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Brief Report

Scalp hair regrowth is associated with improvements in health-related quality of life and psychological symptoms in patients with severe alopecia areata: results from two randomized controlled trials

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Article: 2227299 | Received 28 Mar 2023, Accepted 08 Jun 2023, Published online: 28 Jun 2023

References

  • Liu LY, King AB, Craiglow GB. Health-related quality of life (HRQoL) among patients with alopecia areata (AA): a systematic review. J Am Acad Dermatol. 2016;75(4):1–4.e3. doi: 10.1016/j.jaad.2016.04.035.
  • Toussi A, Barton VR, Le ST, et al. Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: a systematic review. J Am Acad Dermatol. 2021;85(1):162–175. doi: 10.1016/j.jaad.2020.06.047.
  • Messenger A, Harries M. Baricitinib in alopecia areata. N Engl J Med. 2022;386(18):1751–1752. doi: 10.1056/NEJMe2203440.
  • King B, Ohyama M, Kwon O. et al. Two phase 3 trials of baricitinib for alopecia areata. N Engl J Med. 2022;386(18):1687–1699. doi: 10.1056/NEJMoa2110343.
  • Piraccini BM, Ohyama M, Craiglow B, et al. The contribution of hair regrowth to health-related quality of life improvement in patients with alopecia areata treated with baricitinib or placebo. Paper presented at: World Congress for Hair Research 2022; 2022 November 18–21; Melbourne, Australia.
  • Olsen EA, Hordinsky MK, Price VH. et al. Alopecia areata investigational assessment guidelines–part II. National alopecia areata foundation. J Am Acad Dermatol. 2004;51(3):440–447. doi: 10.1016/j.jaad.2003.09.032.
  • Wyrwich KW, Kitchen H, Knight S, et al. The alopecia areata investigator global assessment scale: a measure for evaluating clinically meaningful success in clinical trials. Br J Dermatol. 2020;183(4):702–709. doi: 10.1111/bjd.18883.
  • King B, Ko J, Forman S, et al. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: phase 2 results from a randomized controlled study. J Am Acad Dermatol. 2021;85(4):847–853. doi: 10.1016/j.jaad.2021.05.050.
  • Chren MM. The skindex instruments to measure the effects of skin disease on quality of life. Dermatol Clin. 2012;30(2):231–236, xiii. doi: 10.1016/j.det.2011.11.003.
  • Chren MM. SKINDEX-16 for alopecia areata (SKINDEX-16 for AA). 2018. Available from: https://eprovide.mapi-trust.org/instruments/skindex-16-for-alopecia-areata#contact_and_conditions_of_use.
  • Snaith RP. The hospital anxiety and depression scale. Health Qual Life Outcomes. 2003;1:29. doi: 10.1186/1477-7525-1-29.
  • Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–370. doi: 10.1111/j.1600-0447.1983.tb09716.x.
  • Winnette R, Banerjee A, Sikirica V, et al. Characterizing the relationships between patient-reported outcomes and clinician assessments of alopecia areata in a phase 2a randomized trial of ritlecitinib and brepocitinib. J Eur Acad Dermatol Venereol. 2022;36(4):602–609. doi: 10.1111/jdv.17909.
  • Aldhouse NVJ, Kitchen H, Knight S, et al. You lose your hair, what’s the big deal?’ I was so embarrassed, I was so self-conscious, I was so depressed”: a qualitative interview study to understand the psychosocial burden of alopecia areata. J Patient Rep Outcomes. 2020;4(1):76. doi: 10.1186/s41687-020-00240-7.
  • Edson-Heredia E, Cutts K, Bethesda E, et al. The relationship between the degree of scalp hair loss and health-related quality of life among patients with alopecia areata. J Am Acad Dermatol. 2022;87(3):AB120. Suppl AB120, doi: 10.1016/j.jaad.2022.06.512.