304
Views
36
CrossRef citations to date
0
Altmetric
Review

Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: Where we are now?

, , , , , & show all
Pages 1-6 | Received 22 Jun 2005, Accepted 27 Jun 2005, Published online: 07 Jul 2009

References

  • Patrono C, Bachmann F, Baigent C, et al. Expert consensus document on the use of antiplatelet agents. Eur Heart J 2004; 25: 166–181
  • Peripheral arterial diseases antiplatelet consensus group. Antiplatelet therapy in peripheral arterial disease. Eur J Vasc Endovasc Surg 2003; 26: 1–16
  • Antithrombotic Triallists' Collaboration. Prevention of death, myocardial infarction and stroke by antiplatelet therapy. Br Med J 2002; 324: 71–86
  • Weil J, Colin-Jones D, Langman M, et al. Prophylactic aspirin and risk of peptic ulcer bleeding. Br Med J 1995; 310: 827–830
  • Lai KC, Lam SK, Chu KM, et al. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. New Engl J Med 2002; 346: 2033–2038
  • García Rodríguez LA, Hernadez-Díaz S. The risk of upper gastrointestinal complications associated with non-steroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combination of these agents. Arthritis Res 2001; 3: 98–101
  • Patrono C. Aspirin as an antiplatelet drug. New Engl J Med 1994; 330: 1287–1294
  • Lanas A, Bajador E, Serrano P, et al. Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. New Engl J Med 2000; 343: 834–839
  • Lanas AI. Current approaches to reducing gastrointestinal toxicity of low-dose aspirin. Am J Med 2001; 110(1A)70S–73S
  • Lange RA, Hillis LD. Concurrent antiplatelet and fibrinolytic therapy. New Engl J Med 2005; 352: 1248–1250
  • Daskalopoulou SS, Stansby G, Mikhailidis DP. Clopidogrel and vascular disease prevention. Curr Med Res Opin 2004; 20: 1835–1838
  • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329–1339
  • Harker LA, Boissel J-P, Pilgrim AJ, Gent M. Comparative safety and tolerability of clopidogrel and aspirin. Drug Safety 1999; 21: 325–335
  • Fork F-T, Lafolie P, Tóth E, Lindgärde F. Gastroduodenal tolerance of 75 mg clopidogrel versus 325 mg aspirin in healthy volunteers. Scand J Gastroenterol 2000; 25: 464–469
  • Ng FH, Wong SY, Chang CM, et al. High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease. Aliment Pharmacol Ther 2003; 18: 443–449
  • Ng FH, Wong BCY, Wong SY, Chen WH, Chang CM. Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk – a single-blind, randomized controlled study. Aliment Pharmacol Ther 2004; 19: 359–365
  • Chan FKL, Ching JYL, Hung LCT, et al. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. New Engl J Med 2005; 352: 238–244
  • Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction – 2002: Summary article: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina). Circulation 2002; 106: 1893–1900
  • Leontiadis GI, Sharma VK, Howden CW. Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding. Br Med J 2005; 330: 568
  • Wargo KA, Baty SR, Knowles G. Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding. New Engl J Med 2005; 352: 1716–1718
  • Wolk MJ, Jacobs AK. Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding. New Engl J Med 2005; 352: 1716–1718
  • Leontiadis GI, Sharma VK, Howden CW. Systematic review and meta-analysis: Enhanced efficacy of proton-pump inhibitor therapy for peptic ulcer bleeding in Asia – A post hoc analysis from the Cochrane Collaboration. Aliment Pharmacol Ther 2005; 21: 1055–1061
  • Cryer B. Reducing the risk of gastrointestinal bleeding with antiplatelet therapies. New Engl J Med 2005; 352: 287–289
  • Harvey RF, Lane JA, Murray LJ, Harvey IM, Donovan JL, Nair P. Randomised controlled trial of effects ofHelicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project. Br Med J 2004; 328: 1417–1419
  • Lanas A, Fuentes J, Benito R, Serrano P, Bajador E, Sainz R. Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin. Aliment Pharmacol Ther 2002; 16: 779–786
  • Wu WK, Cho CH. The pharmacological actions of nicotine on the gastrointestinal tract. J Pharmacol Sci 2004; 94: 348–358
  • Rosenstock S, Jorgensen T, Bonnevie O, Andersen L. Risk factors for peptic ulcer disease: A population based prospective cohort study comprising 2416 Danish adults. Gut 2003; 52: 186–193
  • Santander C, Gravalos RG, Gomez-Cedenilla A, Cantero J, Pajares JM. Antimicrobial therapy forHelicobacter pylori infection versus long-term maintenance antisecretion treatment in the prevention of recurrent hemorrhage from peptic ulcer: Prospective nonrandomized trial on 125 patients. Am J Gastroenterol 1996; 91: 1549–1552
  • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. New Engl J Med 2001; 345: 494–502, The Clopidogrel in unstable Angina to prevent recurrent events trial investigators
  • Peters RJG, Mehta SR, Fox KAA, et al. Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes. Circulation 2003; 108: 1682–1687
  • Schleinitz MD, Heidenreich PA. A cost-effectiveness analysis of combination antiplatelet therapy for high-risk acute coronary syndromes: Clopidogrel plus aspirin versus aspirin alone. Ann Intern Med 2005; 142: 251–259
  • Steinhubl SR, Berger PB, Mann JT III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention. J Am Med Assoc 2002; 288: 2411–2420
  • Bhatt DL, Topol EJ. Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk prevention: Rationale and design of the Clopidogrel for high Atherothrombotic risk and ischemic Stabilization, management and avoidance (CHARISMA) trial. Am Heart J 2004; 148: 263–268
  • Diener H-C, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients: Randomised, double-blind, placebo-controlled trial. Lancet 2004; 364: 331–337
  • Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. New Engl J Med 2005; 352: 1179–1189
  • Bertrand ME, Rupprecht H-J, Urban P, Gershlick AH. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting. Circulation 2000; 102: 624–629
  • http://www.commit-ccs2.org, (assessed May 10, 2005)
  • Buresly K, Eisenberg MJ, Zhang X, Pilote L. Bleeding complications associated with combinations of aspirin, thienopyridine derivatives, and warfarin in elderly patients following acute myocardial infarction. Arch Intern Med 2005; 165: 784–789

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.