727
Views
60
CrossRef citations to date
0
Altmetric
Review

“Message in the Platelet” – more than just vestigial mRNA!

, PhD &
Pages 395-404 | Received 13 Feb 2008, Accepted 14 Feb 2008, Published online: 07 Jul 2009

References

  • Weyrich AS, Lindemann S, Zimmerman GA. The evolving role of platelets in inflammation. J Thromb Haemost 2003; 1: 1897–1905
  • Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8: 1227–1234
  • Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest 2005; 115: 3339–3347
  • Italiano JE, Jr, Shivdasani RA. Megakaryocytes and beyond: The birth of platelets. J Thromb Haemost 2003; 1: 1174–1182
  • Italiano JE, Jr, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol 1999; 147: 1299–1312
  • Junt T, Schulze H, Chen Z, et al. Dynamic visualization of thrombopoiesis within bone marrow. Science 2007; 317: 1767–1770
  • Geddis AE, Kaushansky K. Immunology. The root of platelet production. Science 2007; 317: 1689–1691
  • Zucker-Franklin D. Megakaryocyte and platelet structure in thrombocytopoiesis: The effect of cytokines. Stem Cells 1996; 14(Suppl. 1)1–17
  • Ts'ao CH. Rough endoplasmic reticulum and ribosomes in blood platelets. Scand J Haematol 1971; 8: 134–140
  • Booyse FM, Rafelson ME, Jr. Studies on human platelets. I. synthesis of platelet protein in a cell-free system. Biochim Biophys Acta 1968; 166: 689–697
  • Booyse FM, Hoveke TP, Rafelson ME, Jr. Studies on human platelets. II. Protein synthetic activity of various platelet populations. Biochim Biophys Acta 1968; 157: 660–663
  • Philipp CS, Remmler J, Zucker-Franklin D. The effects of Mpl-ligand, interleukin-6 and interleukin-11 on megakaryocyte and platelet alpha-granule proteins. Thromb Haemost 1998; 80: 968–975
  • Jarvis G. Platelets, polysomes and proteins. Trends Pharmacol Sci 2001; 22: 498
  • Ault KA, Rinder HM, Mitchell J, Carmody MB, Vary CP, Hillman RS. The significance of platelets with increased RNA content (reticulated platelets). A measure of the rate of thrombopoiesis. Am J Clin Pathol 1992; 98: 637–646
  • Ault KA, Knowles C. In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation. Exp Hematol 1995; 23: 996–1001
  • Dale GL, Friese P, Hynes LA, Burstein SA. Demonstration that thiazole-orange-positive platelets in the dog are less than 24 hours old. Blood 1995; 85: 1822–1825
  • Robinson M, Machin S, Mackie I, Harrison P. In vivo biotinylation studies: Specificity of labelling of reticulated platelets by thiazole orange and mepacrine. Br J Haematol 2000; 108: 859–864
  • Ingram M, Coopersmith A. Reticulated platelets following acute blood loss. Br J Haematol 1969; 17: 225–229
  • Kienast J, Schmitz G. Flow cytometric analysis of thiazole orange uptake by platelets: A diagnostic aid in the evaluation of thrombocytopenic disorders. Blood 1990; 75: 116–121
  • Harrison P, Robinson MS, Mackie IJ, Machin SJ. Reticulated platelets. Platelets 1997; 8: 379–383
  • Ault KA. Flow cytometric measurement of platelet function and reticulated platelets. Ann N Y Acad Sci 1993; 677: 293–308
  • Richards EM, Baglin TP. Quantitation of reticulated platelets: Methodology and clinical application. Br J Haematol 1995; 91: 445–451
  • Richards EM, Jestice HK, Mahendra P, Scott MA, Marcus RE, Baglin TP. Measurement of reticulated platelets following peripheral blood progenitor cell and bone marrow transplantation: Implications for marrow reconstitution and the use of thrombopoietin. Bone Marrow Transplant 1996; 17: 1029–1033
  • Saxon BR, Mody M, Blanchette VS, Freedman J. Reticulated platelet counts in the assessment of thrombocytopenic disorders. Acta Paediatr Suppl 1998; 424: 65–70
  • Matic GB, Chapman ES, Zaiss M, Rothe G, Schmitz G. Whole blood analysis of reticulated platelets: Improvements of detection and assay stability. Cytometry 1998; 34: 229–234
  • Rinder HM, Munz UJ, Ault KA, Bonan JL, Smith BR. Reticulated platelets in the evaluation of thrombopoietic disorders. Arch Pathol Lab Med 1993; 117: 606–610
  • Robinson MS, Mackie IJ, Khair K, et al. Flow cytometric analysis of reticulated platelets: Evidence for a large proportion of non-specific labelling of dense granules by fluorescent dyes. Br J Haematol 1998; 100: 351–357
  • Jimenez MM, Guedan MJ, Martin LM, Campos JA, Martinez IR, Vilella CT. Measurement of reticulated platelets by simple flow cytometry: An indirect thrombocytopoietic marker. Eur J Intern Med 2006; 17: 541–544
  • Wang C, Smith BR, Ault KA, Rinder HM. Reticulated platelets predict platelet count recovery following chemotherapy. Transfusion 2002; 42: 368–374
  • Balduini CL, Noris P, Spedini P, Belletti S, Zambelli A, Da Prada GA. Relationship between size and thiazole orange fluorescence of platelets in patients undergoing high-dose chemotherapy. Br J Haematol 1999; 106: 202–207
  • Briggs C, Harrison P, Machin SJ. Continuing developments with the automated platelet count. Int J Lab Hematol 2007; 29: 77–91
  • Watanabe K, Takeuchi K, Kawai Y, Ikeda Y, Kubota F, Nakamoto H. Automated measurement of reticulated platelets in estimating thrombopoiesis. Eur J Haematol 1995; 54: 163–171
  • Watanabe K, Kawai Y, Takeuchi K. [Reticulated platelets–automated measurement and clinical utility]. Rinsho Ketsueki 1995; 36: 267–272
  • Briggs C, Harrison P, Grant D, Staves J, Machin SJ. New quantitative parameters on a recently introduced automated blood cell counter–the XE 2100. Clin Lab Haematol 2000; 22: 345–350
  • Segal HC, Briggs C, Kunka S, et al. Accuracy of platelet counting haematology analysers in severe thrombocytopenia and potential impact on platelet transfusion. Br J Haematol 2005; 128: 520–525
  • Zucker ML, Murphy CA, Rachel JM, et al. Immature platelet fraction as a predictor of platelet recovery following hematopoietic progenitor cell transplantation. Lab Hematol 2006; 12: 125–130
  • Briggs C, Kunka S, Hart D, Oguni S, Machin SJ. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. Br J Haematol 2004; 126: 93–99
  • Briggs C, Hart D, Kunka S, Oguni S, Machin SJ. Immature platelet fraction measurement: A future guide to platelet transfusion requirement after haematopoietic stem cell transplantation. Transfus Med 2006; 16: 101–109
  • Abe Y, Wada H, Tomatsu H, et al. A simple technique to determine thrombopoiesis level using immature platelet fraction (IPF). Thromb Res 2006; 118: 463–469
  • Kickler TS, Oguni S, Borowitz MJ. A clinical evaluation of high fluorescent platelet fraction percentage in thrombocytopenia. Am J Clin Pathol 2006; 125: 282–287
  • Newman PJ, Gorski J, White GC, Gidwitz S, Cretney CJ, Aster RH. Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction. J Clin Invest 1988; 82: 739–743
  • Belloc F, Hourdille P, Boisseau MR, Bernard P. Protein synthesis in human platelets correlation with platelet size. Nouv Rev Fr Hematol 1982; 24: 369–373
  • Kieffer N, Guichard J, Farcet JP, Vainchenker W, Breton-Gorius J. Biosynthesis of major platelet proteins in human blood platelets. Eur J Biochem 1987; 164: 189–195
  • Steiner M, Baldini M. Protein synthesis in aging blood platelets. Blood 1969; 33: 628–633
  • Sottile J, Mosher DF, Fullenweider J, George JN. Human platelets contain mRNA transcripts for platelet factor 4 and actin. Thromb Haemost 1989; 62: 1100–1102
  • Fink L, Holschermann H, Kwapiszewska G, et al. Characterization of platelet-specific mRNA by real-time PCR after laser-assisted microdissection. Thromb Haemost 2003; 90: 749–756
  • Wicki AN, Walz A, Gerber-Huber SN, Wenger RH, Vornhagen R, Clemetson KJ. Isolation and characterization of human blood platelet mRNA and construction of a cDNA library in lambda gt11. Confirmation of the platelet derivation by identification of GPIb coding mRNA and cloning of a GPIb coding cDNA insert. Thromb Haemost 1989; 61: 448–453
  • Wenger RH, Wicki AN, Walz A, Kieffer N, Clemetson KJ. Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library. Blood 1989; 73: 1498–1503
  • Djaffar I, Vilette D, Bray PF, Rosa JP. Quantitative isolation of RNA from human platelets. Thromb Res 1991; 62: 127–135
  • Macaulay IC, Carr P, Farrugia R, Watkins NA. Analysing the platelet transcriptome. Vox Sang 2004; 87(Suppl. 2)42–46
  • Macaulay IC, Carr P, Gusnanto A, Ouwehand WH, Fitzgerald D, Watkins NA. Platelet genomics and proteomics in human health and disease. J Clin Invest 2005; 115: 3370–3377
  • Gnatenko DV, Dunn JJ, McCorkle SR, Weissmann D, Perrotta PL, Bahou WF. Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood 2003; 101: 2285–2293
  • Dittrich M, Birschmann I, Pfrang J, et al. Analysis of SAGE data in human platelets: Features of the transcriptome in an anucleate cell. Thromb Haemost 2006; 95: 643–651
  • Bugert P, Kluter H. Profiling of gene transcripts in human platelets: An update of the platelet transcriptome. Platelets 2006; 17: 503–504
  • Kim HL. Comparison of oligonucleotide-microarray and serial analysis of gene expression (SAGE) in transcript profiling analysis of megakaryocytes derived from CD34+ cells. Exp Mol Med 2003; 35: 460–466
  • Shim MH, Hoover A, Blake N, Drachman JG, Reems JA. Gene expression profile of primary human CD34+CD38lo cells differentiating along the megakaryocyte lineage. Exp Hematol 2004; 32: 638–648
  • Macaulay IC, Tijssen MR, Thijssen-Timmer DC, et al. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood 2007; 109: 3260–3269
  • Ouwehand WH. Platelet genomics and the risk of atherothrombosis. J Thromb Haemost 2007; 5(Suppl. 1)188–195
  • McRedmond JP, Park SD, Reilly DF, et al. Integration of proteomics and genomics in platelets: A profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics 2004; 3: 133–144
  • Nanda N, Bao M, Lin H, et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem 2005; 280: 24680–24689
  • Dittrich M, Birschmann I, Stuhlfelder C, et al. Understanding platelets. Lessons from proteomics, genomics and promises from network analysis. Thromb Haemost 2005; 94: 916–925
  • Healy AM, Pickard MD, Pradhan AD, et al. Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 2006; 113: 2278–2284
  • Raghavachari N, Xu X, Harris A, et al. Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 2007; 115: 1551–1562
  • Wang L, Erling P, Bengtsson AA, Truedsson L, Sturfelt G, Erlinge D. Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus. J Thromb Haemost 2004; 2: 1436–1442
  • Tenedini E, Fagioli ME, Vianelli N, et al. Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells. Blood 2004; 104: 3126–3135
  • Krishnan U, Goodall AH, Bugert P. Letter by Krishnan et al regarding article, “Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 2007; 115: e186
  • Bugert P, Dugrillon A, Gunaydin A, Eichler H, Kluter H. Messenger RNA profiling of human platelets by microarray hybridization. Thromb Haemost 2003; 90: 738–748
  • Martens L, Van DP, Van DJ, et al. The human platelet proteome mapped by peptide-centric proteomics: A functional protein profile. Proteomics 2005; 5: 3193–3204
  • Jones CI, Garner SF, Angenent W, et al. Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. J Thromb Haemost 2007; 5: 1756–1765
  • Weyrich AS, Dixon DA, Pabla R, et al. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci USA 1998; 95: 5556–5561
  • Pabla R, Weyrich AS, Dixon DA, et al. Integrin-dependent control of translation: Engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. J Cell Biol 1999; 144: 175–184
  • Weyrich AS, Denis MM, Schwertz H, et al. mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 2007; 109: 1975–1983
  • Brogren H, Karlsson L, Andersson M, Wang L, Erlinge D, Jern S. Platelets synthesize large amounts of active plasminogen activator inhibitor 1. Blood 2004; 104: 3943–3948
  • Weyrich AS, Lindemann S, Tolley ND, et al. Change in protein phenotype without a nucleus: Translational control in platelets. Semin Thromb Hemost 2004; 30: 491–498
  • Roth GJ, Hickey MJ, Chung DW, Hickstein DD. Circulating human blood platelets retain appreciable amounts of poly (A)+ RNA. Biochem Biophys Res Commun 1989; 160: 705–710
  • Lindemann S, Tolley ND, Eyre JR, Kraiss LW, Mahoney TM, Weyrich AS. Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control. J Biol Chem 2001; 276: 33947–33951
  • Denis MM, Tolley ND, Bunting M, et al. Escaping the nuclear confines: Signal-dependent pre-mRNA splicing in anucleate platelets. Cell 2005; 122: 379–391
  • Konig H, Matter N, Bader R, Thiele W, Muller F. Splicing segregation: The minor spliceosome acts outside the nucleus and controls cell proliferation. Cell 2007; 131: 718–729
  • Lindemann S, Tolley ND, Dixon DA, et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol 2001; 154: 485–490
  • Thon JN, Devine DV. Translation of glycoprotein IIIa in stored blood platelets. Transfusion 2007; 47: 2260–2270
  • Schwertz H, Tolley ND, Foulks JM, et al. Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 2006; 203: 2433–2440
  • Osterud B, Bjorklid E. Sources of tissue factor. Semin Thromb Hemost 2006; 32: 11–23
  • Losche W. Platelets and tissue factor. Platelets 2005; 16: 313–319
  • Falati S, Liu Q, Gross P, et al. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med 2003; 197: 1585–1598
  • Furie B, Furie BC. Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. Trends Mol Med 2004; 10: 171–178
  • Panes O, Matus V, Saez CG, Quiroga T, Pereira J, Mezzano D. Human platelets synthesize and express functional tissue factor. Blood 2007; 109: 5242–5250
  • Weyrich AS, Schwertz H, Mackman N. Platelet tissue factor comes of age. Blood 2007; 109: 5069–5070
  • Lindemann S, Gawaz M. The active platelet: Translation and protein synthesis in an anucleate cell. Semin Thromb Hemost 2007; 33: 144–150
  • Brown SB, Clarke MC, Magowan L, Sanderson H, Savill J. Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program. J Biol Chem 2000; 275: 5987–5996
  • Bertino AM, Qi XQ, Li J, Xia Y, Kuter DJ. Apoptotic markers are increased in platelets stored at 37 degrees C. Transfusion 2003; 43: 857–866
  • Mason KD, Carpinelli MR, Fletcher JI, et al. Programmed anuclear cell death delimits platelet life span. Cell 2007; 128: 1173–1186
  • Qi B, Hardwick JM. A Bcl-xL timer sets platelet life span. Cell 2007; 128: 1035–1036
  • McRedmond J. Finding drug targets through analysis of the platelet transcriptome. Curr Pharm Des 2007; 13: 2662–2667
  • Briggs C, Kunka S, Hart D, Oguni S, Machin SJ. Assessment of an Immature platelet fraction (IPF) in peripheral thrombocytopenia. Br J Haematol 2004; 126: 93–99

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.