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Journal of Dermatological Treatment Volume 20, 2009 - Issue 3
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ORIGINAL ARTICLE

Efficacy and tolerability at 3 and 6 months following use of azathioprine for recalcitrant atopic dermatitis in children and young adults

Kam-Lun E. Hon Department of Paediatrics, People's Republic of ChinaCorrespondence[email protected]
,
Gary K. W. Ching Department of Paediatrics, People's Republic of China
,
Ting-Fan Leung Department of Paediatrics, People's Republic of China
,
Chung-Mo Chow Department of Paediatrics, People's Republic of China
,
Kenneth K. C. Lee School of Pharmacy, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, People's Republic of China
&
Pak-Cheung Ng Department of Paediatrics, People's Republic of China
Pages 141-145 | Received 01 Jul 2008, Accepted 21 Sep 2008, Published online: 28 Oct 2009

References

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  • Leung AK, Hon KL, Robson WL. Atopic dermatitis. Adv Pediatr. 2007; 54: 241–73
  • Ellison JA, Patel LM, Ray DW, David TJ, Clayton PF. Hypothalamic-pituitary-adrenal function and glucocorticoid sensitivity in atopic dermatitis. Pediatrics. 2000; 105: 794–9
  • Murphy LA, Atherton D. A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression. Br J Dermatol. 2002; 147: 308–15
  • Young AR. Carcinogenicity of UVB phototherapy assessed. Lancet. 1995; 345: 1431–2
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  • Berth-Jones J, Takwale A, Tan E, Barclay G, Agarwal S, Ahmed I, et al. Azathioprine in severe adult atopic dermatitis: A double-blind, placebo-controlled, crossover trial. Br J Dermatol. 2002; 147: 324–30
  • Hernandez JS, Van Loon JA, Otterness DM, Guerciolini R, Weinshilboum RM. Thiopurine methyltransferase regulation in rat kidney: Immunoprecipitation studies. Xenobiotica. 1991; 21: 451–9
  • Tinel M, Berson A, Pessayre D, Letteron P, Cattoni MP, Horsmans Y, et al. Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population. Br J Clin Pharmacol. 1991; 32: 729–34
  • Jacqz-Aigrain E, Bessa E, Medard Y, Mircheva Y, Vilmer E. Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors. Br J Clin Pharmacol. 1994; 38: 1–8
  • Hon KL, Lam MC, Leung TF, Wong KY, Chow CM, Fok TF, et al. Are age-specific high serum IgE levels associated with worse symptomatology in children with atopic dermatitis?. Int J Dermatol. 2007; 46: 1258–62
  • Murphy LA, Atherton DJ. Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency. Pediatr Dermatol. 2003; 20: 531–4

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