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Original Article

Platelet α- and β-secretase activities: A preliminary study in normal human subjects

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Pages 29-34 | Received 19 May 2008, Accepted 09 Jul 2008, Published online: 07 Jul 2009

References

  • Hardy J, Alsop D. Amyloid deposition as the central event in the aeiology of Alzheimer's disease. Trends Pharmacol Sci 1991; 12: 383–388
  • Haass C, Schlossmacher HG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al. Amyloid-beta peptide is produced by cultured cells during normal metabolism. Nature 1992; 359: 322–325
  • Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C, et al. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 1992; 359: 325–327
  • Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, McClure D, Ward PJ. Cleavage of amyloid-beta peptide during constitutive processing of its precursor. Science 1990; 248: 1122–1124
  • Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990; 248: 492–495
  • Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 mutations linked to familial Alzheimer's disease. Nature Med 1996; 2: 864–870
  • Smith CCT, Betteridge DJ. Plasma β-amyloid (Aβ) 40 concentration, lipid status and age in humans. Neurosci Lett 2004; 367: 48–50
  • Carr DB, Goate A, Morris JC. Current concepts in the pathogenesis of Alzheimer's disease. Am J Med 1997; 103: 3S–10S
  • Chen M, Inestrosa NC, Ross GS, Fernandez HL. Platelets are the primary source of amyloid β-peptide in human blood. Biochem Biophys Res Commun 1995; 213: 96–103
  • Li Q-X, Whyte S, Tanner JE, Evin G, Beyreuther K, Masters CL. Secretion of Alzheimer's disease Aβ amyloid peptide by activated human platelets. Lab Invest 1998; 78: 461–469
  • Smith CCT. Stimulated release of the β-amyloid protein of Alzheimer's disease by normal human platelets. Neurosci Lett 1997; 235: 157–159
  • Knebl J, De Fazio P, Clearfield MB, Little L, McConathy WJ, McPherson R, Lacko AG. Plasma lipids and cholesterol esterification in Alzheimer's disease. Mech Ageing Dev 1994; 73: 69–77
  • Sparks DL. Coronary artery disease, hypertension, apo E and cholesterol: A link to Alzheimer's disease. Ann NY Acad Sci 1997; 826: 128–146
  • Smith CCT, Hyatt PJ, Stanyer L, Betteridge DJ. Platelet secretion of β-amyloid is increased in hypercholesterolaemia. Brain Res 2001; 896: 161–164
  • Baskin F, Rosenberg RN, Iyer L, Hynan L, Cullum CM. Platelet APP isoform ratios correlate with declining cognition in AD. Neurology 2000; 54: 1907–1909
  • Borroni B, Colciaghi F, Corsini P, Akkawi N, Rozzini L, Del Zotto E, Talarico G, Cattabeni F, Lenzi GL, Di Luca M, et al. Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms. Neurol Sci 2002; 23: 207–210
  • Di Luca M, Pastorino L, Bianchetti A, Perez J, Vignolo LA, Lenzi GL, Trabuchi M, Cattabeni F, Padovani A. Differential level of platelet amyloid beta precursor protein isoforms: An early marker for Alzheimer disease. Arch Neurol 1998; 55: 1195–1200
  • Rosenberg RN, Baskin F, Fosmire JA, Risser R, Adams P, Svetlik PD, Honig LS, Cullum CM, Wener MF. Altered amyloid protein processing in platelets of patients with Alzheimer disease. Arch Neurol 1997; 54: 139–144
  • Abraham CR, Marshall DCL, Tibbles HE, Otto K, Long HJ, Billingslea AM, Hastey R, Johnson R, Fine RE, Smith SJ, et al. Platelets and DAMI megakaryocytes possess β-secretase-like activity. J Lab Clin Med 1999; 133: 507–515
  • Johnston JA, Liu WW, Coulson DTR, Todd S, Murphy S, Brennan S, Foy CJ, Craig D, Irvine GB, Pasmore AP. Platelet β-secretase activity is increased in Alzheimer's disease. Neurobiol Aging 2008; 29: 661–668
  • Chen M, Durr J, Fernandez HL. Possible role of calpain in normal processing of β-amyloid precursor protein in human platelets. Biochem Biophys Res Commun 2000; 273: 170–175
  • Smith CCT. Evidence for separate serotonin and catecholamine compartments in human platelets. Biochim Biophys Acta 1996; 1291: 1–4
  • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499–502
  • Borroni B, Colciaghi F, Caltagirone C, Rozzini L, Broglio L, Cattabeni F, Di Luca M, Padovani A. Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type. Arch Neurol 2003; 60: 1740–1744
  • Borroni B, Cociaghi F, Archetti S, Marcello E, Caimi L, Di Luca M, Padovani P. Predicting cognitive decline in Alzheimer disease: Role of platelet amyloid precursor protein. Alzheimer Dis Assoc Disord 2004; 18: 32–34
  • Borroni B, Colciaghi F, Pastorini L, Pettenati C, Cottini E, Rozzini L, Monastero R, Lenzi GL, Cattabeni F, Di Luca M, et al. Amyloid precursor protein in platelets of patients with Alzheimer disease: Effect of acetylcholinesterase inhibitor treatment. Arch Neurol 2001; 58: 442–446
  • Colciaghi F, Marcello E, Borroni B, Zimmermann M, Caltagirone C, Cattabeni F, Padovani A, Di Luca M. Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease. Neurology 2004; 62: 498–501
  • Tang K, Hynan LS, Baskin F, Rosenberg RN. Platelet amyloid precursor protein processing: A bio-marker for Alzheimer's disease. J Neurol Sci 2006; 240: 53–58
  • Mayeux R, Honig LS, Tang M-X, Manly J, Stern Y, Schupf N, Mehta PD. Plasma Aβ40 and Aβ42 and Alzheimer's disease: Relation to age, mortality, and risk. Neurobiol 2003; 61: 1185–1190
  • White JG, Clawson CC. The surface-connected canalicular system of blood platelets – a fenestrated membrane system. Am J Pathol 1980; 101: 353–364
  • Cutler LS, Feinstein MB, Rodan GA, Christian CP. Cytochemical evidence for the segregation of adenylate cyclase, Ca2+ -, Mg2+ -ATPase, K+ - dependent p-nitrophenyl phosphatase in separate membrane compartments in human plaelets. Histochem J 1981; 13: 547–554
  • Enouf J, Bredoux R, Bourdoux N, Sarkadi B, Levy-Toledano. S. Further characterization of the plasma membrane- and intracellular membrane-associated platelet Ca2+ transport systems. Biochem J 1989; 263: 547–552
  • Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, et al. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286: 735–741
  • Pizzulli L, Yang A, Martin JF, Lv¨deritz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998; 19: 80–84
  • Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157–161
  • Karpatkin S. Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. Blood 1978; 51: 307–316
  • Ciabattoni G, Porreca E, Di Febbo C, Di Iorio A, Paganelli R, Bucciarelli T, Pescara L, Del Re L, Giusti C, Falco A, et al. Determinants of platelet activation in Alzheimer's disease. Neurobiol Aging 2007; 28: 336–342
  • Howland DS, Trusko SP, Savage MJ, Reaume AG, Lang DM, Hirsch JD, Maeda N, Siman R, Greenberg BD, Scott RW. Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. J Biol Chem 1998; 273: 16576–16582
  • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Sigel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000; 57: 1439–1443
  • Baskin F, Rosenberg RN, Fang X, Hynan LS, Moore CB, Weiner M, Vega GL. Correlation of statin-increased platelet APP ratios and reduced lipids in AD patients. Neurology 2003; 60: 2006–2007
  • Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK. Ligand binding and calcium influx induce distinct ectodomain/γ-secretase-processing pathways of phB2 receptor. J Biol Chem 2007; 282: 16155–16163

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