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Research Article

Chemical agents that promote chromatin compaction radiosensitize tumour cells

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Pages 1033-1042 | Published online: 03 Jul 2009

  • AJIRO, K., YODA, K., UTSUMI, K. and NISHIKAWA, Y., 1996, Alteration of cell cycle-dependent histone phosphorylations by okadaic acid. Journal of Biological Chemistry, 271, 13197-13201.
  • BIADE, S., STOBBE, C. C. and CHAPMAN, J. D., 1997, The intrinsic radiosensitivity of human tumor cells throughout their cell cycles. Radiation Research, 147, 416-421.
  • BORITZKI, T. J., WOLFARD, T. S., BESSERER, J. A., JACKSON, R. C. and FRY, D. W., 1988, Inhibition of type II topoisomerase by fostriecin. Biochemical Pharmacology, 37, 4063-4068.
  • BREWER, L. R., CORZETT, M. and BALHORN, R., 1999, Protamine-induced condensation and decondensation of the same DNA molecule. Science, 286, 120-123.
  • CHAPMAN, J. D., 1980, Biophysical models of mammalian cell inactivation by radiation. In R. E. Meyn and H. R. Withers (eds), Radiation Biology in Cancer Research (New York: Raven), pp. 21-32.
  • CHAPMAN, J. D., DOERN, S. D., REUVERS, A. P., GILLESPIE, C. J., CHATTERJEE, A., BLAKELY, E. A., SMITH, K. C. and TOBIAS, C. A., 1979, Radioprotection by DMSO of mammalian cells exposed to x-rays and to heavy chargedparticle beams. Radiation and Environmental Biophysics, 16, 29-41.
  • CHAPMAN, J. D., STOBBE, C. C., GALES, T., DAS, I., ZELLMER, D. L., BIADK, S. and MATSUMOTO, Y., 1999, Condensed chromatin and cell inactivation by single-hit kinetics. Radiation Research, 151, 433-441.
  • CHAPMAN, J. D., STOBBE, C. C. and MATSUMOTO, Y., Chromatin compaction and tumor cell radiosensitivity at 2 Gray. American Journal of Clinical Oncology (in press).
  • CHENG, A., BALCZDN, R., Zuo, Z., KOONS, J. S., WALSH, A. H. and HONKANEN, R. E., 1998, Fostriecin-mediated G2-Mphase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity. Cancer Research, 58, 3611-3619.
  • CHIU, S.-M. and OLEINICK, N. L., 1998, Radioprotection of cellular chromatin by the polyamines spermine and putrescine: preferential action against formation of DNAprotein crosslinks. Radiation Research, 149, 543-549.
  • COSTELLO, J. F., BERGER, M. S., HUANG, H. S. and CAVENEE, W. K., 1996, Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Research, 56, 2405-2410.
  • DE JONG, R. S., MULEKR, N. H., UGES, D. R., SLEIJFER, D. T., HOPPENER, F. J., GROEN, H. J., WILLEMSE, P. H., VANDER GRAAF, W. T. and DE VRIES, E. G., 1999, Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. British Journal of Cancer, 79, 882-887.
  • DETTOR, C. M., DEWEY, W. C., WINANS, L. F. and NOEL, J. S., 1972, Enhancement of X-ray damage in synchronous Chinese hamster cells by Hypertonie treatments. Radiation Research, 52, 352-372.
  • DEWEY, W. C., NOEL, J. S. and DETTOR, C. M., 1972, Changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous Chinese hamster cells. Radiation Research, 52, 373-394.
  • ELIA, M. C. and BRADLEY, M. O., 1992, Influence of chromatin structure on the induction of DNA double strand breaks by ionizing radiation. Cancer Research, 52, 1580-1586.
  • GILLESPIE, C. J., CHAPMAN, J. D., REUVERS, A. P. and DUGLE, D. L., 1975, The inactivation of Chinese hamster cells by X-rays: synchronized and exponential cell populations. Radiation Research, 64, 353-364.
  • GOODHEAD, D. T., 1992, Radiation tracks in biological materials: initial damage in cells, DNA and associated structures. In Genes, Cancer and Radiation Protection. NCRP Proceedings No. 13 (NCRP), pp. 25-37.
  • Guo, X. W., TH'NG, J. P. H., SANK, R. A., ANDERSON, H. J., TUDAN, C., BRADBURY, E. M. and ROBERGE, M., 1995, Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation. EMBO Journal, 14, 976-985.
  • GURLEY, L. R., TOBEY, R. A., WALTERS, R. A., HILDEBRAND, C. E., HOHMANN, P. G., D'ANNA, J. A., BARHAM, S. S. and DEAVAN, L. L., 1978, Histone phosphorylation and chromatin structure in synchronized mammalian cells. In J. Jeter, I. L. Cameron, G. M. Padilla and A. M. Zimmerman (eds), Cell Cycle Regulation (New York: Academic Press), pp. 37-60.
  • HIRAND, T., KOBAYASHI, R. and HIRANO, M., 1997, Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Cell, 89, 511-521.
  • JOHNSTON, P. I., OLIVE, P. L. and BRYANT, P. E., 1997, Higherorder chromatin structure-dependent repair of DNA double-strand breaks: modeling the elution of DNA from nucleoids. Radiation Research, 148, 561-567.
  • KIM, Y. B., YOSHIDA, M. and HORINOUCHI, S., 1999, Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase. Annals of the New York Academy of Sciences, 886, 200-203.
  • KOSHLAND, D. and STRUNNIKOV, A., 1996, Mitotic chromosome condensation. Annual Review of Cell and Developmental Biology, 12, 305-333.
  • LAMOND, A. I. and EARNSHAW, W. C., 1998, Structure and function in the nucleus. Science, 280, 547-553.
  • Ll, Y.-M. and CASIDA, J. E., 1992, Cantharidin-binding protein: identification as protein phosphatase 2 A. Proceedings of the National Academy of Sciences, USA, 89, 11867-11870.
  • MALYAPA, R. S., WRIGHT, W. D. and ROTI ROTI, J. L., 1994, Radiation sensitivity correlates with changes in DNA supercoiling and nucleoid content in cells of three Chinese hamster cell lines. Radiation Research, 140, 312-320.
  • MIRKOVITCH, J., CLASSER, S. M. and LAEMMLI, U. K., 1988, Scaffold attachment of DNA loops in metaphase chromosomes. Journal of Molecular Biology, 200, 100-109.
  • NACKERDIEN, Z., MICHIE, J. and BÖHM, L., 1989, Chromatin decondensed by acetylation shows an elevated radiation response. Radiation Research, 117, 234-244.
  • NAKAMURA, K. and ANTOKU, S., 1994, Enhancement of X-ray cell killing in cultured mammalian cells by the protein phosphatase inhibitor Calyculin A. Cancer Research, 54, 2088-2090.
  • NURSE, P., 1990, Universal control mechanism regulating onset of M-phase. Nature, 344, 503-508.
  • PANDITA, T. K. and HITTELMAN, W. N., 1994, Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiation Research, 130, 94-103.
  • POLLARD, K. J., SAMUELS, M. L., CROWLEY, K. A., HANSEN, J. C. and PETERSON, C. L., 1999, Functional interaction between GCN5 and polyamines: a new role for core histone acetylation. EMBO Journal, 18, 5622-5633.
  • RAO, K. R. and FRITZ-NIGGLI, H., 1990, Response of murine small intestine to combined treatment with fostriecin and X rays. British Journal of Radiology, 63, 286-289.
  • ROBERGE, M., TUDAN, C., HUNG, S. M., HARDER, K. W., JIRIK, F. R. and ANDERSON, H., 1994, Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A. Cancer Research, 54, 6115-6121.
  • SCHMIESING, J. A., BALL, A. R., GREGSON, H. C., ALDERTON, J. M., ZHOU, S. and YOKOMORI, K., 1998, Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. Proceedings of the National Academy of Sciences, USA, 95, 12906-12911.
  • STRAHL, B. D. and ALLIS, C. D., 2000, The language of covalent histone modifications. Nature, 403, 41-45.
  • SUGANUMA, M., FUJIKI, H., SUGURI, H., YOSHIZAWA, S., HIROTA, M., NAKAYASU, M., OJIKA, M., WAKAMATSU, K., YAMADA, K. and SUGIMURA, T., 1988, Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-ace tatetype tumor promoter. Proceedings of the National Academy of Sciences, USA, 85, 1768-1771.
  • SUTANI, T., YUASA, T., TOMONAGA, T., DOHMAE, N., TAKIO, K. and YANAGIDA, M., 1999, Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4. Genes and Development, 13, 2271-2283.
  • TERZOUDI, G. I. and PANTELIAS, G. E., 1997, Conversion of DNA damage into chromosome damage in response to cell cycle regulation of chromatin condensation after irradiation. Mutagenesis, 12, 271-276.
  • TOSUJI, H., MABUCHI, I., FUSETANI, N. and NAKAZAWA, T., 1992, Calyculin A induces contractile ring-like apparatus formation and condensation of chromosomes in unfertilized sea urchin eggs. Proceedings of the National Academy of Sciences, USA, 89, 10613-10617.
  • UEMURA, T., OHKURA, H., ADACHI, Y., MORINO, K., SHIOZAKI, K. and YANAGIDA, M., 1987, DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Cell, 50, 917-925.
  • UEMURA, T. and YANAGIDA, M., 1986, Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis. EMBO Journal, 5, 1003-1010.
  • VOURC'H, C., TARUSCIO, D., BOYLE, A. L. and WARD, D. C., 1993, Cell cycle-dependent distribution of telomeres,centromeres, and chromosome-specific subsatellite domains in the interphase nucleus of mouse lymphocytes. Experimental Cell Research, 205, 142-151.
  • WARD, J. F., 1982, Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals. Radiation Research, 86, 185-195.
  • WARTERS, R. L. and LYONS, B. W., 1990, Detection of ionizing radiation-induced DNA double-strand breaks by filter elution is affected by nuclear chromatin structure. Radiation Research, 124, 309-316.
  • WEST, C. M. L., DAVIDSON, S. E., ROBERTS, S. A. and HUNTER, R. D., 1993, Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix. British Journal of Cancer, 68, 819-823.
  • WOLFFE, A., 1998, Chromatin Structure and Function (San Diego: Academic Press).
  • YAMASHITA, K., YASUDA, H., PINES, J., YASUMOTO, K., NISHITANI, H., OHTSUBO, M., HUNTER, T., SUGIMURA, T. and NlSHIMOTO, T., 1990, Okadaic acid, a potent inhibitor of type 1 type 2A protein phosphatases, activates cdc2/Hl kinase and transiently induces a premature mitosis-like state in BHK21 cells. EMBO Journal, 9, 4331-4338.

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