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Gynecological Endocrinology Volume 36, 2020 - Issue 12
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POLYCYSTIC OVARY SYNDROME

Correlation between leptin and IFN-γ involved in granulosa cell apoptosis in PCOS

Juan Wanga Department of Laboratory Medicine, Changzhou TCM Hospital, Changzhou, ChinaView further author information
,
Ping Gongb Department of Obstetrics and Gynecology, Wuxi Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Jiangnan University, Wuxi, ChinaView further author information
,
Chunmei Lia Department of Laboratory Medicine, Changzhou TCM Hospital, Changzhou, ChinaView further author information
,
Meizhen Pana Department of Laboratory Medicine, Changzhou TCM Hospital, Changzhou, ChinaView further author information
,
Zhixiang Dinga Department of Laboratory Medicine, Changzhou TCM Hospital, Changzhou, ChinaView further author information
,
Xian Gea Department of Laboratory Medicine, Changzhou TCM Hospital, Changzhou, ChinaView further author information
,
Weijin Zhua Department of Laboratory Medicine, Changzhou TCM Hospital, Changzhou, ChinaView further author information
&
Bingwei Shia Department of Laboratory Medicine, Changzhou TCM Hospital, Changzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8289-3468View further author information
ORCID Icon show all
Pages 1051-1056 | Received 30 Jul 2019, Accepted 22 Apr 2020, Published online: 12 May 2020

References

  • Duncan WC. A guide to understanding (PCOS). J Fam Plann Reprod Health Care. 2014;40(3):217–225.
  • The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Fertil Steril. 2004;81(1):19–25.
  • Zhong Z, Li F, Li Y, et al. Inhibition of microRNA-19b promotes ovarian granulosa cell proliferation by targeting IGF-1 in polycystic ovary syndrome. Mol Med Rep. 2018;17(4):4889–4898.
  • Cupisti S, Kajaia N, Dittrich R, et al. Body mass index and ovarian function are associated with endocrine and metabolic abnormalities in women with hyperandrogenic syndrome. Eur J Endocrinol. 2008;158(5):711–719.
  • Cioffi JA1, Van Blerkom J, Antczak M, et al. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod. 1997;3(6):467–472.
  • Bluher S, Mantzoros CS. Leptin in reproduction. Curr Opin Endocrinol Diabetes Obes. 2007;14(6):458–464.
  • Gajewski M, Gajewska J, Rzodkiewicz P, et al. Influence of exogenous leptin on redox homeostasis in neutrophils and lymphocytes cultured in synovial fluid isolated from patients with rheumatoid arthritis. Reumatologia. 2016;3(3):103–107.
  • Lam QL, Liu S, Cao X, et al. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol. 2006;36(12):3118–3130.
  • Duleba AJ, Dokras A. Is PCOS an inflammatory process? Fertil Steril. 2012;97(1):7–12.
  • Gong P, Shi B, Wang J, et al. Association between Th1/Th2 immune imbalance and obesity in women with or without polycystic ovary syndrome. Gynecol Endocrinol. 2018;34(8):709–714.
  • Qin L, Xu W, Li X, et al. Differential expression profile of immunological cytokines in local ovary in patients with polycystic ovarian syndrome: analysis by flow cytometry. Eur J Obstet Gynecol Reprod Biol. 2016;197:136–141.
  • Boots CE, Jungheim ES. Inflammation and human ovarian follicular dynamics. Semin Reprod Med. 2015;33(04):270–275.
  • Dawood AS, Elgergawy A, Elhalwagy A. Circulating levels of vitamin D3 and leptin in lean infertile women with polycystic ovary syndrome. J Hum Reprod Sci. 2018;11(4):343–347.
  • Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394(6696):897–901.
  • Matarese G, Sanna V, Lechler RI, et al. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes. 2002 May;51(5):1356–1361.
  • Duggal PS, Van Der Hoek KH, Milner CR, et al. The in vivo and in vitro effects of exogenous leptin on ovulation in the rat. Endocrinology. 2000;141(6):1971–1976.
  • Calvar CE, Intebi AD, Bengolea SV. Leptin in patients with polycystic ovary syndrome. Direct correlation with insulin resistance. Medicina (B Aires). 2003;63(6):704–710.
  • Zheng SH, Du DF, Li XL. Leptin level in women with polycystic ovary syndrome: a systematic review and a meta analysis. Reprod Sci. 2017;24(5):656–670.
  • Song DK, Hong YS, Sung YA, et al. Insulin resistance according to β-cell function in women with polycystic ovary syndrome and normal glucose tolerance. PLoS One. 2017;12(5):e0178120.
  • Vidal H, Auboeuf D, De Vos P, et al. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J Clin Invest. 1996;98(2):251–255.
  • Munakata Y, Kawahara-Miki R, Shiratsuki S, et al. Gene expression patterns in granulosa cells and oocytes at various stages of follicle development as well as in in vitro grown oocyte-and-granulosa cell complexes. J Repord Dev. 2016;62(4):359–366.
  • Mikaeili S, Rashidi BH, Safa M, et al. Altered FoxO3 expression and apoptosis in granulosa cells of women with polycystic ovary syndrome. Arch Gynecol Obstet. 2016;294(1):185–192.
  • Al-Gubory KH, Fowler PA, Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol. 2010;42(10):1634–1650.
  • Lee H-J, Kim JY, Park JE, et al. Induction of Fas-mediated apoptosis by interferon-γ is dependent on granulosa cell differentiation and follicular maturation in the rat ovary. Dev Reprod. 2016;20(4):315–329.
  • Cataldo N, Fujimoto VY, Jaffe RB. Interferon-γ and activin A promote insulin-like growth factor-binding protein-2 and-4 accumulation by human luteininzing granulosa cells, and interferon-γ promotes their apoptosis. J Clin Endocrinol Metab. 1998;83(1):179–186.

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