- ANGELE, S., LAUGE, A., FERNET, M., MOULLAN, N., BEAUVAIS, P., COUTURIER, J., STOPPA-LYONNET, D. and HALL, J., 2003, Phenotypic cellular characterization of an Ataxia telangiectasia patient carrying a causal homozygous missense mutation. Human Mutation, 21, 169-170.
- ARTUSO, M., ESTEVE, A., BRESIL, H., VUILLAUME, M. and HALL, J., 1995, The role of the ataxia telangiectasia gene in the p53, WAFl /CIP1 (p21) - and GADD45-mediated response to DNA damage produced by ionising radiation. Oncogene, 11, 1427-1435.
- BARBER, J. B., WEST, C. M., KILTIE, A. E., ROBERTS, S. A. and SCOTT, D., 2000, Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy. Radiation Research, 153, 570-578.
- BARLOW, C., DENNERY, P. A., SHIGENAGA, M. K., SMITH, M. A., MORROW, J. D., ROBERTS, L. J., WYNSHAW-BORIS, A. and LEVINE, R. L., 1999, Loss of the ataxiatelangiectasia gene product causes oxidative damage in target organs. Proceedings of the National Academy of Sciences, USA, 96, 9915-9919.
- BATTISTI, C., FORMICHI, P., TRIPODI, S. A., MANGIAVACCHI, P., TOSI, P. and FEDERICO, A., 1996, Increased apoptotic response to 2-deoxy-D-ribose in ataxia-telangiectasia. Journal of Neurological Sciences, 144, 128-134.
- BEBB, D. G., WARRINGTON, P. J., DE JONG, G., YU, Z., MOFFAT, J. A., SKOV, K., SPACEY, S., GELMON, K. and GLICKMAN, B. W., 2001, Radiation induced apoptosis in ataxia telangiectasia homozygote, heterozygote and normal cells. Mutation Research, 476, 13-20.
- CANMAN, C. E., WOLFF, A. C., CHEN, C. Y., FORNACE, A. J., JR and KASTAN, M. B., 1994, The p53-dependent Gl cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Research, 54, 5054-5058.
- CHEN, P. C., LAVIN, M. F., KIDSON, C. and Moss, D., 1978, Identification of ataxia telangiectasia heterozygotes, a cancer prone population. Nature, 274, 484-486.
- CHONG, M. J., MURRAY, M. R., GOSINK, E. C., RUSSELL, H. R., SRINIVASAN, A., KAPSETAKI, M., KORSMEYER, S. J. and McKiNNON, P. J., 2000, Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proceedings of the National Academy of Sciences, USA, 97, 889-894.
- DUCHAUD, E., RIDET, A., STOPPA-LYONNET, D., JANIN, N., MOUSTACCHI, E. and ROSSELLI, F., 1996, Deregulated apoptosis in ataxia telangiectasia: association with clinical stigmata and radiosensitivity. Cancer Research, 56, 1400-1404.
- ENNS, L., BARLEY, R. D., PATERSON, M. C. and MIRZAYANS, R., 1998, Radiosensitivity in ataxia telangiectasia fibroblasts is not associated with deregulated apoptosis. Radiation Research, 150, 11-16.
- FERNANDES-ALNEMRI, T., LITWACK, G. and ALNEMRI, E. S., 1994, CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. Journal of Biological Chemistry, 269, 30761-30764.
- FORMICHI, P., BATTISTI, C., TRIPODI, S. A., TOSI, P. and FEDERICO, A., 2000, Apoptotic response and cell cycle transition in ataxia telangiectasia cells exposed to oxidative stress. Life Sciences, 66, 1893-1903.
- GATEI, M., SHKEDY, D., KHANNA, K. K., UZIEL, T., SHILOH, Y., PANDITA, T. K., LAVIN, M. F. and ROTMAN, G., 2001, Ataxia-telangiectasia: chronic activation of damageresponsive functions is reduced by alpha-lipoic acid. Oncogene, 20, 289-294.
- GILAD, S., CHESSA, L., KHOSRAVI, R., RUSSELL, P., GALANTY, Y., PIANE, M., GATTI, R. A., JORGENSEN, T. J., SHILOH, Y. and BAR-SHIRA, A., 1998, Genotype-phenotype relationships in ataxia-telangiectasia and variants. American Journal of Human Genetics, 62, 551-561.
- GILAD, S., KHOSRAVI, R., SHKEDY, D., UZIEL, T., ZIV, Y., SAVITSKY, K., ROTMAN, G., SMITH, S., CHESSA, L., JORGENSEN, T. J., HARNIK, R., FRYDMAN, M., SANAL, O., PORTNOI, S., GOLDWICZ, Z.,JASPERS, N. G., GATTI, R. A., LENOIR, G., LAVIN, M. F., TATSUMI, K., WEGNER, R. D., SHILOH, Y. and BAR-SHIRA, A., 1996, Predominance of null mutations in ataxia-telangiectasia. Human Molecular Genetics, 5, 433-439.
- GUTIERREZ-ENRIQUEZ, S. and HALL, J., 2003, Use of the cytokinesis-block micronucleus assay to measure radiationinduced chromosome damage in lymphoblastoid cell lines. Mutation Research, S35, 1-13.
- HACIA, J. G., SUN, B., HUNT, N., EDGEMON, K., MOSBROOK, D., ROBBINS, C., FODOR, S. P., TAGLE, D. A. and COLLINS, F. S., 1998, Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays. Genome Research, 8, 1245-1258.
- HAIMOVITZ-FRIEDMAN, A., KAN, C. C., EHLEITER, D., PERSAUD, R. S., McLOUGHLIN, M., FUKS, Z. and KOLESNICK, R. N., 1994, Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. Journal of Experimental Medicine, 180, 525-535.
- HANNUN, Y. A., 1996, Functions of ceramide in coordinating cellular responses to stress. Science, 274, 1855-1859.
- HERCEG, Z. and WANG, Z. Q., 1999, Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Molecular and Cellular Biology, 19, 5124-5133.
- HERZOG, K. H., CHONG, M. J., KAPSETAKI, M., MORGAN, J. I. and McKINNON, P. J., 1998, Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science, 280, 1089-1091.
- HUMAR, B., MULLER, H. and SCOTT, R. J., 1997, Elevated frequency of p53-independent apoptosis after irradiation increases levels of DNA breaks in ataxia telangiectasia lymphoblasts. International Journal of Radiation Biology, 72, 257-269.
- JONGMANS, W., ARTUSO, M., VUILLAUME, M., BRESIL, H., JACKSON, S. P. and HALL, J., 1996, The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation. Oncogene, 13, 1133-1138.
- JUNG, M. and DRITSCHILO, A., 2001, NF-kappa B signaling pathway as a target for human tumor radiosensitization. Seminars in Radiation Oncology, 11, 346-351.
- JUNG, M., ZHANG, Y., DIMTCHEV, A. and DRITSCHILO, A., 1998, Impaired regulation of nuclear factor-kappaB results in apoptosis induced by gamma radiation. Radiation Research, 149, 596-601.
- KASTAN, M. B. and LIM, D. S., 2000, The many substrates and functions of ATM. Nature Reviews Molecular Cell Biology, 1, 179-186.
- KASTAN, M. B., ZHAN, Q., EL DEIRY, W. S., CARRIER, F.JACKS, T., WALSH, W. V., PLUNKETT, B. S., VOGELSTEIN, B. and FORNACE, A. J., JR, 1992, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71, 587-597.
- KHANNA, K. K., LAVIN, M. F., JACKSON, S. P. and MULHERN, T. D., 2001, ATM, a central controller of cellular responses to DNA damage. Cell Death and Differentiation, 8, 1052-1065.
- KOJIS, T. L., GATTI, R. A. and SPARKES, R. S., 1991, The cytogenetics of ataxia telangiectasia. Cancer Genetics and Cytogenetics, 56, 143-156.
- LEE, S. J., DIMTCHEV, A., LAVIN, M. F., DRITSCHILO, A. and JUNG, M., 1998, A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB. Oncogene, 17, 1821-1826.
- LIAO, W. C., HAIMOVITZ-FRIEDMAN, A., PERSAUD, R. S., McLOUGHLIN, M., EHLEITER, D., ZHANG, N., GATEI, M., LAVIN, M., KOLESNICK, R. and FUKS, Z., 1999, Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. Journal of Biological Chemistry, 274, 17908-17917.
- MEIJER, A. E., ZHIVOTOVSKY, B. and LEWENSOHN, R., 1999, Epstein-Barr virus-transformed lymphoblastoid cell lines of ataxia telangiectasia patients are defective in X-rayinduced apoptosis. International Journal of Radiation Biology, 75, 709-716.
- MEYN, M. S., 1995, Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Research, 55, 5991-6001.
- MEYN, M. S., STRASFELD, L. and ALLEN, C., 1994, Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia. International Journal of Radiation Biology, 66, S141-S149.
- PERNIN, D., BAY, J. O., UHRHAMMER, N. and BIGNON, Y. J., 1999, ATM heterozygote cells exhibit intermediate levels of apoptosis in response to streptonigrin and etoposide. European Journal of Cancer, 35, 1130-1135.
- PIRET, B., SCHOONBROODT, S. and PIETTE, J., 1999, The ATM protein is required for sustained activation of NF-kappaB following DNA damage. Oncogene, 18, 2261-2271.
- PRASAD, A. V., MOHAN, N., CHANDRASEKAR, B. and MELTZ, M. L., 1994, Activation of nuclear factor kappa B in human lymphoblastoid cells by low-dose ionizing radiation. Radiation Research, 138, 367-372.
- REICHENBACH, J., SCHUBERT, R., SCHINDLER, D., MULLER, K., BOHLES, H. and ZIELEN, S., 2002, Elevated oxidative stress in patients with ataxia telangiectasia. Antioxidants and Redox Signaling, 4, 465-469.
- ROSIN, M. P., OCHS, H. D., GATTI, R. A. and BODER, E., 1989, Heterogeneity of chromosomal breakage levels in epithelial tissue of ataxia-telangiectasia homozygotes and heterozygotes. Human Genetics, 83, 133-138.
- ROTMAN, G. and SHILOH, Y., 1998, ATM: from gene to function. Human Molecular Genetics, 7, 1555-1563.
- SALVESEN, G. S. and DIXIT, V. M., 1997, Caspases: intracellular signaling by proteolysis. Cell, 91, 443-446.
- SAVITSKY, K., BAR-SHIRA, A., GILAD, S., ROTMAN, G., ZIV, Y., VANAGAITE, L., TAGLE, D. A., SMITH, S., UZIEL, T. and SFEZ, S., 1995, A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science, 268, 1749-1753.
- SHI, Y. Q., LI, L., SANAL, O., TEZCAN, I., EMERY, G. C., BLATTMANN, H. and CROMPTON, N. E., 2001, High levels of delayed radiation-induced apoptosis observed in lymphoblastoid cell lines from ataxia-telangiectasia patients. International Journal of Radiation Oncology Biology Physics, 49, 555-559.
- SHIGETA, T., TAKAGI, M., DELIA, D., CHESSA, L., IWATA, S., KANKE, Y., ASADA, M., EGUCHI, M. and MIZUTANI, S., 1999, Defective control of apoptosis and mitotic spindle checkpoint in heterozygous carriers of ATM mutations. Cancer Research, 59, 2602-2607.
- SMITH, G. C., DI FAGAGNA, F., LAKIN, N. D. and JACKSON, S. P., 1999, Cleavage and inactivation of ATM during apoptosis. Molecular and Cellular Biology, 19, 6076-6084.
- STERN, N., HOCHMAN, A., ZEMACH, N., WEIZMAN, N., HAMMEL, I, SHILOH, Y., ROTMAN, G. and BARZILAI, A., 2002, Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atmdeficient mice. Journal of 'Biological Chemistry, 277, 602-608.
- STUMM, M., NEUBAUER, S., KEINDORFF, S., WEGNER, R. D., WIEACKER, P. and SAUER, R., 2001, High frequency of spontaneous translocations revealed by FISH in cells from patients with the cancer-prone syndromes ataxia telangiectasia and Nijmegen breakage syndrome. Cytogenetics and Cell Genetics, 92, 186-191.
- SYLLA, B. S., HUNG, S. C., DAVIDSON, D. M., HATZIVASSILIOU, E., MALININ, N. L., WALLACH, D., GILMORE, T. D., KIEFF, E. and MOSIALOS, G., 1998, Epstein-Barr virustransforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta. Proceedings of the National Academy of Sciences, USA, 95, 10106-10111.
- TAKAGI, M., DELIA, D., CHESSA, L., IWATA, S., SHIGETA, T., KANKE, Y., GOI, K., ASADA, M, EGUCHI, M., KODAMA, C. and MIZUTANI, S., 1998, Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia. Cancer Research, 58, 4923-4929.
- TAKAO, N., LI, Y. and YAMAMOTO, K., 2000, Protective roles for ATM in cellular response to oxidative stress. FEBS Letters, 472, 133-136.
- THORNBERRY, N. A. and LAZEBNIK, Y., 1998, Caspases: enemies within. Science, 281, 1312-1316.
- TONG, X., LIU, B., DONG, Y. and SUN, Z., 2000, Cleavage of ATM during radiation-induced apoptosis: caspase-3-like apoptotic protease as a candidate. International Journal of Radiation Biology, 76, 1387-1395.
- VIT, J. P., MOUSTACCHI, E. and ROSSELLI, F., 2000, ATM protein is required for radiation-induced apoptosis and acts before mitochondrial collapse International Journal of Radiation Biology, 76, 841-851.
- YU, Y. and LITTLE, J. B., 1998, p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines. Cancer Research, 58, 4277-4281.
- ZHANG, N., CHEN, P., KHANNA, K. K., SCOTT, S., GATEI, M., KOZLOV, S., WATTERS, D., SPRING, K., YEN, T. and LAVIN, M. F., 1997, Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. Proceedings of the National Academy of Sciences, USA, 94, 8021-8026.
- ZHANG, Y., DIMTCHEV, A., DRITSCHILO, A. and JUNG, M., 2001, Ionizing radiation-induced apoptosis in ataxiatelangiectasia fibroblasts. Roles of caspase-9 and cellular inhibitor of apoptosis protein-1. Journal of Biological Chemistry, 276, 28842-28848.
- ZHANG, Y., MA, W. Y., KAJI, A., BODE, A. M. and DONG, Z., 2002, Requirement of ATM in UVA-induced signaling and apoptosis. Journal of Biological Chemistry, 277, 3124-3131.
Variation in radiation-induced apoptosis in ataxia telangiectasia lymphoblastoid cell lines
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