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Journal of Dermatological Treatment Volume 20, 2009 - Issue 3
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ORIGINAL ARTICLE

Microneedle penetration and injection past the stratum corneum in humans

Raja K. Sivamani Joint Graduate Group in Bioengineering, University of California at Berkeley and San Francisco, CaliforniaUSA; School of Medicine, University of California, Davis, CaliforniaUSA
,
Boris Stoeber Department of Mechanical Engineering, University of British Columbia, Vancouver, British Columbia, Canada
,
Dorian Liepmann Joint Graduate Group in Bioengineering, University of California at Berkeley and San Francisco, CaliforniaUSA
&
Howard I. Maibach Department of Dermatology, University of California, San Francisco, CaliforniaUSACorrespondence[email protected]
Pages 156-159 | Received 22 Sep 2008, Accepted 26 Sep 2008, Published online: 28 Oct 2009

References

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  • Egawa M, Hirao T, Takahashi M. In vivo estimation of stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy. Acta Derm Venereol. 2007; 87: 4–8
  • Wang PM, Cornwell M, Hill J, Prausnitz MR. Precise microinjection into skin using hollow microneedles. J Invest Dermatol. 2006; 126: 1080–7
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  • Sivamani RK, Stoeber B, Wu GC, Zhai H, Liepmann D, Maibach H. Clinical microneedle injection of methyl nicotinate: Stratum corneum penetration. Skin Res Technol. 2005; 11: 152–6
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  • Stoeber B, Liepmann D. Arrays of hollow out-of-plane microneedles for drug delivery. J Microelectromech Syst. 2005; 14: 472–9
  • Pirot F, Berardesca E, Kalia YN, Singh M, Maibach HI, Guy RH. Stratum corneum thickness and apparent water diffusivity: Facile and noninvasive quantitation in vivo. Pharm Res. 1998; 15: 492–4
  • Reinberg AE, Soudant E, Koulbanis C, Bazin R, Nicolai A, Mechkouri M, et al. Circadian dosing time dependency in the forearm skin penetration of methyl and hexyl nicotinate. Life Sci. 1995; 57: 1507–13
  • Guy RH, Tur E, Schall LM, Elamir S, Maibach HI. Determination of vehicle effects on percutaneous absorption by laser Doppler velocimetry. Arch Dermatol Res. 1986; 278: 500–2
  • Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008; 29: 2113–24

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