Advanced search
Publication Cover
Platelets Volume 13, 2002 - Issue 1
Submit an article Journal homepage
47
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Aggregation of human platelets by gingipain-R from Porphyromonas gingivalis cells and membrane vesicles

K. Pham Department of Restorative Dentistry, Temple University School of Dentistry, 3223 N. Broad St., Philadelphia, Pa. 19128, USA.
,
D. Feik Department of Restorative Dentistry, Temple University School of Dentistry, 3223 N. Broad St., Philadelphia, Pa. 19128, USA.
,
B.F. Hammond Department of Restorative Dentistry, Temple University School of Dentistry, 3223 N. Broad St., Philadelphia, Pa. 19128, USA.
,
T.E. Rams Department of Restorative Dentistry, Temple University School of Dentistry, 3223 N. Broad St., Philadelphia, Pa. 19128, USA.
&
E.J. Whitaker Department of Restorative Dentistry, Temple University School of Dentistry, 3223 N. Broad St., Philadelphia, Pa. 19128, USA.
Pages 21-30 | Published online: 07 Jul 2009

  • Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal disease and cardiovascular disease. J Periodontol 1996; 67: 1123-37.
  • Bergstrom J, Donner W, Eliasson S, Rasminis G, Skofdin H. Myocardial infarction and periodontal disease. J Dent Res 1998; 77 (Special Issue B): Abstr #2872.
  • Colman RW. Platelet activation: role of an ADP receptor. Semin Hematol 1986; 23: 119-28.
  • Connolly AJ, Ishihara H, Kahn ML, Farese RV Jr, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996; 381: 516-9.
  • Curtis MA, Macey M, Slaney JM, Howells GL. Platelet activation by protease I of Porphyromonas gingivalis W83. FEMS Microbiol Lett 1993; 110: 167-73.
  • Curtis MA, Aduse-Opoku J, Slaney JM. Characterization of an adherence and antigenic determinant of the ArgI protease of Porphyromonas gingivalis which is present on multiple gene products. Infect Immun 1996; 64: 2532-9.
  • DeStefano F, Anda RF, Hahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease. Br Meet J 1993; 306: 668-91.
  • Haraszthy VJ, Zambon JJ, Trevisan M, Shah R, Zeid M, Genco RJ. Identificaiton of pathogens in atheromatous plaques. J Dent Res 1998; TJ (Special Issue B): Abstr #273
  • Herzberg MC, Brintzenhofe KL, Clawson CC. Aggregation of human platelets and adhesion of Streptococcus sanguis. Infect Immun 1993; 39: 1457-69.
  • Herzberg MC, MacFarlane GD, Liu P, Erickson PR. The platelet as an inflammatory cell in periodontal diseases. In: Genco RJ, Hamada S, Lehrer JR, McGhee JR, Mergenhagen S, eds. Molecular pathogenesis of periodontal diseases. Washington, DC: ASM Press. 1994: 247-55.
  • Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA. Examining the link between coronary heart disease and the elimination of chronic infections. J Am Dent Assoc 2001; 131: 883-9.
  • Imamura T, Pike RN, Potempa J, Travis J. Pathogenesis of periodontitis: a major arginine-specific proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of kallikrein/kinin pathway. J Clin Invest 1994; 94: 361-7.
  • Imamura T, Potempa J, Pike RN, Travis J. Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis. Infect Immun 1995; 63: 1999-2003.
  • Imamura T, Potempa J, Pike RN, Moore JN, Barton MH, Travis J. Effect of free and vesicle-bound cyusteine proteinases of Porphyromonas gingivalis on plasma clot formation: Implications for bleeding tendency at periodontitis sites. Infect Immun 1995; 63: 4877-2.
  • Imamura T, Potempa J, Tanase S, Travis J. Activation of blood coagulation factor X by argingine-specific cysteine proteinase (gingipain-Rs) from Porphyromonas gingivalis. J Biol Chem 1997; 272: 16062-7.
  • Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willet WC. Poor oral health and coronary heart disease. J Dent Res 1996; 75: 1631-6.
  • Kato Y, Hori S, Fujita, N, Tsuruo, T. A novel anti-platelet monoclonal antibody induces mouse platelet aggregation through an FC receptor-independent mechanism. Biochem Biophys Res Commun 1998; 242: 250-5.
  • Laemmli UK. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
  • Lament RJ, Chan A, Belton CM, Izutsu KT, Dirk V, Weinberg A. Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun 1995; 63: 3878-85.
  • Loesche WJ. Periodontal disease as a risk factor for heart disease. Compendium Continuing Education in Dentistry 1994; 8: 976-1001.
  • Loesche WJ, Eklund S, Earnest R, Burt B. Longitudinal investigation of the role of Streptococcus mutons in human fissure decay. Infect Immun 1979; 26: 498-507.
  • Loesche WJ, Schork A, Terpenning MS, Chen Y-M, Dominguez BL, Grossman N. Assessing the relationship between dental disease and coronary heart disease in elderly U.S. veterans. J Am Dent Assoc 1998; 129: 301-31.
  • Lourbakos A, Yuan Y, Jenkins AL, Travis J, Andrade-Gordon P, Santulli R, et al. Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity. Blood 2001; 97: 3790-7.
  • Manila KJ, Nieminen MS, Valtonen W, Rasi VP, Kesaniemi YA, Syrjala SL, Jungell PS, Isoluoma M, Hietaniemi K, Jokinen MJ. Association betwen dental health and acute myocardial infarction. Br Med J 1989; 298: 779-81.
  • McFarland, J. Nephelometer: an instrument for estimating the number of bacteria in suspension used for calculating the opsonic index and for vaccines. J Am Med Assoc 1907; 14: 1176-8.
  • Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. Lab Invest 1976; 33: 235-49.
  • Papapanou PN, Sandras J, Lindberg K, Duncan MJ, Niederman R. Nannmark U. Porphyromonas gingivalis may multiply and advance within stratified human junctional epithelium in vitro. J Periodont Res 1994; 29: 374-5.
  • Peerschke EIB, Zucker MB, Grant RA, Egan JJ, Johnson MM. Correlation between fibrinogen binding to human platelets and aggregability. Blood 1980; 55: 841-7.
  • Pham K, Rams TE, Feik D, Whitaker EJ, Scott CF, Colman RW. Aggregation of human platelets by Porphyromonas gingivalis. J Dent Res 1998; TJ: 124 (abstr. #148).
  • Pham K, Feik D, Hammond BF, Rams TE, Whitaker EJ. Effect of gingipain-R from Porphyromonas gingivalis membrane vesicles on human platelet aggregation. J Dent Res 2000; 79: 154 (abstr. #88).
  • Pike R, McGraw W, Potempa J, Travis J. Lysine- and arginine-specific proteinases from Porphromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutiins. JBiol Chem 1994; 269: 406-11.
  • Ruggeri ZM, Zimmerman TS. Platelets and von Willebrands disease. Semin Hematol 1985; 22: 203-18.
  • Santoro SA, Cunningham LW. Collagen-mediated platelet aggregation. Evidence for multivalent interactions of intermediate specificity between collagen and platelets. J Clin Invest 1977; 60: 1054-60.
  • Scott CF, Whitaker EJ, Hammond BF, Colman RW. Purification and characterization of a potent 70-kDa thiol lysyl-proteinase (Lysgingipain) from Porphyromonas gingivalis that cleaves kininogens and fibrinogen. J Biol Chem 1992; 268: 7935-42.
  • Sharma A, Novak EK, Sojar HT, Swank RT, Kuramitsu HK, Genco RJ. Porphyromonas gingivalis plaelet aggregation activity: outer membrane vesicles are potent activators of murine platelets. Oral Microbiol Immunol 2000; 15: 393-6.
  • Slots J. Long wave uv-light flucrescenc assay fo identification of black pigmented Bacteroides spp. J Clin Microbiol 1982; 16: 148-51.
  • Slots J. Detection of colonies of Bacteroides gingivalis by arapid fluorescence assay for trypsin-like activity. Oral Microbiol Immunol 1987; 2: 139-41.
  • Smalley JW, Mayrand D, Grenier S. Vesicles. In: Shah HN, Garcia SE, eds. Biology of the species Porphyromonas gingivalis. Boca Raton, FL: CRC Press. 1993: 259-1.
  • Tollefsen DM, Feagler JR, Majerus PW. The binding of thrombin to the surface of human platelets. J Biol Chem 1974; 249:2646-51.
  • Tsakiris DA, Scudder L, Hodivala-Dike K, Hynes RO, Coller BS. Hemostasis in the mouse (Mus musculus): a review. Thromb Haemost 1999; 81: 177-88.
  • Wingrove JA, DiScipio RG, Chen Z, Potempa J, Travis J, Hugli TE. Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas gingivalis. J Biol Chem 1992; 267: 18902-7.
  • Zambon JJ, Grossi S, Dunford R, Harazsthy VI, Preus H, Genco RJ. Epidemiology of subgingival bacterial pathogens in periodontal diseases. In: Genco RJ, Hamada S, Lehrer JR, McGhee JR, Mergenhagen S, eds. Molecular pathogenesis of periodontal diseases. Washington, DC: ASM Press, 1994: 3-12.
  • Zambon JJ, Haraszthy VJ, Grossi S, Genco RJ. Identification of periodontal pathogens in the atheromatous plaque. J Dent Res 1997; 76: 408 (abstr. #3159).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.