325
Views
28
CrossRef citations to date
0
Altmetric
Original Article

Testing agonist-induced platelet aggregation by the Impact-R [Cone and plate(let) analyzer (CPA)]

, , , &
Pages 440-446 | Received 27 Dec 2007, Accepted 26 Mar 2008, Published online: 07 Jul 2009

References

  • Kundu SK, Heilmann EJ, Sio R, Garcia C, Davidson RM, Ostgard RA. Description of an in vitro platelet function analyzer PFA-100™. Semin Thromb Hemost 1995; 21(Suppl 2)106–112
  • Smith JW, Steinhubl SR, Lincoff AM, Coleman JC, Lee TT, Hillman RS, Coller BS. Rapid platelet-function assay: an automated and quantitative cartridge-based method. Circulation 1999; 99: 620–625
  • Steinhubl SR, Kereiakes DJ. Ultegra rapid platelet function analyzer. Platelets, A Michelson. Platelets. Academic Press, San Diego 2002; 317–323
  • Malinin A, Pokov A, Swaim L, Kotob M, Serebruany V. Validation of a VerifyNow-P2Y12 (R) cartridge for monitoring platelet inhibition with clopidogrel. Methods Findings Exp Clin Pharmacol 2006; 28: 315–322
  • Varon D, Dardik R, Shenkman B, Kotev-Emeth S, Farzame N, Tamarin I, Savion N. A new method for quantitative analysis of whole blood platelet interaction with extracellular matrix under flow conditions. Thromb Res 1997; 85: 283–294
  • Shenkman B, Linder N, Savion N, Tamarin I, Dardik R, Kenet G, German B, Varon D. Increased neonatal platelet deposition on subendothelium under flow conditions: The role of plasma von Willebrand disease. Pediatr Res 1999; 45: 270–275
  • Linder N, Shenkman B, Levin E, Sirota L, Vishne TH, Tamarin I, Dardik R, Lubin D, Savion N, Varon D. Deposition of whole blood platelets on extracellular matrix under flow conditions in preterm infants. Arch Dis Child 2002; 86: F127–130
  • Knobler H, Savion N, Shenkman B, Kotev-Emeth S, Varon D. Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients. Thromb Res 1998; 90: 181–190
  • Kenet G, Lubetsky A, Shenkman B, Tamarin I, Dardik R, Rechavi G, Barzilai A, Martinowitz U, Savion N, Varon D. Cone and platelet analyzer (CPA): A new test for the prediction of bleeding among thrombocytopenic patients. Br J Haematol 1998; 101: 255–259
  • Panzer S, Rieger M, Vormittag R, Eichelberger B, Dunkler D, Pabinger I. Platelet function to estimate the bleeding risk in autoimmune thrombocytopenia. Europ J Clin Invest 2007; 37: 814–819
  • Varon D, Lashevski I, Brenner B, Beyar R, Lanir N, Tamarin I, Savion N. Cone and plate(let) analyzer: Monitoring glycoprotein IIb/IIIa antagonists and von Willebrand disease replacement therapy by testing platelet deposition under flow conditions. Am Heart J 1998; 135: S187–193
  • Shenkman B, Inbal A, Tamarin I, Lubetsky A, Savion N, Varon D. Diagnosis of thrombotic thrombocytopenic purpura based on modulation by patient plasma of normal platelet adhesion under flow condition. Br J Haematol 2003; 120: 597–604
  • Levy Y, Shenkman B, Tamarin I, Pauzner R, Shoenfeld Y, Langevitz P, Savion N, Varon D. Increased platelet deposition on extracellular matrix under flow conditions in patients with antiphospholipid syndrome who experience thrombotic events. Arthritis Rheumat 2005; 52: 4011–4017
  • Morrison A, Hornsey VS, Prowse CV, MacGregor IR. Use of the DiaMed Impact R to test platelet function in stored platelet concentrates. Vox Sanguinis 2007; 93: 166–172
  • Osende JI, Fuster V, Lev EI, Shimbo D, Rauch U, Marmur JD, Richard M, Varon D, Badimon JJ. Testing platelet activation with a shear-dependent platelet function test versus aggregation-based tests. Relevance for monitoring long-term glycoprotein IIb/IIIa inhibition. Circulation 2001; 103: 1488–1491
  • Savion N, Shenkman B, Tamarin I, Dardik R, Frojmovic M, Varon D. Transient adhesion refractoriness of circulating platelets under shear stress: The role of partial activation and microaggregate formation by suboptimal ADP concentration. Br J Haematol 2001; 112: 1055–1061
  • Shenkman B, Matetzky S, Fefer P, Hod H, Einav Y, Lubetsky A, Varon D, Savion N. Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests. Thromb Res 2007, in press. doi:10.1016/j.thromres.2007.10.018
  • Spectre G, Brill A, Gural A, Shenkman B, Turetzky N, Savion N, Varon D. A new point-of-care method for monitoring anti-platelet therapy: Application of the cone and plate(let) analyzer. Platelets 2005; 5: 293–299
  • Savion N, Varon D. Impact – the cone and plate(let) analyzer: Testing platelet function and anti-platelet drug response. J Pathphysiol Haemost Thromb 2006; 35: P83–P88
  • Gachet C, Cazenave JP, Ohlmann P, Bouloux C, Defreyn G, Driot F, Maffrand JP. The thienopyridine ticlopidine selectively prevents the inhibitory effects of ADP but not of adrenaline on cAMP levels raised by stimulation of the adenylate cyclase of human platelets by PGE1. Biochem Pharmacol 1990; 40: 2683–2687
  • Juska A. Analysis of effects of adrenaline and collagen on the activity of prostaglandin E1-stimulated human platelet adenylyl cyclase. Blood Coagul Fibrinol 1996; 7: 199–201

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.