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Letter to the Editor

Oral roflumilast as a therapeutic option for psoriasis, what role does it have? Case report and literature review

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Article: 2240456 | Received 23 May 2023, Accepted 19 Jul 2023, Published online: 25 Jul 2023

References

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  • Milakovic M, Gooderham MJ. Phosphodiesterase-4 inhibition in psoriasis. Psoriasis. 2021;11:21–29. doi: 10.2147/ptt.s303634.
  • Maiga MC, Ahidjo BA, Maiga M, et al. Roflumilast, a type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis. Antimicrob Agents Chemother. 2015;59(12):7888–7890. doi: 10.1128/AAC.02145-15.
  • Ring HC, Egeberg A, Zachariae C, et al. Considerable improvement in hidradenitis suppurativa with oral roflumilast therapy. Br J Dermatol. 2022;187(5):813–815. doi: 10.1111/bjd.21744.
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  • Egeberg A, Meteran H, Gyldenløve M, et al. Complete clearance of severe plaque psoriasis with 24 weeks of oral roflumilast therapy. Br J Dermatol. 2021;185(6):1251–1252. doi: 10.1111/bjd.20602.
  • Gyldenløve M, Egeberg A. Killing all the birds with one drug–is oral roflumilast a novel treatment option for psoriasis? J Dermatolog Treat. 2022;33(6):2782–2783. doi: 10.1080/09546634.2022.2069223.
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  • Gyldenløve M, Meteran H, Sørensen JA, et al. Efficacy and safety of oral roflumilast for moderate-to-severe psoriasis—a randomized controlled trial (PSORRO). Lancet Reg Health Eur. 2023;30:100639. doi: 10.1016/j.lanepe.2023.100639.
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