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Ovary

The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: An updated systematic review

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Pages 590-600 | Received 23 Apr 2008, Accepted 16 Jun 2008, Published online: 07 Jul 2009

References

  • Carmina E, Lobo R A. Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathies associated with significant morbidity in women. J Clin Endocrinol Metab 1999; 84: 1897–1899
  • Escobar-Morreale H F, Luque-Ramirez M, San Millan J L. The molecular genetic basis of functional hyperandrogenism and polycystic ovary syndrome. Endocr Rev 2005; 26: 251–282
  • Gambineri A, Pasquali R. Insulin resistance, obesity and metabolic syndrome in polycystic ovary syndrome. Endocrinol Nutr 2006; 53(Suppl 1)49–55
  • Alvarez-Blasco F, Botella-Carretero J I, San Millan J L, Escobar-Morreale H F. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch Intern Med 2006; 166: 2081–2086
  • Dunaif A. Insulin resistance and the polycystic ovary syndrome mechanism and implications for pathogenesis. Endocr Rev 1997; 18: 774–800
  • Ehrmann D A, Cavaghan M K, Barnes R B, Imperial J, Rosenfield R L. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 1999; 22: 141–146
  • Legro R S, Kunselman A R, Dodson W C, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 1999; 84: 165–169
  • Boomsma C M, Eijkemans M J, Hughes E G, Visser G H, Fauser B C, Macklon N S. A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Hum Reprod Update 2006; 12: 673–683
  • Lo J C, Feigenbaum S L, Escobar G J, Yang J, Crites Y M, Ferrara A. Increased prevalence of gestational diabetes mellitus among women with diagnosed polycystic ovary syndrome a population based study. Diabetes Care 2006; 29: 1915–1917
  • Rajkhowa M, Neary R H, Kumpatla P, Garne F L, Jones P W, Obhrai M S, Clayton R N. Altered composition of high density lipoproteins in women with the polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82: 3389–3394
  • Berneis K, Rizzo M, Lazzaroni V, Fruzzetti F, Carmina E. Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2007; 92: 186–189
  • Talbott I, Clerici A, Berga S L, Kuller L, Guzick D, Detre K, Daniels T, Englerg R A. Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: results of a case–control study. J Clin Epidemiol 1998; 51: 415–422
  • Legro R S, Kunselman A R, Dunaif A. Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome. Am J Med 2001; 111: 607–613
  • Lo J C, Feigenbaum S L, Yang J, Pressman A R, Selby J V, Go A S. Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome. J Clin Endocrinol Metab 2006; 91: 1357–1363
  • Apridonidze T, Essah P A, Iuorno M J, Nestler J E. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005; 90: 1929–1935
  • Ehrmann D A, Lljenquist D R, Kasza K, Azziz R, Legro R S, Ghazzi M N. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2006; 91: 48–52
  • Nader S, Riad-Gabriel M G, Saad M F. The effect of a desogestrel containing oral contraceptive on glucose tolerance and leptin concentrations in hyperandrogenic women. J Clin Endocrinol Metab 1997; 82: 3074–3077
  • Morin-Papunen L C, Vauhkonen I, Koivunen R M, Ruokonen A, Martikainen H K, Tapanainen J S. Endocrine and metabolic effects of metformin versus ethinyl estradiol–cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study. J Clin Endocrinol Metab 2000; 85: 3161–3168
  • Tavior A E. Insulin lowering medications in polycystic ovary syndrome. Obstet Gynecol Cim North Am 2000; 27: 583–595
  • Korytkowski M, Mokan M, Horwitz M, Berga S. Metabolic effects of oral contraceptives in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1995; 80: 3327–3334
  • Meyer C, McGrath B P, Teede H J. Effects of medical therapy on insulin resistance and the cardiovascular system in polycystic ovary syndrome. Diabetes Care 2007; 30: 471–478
  • Luque-Ramirez M, Alvarez-Blasco F, Botella-Carretero J I, Martinez-Bermejo E, Lasuncion M A, Escobar-Morreale H F. Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome. J Clin Endocrinol Metab 2007; 92: 2453–2461
  • Morin-Papunen L, Vauhkonen I, Koivunen R, Ruokonen A, Martikainen H, Tapanainen J S. Metformin versus ethinyl estradiol–cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study. J Clin Endocrinol Metab 2003; 88: 148–156
  • Harborne L, Fleming R, Lyall H, Sattar N, Norman J. Metformin or antiandrogen in the treatment of hirsutism in polycystic ovary syndrome. J Clin Endocrinol Metab 2003; 88: 4116–4123
  • Bailey C J, Turner R C. Metformin. N Engl J Med 1996; 334: 574–579
  • Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, Muggeo M. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 2000; 85: 139–146
  • Carlsen S M, Rossvoll O, Bjerve K S, Folling I. Metformin improves blood lipid pattern in nondiabetic patients with coronary heart disease. J Intern Med 1996; 239: 227–233
  • Marquie G. Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. Atherosclerosis 1983; 47: 7–17
  • Lord J, Flight I, Norman R. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, d-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev 2003, CD003053
  • Diamanti-Kandarakis E, Baillargeon J, Iuorno M, Jakubowicz D J, Nestler J E. A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills. J Clin Endocrinol Metab 2003; 88: 1927–1932
  • Fleming R, Hopkinson Z E, Wallace A M, Greer I A, Sattar N. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab 2002; 87: 569–574
  • Rautio K, Tapanainen J S, Ruokonen A, Morin-Papunen L C. Effects of metformin and ethinyl estradiol–cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome. Eur J Endocrinol 2005; 152: 269–275
  • Ehrmann D A, Cavaghan M K, Imperial J, Sturis J, Rosenfield R L, Polonsky K S. Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82: 524–530
  • Velazquez E M, Mendoza S, Hamer T, Sosa F, Glueck C J. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994; 43: 647–654
  • Costello M F, Shrestha B, Eden J, Johnson N P, Sjoblom P. Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review. Hum Reprod 2007; 22: 1200–1209
  • Juni P, Altman D G, Egger M. Assessing the quality of controlled clinical studies. BMJ 2001; 323: 42–46
  • Deeks J J, Altman D G, Bradburn M J. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. Systematic reviews in healthcare: meta-analysis in context, M Egger, G Davey Smith, D G Altman. BMJ Books, London 2001; 285–312
  • Sutton A J, Abrams K R, Jones D R, Sheldon T A, Song F. Methods for meta-analysis in medical research. 1st ed. John Wiley and Sons, ChichesterUK 2000
  • Hatala R, Keitz S, Wyer P, Guyatt G, on behalf of the Evidence–Based Medicine Teaching Tips Working Group. Tips for learners of evidence-based medicine 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results. CMAJ 2005; 172: 661–665
  • Morin-Papunen L, Rautio K, Ruokonen A, Hedberg P, Puukka M, Tapanainen J S. Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003; 88: 4649–4654
  • Mitkov M, Pehlivanov B, Terzieva D. Combined use of metformin and ethinyl estradiol–cyproterone acetate in polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2005; 118: 209–213
  • Jin L N, Yu Q, Ma L K. Clinical analysis of 48 cases polycystic ovary syndrome. Chin J Postgrad Med 2006; 29(7)10–15
  • Teng Y Q, Zheng J H, Han X Y. [Evaluation of clinical efficacy of metformin in treating polycystic ovary syndrome]. J Harbin Med Univ 2007; 41: 405–406
  • Liu J X, Dang J M, Wu Y Z, Zheng N, Wu X K. The effect of combination therapy with metformin and combined cyproterone acetate/ethinyloestradiol on PCOS patients. J Med Postgrad 2006; 19: 530–533
  • Lv L Q, Liu Y, Sun Y Y, Tan K. Effects of metformin combined with cyproterone acetate on clinical features, endocrine and metabolism of non-obese women with polycystic ovarian syndrome. J Huazhong Univ Sci Technol (Med Sci) 2005; 25: 194–197
  • Elter K, Imir G, Durmusoglu F. Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol–cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study. Hum Reprod 2002; 17: 1729–1737
  • Costello M, Shrestha B, Eden J, Sjoblom P, Johnson N. Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Cochrane Database Syst Rev 2007, 1, CD005552

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