Identification of key genes, regulatory factors, and drug target genes of recurrent implantation failure (RIF)

References

• Polanski LT, Baumgarten MN, Quenby S, et al. What exactly do we mean by 'recurrent implantation failure'? A systematic review and opinion. Reprod Biomed. 2014;28(4):409–423.
   PubMed Web of Science ®Google Scholar
• Koot YEM, Hooff SRV, Boomsma CM, et al. An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF. Sci Rep. 2016;6(1):19411.
   PubMedGoogle Scholar
• Revel A. Defective endometrial receptivity. Fertil Steril. 2012;97:1028–1032.
   PubMed Web of Science ®Google Scholar
• Brosens JJ, Salker MS, Teklenburg G, et al. Uterine selection of human embryos at implantation. Sci Rep. 2015;4(1):3894.
   Google Scholar
• Lessey BA. Endometrial receptivity and the window of implantation. Best Prac Res Clin Obstetr Gynaecol. 2000;14:775–788.
   PubMed Web of Science ®Google Scholar
• Dey SK, Lim H, Das SK, et al. Molecular cues to implantation. Endocrine Rev. 2004;25(3):341.
   PubMed Web of Science ®Google Scholar
• Grothusen C, Lalitkumar S, Boggavarapu NR, et al. Recent advances in understanding endometrial receptivity: molecular basis and clinical applications. Am J Reprod Immunol. 2014;72:148–157.
   PubMed Web of Science ®Google Scholar
• Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95:50–60.
   PubMed Web of Science ®Google Scholar
• Nowak I, Wilczyńska K, Wilczyński JR, et al. KIR,LILRB and their ligands’ genes as potential biomarkers in recurrent implantation failure. Arch Immunol Ther Exp. 2017;65(5):391–399.
   PubMed Web of Science ®Google Scholar
• Haouzi D, Assou S, Mahmoud K, et al. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Human Reprod. 2009;24(6):1436.
   PubMed Web of Science ®Google Scholar
• Barrett T, Suzek TO, Troup DB, et al. NCBI GEO: mining millions of expression profiles—database and tools. Nucleic Acids Res. 2004;33(Database issue):D562–6.
   Google Scholar
• Smyth GK., Limma   Linear Models for Microarray Data: Springer New York; 2005.
   Google Scholar
• Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57.
   PubMed Web of Science ®Google Scholar
• Ogata H, Goto S, Sato K, et al. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 1999;27(1):29–34.
   PubMed Web of Science ®Google Scholar
• Sherlock G. Gene Ontology: tool for the unification of biology. Can Inst Food Sci Technol J. 2009;22(415):25–29.
   Google Scholar
• Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: proteinprotein interaction networks, integrated over the tree of life. Nucleic Acids Re. 2015;43(D1):D447.
   PubMed Web of Science ®Google Scholar
• Tang Y, Li M, Wang J, et al. CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks. Biosystems. 2015;127:67–72.
   PubMed Web of Science ®Google Scholar
• Bandettini WP, Kellman P, Mancini C, et al. MultiContrast Delayed Enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: a clinical validation study. J Cardiovasc Magn Reson. 2012;14(1):83.
   PubMed Web of Science ®Google Scholar
• Janky RS, Verfaillie A, Imrichová H, et al. iRegulon: from a gene list to a gene regulatory network using large motif and track collections. PLoS Comput Biol. 2014;10(7):10:e1003731.
   PubMed Web of Science ®Google Scholar
• Zhang B, Kirov S, Snoddy J. WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res. 2005;33(Web Server):W741–8.
   PubMed Web of Science ®Google Scholar
• Zhang S, Lin H, Kong S, et al. Physiological and molecular determinants of embryo implantation. Mol Aspect Med. 2013;34(5):939–980.
   PubMed Web of Science ®Google Scholar
• Hannon T, Innes BA, Lash GE, et al. Effects of local decidua on trophoblast invasion and spiral artery remodeling in focal placenta creta – An immunohistochemical study. Placenta. 2012;33(12):998–1004.
   PubMed Web of Science ®Google Scholar
• Moschos SJ, Mo YY. Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis. J Mol Hist. 2006;37(5-7):309–319.
   PubMed Web of Science ®Google Scholar
• Zhu H, Yu JJ. Gene expression patterns in the histopathological classification of epithelial ovarian cancer. Exper Therap Med. 2010;1:187–192.
   PubMed Web of Science ®Google Scholar
• Robert H, York-Dieter S, Wilkinson CJ, et al. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol. 2005;7:1140–1146.
   PubMed Web of Science ®Google Scholar
• Mccoy RC, Newnham LJ, Ottolini CS, et al. Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos. Human Mol Gen. 2018;27(14):2573.
   PubMed Web of Science ®Google Scholar
• Filigheddu N, Gregnanin I, Porporato PE, et al. Differential expression of MicroRNAs between eutopic and ectopic endometrium in ovarian endometriosis. Biomed Res Int. 2015:2010;369549.
   Google Scholar
• Lin X, Tong L, Feng H, et al. AURKB and MAPK involvement in the regulation of the early stages of mouse zygote development. Sci China Life Sci. 2012;55:47–56.
   PubMed Web of Science ®Google Scholar
• Gonzã¡Lez-Aguilera C, Askjaer P. Dissecting the NUP107 complex. Nucleus. 2012;3:340–348.
   PubMed Web of Science ®Google Scholar
• Ohtani K, Komori H, Ozono E, et al. Distinct transcriptional regulation by E2F in cell growth and tumor suppression. 2008. In: Yoshida K, editors. Control of cellular physiology by E2F transcription factors. Transworld Research Network. Kerala: Research Signpost. p. 91–106.
   Google Scholar
• Zhu F, Zhu Q, Ye D, et al. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Res. 2018;46(12):6026.
   PubMed Web of Science ®Google Scholar
• Nabeshima R, Nishimura O, Maeda T, et al. Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Elife. 2018;7:pii: e36435.
   PubMed Web of Science ®Google Scholar
• Wang K, Liu F, Zhou LY, et al. The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489. Circ Res. 2014;114(9):1377–1388.
   PubMed Web of Science ®Google Scholar
• Kikkawa N, Hanazawa T, Fujimura L, et al. miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC). Br J Cancer. 2010;103(6):877–884.
   PubMed Web of Science ®Google Scholar
• Hsu CY, Hsieh TH, Tsai CF, et al. miRNA‐199a‐5p regulates VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis. J Pathol. 2014;232:330–343.
   PubMed Web of Science ®Google Scholar
• Fujiwara H, Araki Y, Imakawa K, et al. Dual positive regulation of embryo implantation by endocrine and immune systems – step-by-step maternal recognition of the developing embryo. Am J Reprod Immunol. 2016;75(3):281–289.
   PubMed Web of Science ®Google Scholar
• Rae MT, Hillier SG. Steroid signalling in the ovarian surface epithelium. Trend Endocrinol Metab. 2005;16:327–333.
   PubMed Web of Science ®Google Scholar
• Rae MT, Niven D, Critchley HO, et al. Antiinflammatory steroid action in human ovarian surface epithelial cells. J Clin Endocrinol Metab. 2004;89(9):4538–4544.
   PubMed Web of Science ®Google Scholar
• Tuckerman E, Mariee N, Prakash A, et al. Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol. 2010;87(1-2):60–66.
   PubMed Web of Science ®Google Scholar
• McDonald SE, Henderson TA, Gomez-Sanchez CE, et al. 11β-Hydroxysteroid dehydrogenases in human endometrium. Mol Cell Endocrinol. 2006;248:72–78.
   PubMed Web of Science ®Google Scholar
• Polter AM, Li X. 5-HT1A receptor-regulated signal transduction pathways in brain. Cell Signalling. 2010;22(10):1406–1412.
   PubMed Web of Science ®Google Scholar
• Miller BH, Schultz LE, Long BC, et al. Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Mamm Genome. 2010;21(5-6):247–257.
   PubMed Web of Science ®Google Scholar
• Kiranmai G, Li A, Kossenkov AV, et al. The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis. Nat Commun. 2016;7:10715.
   PubMed Web of Science ®Google Scholar
• Long M, Ming Z, Xu S, et al. miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer. Mol Cancer. 2017;16(1):167.
   PubMedGoogle Scholar
• Crosignani PG, Fraccaro M, Rubin BL. Genetic control of gamete production and function. Salt Lake City: Academic Press; 1982.
   Google Scholar
• Stern C, Pertile M, Norris H, et al. Chromosome translocations in couples with in-vitro fertilization implantation failure. Human Reprod. 1999;14(8):2097–2101.
   PubMed Web of Science ®Google Scholar
• Raziel A, Friedler S, Schachter M, et al. Increased frequency of female partner chromosomal abnormalities in patients with high-order implantation failure after in vitro fertilization. Fertil Steril. 2002;78(3):515–519.
   PubMed Web of Science ®Google Scholar