Current alternative and complementary therapies used in menopause

References

• Gold E, Bromberger J, Crawford S. Factors associated with age at natural menopause in a multiethnic sample of midlife women. Am J Epidemiol 2001; 153: 865–874
   PubMed Web of Science ®Google Scholar
• McKinlay S, Bifano N, McKinlay J. Smoking and age at menopause in women. Ann Intern Med 1985; 103: 350–356
   PubMed Web of Science ®Google Scholar
• Kang H, Ansbacher R, Hammoud M. Use of alternative and complementary medicine in menopause. Int J Gynaecol Obstet 2002; 79: 195–207
   PubMed Web of Science ®Google Scholar
• McBane S. Easing vasomotor symptoms: besides HRT, what works. JAAPA 2008; 21: 26–32
   Google Scholar
• Geller S, Studee L. Contemporary alternatives to plant estrogens for menopause. Maturitas 2006; 55(Suppl 1)3–13
   Google Scholar
• Wuttke W, Jarry H, Becker T, Schultens A, Christoffel V, Gorkow C, Seidlova-Wuttke D. Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?. Maturitas 2003; 44(Suppl 1)9–20
   PubMedGoogle Scholar
• Wiebe J. Progesterone metabolites in breast cancer. Endocr Relat Cancer 2006; 13: 717–738
   PubMed Web of Science ®Google Scholar
• Yager J D, Davidson N E. Estrogen Carcinogenesis in Breast Cancer. NEJM 2006; 354: 270–282
   PubMed Web of Science ®Google Scholar
• Zava D, Dollbaum C, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998; 217: 369–378
   PubMed Web of Science ®Google Scholar
• Schairer C, Lubin J, Troisi R, Sturgeon S, Brinton L, Hoover R. Menopausal estrogen and estrogen-progestin replacement therapy and breast-cancer risk. JAMA 2000; 283: 485–491
   PubMed Web of Science ®Google Scholar
• Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003; 362: 419–427
   PubMed Web of Science ®Google Scholar
• Rossouw J, Anderson G, Prentice R, LaCroix A Z, Kooperberg C, Stefanick M L, Jackson R D, Beresford S AA, Howard B V, Johnson K C, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321–333
   PubMed Web of Science ®Google Scholar
• Beral V, Banks E, Reeves G. Evidence from randomised trials on the long-term effects of hormone replacement therapy. Lancet 2002; 360: 942–444
   PubMed Web of Science ®Google Scholar
• Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F. Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Int J Cancer 2005; 114: 448–454
   PubMed Web of Science ®Google Scholar
• Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer: collaborative Group on Hormonal Factors in Breast Cancer. Lancet 1997; 350: 1047–1059
   PubMed Web of Science ®Google Scholar
• Cheema D, Coomarasamy A, El-Toukhy T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review. Arch Gynecol Obstet 2007; 276: 463–469
   PubMedGoogle Scholar
• Nelson H, Vesco K, Haney E, Fu R, Nedrow A, Miller J, Nicolaidis C, Walker M, Humphrey L. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006; 295: 2057–2071
   PubMed Web of Science ®Google Scholar
• National Institutes of Heatlh State-of-the-Science Conference Statement: Management of Menopause-Related Symptoms
   Google Scholar
• Hickey M, Saunders C, Stuckey B. Non-hormonal treatments for menopausal symptoms. Maturitas 2007; 57
   Google Scholar
• Albertazzi P. Non-estrogenic approaches for the treatment of climacteric symptoms. Climacteric 2007; 10: 115–120
   PubMed Web of Science ®Google Scholar
• Guttuso T. Gabapentin's effect on hot flashes and hypothermia. Neurology 2000; 54: 2161–2163
   PubMed Web of Science ®Google Scholar
• Guttuso T, Kurlan R, McDermott M, Kieburtz K. Gabapentin's effect on hot flashes in postmenopausal women: a randomised control trial. Obstet Gynecol 2003; 101: 337–345
   PubMed Web of Science ®Google Scholar
• Pandya K J, Morrow G R, Roscoe J A, Zhao H, Hickok J T, Pajon E, Sweeney T J, Banerjee T K, Flynn P J. Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 2005; 366: 818–824
   PubMed Web of Science ®Google Scholar
• Reddy S V, Warner H, Guttuso Jr T, Messing S, DiGrazio W, Thornburg L, Guzick D S. Gabapentin, oestrogen and placebo for treating hot flushes: a randomised controlled trial. Obstet Gynecol 2006; 108: 41–48
   PubMed Web of Science ®Google Scholar
• Evans M, Pritts E, Vittinghoff E, McClish K, Morgan K S, Jaffe R B. Management of postmenopausal hot flashes with venlafaxine hydrochloride: a randomised controlled trial. Obstet Gynecol 2005; 105: 61–66
   Google Scholar
• Stearns V, Beebe K, Ivengar M, Dube E. Paroxetine controlled release in the treatment of menopausal hot flashes: a randomised controlled trial. JAMA 2003; 289: 2827–2834
   PubMed Web of Science ®Google Scholar
• Stearns V, Slack R, Greep N, Henry-Tilman R, Osborne M, Bunnell C, Ullmer L, Gallagher A, Cullen J, Gehan E, et al. Paroxetine is an effective treatment for hot flashes: results from a prospective randomised clinical trial. J Clin Oncol 2005; 23: 6919–6930
   PubMed Web of Science ®Google Scholar
• Loprinzi C, Kugler J, Sloan J, et al. Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trial. Lancet 2000; 356: 2059–2063
   PubMed Web of Science ®Google Scholar
• Weitzner M, Moncello J, Jacobsen P B, Minton S. A pilot trial of paroxetine for the treatment of hot flashes and associated symptoms in women with breast cancer. J Pain Symptom Manage 2002; 23
   Google Scholar
• Barton D L, Loprinzi C L, Quella S K, Sloan J A, Veeder M H, Egner J R, Fidler P, Stella P J, Swan D K, Vaught N L, et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol 1998; 16: 495–500
   PubMed Web of Science ®Google Scholar
• Blatt M, Wiesbader H, Kupperman H. Vitamin E and climacteric syndrome. Ann Intern Med 1953; 91: 792–796
   Google Scholar
• Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002; 137: 805–813
   PubMed Web of Science ®Google Scholar
• Komesaroff P, Black C V, Cable V, Sudhir K. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 2001; 4: 144–150
   PubMedGoogle Scholar
• Huntley A, Ernst E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Menopause 2003; 10: 465–476
   PubMed Web of Science ®Google Scholar
• Wiklund I, Mattsson L A, Lindgren R, Limoni C. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Int J Clin Pharmacol Res 1999; 19: 89–99
   PubMedGoogle Scholar
• Tode T, Kikuchi Y, Hirata J, Kita T, Nakata H, Nagata I. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet 1999; 67: 169–174
   PubMed Web of Science ®Google Scholar
• Nedrow A, Miller J, Walker M, Nygren P, Huffman L H, Nelson H D. Complementary and alternative therapies for the management of menopause-related symptoms: a systematic evidence review. Arch Intern Med 2006; 166: 1453–1465
   PubMed Web of Science ®Google Scholar
• Hartley D, Elsabagh S, Se F. Gincosan (a combination of Ginkgo biloba and Panax ginseng): the effects on mood and cognition of 6 and 12 weeks' treatment in post-menopausal women. Nutr Neurosci 2004; 7: 325–333
   PubMed Web of Science ®Google Scholar
• Greenspan E. Ginseng and vaginal bleeding. JAMA 1983; 249: 2018
   PubMedGoogle Scholar
• Hopkins M, Androff L, Benninghoff A. Ginseng face cream and unexplained vaginal bleeding. Am J Obstet Gynecol 1988; 159: 1121–1122
   PubMed Web of Science ®Google Scholar
• Punnonen R, Lukola A. Oestrogen-like effect of ginseng. BMJ 1980; 281: 1110
   PubMed Web of Science ®Google Scholar
• Atkinson C, Warren R, Sala E, Dowsett M, Dunning A, Healey C, Runswick S, Day N, Bingham S. Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial. Breast Cancer Res 2004; 6: 140–142
   Google Scholar
• Baber R, Templeman C, Morton T, Kelly G, West L. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric 1999; 2: 85–92
   PubMedGoogle Scholar
• Crisafulli A, Marini H, Bitto A, Altavilla D, Squadrito G, Romeo A, Adamo E B, Marini R, D'Anna R, Corrado F, et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause 2004; 11: 400–404
   PubMed Web of Science ®Google Scholar
• Knight D, Howes J, Eden J. The effect of Promensil, an isoflavone extract, on menopausal symptoms. Climacteric 1999; 2: 79–84
   PubMedGoogle Scholar
• Tice J, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings S R. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003; 290: 207–214
   PubMed Web of Science ®Google Scholar
• van de Weijer P, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002; 42: 187–193
   PubMed Web of Science ®Google Scholar
• Tempfer C B, Bentz E K, Leodolter S, Tscherne G, Reuss F, Cross H S, Huber J C. Phytoestrogens in clinical practice: a review of the literature. Fertil Steril 2007; 87: 1243–1249
   PubMed Web of Science ®Google Scholar
• Thompson Coon J, Pittler M H, Ernst E. Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. Phytomedicine 2007; 14: 153–159
   PubMed Web of Science ®Google Scholar
• Howes J B, Sullivan D, Lai N, Nestel P, Pomeroy S, West L, Eden J A, Howes L G. The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemia. Atherosclerosis 2000; 152: 143–147
   PubMed Web of Science ®Google Scholar
• Nestel P J, Pomeroy S K, Komesaroff P, Behrsing J, Cameron J D, West L. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999; 84: 895–898
   PubMed Web of Science ®Google Scholar
• Chedraui P, Hidalgo L, San Miguel G, Morocho N, Ross S. Red clover extract (MF11RCE) supplementation and postmenopausal vaginal and sexual health. Int J Gynecol Obstet 2006; 95: 296–297
   PubMed Web of Science ®Google Scholar
• Chenoy R, Hussain S, Tayob Y, O'Brien P M, Moss M Y, Morse P F. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. BMJ 2004; 308: 501–503
   Google Scholar
• Amato P, Christophe S, Mellon P. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002; 9: 145–150
   PubMed Web of Science ®Google Scholar
• Hirata J D, Swiersz L M, Zell B, Small R, Ettinger B. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997; 68: 981–986
   PubMed Web of Science ®Google Scholar
• Kupfersztain C, Rotem C, Fagot R, Kaplan B. The immediate effect of natural plant extract. Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. Clin Exp Obstet Gynecol 2003; 30: 203–206
   PubMedGoogle Scholar
• Cimicifuga racemosa. Alternative Medicines Review. Alternative Medicines Review [cited 15th July 2008], Available from: http://findarticles.com/p/articles/mi_m0FDN/is_2_8/ai_103194441/pg_1?tag=artBody;col1
   Google Scholar
• Dog T, Powell K, Weisman S. Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief. Menopause 2003; 10: 299–313
   PubMed Web of Science ®Google Scholar
• Burdette J E, Liu J, Chen S N, Fabricant D S, Piersen C E, Barker E L, Pezzuto J M, Mesecar A, Van Breemen R B, Farnsworth N R, Bolton J L. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem 2003; 51: 5661–5670
   PubMed Web of Science ®Google Scholar
• Frei-Kleiner S, Schaffner W, Rahlfs V. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas 2005; 51: 397–404
   PubMed Web of Science ®Google Scholar
• Newton K M, Reed S D, Grothaus L, Ehrlich K, Guiltinan J, Ludman E, Lacroix A Z. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001; 19: 2739–2745
   Google Scholar
• Osmers R, Friede M, Liske E. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol 2005; 105: 1074–1078
   PubMed Web of Science ®Google Scholar
• Pockaj B, Gallagher J, Loprinzi C, Stella P J, Barton D L, Sloan J A, Lavasseur B I, Rao R M, Fitch T R, Rowland K M, et al. Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes. J Clin Oncol 2006; 24: 2836–2841
   PubMed Web of Science ®Google Scholar
• Uebelhack R, Blohmer J U, Graubaum H J, Busch R, Gruenwald J, Wernecke K D. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006; 107: 247–255
   PubMed Web of Science ®Google Scholar
• Verhoeven M, Van der Mooren M, Van de Weijer P. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. Menopause 2005; 12: 412–420
   PubMed Web of Science ®Google Scholar
• Wuttke W, Seidlove-Wuttke G. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003; 14(Suppl 1)67–77
   Google Scholar
• Newton K M, Reed S D, LaCroix A Z, Grothaus L C, Ehrlich K, Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006; 145: 869–879
   PubMed Web of Science ®Google Scholar
• Kurzer M. Phytoestrogen supplement use by women. J Nutr 2003; 113(Suppl)1983S–1986S
   Google Scholar
• Lethaby A E, Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews 2007. Cochrane Database Syst Rev 2007; 4, Art. No.: CD001395. DOI: 10.1002/14651858. CD001395.pub3
   Google Scholar
• St Germain A, Peterson C T, Robinson J G, Alekel L. Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms curing 24 weeks of treatment. Menopause 2001; 8: 17–26
   PubMed Web of Science ®Google Scholar
• Messina M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid 2006; 16: 249–258
   PubMed Web of Science ®Google Scholar
• Irvin J H, Domar A D, Clark C, Zuttermeister P C, Friedman R. The effects of relaxation response training on menopausal symptoms. J Psychosom Obstet Gynaecol 1996; 17: 202–207
   PubMed Web of Science ®Google Scholar
• Thurston R, Joffe H, Soares C, Harlow B. Physical activity and risk of vasomotor symptoms in women with and without a history of depression: results from the Harvard Study of Moods and Cycles. Menopause 2006; 13: 553–560
   PubMed Web of Science ®Google Scholar
• Daley A, Macarthur C, Mutrie N, Stokes-Lampard H. Exercise for vasomotor menopausal symptoms. Cochrane Database Syst Rev 2007; 4: CD006108.
   Google Scholar
• Schmitz K H, Warren M, Rundle A G, Williams N I, Gross M D, Kurzer M S. Exercise Effect on Oxidative Stress Is Independent of Change in Estrogen Metabolism. Cancer Epidemiol Biomarkers Prev 2008; 17: 220–223
   PubMed Web of Science ®Google Scholar
• Ganz P A, Greendale G A, Petersen L, Zibecchi L, Kahn B, Belin T R. Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. J Natl Cancer Inst 2000; 92: 1054–1064
   PubMed Web of Science ®Google Scholar
• Pines A, Berry E M. Exercise in the menopause – an update. Climacteric 2007; 10: 42
   PubMed Web of Science ®Google Scholar
• Towey M, Bundy C, Cordingley L. Psychological and social interventions in the menopause. Curr Opin Obstet Gynecol 2006; 18: 413–417
   PubMed Web of Science ®Google Scholar
• Allen L A, Dobkin R D, Boohar E M, Woolfolk R L. Cognitive behavior therapy for menopausal hot flashes: two case reports. Maturitas 2006; 54: 95–99
   PubMed Web of Science ®Google Scholar
• Wyon Y, Wijma K, Nedstrand E, Hammar M. A comparison of acupuncture and oral estradiol treatment of vasomotor symptoms in postmenopausal women. Climacteric 2004; 7: 153–164
   PubMed Web of Science ®Google Scholar