1,376
Views
0
CrossRef citations to date
0
Altmetric
Article

Patients’ willingness to accept adverse event and cost tradeoffs from oral nicotinamide for reduced risk of non-melanoma skin cancer

ORCID Icon, , , , &
Article: 2247105 | Received 11 Jul 2023, Accepted 07 Aug 2023, Published online: 17 Aug 2023

References

  • cancer.net. Skin cancer (non-melanoma): statistics. Available from: https://www.cancer.net/cancer–types/skin–cancer–non–melanoma/statistics
  • United States Department of Health and Human Services. The surgeon general’s call to action to prevent skin cancer. Washington (DC): Office of the Surgeon General; 2014.
  • Chen AC, Martin AJ, Choy B, et al. A phase 3 randomized trial of nicotinamide for skin–cancer chemoprevention. N Engl J Med. 2015;373(17):1–6. doi:10.1056/NEJMoa1506197.
  • Zhao Y. Nicotinamide for skin–cancer chemoprevention. N Engl J Med. 2016;374(8):789. doi:10.1056/NEJMc1514791.
  • Johnson F, Lancsar E, Marshall D, et al. Constructing experimental designs for discrete–choice experiments: report of the ISPOR conjoint analysis discrete–choice experiment experimental design good research practices task force. Value Health. 2013;16:3–13. doi:10.1016/j.jval.2012.08.2223.
  • Kuhfeld W. Marketing research methods in SAS: experimental design, choice, conjoint, and graphical techniques. Cary (NC): SAS Institute Inc.; 2010.
  • Kuhfeld W, Tobias F, Garratt M. Efficient experimental design with marketing research applications. J Mark Res. 1994;31(4):545–557. doi:10.1177/002224379403100408.
  • Campbell D, Boeri M, Doherty E, et al. Learning, fatigue and preference formation in discrete choice experiments. J Econ Behav Organ. 2015;119:345–363. doi:10.1016/j.jebo.2015.08.018.
  • Maddala T, Philips K, Johnson F. An experiment simplifying conjoint analysis designs for measuring preferences. Health Econ. 2003;12(12):1035–1047. doi:10.1002/hec.798.
  • Train K. Discrete choice methods with simulation. 2nd ed. Cambridge (UK): Cambridge University Press; 2009.
  • Train K, Sonnier G. Mixed logit with bounded distributions of correlated partworths. In: Scarpa R, Albertini A, editors. Applications of simulation methods in environmental and ­resource economics. Dordrecht: Springer Publisher; 2005. p. 117–134.
  • Hauber A, González J, Groothuis–Oudshoorn C, et al. Statistical methods for the analysis of discrete choice experiments: a report of the ISPOR conjoint analysis experimental design task force. Value Health. 2016;19(4):300–315. doi:10.1016/j.jval.2016.04.004.
  • Gonzalez JM, Boeri M. The impact of the risk functional form assumptions on maximum acceptable risk measures. Patient. 2021;14(6):827–836. doi:10.1007/s40271-021-00518-y.
  • Hensher D, Rose J, Greene W. Applied choice analysis. Cambridge (UK): Cambridge University Press; 2005.
  • Amazon. 2022. Available from: https://www.amazon.com/Nutricost-Niacinamide-Vitamin-500mg-Capsules/dp/B01M9GIV8S/ref=sr_1_2?keywords=nicotinamide&qid=1664366497&qu=eyJxc2MiOiI0LjQzIiwicXNhIjoiMy45NSIsInFzcCI6IjMuODcifQ%3D%3D&sr=8-2&th=1
  • United States Census Data. Available from: www.data.census.gov
  • Allen NC, Martin AJ, Snaidr VA, et al. Nicotinamide for skin-cancer chemoprevention in transplant recipients. New Eng J Med. 2023;388(9):804–812. doi:10.1056/NEJMoa2203086.
  • Gale EA, Bingley PJ, Emmett CL, et al. European nicotinamide diabetes intervention trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet. 2004;363(9413):925–931. doi:10.1016/S0140-6736(04)15786-3.
  • Hwang ES, Song SB. Possible adverse effects of high-dose nicotinamide: mechanisms and safety assessment. Biomolecules. 2020;10(5). doi:10.3390/biom10050687.
  • Minocha R, Martin AJ, Chen AC, et al. A reduction in inflammatory macrophages may contribute to skin cancer chemoprevention by nicotinamide. J Invest Dermatol. 2019;139(2):467–469. doi:10.1016/j.jid.2018.08.018.
  • Chistiakov DA, Killingsworth MC, Myasoedova VA, et al. CD68/macrosialin: not just a histochemical marker. Lab Invest. 2017;97(1):4–13. doi:10.1038/labinvest.2016.116.
  • Mainville L, Smilga AS, Fortin PR. Effect of nicotinamide in skin cancer and actinic keratoses chemoprophylaxis, and adverse effects related to nicotinamide: a systematic review and meta-analysis. J Cutan Med Surg. 2022;26(3):297–308. doi:10.1177/12034754221078201.
  • Williams AC, Ramsden DB. Nicotinamide homeostasis: a xenobiotic pathway that is key to development and degenerative diseases. Med Hypotheses. 2005;65(2):353–362. doi:10.1016/j.mehy.2005.01.042.
  • Hong W, Mo F, Zhang Z, et al. Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD + metabolism. Front Cell Dev Biol. 2020;8:246. doi:10.3389/fcell.2020.00246.