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International Journal of Radiation Biology Volume 77, 2001 - Issue 4
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Research Article

A mathematical model for cell density and proliferation in squamous epithelium after single-dose irradiation

W. DORR Klinik und Poliklinik für Strahltherapie und Radio-onkologie, Medizinische Fakultät Carl Gustav Carus Der Technischen Universität, D-01307 Dresden, Germany
&
M. N. OBEYESEKERE Department of Biomathematics, UT MD Anderson Cancer Center, Houston, TX 77030, USA
Pages 497-505 | Published online: 03 Jul 2009

  • AL-BARWARI, S. E. and POTTEN, C. S., 1976, Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. International Journal of Radiation Biology, 30, 201-216.
  • BARENDSEN, G. W., 1982, Dose fractionation, dose rate and isoefifect relationships for normal tissue responses. International Journal of Radiation Oncology, Biology, Physics, 8, 1981-1997.
  • BARRANDON, Y. and GREEN, H., 1987, Three clonal types of keratinocytes with different capacities for multiplication. Proceedings of the National Academy of Sciences, USA, 84, 2302-2306.
  • CHEN, F. D. and HENDRY, J. H., 1986, The radiosensitivity of microcolony- and macrocolony-forming cells in mouse tail epidermis. British Journal of Radiology, 59, 389-395.
  • CHEN, F. D. and HENDRY, J. H., 1988, Residual skin injury after repeated irradiation: differences observed using healing, macrocolony, and microcolony endpoints. International Journal of Radiation Oncology, Biology, Physics, 15, 943-948.
  • DÖRR, W., 1994, Repopulation in mouse oral mucosa: treatment splits. Radiotherapy and Oncology, 33, 139-147.
  • DÖRR, W., 1997, Three A's of repopulation during fractionated irradiation of squamous epithelia: asymmetry loss, acceleration of stem cell divisions and abortive divisions. International Journal of Radiation Biology, 72, 635-643.
  • DÖRR, W, 1998, Radiobiological models of normal tissue reactions. Strahlentherapie und Onkologie, 174 (suppl. III), 4-7.
  • DÖRR, W., BRANKOVIC, K. AND HARTMANN, B., 2000, Repopulation in mouse oral mucosa: changes in the effect of dose fractionation. International Journal of Radiation Biology, 76, 383-390.
  • DÖRR, W., BREITNER, A. and KUMMERMEHR, J., 1993, Capacity and kinetics of SLD repair in mouse tongue epithelium. Radiotherapy and Oncology, 27, 36-45.
  • DÖRR, W., EMMENDÖRFER, H., HAIDE, E. and KUMMERMEHR, J., 1994, Proliferation equivalent of 'accelerated repopulation' in mouse oral mucosa. International Journal of Radiation Biology, 66, 157-167.
  • DU+00DRR, W., EMMENDÖRFER, H. and WEBER-FRISCH, M., 1996, Tissue kinetics in mouse tongue mucosa during daily fractionated radiotherapy. Cell Proliferation, 29, 495-504.
  • DÖRR, W. and KUMMERMEHR, J., 1990, Accelerated repopulation of mouse tongue epithelium during fractionated irradiations or following single doses. Radiotherapy and Oncology, 17, 249-259.
  • DÖRR, W. and KUMMERMEHR, J., 1991, Proliferation kinetics of mouse tongue epithelium under normal conditions and following single dose irradiation. Virchows Archive B, 60, 287-294.
  • DÖRR, W. and TROTT, K.-R., 2000, Strahlenbiologie der Normalgewebe. In W. Dörr, J. S. Zimmermann and M. H. Seegenschmiedt (eds), Nebenwirkungen in der Radioonkologie (Munich: Urban & Vogel), pp. 9-23.
  • DÖRR, W. and WEBER-FRISCH, M., 1995a, Repopulation response of mouse oral mucosa during unconventional radiotherapy protocols. Radiotherapy and Oncology, 37, 230-236.
  • DÖRR, W. and WEBER-FRISCH. M., 1995b, Effect of changing weekly dose on accelerated repopulation during fractionated irradiation of mouse tongue mucosa. International Journal of Radiation Biology, 67, 577-585.
  • DOUGLAS, B. G. and FOWLER, J. F., 1976, The effect of multiple small doses of X-rays on skin reactions in the mouse and a basic interpretation. Radiation Research, 66, 401-426.
  • EMERY, E. W., DENEKAMP, J., BALL, M. M. and FIELD, S. B., 1970, Survival of mouse skin epithelial cells following single and divided doses of X-rays. Radiation Research, 41, 450-466.
  • FOWLER, J. F., DENEKAMP, J., DELAPEYRE, C., HARRIS, S. R. and SHELDON, P. W., 1974, Skin reactions in mice after multifraction X-irradiation. International Journal of Radiation Biology, 25, 213-223.
  • HOPEWELL, J. W. and VAN DEN AARDWEG, G. J., Studies of dose-fractionation on early and late responses in pig skin: a reappraisal of the importance of the overall treatment time and its effects on radiosensitization and incomplete repair. International Journal of Radiation, Oncology, Biology, Physics, 21, 1441-1450.
  • JONES, P. H., 1997, Epithelial stem cells. Bioessays, 19, 683-690.
  • JONES, P. H., HARPER, S. and WATT, F. M., 1995, Stem cell patterning and fate in human epidermis. Cell, 80, 83-93.
  • JONES, P. H. and WATT, F. M., 1993, Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell, 73, 713-724.
  • KELLETT, M., HUME, W. J. and POTTEN, C. S., 1989, A topographical study of the circadian rhythm in labelling index of mouse gingival and floor-of-mouth epithelium, including changes in labelling activity with individual cell position on the epithelial ridges. Archives of Oral Biology, 34, 321-328.
  • MILLER, J. M., LAVKER, R. M. and SUN, T. T., 1997, Keratinocyte stem cells of cornea, skin and hair follicles. In C. S. Potten (ed.), Stem Cells (London: Academic Press), pp. 331-362.
  • MORRIS, R. J., FISCHER, S. M. and SLAGA, T. J., 1985, Evidence that the centrally and peripherally located cells in the murine epidermal proliferative unit are two distinct cell populations. Journal of Investigative Dermatology, 84, 277-281.
  • MORRIS, G. M. and HOPEWELL, J. W., 1985, Pig epidermis: a cell kinetic study. Cell Tissue Kinetics, 18, 407-415.
  • MOULDER, J. E. and FISCHER, J. J., 1976, Radiation reaction of rat skin. The role of the number of fractions and the overall treatment time. Cancer, 37, 2762-2767.
  • PARKINSON, E. K., HUME, W. J. and POTTEN, C. S., 1986, The radiosensitivity of cultured human and mouse keratinocytes. International Journal of Radiation Biology, 50, 717-726.
  • PAVLOVITCH, J. H., RIZK RABIN, M., GERVAISE, M., METEZEAU, P. and GRUNWALD, D., 1989, Cell subpopulations within proliferative and differentiating compartments of epidermis. American Journal of Physiology, 256, C977-C986.
  • POTTEN, C. S., 1974 The epidermal proliferative unit: the possible role of the central basal cell. Cell Tissue Kinetics, 7, 77-88.
  • POTTEN, C. S. and ALLEN, T. D., 1975, Control of epidermal proliferative units (EPUs). An hypothesis based on the arrangement of neighbouring differentiated cells. Differentiation, 3, 161-165.
  • POTTEN, C. S. and HENDRY, J. H., 1973, Clonogenic cells and stem cells in epidermis. International Journal of Radiation Biology, 24, 537-540.
  • POTTEN, C. S. and LOEFFLER, M., 1987, Epidermal cell proliferation. I. Changes with time in the proportion of isolated, paired and clustered labelled cells in sheets of murine epidermis. Virchows Archives B, 53, 279-285.
  • REZVANI, M., HOPEWELL, J. W., MORRIS, G. M., WILDING, D., WHITEHOUSE, E., ROBBINS, M. E. and CORTINA, B. M., 1998. Repair, repopulation and cell cycle redistribution in rat foot skin. Radiotherapy and Oncology, 46, 193- 199.
  • RUIFROK, A. C., MASON, K. A., HUNTER, N. and THAMES, H. D, 1994, Changes in radiation sensitivity of mouse skin during fractionated and prolonged treatments. Radiation Research, 139, 334-343.
  • THAMES, H. D., WITHERS, H. R. and PETERS, L. J., 1984, Tissue repair capacity and repair kinetics deduced from multifractionated or continuous irradiation regimes with incomplete repair. British Journal of Cancer, 49 (suppl. VI), 263-269.
  • TURESSON, I. and THAMES, H. D., 1989, Repair capacity and kinetics of human skin during fractionated radiotherapy: erythema, desquamation, and telangiectasia after 3 and 5 year's follow-up. Radiotherapy and Oncology, 15, 169-188.
  • WATT, F. M., 1998, Epidermal stem cells: markers, patterning and the control of stem cell fate. Philosophical Transactions of the Royal Society of London B, Biological Sciences, 353, 831-837.
  • WITHERS, H. R., 1967, The dose-survival relationship for irradiation of epithelial cells of mouse skin. British Journal of Radiology, 40, 187-194.

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