2011;17:495–500.
  • Anderson SA, Barry JA, Hardiman PJ. Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: a systematic review and meta-analysis. Int J Cardiol. 2014;176:486–487.
  • Carmina E. Cardiovascular risk and events in polycystic ovary syndrome. Climacteric. 2009;12:22–25.
  • Carmina E. Polycystic ovary syndrome: metabolic consequences and long-term management. Scand J Clin Lab Invest. 2014;74:23–26.
  • Shaw LJ, Bairey Merz CN, Azziz R, et al. Withdrawn: postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health—National heart, lung, and blood institute sponsored women’s ischemia syndrome evaluation. J Clin Endocrinol Metab. 2008;93:1276–1284.
  • Shaw L. Withdrawn by author. J Clin Endocrinol Metab. 2015;100:1206.
  • Wild S, Pierpoint T, McKeigue P, et al. Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study. Clin Endocrinol (Oxf). 2000;52:595–600.
  • Pierpoint T, McKeigue P, Isaacs A, et al. Mortality of women with polycystic ovary syndrome at long-term follow-up. J Clin Epidemiol. 1998;51:581–586.
  • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.
  • Higgins JP, Altman DG, Gøtzsche PC, et al. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.
  • Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25:603–605.
  • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101.
  • Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455–463.
  • Nyaga VN, Arbyn M, Aerts M. Metaprop: a Stata command to perform meta-analysis of binomial data. Arch Public Health. 2014;72:39
  • L'Abbé KA, Detsky AS, O'rourke K. Meta-analysis in clinical research. Ann Intern Med. 1987;107:224–233.
  • Sweeting M, J, Sutton A, C, Lambert P. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data . Stat Med. 2004;23:1351–1375.
  • Calderon-Margalit R, Siscovick D, Merkin SS, et al. Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thicknesssignificance: the coronary artery risk development in young adults women’s study. Arterioscler Thromb Vasc Biol. 2014;34:2688–2694.
  • Ding D-C, Tsai I-J, Wang J-H, et al. Coronary artery disease risk in young women with polycystic ovary syndrome. Oncotarget. 2018;9:8756.
  • Glintborg D, Rubin KH, Nybo M, et al. Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome. Eur J Endocrinol. 2015;172:627–638.
  • Hart R, Doherty DA. The potential implications of a PCOS diagnosis on a woman’s long-term health using data linkage. J Clin Endocrinol Metabol. 2015;100:911–919.
  • Lo JC, Feigenbaum SL, Yang J, et al. Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91:1357–1363.
  • Mani H, Levy MJ, Davies MJ, et al. Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20‐year retrospective cohort study. Clin Endocrinol. 2013;78:926–934.
  • Merz CNB, Shaw LJ, Azziz R, et al. Cardiovascular disease and 10-year mortality in postmenopausal women with clinical features of polycystic ovary syndrome. J Women’s Health. 2016;25:875–881.
  • Meun C, Franco OH, Dhana K, et al. High androgens in postmenopausal women and the risk for atherosclerosis and cardiovascular disease: the Rotterdam Study. J Clin Endocrinol Metabol. 2018;103:1622–1630.
  • Okoroh EM, Boulet SL, George MG, et al. Assessing the intersection of cardiovascular disease, venous thromboembolism, and polycystic ovary syndrome. Thromb Res. 2015;136:1165–1168.
  • Sirmans SM, Parish RC, Blake S, et al. Epidemiology and comorbidities of polycystic ovary syndrome in an indigent population. J Invest Med. 2014;62:868–874.
  • Haakova L, Cibula D, Rezabek K, et al. Pregnancy outcome in women with PCOS and in controls matched by age and weight. Hum Reprod. 2003;18:1438–1441.
  • Iftikhar S, Collazo-Clavell M, Roger VL, et al. Risk of cardiovascular events in patients with polycystic ovary syndrome. Neth J Med. 2012;70:74.
  • Lunde O, Tanbo T. Polycystic ovary syndrome: a follow-up study on diabetes mellitus, cardiovascular disease and malignancy 15–25 years after ovarian wedge resection. Gynecol Endocrinol. 2007;23:704–709.
  • Schmidt J, Landin-Wilhelmsen K, Brännström M, et al. Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study. J Clin Endocrinol Metab. 2011;96:3794–3803.
  • Lidegaard Ø, Nielsen LH, Skovlund CW, et al. Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9. BMJ. 2011;343:d6423.
  • Abubakar I, Tillmann T, Banerjee A. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013. A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–171.
  • Bhatnagar P, Wickramasinghe K, Williams J, et al. The epidemiology of cardiovascular disease in the UK 2014. Heart. 2015;101:1182.
  • Guastella E, Longo RA, Carmina E. Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes. Fertil Steril. 2010;94:2197–2201.
  • Azziz R, Carmina E, Chen Z, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057.
  • Elting MW, Korsen TJ, Rekers-Mombarg LT, et al. Women with polycystic ovary syndrome gain regular menstrual cycles when ageing. Hum Reprod. 2000;15:24–28.
  • Carmina E, Campagna A, Lobo R. Emergence of ovulatory cycles with aging in women with polycystic ovary syndrome (PCOS) alters the trajectory of cardiovascular and metabolic risk factors. Hum Reprod. 2013;28:2245–2252.
  • Tehrani FR, Montazeri SA, Hosseinpanah F, et al. Trend of cardio-metabolic risk factors in polycystic ovary syndrome: a population-based prospective cohort study. PloS One. 2015;10:e0137609.
  • Jaliseh HK, Tehrani FR, Behboudi-Gandevani S, et al. Polycystic ovary syndrome is a risk factor for diabetes and prediabetes in middle-aged but not elderly women: a long-term population-based follow-up study. Fertil Steril. 2017;108:1078–1084.
  • Crouse IIJ, Bots ML, Evans GW, et al. Does baseline carotid intima–media thickness modify the effect of rosuvastatin when compared with placebo on carotid intima–media thickness progression? The METEOR study. Eur J Cardiovasc Prev Rehabil. 2010;17:223–229.
  • Lloyd-Jones DM, Leip EP, Larson MG, et al. Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation. 2006;113:791–798.
  • Lloyd-Jones DM, Dyer AR, Wang R, et al. Risk factor burden in middle age and lifetime risks for cardiovascular and non-cardiovascular death (Chicago Heart Association Detection Project in Industry). Am J Cardiol. 2007;99:535–540.

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