1,276
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Effectiveness of switching from baricitinib 4 mg to upadacitinib 30 mg in patients with moderate-to-severe atopic dermatitis: a real-world clinical practice in Japan

ORCID Icon, , , ORCID Icon, & ORCID Icon
Article: 2276043 | Received 18 Sep 2023, Accepted 20 Oct 2023, Published online: 10 Dec 2023

References

  • Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):1–9. doi:10.1016/j.jaad.2013.10.010.
  • Carroll CL, Balkrishnan R, Feldman SR, et al. The burden of atopic dermatitis: impact on the patient, family, and society. Pediatr Dermatol. 2005;22(3):192–199. doi:10.1111/j.1525-1470.2005.22303.x.
  • Brunner PM, Guttman-Yassky E, Leung DY. The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies. J Allergy Clin Immunol. 2017;139(4s):S65–S76. doi:10.1016/j.jaci.2017.01.011.
  • Weidinger S, Beck LA, Bieber T, et al. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1. doi:10.1038/s41572-018-0001-z.
  • Howell MD, Kuo FI, Smith PA. Targeting the Janus kinase family in autoimmune skin diseases. Front Immunol. 2019;10:2342. doi:10.3389/fimmu.2019.02342.
  • Ferreira S, Guttman-Yassky E, Torres T. Selective JAK1 inhibitors for the treatment of atopic dermatitis: focus on upadacitinib and abrocitinib. Am J Clin Dermatol. 2020;21(6):783–798. doi:10.1007/s40257-020-00548-6.
  • Guttman-Yassky E, Thaçi D, Pangan AL, et al. Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2020;145(3):877–884. Mardoi:10.1016/j.jaci.2019.11.025.
  • Blauvelt A, Teixeira HD, Simpson EL, et al. Efficacy and safety of upadacitinib vs dupilumab in adults with moderate-to-Severe atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2021;157(9):1047–1055. doi:10.1001/jamadermatol.2021.3023.
  • Guttman-Yassky E, Teixeira HD, Simpson EL, et al. Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (measure up 1 and measure up 2): results from two replicate double-blind, randomised controlled phase 3 trials. Lancet. 2021;397(10290):2151–2168. doi:10.1016/S0140-6736(21)00588-2.
  • Reich K, Teixeira HD, de Bruin-Weller M, et al. Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD up): results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2021;397(10290):2169–2181. doi:10.1016/S0140-6736(21)00589-4.
  • Hagino T, Saeki H, Kanda N. The efficacy and safety of upadacitinib treatment for moderate to severe atopic dermatitis in real-world practice in Japan. J Dermatol. 2022;49(11):1158–1167. doi:10.1111/1346-8138.16549.
  • Hagino T, Saeki H, Fujimoto E, et al. Efficacy and safety of baricitinib treatment for moderate to severe atopic dermatitis in real-world practice in Japan. J Dermatol. 2023;50(7):869–879. Juldoi:10.1111/1346-8138.16763.
  • Hagino T, Saeki H, Fujimoto E, et al. The differential effects of upadacitinib treatment on skin rashes of four anatomical sites in patients with atopic dermatitis. J Dermatolog Treat. 2023;34(1):2212095.
  • Hagino T, Saeki H, Fujimoto E, et al. Background factors predicting the occurrence of herpes zoster in atopic dermatitis patients treated with upadacitinib. J Dermatol. 2023;50(10):1301–1312. doi:10.1111/1346-8138.16879.
  • Hagino T, Yoshida M, Hamada R, et al. Therapeutic effectiveness of upadacitinib on individual types of rash in japanese patients with moderate-to-severe atopic dermatitis. J Dermatol. 2023;2023:16950. doi:10.1111/1346-8138.16950.
  • Hagino T, Saeki H, Fujimoto E, et al. The eosinophil-to-Lymphocyte ratio acts as an indicator for improvement of clinical signs and itch by upadacitinib treatment in atopic dermatitis. J Clin Med. 2023;12(6):2201. doi:10.3390/jcm12062201.
  • Drucker AM, Morra DE, Prieto-Merino D, et al. Systemic immunomodulatory treatments for atopic dermatitis: update of a living systematic review and network meta-analysis. JAMA Dermatol. 2022;158(5):523–532. doi:10.1001/jamadermatol.2022.0455.
  • Wan H, Jia H, Xia T, et al. Comparative efficacy and safety of abrocitinib, baricitinib, and upadacitinib for moderate-to-severe atopic dermatitis: a network meta-analysis. Dermatol Ther. 2022;35(9):e15636.
  • Saeki H, Ohya Y, Furuta J, et al. Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2021. Allergol Int. 2022;71(4):448–458. doi:10.1016/j.alit.2022.06.009.
  • Traves PG, Murray B, Campigotto F, et al. JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib. Ann Rheum Dis. 2021;80(7):865–875. doi:10.1136/annrheumdis-2020-219012.
  • McInnes IB, Byers NL, Higgs RE, et al. Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations. Arthritis Res Ther. 2019;21(1):183. doi:10.1186/s13075-019-1964-1.
  • Meng J, Li Y, Fischer MJM, et al. Th2 modulation of transient receptor potential channels: an unmet therapeutic intervention for atopic dermatitis. Front Immunol. 2021;12:696784. doi:10.3389/fimmu.2021.696784.
  • Kunimura K, Fukui Y. The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. Int Immunol. 2021;33(12):731–736. doi:10.1093/intimm/dxab065.
  • Vittrup I, Krogh NS, Larsen HHP, et al. A nationwide 104 weeks real-world study of dupilumab in adults with atopic dermatitis: ineffectiveness in head-and-neck dermatitis. J Eur Acad Dermatol Venereol. 2023;37(5):1046–1055. doi:10.1111/jdv.18849.
  • Maarouf M, Saberian C, Lio PA, et al. Head-and-neck dermatitis: diagnostic difficulties and management pearls. Pediatr Dermatol. 2018;35(6):748–753. doi:10.1111/pde.13642.
  • Darabi K, Hostetler SG, Bechtel MA, et al. The role of malassezia in atopic dermatitis affecting the head and neck of adults. J Am Acad Dermatol. 2009;60(1):125–136. Jandoi:10.1016/j.jaad.2008.07.058.
  • Chu H, Kim SM, Zhang K, et al. Head and neck dermatitis is exacerbated by malassezia furfur colonization, skin barrier disruption, and immune dysregulation. Front Immunol. 2023;14:1114321. doi:10.3389/fimmu.2023.1114321.
  • Uchida H, Kamata M, Egawa S, et al. Newly developed erythema and red papules in the face and neck with detection of demodex during dupilumab treatment for atopic dermatitis improved by discontinuation of dupilumab, switching to upadacitinib or treatment with oral ivermectin: a report of two cases. J Eur Acad Dermatol Venereol. 2023;37(3):e300–e302. doi:10.1111/jdv.18743.
  • Gori N, Ippoliti E, Antonelli F, et al. Successful response to upadacitinib in the treatment of atopic dermatitis lesions involving sensitive and visible areas resistant to dupilumab treatment. Clin Exp Dermatol. 2023;48(5):558–559. doi:10.1093/ced/llad040.
  • Fujita H, Asahina A, Sugaya M, et al. Differential production of Th1- and Th2-type chemokines by mouse langerhans cells and splenic dendritic cells. J Invest Dermatol. 2005;124(2):343–350. doi:10.1111/j.0022-202X.2004.23607.x.
  • Kim BS, Siracusa MC, Saenz SA, et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med. 2013;5(170):170ra16. doi:10.1126/scitranslmed.3005374.
  • Luo J, Zhu Z, Zhai Y, et al. The role of TSLP in atopic dermatitis: from pathogenetic molecule to therapeutical target. Mediators Inflamm. 2023;2023:7697699–7697698.
  • Kunsleben N, Rüdrich U, Gehring M, et al. IL-31 induces chemotaxis, calcium mobilization, release of reactive oxygen species, and CCL26 in eosinophils, which are capable to release IL-31. J Invest Dermatol. 2015;135(7):1908–1911. doi:10.1038/jid.2015.106.
  • Nakashima C, Otsuka A, Kabashima K. Interleukin-31 and interleukin-31 receptor: new therapeutic targets for atopic dermatitis. Exp Dermatol. 2018;27(4):327–331. doi:10.1111/exd.13533.
  • Chalubinski M, Wojdan K, Luczak E, et al. IL-33 and IL-4 impair barrier functions of human vascular endothelium via different mechanisms. Vascul Pharmacol. 2015;73:57–63. doi:10.1016/j.vph.2015.07.012.
  • Leung DYM, Bissonnette R, Kreimer S, et al. Dupilumab inhibits vascular leakage of blood proteins into atopic dermatitis skin. J Allergy Clin Immunol Pract. 2023;11(5):1421–1428. doi:10.1016/j.jaip.2023.03.020.
  • Amarbayasgalan T, Takahashi H, Dekio I, et al. Content of vascular endothelial growth factor in stratum corneum well correlates to local severity of acute inflammation in patients with atopic dermatitis. Int Arch Allergy Immunol. 2012;157(3):251–258. doi:10.1159/000327556.
  • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669–676. doi:10.1038/nm0603-669.
  • Ashina K, Tsubosaka Y, Kobayashi K, et al. VEGF-induced blood flow increase causes vascular hyper-permeability in vivo. Biochem Biophys Res Commun. 2015;464(2):590–595. doi:10.1016/j.bbrc.2015.07.014.
  • Livesey A, Garty F, Shipman AR, et al. Lactate dehydrogenase in dermatology practice. Clin Exp Dermatol. 2020;45(5):539–543. doi:10.1111/ced.14134.
  • Yang Z, Wu CM, Targ S, et al. IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells. J Exp Med. 2020;217(5):e20190472.
  • U.S. Food and Drug Administration. FDA requires warnings about increased risk of serious heart-related events, cancer, blood clots, and death for JAK inhibitors that treat certain chronic inflammatory conditions; [cited 2021 Sep 1. Available from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-requires-warnings-about-increased-risk-serious-heart-related-events-cancer-blood-clots-and-death.