95
Views
0
CrossRef citations to date
0
Altmetric
Original Article

GATA-1, G208S macrothrombocytes are deficient in talin: Immunofluorescence studies

, M.D, &
Pages 216-224 | Received 10 Feb 2009, Accepted 24 Feb 2009, Published online: 07 Jul 2009

References

  • Thompson AR, Wood WG, Stamatoyannopoulous G. X-linked syndrome of platelet dysfunction, thrombocytopenia and imbalanced globin chain synthesis with hemolysis. Blood 1977; 50: 303–316
  • Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D’Agati V, Orkin SH, Costantini F. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 1931; 349: 257–260
  • Weiss MJ, Keller G, Orkin SH. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev 1994; 8: 1184–1197
  • Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anemia and thrombocytopenia due to an inherited mutation in GATA-1. Nat Genet 2000; 24: 266–270
  • Freson K, Devriendt K, Matthijs G, Van Hoof A, De Vos R, Thys C, Minner K, Hoylaerts M, Vermylen J, Van Geet C. Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA-1 mutation. Blood 2001; 98: 85–92
  • Freson K, Matthijs G, Thys C, Marien P, Hoylaerts M, Vermylen J, Van Geet C. Different substitutions at residue D218 of the X-linked transcription factor GATA-1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation. Hum Mol Genet 2002; 11: 147–152
  • Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. Embo J 1997; 16: 3965–3973
  • Mehaffey MG, Newton EL, Ghandi MJ, Crossley M, Drachman JG. X-linked thrombocytopenia caused by a novel mutation of GATA-1. Blood 2001; 98: 2681–2688
  • Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA. Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood 1999; 93: 2867–2875
  • Phillips JD, Steensma DP, Spangrude GJ, Kushner JP. Congenital erythropoietic porphyria, β-thalassemia intermedia and thrombocytopenia due to a GATA-1 mutation. Blood 2005; 106: 15a
  • Balduini CL, Pecci A, Loffredo G, Iyyo P, Noris P, Grosso M, Bergamaschi G, Rosti V, Magrini U, Ceresa IF, et al. Effects of the R216Q mutation of GATA-1 on erthropoiesis and megakaryocytopoiesis. Blood 2004; 91: 129–140
  • White JG, Nichols WL, Steensma DP. Platelet pathology in X-linked GATA-1 dyperythropoietic macrothrombocytopenia I Ultrastructure. Platelets 2007; 18: 273–283
  • White JG, Nichols WL, Steensma DP. Platelet pathology in X-linked GATA-1 dyperythropoietic macrothrombocytopenia II Cytochemistry. Platelets 2007; 18: 436–450
  • White JG. Platelet pathology in carriers of the X-linked GATA-1 macrothrombocytopenia. Platelets 2007; 18: 620–627
  • White JG, Thomas A. Platelet structural pathology in a patient with the X-linked GATA-1 mutation. 15 Platelets 2009; 20(16)41–49, In Press
  • White JG, Burris SM. The cytoskeletons of X-linked GATA-1, G208S macrothrombocytes are deficient in Talin. Platelets (In Press)
  • White JG. Fine structural alterations induced in platelets by adenosine diposphate. Blood 1968; 31: 604–622
  • Bertagnolli ME, Locke SJ, Hensler ME, Bray PF, Becherle MC. Talin distribution and phosphorization in thrombin-activated platelets. J Cell Sci 1993; 106: 1189–1199
  • Burridge K, Connell L. A new protein of adhesion plaques and ruffling membranes. J Cell Biol 1983; 97: 359–367
  • Burridge K, Mangeat P. An interaction between vinculin and talin. Nature 1984; 308: 744–746
  • O’Halloran T, Beckerle MC, Burride K. Identification of talin as a major cytoplasmic protein implicated in platelet activation. Nature 1985; 317: 449–451
  • Beckerle MC, Miller DE, Bertagnolli ME, Locke SJ. Activation-dependent redistribution of the adhesion plaque protein, talin in intact platelets. J Cell Biol 1989; 109: 3333–3346
  • Ratnikov BI, Partridge AW, Ginsberg MH. Integrin activation by talin. J Thromb Hemosta 2005; 3: 1783–1790
  • Shattil SJ, Newman PJ. Integrins: Dynamic scaffolds for adhesion and signaling in platelets. Blood 2004; 1004: 1606–1615
  • Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weishert RAM, Ye F, Tiedt R, Sboda RC, Monkley SJ, Critchley DR, et al. Talin is required for integrin mediated platelet function in hemostasis and thrombosis. J Exper Med 2007; 204: 3103–3111
  • Hughan SC, Senis Y, Bent D, Thomas A, Frampton J, Vyas P, Watson SP. Selective impairment of platelet activation to collagen in the absence of GATA-1. Blood 2005; 105: 4369–4376
  • Calaminus SDJ, Thomas S, McCarty OJT, Machesky LM, Watson SP. Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. J Thromb Hemosta 2008; 6: 1944–1952

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.