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CONTRACEPTION OR MENOPAUSE STILL HAVE

Bleeding profile of women with cardiovascular risk factors using a drospirenone only pill with 4 mg over nine cycles compared to desogestrel 0.075 mg

ORCID Icon, &
Pages 333-338 | Received 18 Nov 2021, Accepted 22 Feb 2022, Published online: 09 Mar 2022

References

  • Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2008;61:171–180.
  • Schindler AE. Non-Contraceptive benefits of oral hormonal contraceptives. Int J Endocrinol Metab. 2013;11:41–47.
  • Regidor PA, Colli E, Schindler AE. Drospirenone as estrogen-free pill and hemostasis: coagulatory study results comparing a novel 4 mg formulation in a 24 + 4 cycle with desogestrel 75 μg per day. Gynecol Endocrinol. 2016;32(9):749–751.
  • PRAC referral assessment report. Procedure under Article 31 of Directive 2001/83/EC resulting from pharmacovigilance data. Combined hormonal contraceptives containing medicinal products INN: chlormadinone, desogestrel, dienogest, drospirenone, etonogestrel, gestodene, nomegestrol, norelgestromin or norgestimate. 2013. Procedure No. EMEA/H/A-31/1356.
  • WHO Medical eligibility criteria for contraceptive use. 5th ed. 2015; 47–61.
  • Jabbour HN, Kelly RW, Fraser HM, et al. Endocrine regulation of menstruation. Endocr Rev. 2006;27:17–46.
  • Smith OP, Critchley HO. Progestogen-only contraception and endometrial breakthrough bleeding. Angiogenesis. 2005;8:117–126.
  • Rice CF, Killick SR, Dieben T, et al. A comparison of the inhibition of ovulation achieved by desogestrel 75mg and levonorgestrel 30mg daily. Hum Reprod. 1999;14:982–985.
  • Rice C, Killick S, Hickling D, et al. Ovarian activity and vaginal bleeding patterns with a desogestrel-only preparation at three different doses. Hum Reprod. 1996;11(4):737–740.
  • Palacios S, Regidor PA, Colli E, et al. Oestrogen-free oral contraception with a 4 milligram drospirenone-only pill: new data and a review of the literature. Eur J Contracept Reprod Health Care. 2020;25(3):221–227.
  • Archer DF, Ahrendt HJ, Drouin D. Drospirenone-only oral contraceptive: results from a multicenter noncomparative trial of efficacy, safety and tolerability. Contraception. 2015;92:439–444.
  • Palacios S, Colli E, Regidor PA. Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone-only pill. Acta Obstet Gynecol Scand. 2019;98:1549–1557.
  • Vogel B, Acevedo M, Appelman Y, et al. The lancet women and cardiovascular disease commission: reducing the global burden by 2030. Lancet Commiss. 2021;397(10292):2385–2438.
  • Bateman BT, Shaw KM, Kuklina EV, et al. Hypertension in women of reproductive age in the United States: NHANES 1999–2008. PLoS One. 2012;7:e36171.
  • Wilsgaard T, Schirmer H, Arnesen E. Impact of body weight on blood pressure with a focus on sex differences: the Tromso study, 1986–1995. Arch Intern Med. 2000;160:2847–2853.
  • Wilson PWF, D’Agostino RB, Sullivan L, et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002;162:1867–1872.
  • Bhupathiraju SN, Hu FB. Epidemiology of obesity and diabetes and their cardiovascular complications. Circ Res. 2016;118:1723–1735.
  • Huxley RR, Woodward M. Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies. Lancet. 2011;378:1297–1305.
  • Collaborators GBDT. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the global burden of disease study 2015. Lancet. 2017;389:1885–1906.
  • Practice Guideline. ACOG practice bulletin no. 206: use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2019;133:e128–e150.
  • Farley TM, Meirik O, Chang CL, et al. Combined oral contraceptives, smoking, and cardiovascular risk. J Epidemiol Community Health. 1998;52:775–785.
  • Curtis KM, Mohllajee AP, Martins SL, et al. Combined oral contraceptive use among women with hypertension: a systematic review. Contraception. 2006;73:179–188.
  • Stampfer MJ, Willett WC, Colditz GA, et al. A prospective study of past use of oral contraceptive agents and risk of cardiovascular diseases. N Engl J Med. 1988;319:1313–1317.
  • Kuhl H. Effects of progestogens on haemostasis. Maturitas. 1996;24:1–19.
  • Winkler UH. Hormone replacement therapy and haemostasis: principles of a complex interaction. Maturitas. 1996;24:131–145.
  • Schindler AE. Differential effects on progestins on haemostasis. Maturitas. 2003;46:31–373.
  • Regidor PA, Colli E, Palacios S. Overall and bleeding-related discontinuation rates of a new oral contraceptive containing 4 mg drospirenone only in a 24/4 regimen and comparison to 0.075 mg desogestrel. Gynecol Endocrinol. 2021;37(12):1121–1127.