Advanced search
Publication Cover
Journal of Dermatological Treatment Volume 34, 2023 - Issue 1
Submit an article Journal homepage
2,049
Views
0
CrossRef citations to date
0
Altmetric
Brief Report

A 52-week multicenter retrospective real-world study on effectiveness and safety of dupilumab in children with atopic dermatitis aged from 6 to 11 years

Cataldo Patrunoa Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, ItalyView further author information
,
Gabriella Fabbrocinib Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, ItalyView further author information
,
Giuseppe Laulettab Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, ItalyView further author information
,
Valeria Boccalettic Department of Medicine, Section of Dermatology, University of Brescia, Brescia, ItalyView further author information
,
Cristiana Colonnad Pediatric Dermatology Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyView further author information
,
Riccardo Cavallid Pediatric Dermatology Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyView further author information
,
Iria Nerie Unit of Dermatology, IRCCS AOU di Policlinico S Orsola, University of Bologna, Bologna, ItalyView further author information
,
Michela Ortoncellif Department of Medical Sciences, Division of Dermatology, University of Turin, Turin, ItalyView further author information
,
Donatella Schenag Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, ItalyView further author information
,
Luca Stingenih Department of Medicine and Surgery, Dermatology Section, University of Perugia, Perugia, ItalyView further author information
,
Katharina Hanselh Department of Medicine and Surgery, Dermatology Section, University of Perugia, Perugia, ItalyView further author information
,
Vincenzo Piccoloi Dermatology Unit, University of Campania Luigi Vanvitelli, Caserta, ItalyView further author information
,
Eugenia Veronica Di Brizzii Dermatology Unit, University of Campania Luigi Vanvitelli, Caserta, ItalyView further author information
,
Concetta Potenzaj Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit "Daniele Innocenzi", Sapienza University of Rome, Polo Pontino, Latina, ItalyView further author information
,
Ersilia Tolinoj Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit "Daniele Innocenzi", Sapienza University of Rome, Polo Pontino, Latina, ItalyView further author information
,
Luca Bianchik Dermatology Unit, Policlinico Tor Vergata, System Medicine Department, University of Tor Vergata, Rome, ItalyView further author information
,
Sara Mantik Dermatology Unit, Policlinico Tor Vergata, System Medicine Department, University of Tor Vergata, Rome, ItalyView further author information
,
Rocco De Pasqualel U.O. Dermatologia, Ospedale San Marco, Catania, ItalyView further author information
,
Vito Di Lerniam Dermatology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, ItalyView further author information
,
Lucia Caminitin Policlinico Hospital-University of Messina, Messina, ItalyView further author information
,
Elena Gallio UOS Immuno Allergologia dell’Età evolutiva, Ospedale San Pietro-Fatebenefratelli, Roma, ItalyView further author information
,
Paola Coppop Pediatric Endocrinology Unit, Regina Margherita Children’s Hospital, Città Della Salute e Della Scienza di Torino, Torino, ItalyView further author information
,
Andrea Chiricozziq Dermatologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;r Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-6739-0387View further author information
ORCID Icon,
Clara De Simoneq Dermatologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;r Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyView further author information
,
Cristina Guerrieroq Dermatologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyView further author information
,
Fabrizio Giuseppe Amorusos Dermatology Unit, Azienda Ospedaliera di Cosenza, Cosenza, ItalyView further author information
,
Eugenio Provenzanos Dermatology Unit, Azienda Ospedaliera di Cosenza, Cosenza, ItalyView further author information
,
Salvatore Leonardit Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Catania, ItalyView further author information
,
Amelia Licariu Department of Pediatrics, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyView further author information
,
Gian Luigi Marsegliau Department of Pediatrics, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyView further author information
,
Antonino Palermov Department of Pediatrics, Garibaldi Hospital, Catania, ItalyView further author information
,
Sabrina Di Pillow Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Chieti, ItalyView further author information
,
Daniele Russow Pediatric Allergy and Pulmonology Unit, Department of Pediatrics, University of Chieti-Pescara, Chieti, ItalyView further author information
,
Viviana Moschesex Pediatric Allergology and Immunology Unit, University of Rome Tor Vergata, Policlinico Tor Vergata, Rome, ItalyView further author information
,
Vincenzo Patellay Department of Medicine, Division of Allergy and Clinical Immunology, "Santa Maria della Speranza" Hospital, Battipaglia, SA, ItalyView further author information
,
Tiziana Pedutoy Department of Medicine, Division of Allergy and Clinical Immunology, "Santa Maria della Speranza" Hospital, Battipaglia, SA, ItalyView further author information
,
Caterina Ferreliz Department of Medical Sciences, and Public Health, Dermatology Clinic, University of Cagliari, Cagliari, ItalyView further author information
,
Paola Zangariaa Research Unit of Clinical Immunology and Vaccinology, Academic Department of Pediatrics (DPUO), Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyView further author information
,
Federica Veroneseab Dermatologic Clinic, AOU Maggiore della Carità Hospital, Novara, ItalyView further author information
,
Samantha Federica Bertiac Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, ItalyView further author information
,
Michaela Gruberad Department of Pediatrics, Central Hospital of Bolzano, Bolzano, ItalyView further author information
,
Elena Pezzoloae Dermatology Unit, Ospedale San Bortolo, Vicenza, ItalyView further author information
,
Stefania Termineaf Division of Dermatology, Santa Chiara Hospital, Trento, ItalyView further author information
,
Rosanna Sattaag Dipartimento Scienze Mediche, Chirurgiche e Sperimentali, Università di Sassari, Sassari, ItalyView further author information
,
Federica Dragoniah UOC Dermatologia Ospedale San Donato, Arezzo, ItalyView further author information
,
Maria Espositoai Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, ItalyView further author information
,
Maria Concetta Fargnoliai Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, ItalyView further author information
,
Paolo Chiodinii Dermatology Unit, University of Campania Luigi Vanvitelli, Caserta, ItalyView further author information
,
Ylenia Valloneb Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, ItalyView further author information
,
Francesca di Vicob Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, ItalyView further author information
,
Vincenzo Piconeb Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, ItalyView further author information
&
Maddalena Napolitanob Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, ItalyCorrespondence[email protected]
View further author information
 show all
Article: 2246602 | Received 23 Apr 2023, Accepted 21 Jul 2023, Published online: 14 Aug 2023

References

  • Paller AS, Siegfried EC, Thaçi D, et al. Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: a randomized, double-blinded, placebo-controlled phase 3 trial. J Am Acad Dermatol. 2020;83(5):1–6. doi: 10.1016/j.jaad.2020.06.054.
  • Cork MJ, Thaçi D, Eichenfield LF, et al. Dupilumab provides favourable long-term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled severe atopic dermatitis: results from an open-label phase IIa study and subsequent phase III open-label extension study. Br J Dermatol. 2021;184(5):857–870. PMCID: PMC8247037. doi: 10.1111/bjd.19460.
  • Paller AS, Siegfried EC, Cork MJ, et al. Laboratory safety from a randomized 16-week phase III study of dupilumab in children aged 6 months to 5 years with moderate-to-severe atopic dermatitis. Paediatr Drugs. 2023;25(1):67–77. doi: 10.1007/s40272-022-00553-8.
  • Paller AS, Simpson EL, Siegfried EC, et al. Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2022;400(10356):908–919. doi: 10.1016/S0140-6736(22)01539-2.
  • Yang N, Ye Y, Shao J, et al. Efficacy of dupilumab in children 6 months to 11 years old with atopic dermatitis: a retrospective real-world study in China. Dermatitis. 2023. doi: 10.1089/derm.2022.0069
  • Pagan AD, David E, Ungar B, et al. Dupilumab improves clinical scores in children and adolescents with moderate to severe atopic dermatitis: a real-world, single-center study. J Allergy Clin Immunol Pract. 2022;10(9):2378–2385. doi: 10.1016/j.jaip.2022.06.014.
  • Lasek A, Bellon N, Mallet S, et al. Effectiveness and safety of dupilumab in the treatment of atopic dermatitis in children (6-11 years): data from a french multicentre retrospective cohort in daily practice. J Eur Acad Dermatol Venereol. 2022;36(12):2423–2429. doi: 10.1111/jdv.18450.
  • Colonna C, Zussino M, Monzani NA, et al. Treatment of children from 6 to 11 years old affected by moderate-severe atopic dermatitis with dupilumab: a first perspective from a single-center real-life experience in Italy. J Eur Acad Dermatol Venereol. 2022;36(6):e478–e480. doi: 10.1111/jdv.17963.
  • Napolitano M, Fabbrocini G, Neri I, et al. Dupilumab treatment in children aged 6–11 years with atopic dermatitis: a multicentre, real-life study. Paediatr Drugs. 2022;24(6):671–678. doi: 10.1007/s40272-022-00531-0.
  • Blauvelt A, Guttman-Yassky E, Paller AS, et al. Long-term efficacy and safety of dupilumab in adolescents with moderate-to-severe atopic dermatitis: results through week 52 from a phase III Open-Label extension trial (LIBERTY AD PED-OLE). Am J Clin Dermatol. 2022;23(3):365–383. doi: 10.1007/s40257-022-00683-2.
  • Stingeni L, Bianchi L, Antonelli E, et al. A 52-week update of a multicentre italian real-world experience on effectiveness and safety of dupilumab in adolescents with moderate-to-severe atopic dermatitis. J Eur Acad Dermatol Venereol. 2023;37(3):e384–e388. doi: 10.1111/jdv.18648.
  • Silverberg JI, Lynde CW, Abuabara K, et al. Efficacy and safety of dupilumab maintained in adults ≥60 years of age with moderate-to-Severe atopic dermatitis: analysis of pooled data from four randomized clinical trials. Am J Clin Dermatol. 2023;24(4):673. doi: 10.1007/s40257-022-00754-4.
  • Patruno C, Fabbrocini G, Longo G, et al. Effectiveness and safety of long-term dupilumab treatment in elderly patients with atopic dermatitis: a multicenter real-life observational study. Am J Clin Dermatol. 2021;22(4):581–586. doi: 10.1007/s40257-021-00597-5.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.