818
Views
145
CrossRef citations to date
0
Altmetric
PCOS

Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome

, , &
Pages 139-144 | Received 30 Oct 2007, Accepted 10 Jan 2008, Published online: 07 Jul 2009

References

  • Taylor A E. Polycystic ovary syndrome. Endocrinol Metab North Am 1998; 27: 877–902
  • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41–47
  • Zawadsky J K, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Current Issues in Endocrinology and Metabolism: Polycystic Ovary Syndrome, A Dunaif, J R Givens, F P Haseltine, G R Merriam. Blackwell Scientific Publications, CambridgeUK 1992; 377–384
  • Baillargeon J P, Iuorno M J, Nestler J E. Insulin sensitizers for polycystic ovary syndrome. Clin Obstet Gynecol 2003; 46: 325–340
  • Genazzani A D, Battaglia C, Malavasi B, Strucchi C, Tortolani F, Gamba O. Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome. Fertil Steril 2004; 81: 114–119
  • Genazzani A D, Lanzoni C, Ricchieri F, Baraldi E, Casarosa E, Jasonni V M. Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia. Gynecol Endocrinol 2007; 23: 146–152
  • Dunaif A, Segal K R, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989; 38: 1165–1174
  • De Leo V, La Marca A, Petraglia F. Insulin-lowering agents in the management of polycystic ovary syndrome. End Rev 2003; 24: 633–667
  • Ciampelli M, Fulghesu A M, Cucinelli F, Pavone V, Ronsisvalle E, Guido M, Caruso A, Lanzone A. Impact of insulin and body mass index on metabolic and endocrine variables in polycystic ovary syndrome. Metabolism 1999; 48: 167–172
  • Romero G, Larner J. Insulin mediators and the mechanism of insulin action. Adv Pharmacol 1993; 24: 21–50
  • Saltiel A R. Second messengers of insulin action. Diabetes Care 1990; 13: 244–256
  • Kennington A S, Hill C R, Craig J, Bogardus C, Raz I, Ortmeyer H K, Hansen B C, Romero G, Larner J. Low urinary chiroinositol excretion in non-insulin-dependent diabetes mellitus. N Engl J Med 1990; 323: 373–378
  • Asplin I, Galasko G, Larner J. Chiro-inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects. Proc Natl Acad Sci USA 1993; 90: 5924–5928
  • Nestler J E, Jakubowicz D J, Reamer P, Gunn R D, Allan G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med 1999; 340: 1314–1320
  • Iuorno M J, Jakubowicz D J, Baillargeon J P, Dillon P, Gunn R D, Allan G, Nestler J E. Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome. Endocr Pract 2002; 8: 417–423
  • Baillargeon J P, Diamanti-Kandarakis E, Ostlund R E, Apridonidze T, Iuorno M J, Nestler J E. Altered D-Chiro-Inositol urinary clearance in women with polycystic ovary syndrome. Diabetes Care 2006; 29: 300–305
  • Gerli S, Mignosa M, Di Renzo G C. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci 2003; 7: 151–159
  • Chiu T TY, Rogers M S, Law E LK, Briton-Jones C M, Cheung L P, Haines C J. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod 2002; 6: 1591–1596
  • Chiu T TY, Rogers M S, Briton-Jones C, Haines C. Effects of myo-inositol in the in-vitro maturation and subsequent development of mouse oocyte. Hum Reprod 2003; 18: 408–416
  • Haffner S M, Miettinem H, Stern M P. The homeostasis model in the San Antonio Hearth Study. Diabetes Care 1997; 20: 1087–1092
  • Legro R S, Finegood D, Dunaif A. Fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1998; 83: 2694–2698
  • Genazzani A D, Petraglia F, Fabbri G, Monzani A, Montanini V, Genazzani A R. Evidence of luteinizing hormone secretion in hypothalamic amenorrhea associated with weight loss. Fertil Steril 1990; 54: 222–226
  • Genazzani A D, Petraglia F, Benatti R, Montanini V, Algeri I, Volpe A, Genazzani A R. Luteinizing hormone (LH) secretory burst duration is indipendent from LH, prolactin or gonadal steroid plasma levels in amenorrheic women. J Clin Endocrinol Metab 1991; 72: 1220–1225
  • Genazzani A D, Petraglia F, Pianazzi F, Volpogni C, Genazzani A R. The concomitant release of androstenedione with cortisol and luteinizing hormone pulsatilee releases distinguishes adrenal from ovarian hyperandrogenism. Gynecol Endocrinol 1993; 7: 33–41
  • Baker L, Piddington R, Goldman A, Egler J, Moehring J. Myo-Inositol and prostaglandin reverse the glucose inhibition of neural tube fusion in cultured mouse embryos. Diabetologia 1990; 33: 593–596
  • Kolodziejczyk B, Duleba A J, Spaczynski R Z, Pawelczyk L. Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril 2000; 73: 1149–1154
  • Asuncion M, Calvo R M, San Millan J L, Sancho J, Avila S, Escobar Morreale H-F, et al. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab 2000; 85: 2434–2438
  • Knochenhauser E S, Key T J, Kahsar-Miller M, Waggoner W, Boots L R, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the south-eastern United States: a prospective study. J Clin Endocrinol Metab 1998; 83: 3078–3082
  • Nestler J E. Insulin resistance and the polycystic ovary syndrome: recent advances. Curr Opin Endocrinol Diabetes 2000; 7: 345–349
  • Dunaif A, Xia J, Book C B, Schenker E, Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblast and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 1995; 96: 801–810
  • Lobo R A, Carmina E. The importance of diagnosing the polycystic ovary syndrome. Ann Intern Med 2000; 132: 989–993
  • Hasegawa I, Murakawa H, Suzuki M, Yamamoto Y, Kurabayashi T. Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistancerelated polycystic ovary syndrome. Fertil Steril 1999; 71: 323–327
  • Mitwally M F, Kuscu N K, Yalcinkaya T M. High ovulatory rates with use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome. Hum Reprod 1999; 14: 2700–2703
  • Ehrmann D A, Schneider D J, Sobel B E, Cavaghan M K, Imperial J, Rosenfield R L, Polonski K S. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82: 2108–2116
  • Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R. The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab 1996; 81: 3299–3306
  • Nestler J E, Powers L P, Matt D W, Steingold K A, Plymates R, Rittmaster R S, Clore J N, Blackand W G. A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab 1991; 72: 83–89
  • Larner J. Insulin-signaling mechanisms: lessons from the old testament of glycogen metabolism and the new testament of molecular biology. Diabetes 1988; 37: 262–275
  • Saltiel A R. Second messengers of insulin action. Diabetes Care 1990; 13: 244–256
  • Papaleo E, Unfer V, Beillargeon J P, De Santis L, Fusi F, Brigante C, Marelli G, Cino I, Redaelli A, Ferrari A. Myo-inositol in patients with polycystic ovary syndrome a novel method for ovulation induction. Gynecol Endocrinol 2007; 23: 700–703

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.