- interchanges induced with c-rays between the speci? c Barquinero, J. F., Knehr, S., Brasselmann, H., Figel, M. and
- chromosomes indicates some sort of statistical prefer-Bauchinger, M., 1998, DNA-proportional distribution
- ence for association of certain pairs of chromosomes. of radiation-induced chromosome aberrations analysed by ? uorescence in situ hybridization painting of all chro-
- Diåerent nuclear localization of chromosomes 18 mosomes of a human female karyotype. International Journal
- and 19 was observed by Croft et al. (1999). The most of Radiation Biology, 74, 315-323.
- recent results show the pre-existence of functional Brenner, D. J., 1987, Concerning the nature of the initial
- association between chromosome domains, which is damage required for the production of radiation-induced
- a target for radiation-induced exchanges (Nikiforova exchange aberrations. International Journal of Radiation Biology, 52, 805-809.
- et al. 2000). These authors show that two genes that Chen, A. M., Lucas, J. N., Brenner, D. J., Hill, F. S. and
- are subjected to intrachromosomal inversion in thyr-Sachs, R. K., 1996, Proximity eåects for chromosome
- oid cells after irradiation with ionizing radiation are aberrations measured by FISH. International Journal of
- juxtaposed in 35% of healthy thyroid cells. These Radiation Biology, 69, 411-420.
- results suggest that all observed exchanges are the
- CigarraÂn, S., Barrios, L., Barquinero, J. F., CaballiÂn, M. R., Ribas, M. and Egoscue, J., 1998, Relationship
- sites where pre-existing functional associations are
- between the DNA content of human chromosomes andU. and Bauchinger, M., 1996, Chromosome analysis by
- their involvement in radiation-induced structural aberra-? uorescence in situ hybridization: further indications for
- tions, analysed by painting. International Journal of Radiationa non-DNA-proportional involvement of single chromo-
- Biology, 74, 449-455.somesinradiation-inducedstructuralaberrations.
- Cremer, T., Dietzel, S., Eils, R., Lichter, P. and Cremer,International Journal of Radiation Biology, 70, 385-392.
- C., 1995, Chromosome territories, nuclear matrix ? la-Kozubek, M., Kozubek, S., LukaÂsÆovaÂ, E., MarecÏkovaÂ, A.,
- ments and inter-chromatin channels: a topological viewBaÂrtovaÂ, E., SkalniÂkovaÂ, M. and JergovaÂ, A, 1999,
- on nuclear architecture and function. In P. E. BrandhamHigh-resolution cytometry: automated 2-D and 3-D ana-
- and M. D. Bennett (eds), Kew Chromosome Conference IVlysis of hybridization dots in interphase cell nuclei using
- (London: Kew Royal Botanic Gardens), pp. 63-81.multi-color FISH and CCD microscopy. Cytometry, 36,
- Croft, J. A., Bridger, J. M., Boyle, S., Pertry, P., Teague,279-293.
- P. and Bickmore, W. A., 1999, Diåerences in the localiz-Kozubek, S., LukaÂsÆovaÂ, E., RyÂznar, L., Kozubek, M.,
- ation and morphology of chromosomes in the human LisÆkovaÂ, A., Govorun, R. D., Krasavin, E. A. and
- nucleus. Journal of Cell Biology, 145, 1119-1131. Horneck, G., 1997, Distribution of ABL and BCR genes
- Dolling, J. A., Boreham, D. R., Brown, D. L., Raaphorst,in cell nuclei of normal and irradiated lymphocytes. Blood,
- G. P. and Mitchel, R. E. J., 1997, Rearrangement of89, 4537-4545.
- human cell homologous chromosome domains in response Lucas, J. N. and Sachs, R. K., 1993, Using three-colour
- to ionizing radiation. International Journal of Radiation chromosome painting to test chromosome aberration
- Biology, 72, 303-311. models. Proceedings of the National Academy of Sciences, USA,
- Durante, M., Furusawa, Y., George, K., Gialanella, G.,90, 1484-1487.
- Greco, O., Grossi, G., Matsufuji, N., Pugliese, M. LukaÂsÆovaÂ, E., Kozubek, S., Kozubek, M., Kroha, V.,
- and Yang, T. C., 1998, Rejoining and misrejoining of MarecÏkovaÂ, A., SkalniÂkovaÂ, M., BaÂrtovaÂ, E. and
- radiation-induced chromatin breaks. IV. Charged par-SÏlotovaÂ, J., 1999, Chromosomes participating in translo-
- ticles. Radiation Research, 149, 446-454. cations typical of malignant haemoblastoses are also
- Durante, M., George, K., Wu, H.-L. and Yang, T. C., 1996, involved in exchange aberrations induced by fast neut-
- Kinetics of rejoining and misrejoining of radiation-rons. Radiation Research, 151, 375-384.
- induced chromatin breaks. I. Experiments in human Manuelidis, L., 1985, Individual interphase chromosome
- lymphocytes. Radiation Research, 145, 274-280. domains revealed by in situ hybridization. Human Genetics,
- Edwards, A. A., Moiseenko, V. V. and Nikjoo, H., 1994, 71, 291-294.
- Modelling of DNA breaks and the formation of chromo-Marshall, W. F., Straight, A., Marko, J. F., Swedlow, J.,
- some aberrations. International Journal of Radiation Biology, Dernburg, A., Belmont, A., Murray, A. W., Agard,
- 66, 633-637. D. A. and Sedat, J. W., 1997, Interphase chromosomes
- Ferreira, J., Paollella, G., Ramos, C. and Lamond, A. I., undergo constrained diåusional motion in living cells.
- 1997, Spatial organization of large-scale chromatin Current Biology, 7, 930-939.
- domains in the nucleus: A magni? ed view of single Nikiforova, M. N., Stringer, J. R, Blough, R., Medvedovic,
- chromosome territories. Journal of Cell Biology, 139, M., Fagin, J. A. and Nikiforov, J. E., 2000, Proximity
- 1597-1610. of chromosomal loci that participate in radiation-induced
- Gillert, E., Leis, T., Repp, R., Reichel, M., HoÈsch, A., rearrangements in human cells. Science, 290, 138-141.
- Breitenlohner, I., AngermuÈller, S., Borkhardt, A., Prise, K. M., 1994, Use of radiation quality as a probe for DNA
- Harbott, J., Lampert, F., Griesinger, F., Greil, J., lesion complexity. International Journal of Radiation Biology,
- Fey, G. H. and Marschalek, R., 1999, A DNA damage 65, 43-48.
- repair mechanism is involved in the origin of chromo-Rabbitts, T. H., 1994, Chromosomal translocations in human
- somal translocations t(4;11) in primary leukemic cells. cancer. Nature, 372, 143-149.
- Oncogene, 18, 4663-4671. Rogakou, E. P., Boon, C., Redon, C. and Bonner, W. M.,
- Greinert, R., Boguhn, O., Detzler, E., Thieke, C. and 1999, Magabase chromatin domains involved in DNA
- Harder, D., 1999, Biophysical models for the formation double-strand break in vivo. Journal of Cell Biology, 146,
- of radiation-induced chromosome aberrations based upon 905-915.
- the experimental observations made under PCC and Sachs, R. K, Chen, A. M. and Brenner, D. J., 1997, Review:
- mitotic conditions. In C. Baumstark-Khan, S. Kozubek Proximity eåects in the production of chromosome aber-
- and G. Horneck (eds), Fundamentals for the Assessment of rations by ionizing radiation. International Journal of
- Risks from Environmental Radiation (Amsterdam: Kluwer), Radiation Biology, 71, 1-19.
- pp. 209-218. Sachs, R. K., Rogoff, A., Chen, A. M., Simpson, P. J., Savage,
- JirsovaÂ, P., BaÂrtovaÂ, E., Kozubek, S., Kozubek, M., J. R. K., Hahnfeldt, P. and Hlatky, L. R., 2000,
- LukaÂsÏovaÂ, E., CafourkovaÂ, A., KoutnaÂ, I. and Underprediction of visibly complex chromosome aberra-
- SkalnõÂkovaÂ, M., 2000, Nuclear distribution of the cen-tions by a recombinational-repair (’one-hit‚) model.
- tromeric heterochromatin and the p53 gene of human International Journal of Radiation Biology, 76, 129-148.
- leukemic cell lines after irradiation. Radiation Research, Sadoni, N., Langer, S., Fauth, C., Bernardi, G., Cremer, T.,
- 155, 69-77. Turner, B. M. and Zink, D., 1999, Nuclear organization
- Johnson, K. L., Brenner, D. J., Nath, J., Tucker, J. D. and of mammalian genomes: Polar chromosome territoriesGeard, C. R., 1999, Radiation-induced breakpoint misre-built up functionally distinct higher order compartments.joining in human chromosomes: random or non-random? Journal of Cell Biology, 146, 1211-1226.International Journal of Radiation Biology, 75, 131-141. Savage, J. R. K., 1993, Interchange and intra-nuclear architec-
- Kanaar, R., Hoeijmakers, J. H. J. and van Gent, D. C., 1998, ture. Environmental and Molecular Mutagenesis, 22, 234-244.
- Molecular mechanisms of DNA double-strand break Savage, J. R. K., 2000, Proximity matters. Science, 290, 62-63.
- repair. Trends in Cell Biology, 8, 483-489.
- Knehr, S., Zitzelberger, H., Braselmann, H., Nahrstedt,Savage, J. R. K. and Papworth, D. G., 1973, The relationship
- of radiation-induced yield to chromosome arm number.Strachan, T. and Read, A. P., 1996, Organisation and expression of human genome. In Human Molecular Genetics (New
- Mutation Research, 19, 139-143.
- Savage, J. R. K. and Papworth, D. G., 1982, Frequency andYork: Wiley) pp. 147-182. Tucker, J. D., Morgan, W. F., Awa, A. A., Bauchinger, M.,
- distribution studies of asymmetrical versus symmetrical
- chromosome aberrations. Mutation Research, 95, 7-18.Blakey, D., Cornforth, M. N., Littlefield, L. G., Natarajan, A. T. and Shasserre, C., 1995, A proposed
- Shelby, R. D., Hahn, K. M. and Sullivan, K. F., 1996,
- Dynamic elastic behavior of a-satellite DNA domainssystem for scoring structural aberrations detected by chromosomal painting. Cytogenetics and Cell Genetics, 68,
- visualized in situ in living human cells. Journal of Cell
- Biology, 135, 545-557.211-221. Weber, K. and Flentje, M., 1993, Lethality of heavy ion-
- Spector, D. L., Goldman, R. D. and Leiwand, L. A., 1998,
- Isolation and stimulation of lymphocytes. In Cells: Ainduced DNA double-strand breaks in mammalian cells. International Journal of Radiation Biology, 64, 169-179.
- Laboratory Manual, vol. 1: Culture and Biochemical Analysis of
- Cells(ColdSpringHarbor:ColdSpringHarborZink, D. and Cremer, T., 1998, Chromosome dynamics in nuclei of living cells. Current Biology, 8, R321-324.
- Laboratory Press), pp. 7.1-3.
International Journal of Radiation Biology
Volume 77, 2001 - Issue 4