A novel predictive method for risk stratification in acne patients receiving isotretinoin: an analysis of laboratory abnormalities and changes in inflammatory parameters

References

• Ahmad HM. Analysis of clinical efficacy, side effects, and laboratory changes among patients with acne vulgaris receiving single versus twice daily dose of oral isotretinoin. Dermatol Ther. 2015;28(3):1–7. doi:10.1111/dth.12213.
   Web of Science ®Google Scholar
• Alajaji A, Alrawaf FA, Alosayli SI, et al. Laboratory abnormalities in acne patients treated with oral isotretinoin: a retrospective epidemiological study. Cureus. 2021;13(10):e19031. doi:10.7759/cureus.19031.
   PubMedGoogle Scholar
• Vieira AS, Beijamini V, Melchiors AC. The effect of isotretinoin on triglycerides and liver aminotransferases. An Bras Dermatol. 2012;87(3):382–387. doi:10.1590/s0365-05962012000300005.
   PubMed Web of Science ®Google Scholar
• Kızılyel O, Metin MS, Elmas ÖF, et al. Effects of oral isotretinoin on lipids and liver enzymes in acne patients. Cutis. 2014;94(5):234–238. https://pubmed.ncbi.nlm.nih.gov/25474452/
   PubMed Web of Science ®Google Scholar
• Macek C. Synthetic vitamin a analogue (isotretinoin) awaiting approval for cystic acne therapy. JAMA. 1982;247(13):1800–1801.
   PubMedGoogle Scholar
• Park YJ, Shin HY, Choi WK, et al. Optimal laboratory testing protocol for patients with acne taking oral isotretinoin. World J Clin Cases. 2023;11(11):2435–2442. doi:10.12998/wjcc.v11.i11.2435.
   Web of Science ®Google Scholar
• Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009;1(3):162–169. doi:10.4161/derm.1.3.9364.
   PubMedGoogle Scholar
• Turan Ç, Metin N. A novel inflammatory marker in the follow-up of moderate-to-Severe acne vulgaris administered isotretinoin: systemic immune-Inflammation index (SII). Curr Health Sci J. 2022;48(1):63–67. doi:10.12865/CHSJ.48.01.09.
   PubMedGoogle Scholar
• Ataseven A, Kurtipek G, Ozturk P. Neutrophil lymphocyte ratio in patients receiving isotretinoin for acne vulgaris. Med Sci | Int Med J. 2014;3(1):1026. doi:10.5455/medscience.2013.02.8101.
   Google Scholar
• Seçkin HY, Baş Y, Takçı Z, et al. Effects of isotretinoin on the inflammatory markers and the platelet counts in patients with acne vulgaris. Cutan Ocul Toxicol. 2016;35;(2):89–91. doi:10.3109/15569527.2015.1021927.
   PubMed Web of Science ®Google Scholar
• Cosansu NC, Yuksekal G, Turan U, et al. Investigation of systemic immune-inflammation index and systemic inflammation response index as an indicator of the anti-inflammatuary effect of isotretinoin in patients with acne vulgaris. Cutan Ocul Toxicol. 2022;41(2):174–178. doi:10.1080/15569527.2022.2081700.
   PubMed Web of Science ®Google Scholar
• Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945–973.e33. doi:10.1016/j.jaad.2015.12.037.
   PubMed Web of Science ®Google Scholar
• Barbieri JS, Shin DB, Wang S, et al. The clinical utility of laboratory monitoring during isotretinoin therapy for acne and changes to monitoring practices over time. J Am Acad Dermatol. 2020;82(1):72–79. doi:10.1016/j.jaad.2019.06.025.
   PubMed Web of Science ®Google Scholar
• Tkachenko E, Sharma P, Mostaghimi A. Abnormal baseline lab results rarely lead to treatment modification for patients on isotretinoin. Dermatology. 2020;236(6):517–520. doi:10.1159/000505451.
   PubMed Web of Science ®Google Scholar
• Opel D, Kramer ON, Chevalier M, et al. Not every patient needs a triglyceride check, but all can get pancreatitis: a systematic review and clinical characterization of isotretinoin-associated pancreatitis. Br J Dermatol. 2017;177(4):960–966. doi:10.1111/bjd.15207.
   PubMed Web of Science ®Google Scholar
• Lee YH, Scharnitz TP, Muscat J, et al. Laboratory monitoring during isotretinoin therapy for acne. JAMA Dermatol. 2016;152(1):35–44. doi:10.1001/jamadermatol.2015.3091.
   PubMed Web of Science ®Google Scholar
• Zane LT, Leyden WA, Marqueling AL, et al. A population-based analysis of laboratory abnormalities during isotretinoin therapy for acne vulgaris. Arch Dermatol. 2006;142(8):1016–1022. doi:10.1001/archderm.142.8.1016.
   PubMedGoogle Scholar
• Altman RS, Altman LJ, Altman JS. A proposed set of new guidelines for routine blood tests during isotretinoin therapy for acne vulgaris. Dermatology. 2002;204(3):232–235. doi:10.1159/000057887.
   PubMed Web of Science ®Google Scholar
• Hansen TJ, Lucking S, Miller JJ, et al. Standardized laboratory monitoring with use of isotretinoin in acne. J Am Acad Dermatol. 2016;75(2):323–328. doi:10.1016/j.jaad.2016.03.019.
   PubMed Web of Science ®Google Scholar
• Affleck A, Jackson D, Williams HC, et al. Is routine laboratory testing in healthy young patients taking isotretinoin necessary: a critically appraised topic. Br J Dermatol. 2022;187(6):857–865. doi:10.1111/bjd.21840.
   PubMed Web of Science ®Google Scholar
• Dessinioti C, Zouboulis CC, Bettoli V, et al. Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin. J Eur Acad Dermatol Venereol. 2020;34(10):2229–2240. doi:10.1111/jdv.16430.
   PubMed Web of Science ®Google Scholar
• Öktem A, Hayran Y, Arı E, et al. Minimize the regular laboratory monitoring during the systemic isotretinoin treatment: data of 704 patients with acne vulgaris. J Dermatolog Treat. 2019;30(8):813–817. doi:10.1080/09546634.2019.1591578.
   PubMed Web of Science ®Google Scholar
• Shah R, Kroshinsky D. Re-evaluating the need for routine laboratory monitoring in patients taking isotretinoin: a retrospective analysis. J Am Acad Dermatol. 2021;85(2):504–506. doi:10.1016/j.jaad.2018.10.005.
   Web of Science ®Google Scholar
• Ben-Shoshan D, Gomolin A, Litvinov IV, et al. Time to change guidelines for laboratory monitoring during isotretinoin treatment. J Cutan Med Surg. 2020;24(1):92–93. doi:10.1177/1203475419879882.
   Web of Science ®Google Scholar
• National Institute for Health and Care Excellence. British National Formulary (BNF). https://bnf.nice.org.uk (last accessed 15 November 2023).
   Google Scholar
• Electronic Medicines Compendium. Roaccutane 20 mg soft capsules.https://www.medicines.org.uk/emc/product/6470/smpc (last accessed 15 November 2023).
   Google Scholar
• Goodfield MJD, Cox NH, Bowser A, et al. Advice on the safe introduction and continued use of isotretinoin in acne in the U.K. 2010. Br J Dermatol. 2010;162(6):1172–1179. doi:10.1111/j.1365-2133.2010.09836.x.
   PubMed Web of Science ®Google Scholar
• Tanghetti EA. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol. 2013;6(9):27–35.
   PubMedGoogle Scholar
• Kutlu Ö. Effect of isotretinoin treatment on the inflammatory markers in patients with acne vulgaris: can monocyte/HDL be a new indicator for inflammatory activity of isotretinoin treatment? Cutan Ocul Toxicol. 2020;39(1):67–70. doi:10.1080/15569527.2019.1701485.
   PubMed Web of Science ®Google Scholar