Advanced search
Publication Cover
International Journal of Radiation Biology Volume 77, 2001 - Issue 2
Submit an article Journal homepage
53
Views
74
CrossRef citations to date
0
Altmetric
Research Article

High- and low-LET induced chromosome damage in human lymphocytes: a time-course of aberrations in metaphase and interphase

K. George NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Houston, TX 77058, USA and Wyle Laboratories, 1290 Hercules Drive, Houston, TX 77058, USA; Kelsey-Seybold Clinic and NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Houston, TX 77058, USA
,
H. Wu NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Houston, TX 77058, USA and Wyle Laboratories, 1290 Hercules Drive, Houston, TX 77058, USA; Wyle Laboratories, 1290 Hercules Drive, Houston, TX 77058, USA
,
V. Willingham Kelsey-Seybold Clinic and NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Houston, TX 77058, USA
,
Y. Furusawa International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
,
T. Kawata NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Houston, TX 77058, USA
&
F. A. Cucinotta NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory, Houston, TX 77058, USA and Wyle Laboratories, 1290 Hercules Drive, Houston, TX 77058, USA
Pages 175-183 | Published online: 03 Jul 2009

  • ANDERSON, R. M., MARSDEN, S. J., WRIGHT, E. G., KADHIM, M. A., GOODHEAD, D. T. and GRIFFIN, C. S., 2000, Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alphaparticles. International Journal of Radiation Biology, 76, 31-40.
  • BLAKELEY, E. A., CHANG, P. Y. and LOMMEL, L., 1985, Cell cycle recovery from heavy-ion damage. Radiation Research, 104, 145-157.
  • CUCINOTTA, F. A., NIKJOO, H. and GOODHEAD, D., 1998, The effects of delta-rays on the number of particle-track traversais per cell in laboratory and space exposures. Radiation Research, 150, 115-119.
  • DURANTE, M, FURUSAWA, Y, GEORGE, K., GIALANELLA, G., GRECO, G., GROSSI, G., MATSUFUJI, N., PUGLIESE, M. and YANG, T. C., 1998b, Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles. Radiation Research, 149, 446-454.
  • DURANTE, M., FURUSAWA, Y. and GOTOH, E., 1998a, A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. International Journal of Radiation Biology, 74, 457-462.
  • DURANTE, M., FURUSAWA, Y., MAJIMA, H., KAWATA, T. and GOTOH, E., 1999, association between G2-phase block and repair of radiation-induced chromosome fragments in human lymphocytes. Radiation Research, 151, 670-676.
  • DURANTE, M., GEORGE, K. and YANG, T. C., 1997, Biodosimetry of ionizing radiation by selective painting of prematurely condensed chromosomes in human lymphocytes. Radiation Research, 148, S45-50.
  • EDWARDS, A. A., 1997, The use of chromosomal aberrations in human lymphocytes for biological dosimetry. Radiation Research, 148, S39-44.
  • EDWARDS, A. A., FINNON, P., MOQUET, J. E., LLOYD, D. C., DARROUDI, F. and NATARAJAN, A. T, 1994, The effect of high energy neon ions in producing chromosome aberrations in human lymphocytes. Radiation Protection Dosimetry, 52, 299-303.
  • GOTOH, E., ASAKAWA, Y. and KOSAKA, H., 1995, Inhibition of protein serine/threonine phosphatases directly induces premature chromosome condensation in mammalian somatic cells. Biomedical Research, 16, 63-68.
  • GRIFFIN, C. S., MARSDEN, S. J., STEVENS, D. L., SIMPSON, P. and SAVAGE, J. R. K., 1995, Frequencies of complex chromosome exchange aberrations induced by 238Pu alpha-particles and detected by fluorescence in situ hybridization using single chromosome-specific probes. International Journal of Radiation Biology, 67, 431-439.
  • GRIGOROVA, M., BRAND, R., XIAO, Y. and NATARAJAN, A. T., 1998, Frequencies and types of exchange aberrations induced by x-rays and neutrons in Chinese hamster splenocytes detected by FISH using chromosome-specific DNS libraries. International Journal of Radiation Biology, 74, 297-314.
  • LINDHOLM, C., MAKELAINEN, I., PAILE, W., KOIVISTOINEN, A. and SALOMAA, S., 1999, Domestic radon exposure and the frequency of stable or unstable chromosomal aberrations in lymphocytes. International Journal of Radiation Biology, 75, 921-928.
  • OBE, G. JOHANNES, I., JOHANNES, C., HALLMAN, K., REITZ, G. and FACIUS, R., 1997 Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. International Journal of Radiation Biology, 72, 727-734.
  • PINKEL, D., STRUAME, T., COLLINS, C., FUSCOE, J., SEGRAVES, R., LUCAS, J. and GRAY, J., 1986, Cytogenetic analysis using quantitative high sensitivity fluorescence hybridization. Proceedings of the National Academy of Sciences, USA, 82, 2934-2938.
  • RITTER, S., NASONOVA, E., GUDOWSKA-NOWAK, E., SCHOLZ, M. and KRAFT, G., 2000, High-LET-induced chromosome aberrations in V79 cells analysed in first and second post-irradiation metaphases. International Journal of Radiation Biology, 76, 149-161.
  • RITTER, S., NASONOVA, E., SCHOLTZ, M., KRAFT-WEYRATHER, W. and KRAFT, G., 1996, Comparison of chromosomal damage induced by X-rays and Ar ions with an LET of 1840 keV/micrometer in G! V79 cells. International Journal of Radiation Biology, 69, 155-166.
  • SAVAGE. J. R. K. and SIMPSON, P. J., 1994, On scoring of FISH-'painted' chromosome-type exchange aberrations. Mutation Research, 307, 345-355.
  • SCHOLZ, M., KRAFT-WEYRATHER, W., RITTER, S. and KRAFT, G., 1994. Cell cycle delays induced by heavy ion irradiation of synchronous mammalian cells. International Journal of Radiation Biology, 66, 59-75.
  • SCHOLZ, M., RITTER, S. and KRAFT, G., 1998, Analysis of chromosome damage based on the time-course of aberrations. International Journal of Radiation Biology, 74, 325-331.
  • TANAKA, K., GAJENDIRAN, N., ENDO, S., KOMASTSU, K., HOSHI, M. and KAMADA, M., 1999, Neutron energy-dependent initial DNA damage and chromosomal exchange. Radiation Research, 40, 36-44.
  • TESTARD, I., DUTRILLAUX, B. and SABATIER, L., 1997. Chromosomal aberrations induced in human lymphocytes by high-LET irradiation. International Journal of Radiation Biology, 72, 423-433.
  • TESTARD, I., RICOUL, M., HOFFSCHIR, F., FLURY-HEARD, A., DUTRILLAUX, B., FEDERENKO, B., GERASIMENKO, V. and SABATIER, L., 1996, Radiation-induced chromosome damage in astronauts' lymphocytes. International Journal of Radiation Biology, 70, 403-411.
  • WU, H., DURANTE, M., GEORGE, K. and YANG, T. C., 1997, Induction of chromosome aberrations in human cells by charged particles. Radiation Research, 148, S102-107.
  • Wu, H., GEORGE, K. and YANG, T. C., 1998, Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes. International Journal of Radiation Biology, 73, 521-528.
  • YAMADA, S., DURANTE, M., ANDO, K., FURUSAWA, Y., KAWATA, T., MAJIMA, H. and TSUJII, H., 2000, Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity. Cancer Letters, 150, 215-221.
  • YANG, T. C., GEORGE, K., JOHNSON, A. S., DURANTE, M. and FEDERENKO, B. S., 1997, Biodosimetry results from space flight Mir-18. Radiation Research, 148, S17-23, 1997.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.