Advanced search
Publication Cover
International Journal of Radiation Biology Volume 77, 2001 - Issue 3
Submit an article Journal homepage
18
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Absence of protective role of afferent nerves in early intestinal mucosal alterations induced by abdominal irradiation in rats

C. Picard Institut de Protection et de Sureté Nucléaire, Digestive Radiobiology Unit, BP n°6, 92265 Fontenay-aux-Roses, France
,
J. Wysocki Institut de Protection et de Sureté Nucléaire, Digestive Radiobiology Unit, BP n°6, 92265 Fontenay-aux-Roses, France
,
C. Linard Institut de Protection et de Sureté Nucléaire, Digestive Radiobiology Unit, BP n°6, 92265 Fontenay-aux-Roses, France
,
R. Garcia-Villar Institut National de la Recherche Agronomique, Neuro-Gastroenterology & Nutrition Unit, BP n°3, 31931 Toulouse Cedex, France
,
L. Bueno Institut National de la Recherche Agronomique, Neuro-Gastroenterology & Nutrition Unit, BP n°3, 31931 Toulouse Cedex, France
,
N. M. Griffiths Institut de Protection et de Sureté Nucléaire, Digestive Radiobiology Unit, BP n°6, 92265 Fontenay-aux-Roses, France
&
J. Fioramonti Institut National de la Recherche Agronomique, Neuro-Gastroenterology & Nutrition Unit, BP n°3, 31931 Toulouse Cedex, France
 show all
Pages 349-356 | Published online: 03 Jul 2009

  • ARAI, T., KIDA, Y., HARMON, B. V. and GOB, G. C., 1996, Expression and localization of clusterin mRNA in the small and large intestine of the irradiated rat : its relationship with apoptosis. International Journal of Radiation Biology, 69, 547-553.
  • BRADLEY, P. P., PRIEBAT, D. A., CHRISTENSEN, R. D. and ROTHSTEIN, G., 1982, Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. Journal of Investigative Dermatology, 78, 206-209.
  • BUELL, M. G. and HARDING, R. K., 1989, Proinflammatory effects of local abdominal irradiation on rat gastrointestinal tract. Digestive Diseases and Sciences, 34, 390-399.
  • CHUN, H., SASAKI, M., FUJIYAMA, Y. and BAMBA, T., 1997, Effect of enterai glutamine on intestinal permeability and bacterial translocation after abdominal radiation injury in rats. Journal of Gastroenterologe, 32, 189-95.
  • CONARD, R. A., 1956, Some effects of ionizing radiation on the physiology of the gastrointestinal tract: a review. Radiation Research, 5, 167-188.
  • CUMMINS, A. G., ANTONIOU, D. and THOMPSON, F. M., 1994, Neuropeptide depletion by capsaicin does not prevent mucosal mast cell activationin the rat at weaning. Immunology and Cell Biology, 72, 230-233.
  • CUMMINS, A. G., MUNRO, G. H., HUNTLEY, J. F., MILLER, H. R. and FERGUSSON, A., 1989, Separate effects of irradiation and of graft-versus-host reaction on rat mucosal mast cells. Gut, 30, 355-360.
  • DOMEK, M. J., BLACKMAN, E. I., KAO, J., ZHANG, X. Y., IWATA, F., SENO, K. and LEUNG, F. W., 1997, Functional ablation of afferent nerves aggravates dextran sulphate sodium-induced colonie damage in rats. Journal of Gastroenterology and Hepatology, 12, 698-702.
  • EMPEY, L. R., PAPP, J. D., JEWELL, L. D. and FEDORAK, R. N., 1992, Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats. Digestive Diseases and Sciences, 37, 205-214.
  • ERICKSON, B. A., OTTERSON, M. F., MOULDER, J. E. and SARNA, K., 1994, Altered motility causes the early gastrointestinal toxicity of irradiation International Journal of Radiation, Oncology, Biology, Physics, 28, 905-912.
  • ESPOSITO, V., LINARD, C., MAUBERT, C., AIGUEPERSE, J. and GOURMELON, P., 1996, Modulation of gut Substance P after whole-body irradiation. A new pathological feature. Digestive Diseases Science, 41, 2070-2077.
  • EYSSELEIN, V. E., REINSHAGEN, M., PATEL, A., DAVIS, W., NAST, C. and STERNINI, C., 1992, Calcitonin gene-related peptide in inflammatory bowel disease and experimentally induced colitis. Annals New York Academy of Sciences, 657, 319-327.
  • FARBER, A., CONNORS, J. P., FRIEDLANDER, R. M., WAGNER, R. J., POWELL, R. J. and CRONENWETT, J. L., 1999, A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice. Journal of Vascular Surgery, 30, 752-760.
  • FORSGREN, S., HOCKERFELT, U., NORRGARD, O., HENRIKSSON, R. and FRANZEN, L., 2000, Pronounced substance P innervation in irradiation-induced enteropathy-a study on human colon. Regulatory Peptides, 88, 1-13.
  • FRANÇOIS, A., AIGUEPERSE, J., GOURMELON, P., MACNAUGHTON, W. K. and GRIFFITHS, N. M., 1998, Exposure to ionizing radiation modifies neurally evoked electrolyte transport and some inflammatory responses in rat colon in vitro. International Journal of Radiation Biology, 73, 93-101.
  • GAMSE, R., 1982, Capsaicin and nociception in the rat and mouse. Possible role of substance P. Naunyn-Schmiedeberg's Archwes of Pharmacology, 320, 205-216.
  • GUNTER-SMITH, P. J., 1986, Gamma radiation affects active electrolyte transport by rabbit lleum: basal Na and Cl transport. American Journal of Physiology, 250, G540-G545.
  • HARARI, Y., KESTER, D., TRAVIS, E., WALLACE, J. and CASTRO, G., 1994, Intestinal anaphylaxis: radiation-induced suppression. American Journal of Physiology, 267, G709-G715.
  • HIRSCHOWITZ, L. and RODE, J., 1991, Changes in neurons, neuroendocrine cells and nerve fibres in the lamina propria of irradiated bowel. Virchows Archwes A Pathology Anatomy Histopathology, 418, 163-168.
  • HOCKERFELT, U., HENRIKSSON, R., FRANZEN, L., NORRGARD, O. and FORSGREN, S., 1999, Irradiation induces marked immunohistochemical expression of vasoactive intestinal peptide in colonie mucosa of man. Digestive Diseases Science, 44, 393-401.
  • HOCKERFELT, U., L., F., KJORELL, U. and FORSGREN, S., 2000, Parallel increase in substance P and VIP in rat duodenum in response to irradiation. Peptides, 21, 271-281.
  • HOLZER, P., 1991, Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacological Reviews, 43, 143-201.
  • HOLZER, P., 1998, Implications of tachykinins and calcitonin gene-related peptide in inflammatory bowel disease. Digestion, 59, 269-283.
  • KEATES, A. C., CASTAGLIUOLO, I., QIU, B., NIKULASSON, S., SENGUPTA, A. and POTHOULAKIS, C., 1998, CGRP upregulation in dorsal root ganglia and Deal mucosa during Closfridium difficile toxin A-induced enteritis. American Journal of Physiology, 274, G196-G202.
  • KERANEN, U., KIVILUOTO, T., JARVINEN, H., BACK, N., KIVILAAKSO, E. and SOINILA, S., 1995, Changes in substance P-immunoractive innervation of human colon associated with ulcerative colitis. Digestive Diseases Science, 40, 2250-2258.
  • MACNAUGHTON, W. K. and PRUD'HOMME-LALONDE, L., 1995, Exposure to ionizing radiation alters vasoreactivity in rat jejunum ex vivo. Canadian Journal of Physiology and Pharmacology, 73, 699-705.
  • MACNAUGHTON, W. K., AURORA, A. R., BHAMRA, J., SHARKEY, K. A. and MILLER, M. J. S., 1998, Expression, activity and cellular localization of inducible nitric oxide synthase in rat ileum and colon post-irradiation. International Journal of Radiation Biology, 74, 255-264.
  • MACNAUGHTON, W. K., LEACH, K. E., PRUD'HOMME-LALONDE, L. and HARDING, R. K., 1997, Exposure to ionizing radiation increases responsiveness to neural secretory stimuli in the ferret jejunum in vitro. International Journal of Radiation Biology, 72, 219-226.
  • MACNAUGHTON, W. K., LEACH, K. E., PRUD'HOMME-Lalonde, L., Ho, W. and SHARKEY, K. A., 1994, Ionizing radiation reduces neurally evoked electrolyte transport in rat ileum through a mast cell-dependent mechanism. Gastroenterology, 106, 324-335.
  • MAGGI, C. A., 1997, The effects of tachykinins on inflammatory and immune cells. Regulatory Peptides, 78, 75-90.
  • MAZELIN, L., THEODOROU, V., FIORAMONTI, J. and BUENO, L., 1999, Vagally dependent protective action of calcitonin gene-related peptide on colitis. Peptides, 20, 1367-1374.
  • MAZELIN, L., THEODOROU, V., MORE, J., EDMONDS-Alt, X., FIORAMONTI, J. and BUENO, L., 1998b, Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs. Life Science, 63, 293-304.
  • MAZELIN, L., THEODOROU, V., MORE, J., FIORAMONTI, J. and BUÉNO, L., 1998a, Protective role of vagal afferents in experimentally-induced colitis in rats. Journal of Autonomie Nervous System, 73, 38-45.
  • McCAFFERTY, D. M., WALLACE, J. L. and SHARKEY, K. A., 1997, Effects of chemical sympathectomy and sensory nerve ablation on experimental colitis in the rat. American Journal of Physiology, 272, G272-G280.
  • MERRITT, A. J., JONES, L. S. and POTTEN, C. S., 1996, Apoptosis in murine intestinal crypts. In Techniques in Apoptosis, edited by T. G. Cotter and S. G. Martin (London: Portland press), pp. 269-299.
  • MILLER, M. J. S., SADOWSKA-KROWICKA, H., JENG, A. Y., CHOTINARUEMOL, S., WONG, M., CLARK, D. A., Ho, W. and SHARKEY, K. A., 1993, Substance P levels in experimental ileitis in guinea pigs: effects of misoprostol. American Journal of Physiology, 265, G321-G330.
  • POTTEN, C. S. and GRANT, H. K., 1998, The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine. British Journal of Cancer, 78, 993-1003.
  • REINSHAGEN, M., ADLER, G. and EYSSELEIN, V. E., 1995, Substance P gene expression in acute experimental colitis. Regulatory Peptides, 53-58.
  • REINSHAGEN, M., FLAMIG, G., ERNST, S., GEERLING, L, WONG, H., WALSH, J., EYSSELEIN, V. and ADLER, G., 1998, Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonie injury. Journal of Pharmacology and Experimental Therapeutics, 286, 657-661.
  • REINSHAGEN, M., PATEL, A., SOTTILI, M., FRENCH, S., STERNINI, C. and EYSSELEIN, V. E., 1996, Action of sensory neurons in an experimental rat colitis model of injury and repair. American Journal of Physiology, 270, G79-G86.
  • ROBERTS, I. S., JONES, C. J. and STODDART, R. W., 1990, Lectin histochemistry of the mast cell: heterogeneity of rodent and human mast cell populations. Histochemical Journal, 22, 73-80.
  • RUIFROK, A. C. C., MASON, K. A., LOZANO, G. and THAMES, H. D., 1997, Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment. Radiation Research, 147, 1-12.
  • SEDGWICK, D. M. and FERGUSON, A., 1994, Dose-response studies of depletion and repopulation of rat intestinal mucosal mast cells after irradiation. International Journal of Radiation Biology, 65, 483-495.
  • SHARKEY, K. A., 1992, Substance P and calcitonin gene-related peptide (CGRP) in gastrointestinal inflammation. Annals New York Academy of Sciences, 664, 425-442.
  • SHEA-DONOHUE, T., GOLDHILL, J. M., MONTCALM-MAZZILLI, E., COLLETON, C., PINEIRO-CARRERO, V. M. and SJOGREN, R. W., 1997, Role of sensory afferents in the myoelectric response to acute enteric inflammation in the rabbit. American Journal of Physiology, 273, G447-G455.
  • STERNINI, C., REEVE, J. R. and BRECHA, N., 1987, Distribution and characterization of Calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats. Gastroenterology, 93, 852-862.
  • TRACHTENBERG, J. T., 1998, Fibers apoptosis in developing rat muscles is regulates by activity, neuregulin. Developmental Biology, 196, 193-203.
  • WALLACE, J. L., MACKNIGHT, G. W. and BEFUS, A. D., 1992, Capsaicin-induced hyperemia in the stomach: possible contribution of mast cells. American Journal of Physiology, 263, G209-G214.
  • YEOH, E., HOROWITZ, M., Russo, A., MUECKE, T., ROBB, T., MADDOX, A. and CHATTERTON, B., 1993, Effect of pelvic irradiation on gastrointestinal function: a prospective longitudinal study. American Journal of Medicine, 95, 397-406.
  • ZHANG, C., CAI, W., Li, Y., HUANG, W. and SU, H., 1998, Quantitative analysis of calcitonin gene-related peptide and neuropeptide Y -immunoreactive nerve fibers in mesenteric blood vessels of rats irradiated with cobalt-60 gamma rays. Radiation Research, 149, 19-26.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.