126
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Clopidogrel (Plavix®) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding

, , , &
Pages 325-332 | Published online: 07 Jul 2009

References

  • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329–39.
  • Mehta S R, Yusuf S. The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease. Eur Heart J 2000; 21: 2033–41.
  • Hongo R H, Ley J, Dick S E, Yee R R. The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. J Am Coll Cardiol 2002; 40: 231–7.
  • Yende S, Wunderink R G. Effect of clopidogrel on bleeding after coronary artery bypass surgery. Crit Care Med 2001; 29: 2271–5.
  • Tuman K J, Spiess B D, McCarthy R J, Ivankovich A D. Comparison of viscoelastic measures of coagulation after cardiopulmonary bypass. Anesth Analg 1989; 69: 69–75.
  • Shore-Lesserson L, Manspeizer H E, DePerio M, Francis S, Vela-Cantos F, Ergin M A. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analesia 1999; 88: 312–9.
  • Khurana S, Mattson J C, Westley S, O’Neill W W, Timmis G C, Safian R D. Monitoring platelet glycoprotein IIb/IIIa-fibrin interaction with tissue factor-activated thromboelastography. J Lab Clin Med 1997; 130: 401–11.
  • Storey R F, May J A, Wilcox R G, Heptinstall S. A whole blood assay of inhibition of platelet aggregation by glycopro- tein IIb/IIIa antagonists: comparison with other aggregation methodologies. Thromb Haemost 1999; 82: 1307–11.
  • Lau W C, Waskell L A, Watkins P B, Neer C J, Horowitz K, Hopp A S, Tait A R, Carville D G, Guyer K E, Bates E R. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug–drug interaction. Circulation2003; 107: 32–7.
  • Thiagarajan P, Tait J F. Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles. J Biol Chem 1991; 266: 24302–7.
  • Harker L A, Marzec U M, Kelly A B, Chronos N R, Sundell I B, Hanson S R, Herbert J M. Clopidogrel inhibition of stent, graft, and vascular thrombogenesis with antithrombotic enhancement by aspirin in nonhuman primates. Circulation 1998; 98: 2461–9.
  • Jarvis G E, Humphries R G, Robertson M J, Leff P. ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors. Br J Pharmacol 2000; 129: 275–82.
  • Storey R F, Sanderson H M, White A E, May J A, Cameron K E, Heptinstall S. The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity. Br J Haematol 2000; 110: 925–34.
  • Kikura M, Kazama T, Ikeda T, Sato S. Disaggregatory effects of prostaglandin E1, amrinone and milrinone on platelet aggregation in human whole blood. Platelets 2000; 11: 446–58.
  • Foster C J, Prosser D M, Agans J M, Zhai Y, Smith M D, Lachowicz J E, Zhang F L, Gustafson E, Monsma F J, Jr., Wiekowski M T, Abbondanzo S J, Cook D N, Bayne M L, Lira S A, Chintala M S. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001; 107: 1591–8.
  • Covic L, Singh C, Smith H, Kuliopulos A. Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome. Thromb Haemost 2002; 87: 722–7.
  • Barragan P, Bouvier J L, Roquebert P O, Macaluso G, Commeau P, Comet B, Lafont A, Camoin L, Walter U, Eigenthaler M. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator- stimulated phosphoprotein phosphorylation. Cathet Cardiovasc Int 2003; 59: 295–302.
  • Clark S C, Vitale N, Zacharias J, Forty J. Effect of low molecular weight heparin (fragmin) on bleeding after cardiac surgery. Ann Thorac Surg 2000; 69: 762–4; discussion 764–5.
  • Genoni M, Zeller D, Bertel O, Maloigne M, Turina M. Tirofiban therapy does not increase the risk of hemorrhage after emergency coronary surgery. J Thorac Cardiovasc Surg 2001; 122: 630–2.
  • Puskas J D, Williams W H, Duke P G, Staples J R, Glas K E, Marshall J J, Leimbach M, Huber P, Garas S, Sammons B H, McCall S A, Petersen R J, Bailey D E, Chu H, Mahoney E M, Weintraub W S, Guyton R A, Lytle B W, Bonchek L I. Off- pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: A prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003; 125: 797–808.
  • Nader N D, Khadra W Z, Reich N T, Bacon D R, Salerno T A, Panos A L. Blood product use in cardiac revasculariza- tion: comparison of on- and off-pump techniques. Ann Thorac Surg 1999; 68: 1640–3.
  • Tanaka K A, Vega J D, Kelly A B, Hanson S R, Levy J H. Off-pump coronary bypass surgery in eptifibatide-induced thrombocytopenia. J Thromb Haemost 2003; 1: 392–394.
  • David J L, Limet R. Antiplatelet activity of clopidogrel in coronary artery bypass graft surgery patients. Thromb Haemost 1999; 82: 1417–21.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.