Long-term effects of a combination of isoflavones, agnus castus and magnolia extracts on climacteric symptoms and cardiometabolic risk profile in postmenopausal women

References

• Santoro N. Perimenopause: from research to practice. J Womens Health (Larchmt). 2016;25(4):332–339.
   PubMed Web of Science ®Google Scholar
• Schneider HPG, Birkhäuser M. Quality of life in climacteric women. Climacteric. 2017;20(3):187–194.
   PubMed Web of Science ®Google Scholar
• Graziottin A, Banerji V, Hall G. Vasomotor symptoms and neurovegetative comorbidities on the menopause: insights from an Italian quantitative research. Gynecol Endocrinol. 2019;35(9):762–766.
   PubMed Web of Science ®Google Scholar
• Sagraves R. Estrogen therapy for postmenopausal symptoms and prevention of osteoporosis. J Clin Pharmacol. 1995;35(9S):2S–10S.
   PubMedGoogle Scholar
• Ratka A. Menopausal hot flashes and development of cognitive impairment. Ann N Y Acad Sci. 2005;1052:11–26.
   PubMed Web of Science ®Google Scholar
• Thurston RC, El Khoudary SR, Sutton-Tyrrell K, et al. Are vasomotor symptoms associated with alterations in hemostatic and inflammatory markers? Findings from the Study of Women’s Health across the Nation. Menopause. 2011;18(10):1044–1051.
   PubMed Web of Science ®Google Scholar
• Biglia N, Cagnacci A, Gambacciani M, et al. Vasomotor symptoms in menopause: a biomarker of cardiovascular disease risk and other chronic diseases? Climacteric. 2017;20(4):306–312.
   PubMed Web of Science ®Google Scholar
• Bechlioulis A, Kalantaridou SN, Naka KK, et al. Endothelial function, but not carotid intima-media thickness, is affected early in menopause and is associated with severity of hot flushes. J Clin Endocrinol Metab. 2010;95(3):1199–1206.
   PubMed Web of Science ®Google Scholar
• Charkoudian N, Hart ECJ, Barnes JN, et al. Autonomic control of body temperature and blood pressure: influences of female sex hormones. Clin Auton Res. 2017;27(3):149–155.
   PubMed Web of Science ®Google Scholar
• Marjoribanks J, Farquhar C, Roberts H, et al. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 2012;(7):CD004143.
   PubMed Web of Science ®Google Scholar
• Albertazzi PA. A review of non-hormonal options for the relief of menopausal symptoms. Treat Endocrinol. 2006;5(2):101–113.
   PubMedGoogle Scholar
• Glazier MG, Bowman MA. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med. 2001;161(9):1161–1172.
   PubMedGoogle Scholar
• Gencel VB, Benjamin MM, Bahou SN, et al. Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev Med Chem. 2012;12(2):149–174.
   PubMed Web of Science ®Google Scholar
• Zhao L, Mao Z, Brinton RD. A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. Endocrinology. 2009;150(2):770–783.
   PubMed Web of Science ®Google Scholar
• Benvenuti C, Setnikar I. Effect of Lactobacillus sporogenes on oral isoflavones bioavailability, single dose pharmacokinetic study in menopausal women. Arzneimittelforschung. 2011;61(11):605–609.
   PubMed Web of Science ®Google Scholar
• Lucks BC, Sørensen J, Veal L. Vitexagnus-castus essential oil and menopausal balance: a self-care survey. Complement Ther Nurs Midwifery. 2002;8(3):148–154.
   PubMedGoogle Scholar
• Mucci M, Carraro C, Mancino P, et al. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium, controlled clinical study in menopause. Minerva Ginecol. 2006;58(4):323–334.
   PubMedGoogle Scholar
• Maffei S, Guiducci L, Cugusi L, et al. Women-specific predictors of cardiovascular disease risk - new paradigms. Int J Cardiol. 2019;286:190–197.
   PubMed Web of Science ®Google Scholar
• Greene JG, Hart DM. Evaluation of a psychological treatment programme for climacteric women. Maturitas. 1987;9(1):41–48.
   PubMed Web of Science ®Google Scholar
• Morin CM. Insomnia: psychological assessment and management. New York: Guilford Press; 1993.
   Google Scholar
• Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297–307.
   PubMed Web of Science ®Google Scholar
• Kotsopoulos J. Menopausal hormones: definitive evidence for breast cancer. Lancet. 2019;394(10204):1116–1118.
   PubMed Web of Science ®Google Scholar
• Petri Nahas E, Nahás Neto J, De Luca L, et al. Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas. 2004;48(4):372–380.
   PubMed Web of Science ®Google Scholar
• Nahas EA, Nahas-Neto J, Orsatti FL, et al. Efficacy and safety of a soy isoflavone extract in postmenopausal women: a randomized, double-blind, and placebo-controlled study. Maturitas. 2007;58(3):249–258.
   PubMed Web of Science ®Google Scholar
• Ferrari A. Soy extract phytoestrogens with high dose of isoflavones for menopausal symptoms. J Obstet Gynaecol Res. 2009;35(6):1083–1090.
   PubMed Web of Science ®Google Scholar
• Carmignani LO, Pedro AO, Costa-Paiva LH, et al. The effect of dietary soy supplementation compared to estrogen and placebo on menopausal symptoms: a randomized controlled trial. Maturitas. 2010;67(3):262–269.
   PubMed Web of Science ®Google Scholar
• Aso T, Uchiyama S, Matsumura Y, et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health (Larchmt). 2012;21(1):92–100.
   PubMed Web of Science ®Google Scholar
• Van Patten CL, Olivotto IA, Chambers GK, et al. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol. 2002;20(6):1449–1455.
   PubMed Web of Science ®Google Scholar
• Penotti M, Fabio E, Modena AB, et al. Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril. 2003;79(5):1112–1117.
   PubMed Web of Science ®Google Scholar
• Lewis JE, Nickell LA, Thompson LU, et al. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause. 2006;13(4):631–642.
   PubMed Web of Science ®Google Scholar
• Newton KM, Reed SD, LaCroix AZ, et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med. 2006;145(12):869–879.
   PubMed Web of Science ®Google Scholar
• Reed SD, Newton KM, LaCroix AZ, et al. Vaginal, endometrial, and reproductive hormone findings: randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study. Menopause. 2008;15(1):51–58.
   PubMed Web of Science ®Google Scholar
• Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric. 2015;18(2):260–269.
   PubMed Web of Science ®Google Scholar
• De Franciscis P, Grauso F, Luisi A, et al. Adding Agnus castus and Magnolia to soy isoflavones relieves sleep disturbances besides postmenopausal vasomotor Symptoms-Long term safety and effectiveness. Nutrients. 2017;9(2):129.
   Web of Science ®Google Scholar
• De Leo V, Monti M, Cappelli V, et al. Clinical activity of the combination of isoflavones, Agnus castus and Magnolia (estromineral serena plus) in the menopause. Womens Health Gynecol. 2017;3:57.
   Google Scholar
• Husain D, Khanna K, Puri S, et al. Supplementation of soy isoflavones improved sex hormones, blood pressure, and postmenopausal symptoms. J Am Coll Nutr. 2015;34(1):42–48.
   PubMed Web of Science ®Google Scholar
• Silva H. The vascular effects of isolated isoflavones—a focus on the determinants of blood pressure regulation. Biology (Basel). 2021;10(1):49.
   PubMedGoogle Scholar
• Kou T, Wang Q, Cai J, et al. Effect of soybean protein on blood pressure in postmenopausal women: a meta-analysis of randomized controlled trials. Food Funct. 2017;8(8):2663–2671.
   PubMed Web of Science ®Google Scholar
• Yamagata K. Soy isoflavones inhibit endothelial cell dysfunction and prevent cardiovascular disease. J Cardiovasc Pharmacol. 2019;74(3):201–209.
   PubMed Web of Science ®Google Scholar
• Xin X, Chen C, Hu YY, et al. Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD). Biomed Pharmacother. 2019;117:109047.
   PubMed Web of Science ®Google Scholar
• Villa P, Costantini B, Suriano R, et al. The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status. J Clin Endocrinol Metab. 2009;94(2):552–558.
   PubMed Web of Science ®Google Scholar
• Sathyapalan T, Aye M, Rigby AS, et al. Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause. Nutr Metab Cardiovasc Dis. 2018;28(7):691–697.
   PubMed Web of Science ®Google Scholar
• Dent SB, Peterson CT, Brace LD, et al. Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors. J Nutr. 2001;131(9):2280–2287.
   PubMed Web of Science ®Google Scholar
• Pasterkamp G, Algra A, Grobbee DE, et al. Homocysteine and the stage of atherosclerotic disease: a study in patients suffering from clinically silent and clinically manifest atherosclerotic disease. Eur J Clin Invest. 2002;32(5):309–315.
   PubMed Web of Science ®Google Scholar
• Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;14:6.
   PubMed Web of Science ®Google Scholar
• Cao Z, Jia Y, Zhu B. BNP and NT-proBNP as diagnostic biomarkers for cardiac dysfunction in both clinical and forensic medicine. Int J Mol Sci. 2019;20:1820.
   PubMed Web of Science ®Google Scholar
• Song X, Zeng R, Ni L, et al. The effect of soy or isoflavones on homocysteine levels: a Meta-analysis of randomised controlled trials. J Hum Nutr Diet. 2016;29(6):797–804.
   PubMed Web of Science ®Google Scholar
• Marini H, Bitto A, Altavilla D, et al. Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: a follow-up study. Nutr Metab Cardiovasc Dis. 2010;20(5):332–340.
   PubMed Web of Science ®Google Scholar
• De Leo V, Benvenuti C. Clinical activity of a combination of isoflavones, Agnus castus and Magnolia in the menopause: a controlled study on estromineral serena Plus. Gynecol Obstet (Sunnyvale). 2020;10:528.
   Google Scholar
• Atteritano M, Marini H, Minutoli L, et al. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab. 2007;92(8):3068–3075.
   PubMed Web of Science ®Google Scholar
• García-Lafuente A, Guillamón E, Villares A, et al. Flavonoids as anti-inflammatory agents: Implications in cancer and cardiovascular disease. Inflamm Res. 2009;58(9):537–552.
   PubMed Web of Science ®Google Scholar