Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients

References

• Asghar SJ, Tanay VAMI, Baker GB, Greenshaw A, Silverstone PH. Poor relationship of plasma amphetamine levels to physiologic, subjective, cognitive and biochemical measures in healthy volunteers. Human Psychopharmacology 2003; 18: 291–299
   PubMedGoogle Scholar
• Berridge MJ, Downes CP, Hanley MR. Lithium amplifies agonist-dependent phosphatidyl-inositol responses in brain and salivary glands. Biochemical Journal 1982; 206: 587–595
   PubMed Web of Science ®Google Scholar
• Berridge MJ, Irvine RF. Inositol phosphates and cell signaling. Nature 1989; 341: 197–204
   PubMed Web of Science ®Google Scholar
• Brambilla P, Stanley JA, Sassi RB, Nicoletti MA, Mallinger AG, Keshavan MS, Soares JC. 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration. Neuropsychopharmacology 2004; 29: 1918–1924
   PubMed Web of Science ®Google Scholar
• Bruhn H, Stoppe G, Staedt J, Merboldt KD, Hänicke W, Frahm J (1993) Quantitative proton MRS in vivo shows cerebral myo-inositol and cholines to be unchanged in manic-depressive patients treated with lithium [abstract]. 12th Annual Scientific Meeting, Proceedings of the Society of Magnetic Resonance Med Annual Meeting, New York, August 14–20, 1993, 1543
   Google Scholar
• Cecil KM, DelBello MP, Moray R, Strakowski SM. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disorder 2002; 4: 357–365
   PubMed Web of Science ®Google Scholar
• Chang K, Adleman N, Dienes K, Barnea-Goraly N, Reiss A, Ketter T. Decreased N-acetylaspartate in children and familial bipolar disorder. Biological Psychiatry 2003; 53: 1059–1065
   PubMed Web of Science ®Google Scholar
• Dager SR, Friedman SD, Parow A, Demopulos C, Stoll AL, Lyoo IK, et al. Brain metabolic alterations in medication-free patients with bipolar disorder. Archives of General Psychiatry 2004; 61: 450–458
   PubMed Web of Science ®Google Scholar
• Deicken RF, Fein G, Weiner MW. Abnormal frontal lobe phosphorus metabolism in bipolar disorder. American Journal of Psychiatry 1995a; 152: 915–918
   PubMedGoogle Scholar
• Deicken RF, Weiner MW, Fein G. Decreased temporal lobe phosphomonoesters in bipolar disorder. Journal of Affective Disorder 1995b; 33: 198–199
   Google Scholar
• Diehl DJ, Gershon S. The role of dopamine in mood disorders. Comprehensive Psychiatry 1992; 33: 115–120
   PubMed Web of Science ®Google Scholar
• Frey R, Metzler D, Fischer P, Heiden A, Scharfetter J, Moser E, Kasper S. Myo-inositol in depressive and healthy subjects determined by frontal 1H-magnetic resonance spectroscopy at 1.5 tesla. Journal of Psychiatric Research 1998; 32: 411–420
   PubMed Web of Science ®Google Scholar
• Friedman SD, Dager SR, Parow A, Hirashima F, Demopulos C, Stoll AL, et al. Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. Biological Psychiatry 2004; 56: 340–348
   PubMed Web of Science ®Google Scholar
• Frye MA, Watzl J, Banakar S, O'Neill J, Mintz J, Davanzo P, et al. Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology 2007a; 32: 2490–2499
   PubMed Web of Science ®Google Scholar
• Frye MA, Thomas MA, Yue K, Binesh N, Davanzo P, Ventura J, et al. Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: A study using 3-Tesla proton magnetic resonance spectroscopy. Psychiatry Research 2007b; 154: 259–265
   PubMedGoogle Scholar
• Godfrey PP, McCkye SJ, White AM, Wood AJ, Grahame-Smith DG. Subacute and chronic in vivo lithium treatment inhibits agonist- and sodium fluoride-stimulated inositol phosphate production in rat cortex. Journal of Neurochemistry 1989; 52: 498–506
   PubMed Web of Science ®Google Scholar
• Hallcher LM, Sherman WR. The effect of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. Journal of Biological Chemistry 1980; 255: 10896–10901
   PubMed Web of Science ®Google Scholar
• Hamakawa H, Murashita J, Yamada N, Inubushi T, Kato N, Kato T. Reduced intracellular pH in the basal ganglia and whole brain measured by 31P-MRS in bipolar disorder. Neuroscience of Clinical Psychiatry 2004; 58: 82–88
   PubMed Web of Science ®Google Scholar
• Hirvonen MR. Cerebral lithium, inositol and inositol monophosphates. Pharmacology & Toxicology 1991; 69: 22–27
   PubMedGoogle Scholar
• Jacobs D, Silverstone T. Dextroamphetamine induced arousal in human subjects as a model for mania. Psychological Medicine 1986; 16: 323–329
   PubMed Web of Science ®Google Scholar
• Kato T, Shioiri T, Takahashi S, Inubushi T. Measurement of brain phosphoinositide metabolism in biplolar patients using in vivo 31P MRS. Journal of Affective Disorder 1991; 22: 185–190
   PubMed Web of Science ®Google Scholar
• Kato T, Takahashi S, Shioiri T, Inubushi T. Brain phosphorus metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. Journal of Affective Disorder 1992; 26: 223–230
   PubMed Web of Science ®Google Scholar
• Kato T, Takahashi S, Shioiri T, Inubushi T. Alterations in brain phosphorus metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. Journal of Affective Disorder 1993; 27: 53–59
   PubMed Web of Science ®Google Scholar
• Kato T, Shioiri T, Murashita J, Hamakawa H, Inubushi T, Takahashi S. Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder. Psychiatric Research: Neuroimaging 1994a; 55: 41–50
   Web of Science ®Google Scholar
• Kato T, Takahashi S, Shioiri T, Murashita J, Hamakawa H, Inubushi T. Reductions of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. Journal of Affective Disorder 1994b; 31: 125–133
   PubMed Web of Science ®Google Scholar
• Kato T, Shioiri T, Murashita J, Hamakawa H, Takahashi Y, Inubushi T, Takahashi S. Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS. Psychological Medicine 1995; 25: 557–566
   PubMed Web of Science ®Google Scholar
• Kato T, Murashita J, Kamiya A, Shioiri T, Kato N, Inubushi T. Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: A confirmation in drug-free patients and correlation with white matter hyperintensity. European Archives of Psychiatric and Clinical Neuroscience 1998; 248: 301–306
   PubMedGoogle Scholar
• Kim H, McGrath BM, Silverstone PH. A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders – focus on magnetic resonance spectroscopy (MRS) studies. Human Psychopharmacology 2005; 20: 309–326
   PubMed Web of Science ®Google Scholar
• Majerus PW, Connolly TM, Bansal VS, Inhorn RC, Ross TS, Lips DL. Inositol phosphates: Synthesis and degradation. Journal of Biological Chemistry 1988; 263: 3051–3054
   PubMed Web of Science ®Google Scholar
• Masand PS, Tesar GE. Use of stimulants in the medically ill. Psychiatric Clinics of North America 1996; 19: 515–547
   PubMed Web of Science ®Google Scholar
• McGrath BM, McKay R, Dave S, Seres P, Weljie AM, Slupsky CM, et al. Acute dextroamphetamine administration does not alter brain myo-inositol levels in humans and animals: MRS investigations at 3T and 18.8T. Neuroscience Research 2008, in press
   PubMedGoogle Scholar
• Moore GJ, Bebchuk JM, Parrish JK, Faulk MW, Arfken CL, Strahl-Bevacqua J, Manji HK. Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. American Journal of Psychiatry 1999; 156: 1902–1908
   PubMed Web of Science ®Google Scholar
• Moore GJ, Breeze J, Gruber SA, Babb SM, Frederic B. de B, et al. Choline, myo-inositol and mood in bipolar disorder: A proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disorder 2000; 2: 207–216
   PubMedGoogle Scholar
• Murashita J, Kato T, Shioiri T, Inubushi T, Kato N. Altered brain energy metabolism in lithium-resistant bipolar disorder detected by photic stimulated 31P-MR spectroscopy. Psychological Medicine 2000; 30: 107–115
   PubMedGoogle Scholar
• O’Donnell T, Rotzinger S, Nakashima TT, Hanstock CC, Ulrich M, Silverstone P. Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain. Brain Research 2000; 880: 84–91
   PubMed Web of Science ®Google Scholar
• Öngur D, Jensen JE, Prescot AP, Stork C, Lundy M, Cohn BM, Renshaw PJ. Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biological Psychiatry 2008; 16: 718–726
   Google Scholar
• Patel NC, DelBello MP, Cecil KM, Adler CM, Bryan HS, Stanford KE, Strakowski SM. Lithium treatment effects on myo-inositol in adolescents with bipolar depression. Biological Psychiatry 2006; 60: 998–1004
   PubMed Web of Science ®Google Scholar
• Preece NE, Gadian DG, Houseman J, Williams SR. Lithium-induced modulation of cerebral inositol phosphate metabolism in the rat: A multinuclear magnetic resonance study in vivo. Lithium 1992; 3: 287–297
   Google Scholar
• Renshaw PF, Summers JJ, Renshaw CE, Hines KG, Leigh JS. Changes in the 31P-NMR spectra of cats receiving lithium chloride systematically. Biological Psychiatry 1986; 21: 694–698
   PubMed Web of Science ®Google Scholar
• Scherk H, Backens M, Schneider-Axmann T, Usher J, Kemmer C, Reith W, Falkai P, Gruber O. Cortical neurochemistry in euthymic patients with bipolar I disorder. World Journal of Biological Psychiatry 2007; 1–10
   Google Scholar
• Sharma R, Venkatasubramanian PN, Barany M, Davis JM. Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients. Schizophrenia Research 1992; 8: 43–49
   PubMed Web of Science ®Google Scholar
• Sherman WR, Munsell LY, Gish BG, Honchar MP. Effects of systematically administered lithium on phosphoinositide metabolism in rat brain, kidney, and testis. Journal of Neurochemistry 1985; 44: 798–807
   PubMed Web of Science ®Google Scholar
• Silverstone PH, Hanstock CC, Fabian J, Staab R, Allen PS. Chronic lithium does not alter human myo-inositol or phosphomonoester concentrations as measured by 1H and 31P MRS. Biological Psychiatry 1996; 40: 235–246
   PubMedGoogle Scholar
• Silverstone PH, Rotzinger S, Pukhovsky A, Hanstock CC. Effects of lithium and amphetamine on inositol metabolism in human brain as measured by 1H and 31P MRS. Biological Psychiatry 1999; 46: 1634–1641
   PubMedGoogle Scholar
• Silverstone PH, Asghar SJ, O’Donnell T, Ulrich M, Hanstock CC. Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients. World Journal of Biological Psychiatry 2004; 5: 38–44
   PubMed Web of Science ®Google Scholar
• Silverstone PH, Pukhovsky A, Rotzinger S. Lithium does not attenuate the effects of dextroamphetamine in healthy volunteers. Psychiatry Research 1998; 79: 219–226
   PubMedGoogle Scholar
• Silverstone T, Wells B, Trenchard E. Differential dose-response effects of dexamphetamine sulphate on hunger, arousal and mood in human volunteers. Psychopharmacology 1983; 79: 242–245
   PubMedGoogle Scholar
• Silverstone PH, Wu RH, O'Donnell T, Ulrich M, Asghar SJ, Hanstock CC. Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients. Human Psychopharmacology Clinical and Experimental 2002; 17: 321–327
   PubMedGoogle Scholar
• Simister RJ, McLean MA, Barker GJ, Duncan JS. Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy. Neurology 2003; 61: 897–902
   PubMedGoogle Scholar
• Simister RJ, McLean MA, Barker GJ, Duncan JS. The effect of sodium valproate on proton MRS visible neurochemical concentrations. Epilepsy Research 2007; 74: 215–219
   PubMedGoogle Scholar
• Strange K, Morrison R, Heilig CW, DiPietro S, Gullans SR. Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells. American Journal of Physiology 1991; 260: C784–C790
   Google Scholar
• Sun GY, Navidi M, Yoa FG, Lin TN, Orth OE, Stubbs EB, MacQuarrie RA. Lithium effects on inositol phospholipids and inositol phosphates: Evaluation of an in vivo model for assessing polyphosphoinositide turnover in brain. Journal of Neurochemistry 1992; 58: 290–297
   PubMedGoogle Scholar
• Vadnal R, Parthasarathy R. Myo-inositol monophosphatase: Diverse effects of lithium, carbamazepine, and valproate. Neuropsychopharmacology 1995; 12: 277–285
   PubMed Web of Science ®Google Scholar
• Winsberg ME, Sachs N, Tate DL, Adalsteinsson E, Spielman D, Ketter TA. Decreased dorsolateral prefrontal N-acetylaspartate in bipolar disorder. Biological Psychiatry 2000; 47: 475–481
   PubMed Web of Science ®Google Scholar
• Wu RH, O’Donnell T, Ulrich M, Asghar SJ, Hanstock CC, Silverstone PH. Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate. Annals of General Hospital Psychiatry 2004; 3: 13
   PubMedGoogle Scholar
• Yuldiz A, Sachs GS, Dorer DJ, Renshaw PF. 31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: A meta-analysis. Psychiatric Research: Neuroimaging sect 2001; 106: 181–191
   PubMedGoogle Scholar