Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse

References

• AKIMOTO, T., HUNTER, N. R., BUCHMILLER, L., MASON, K., ANG, K. K. and Mr[As, L., 1999, Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clinical Cancer Research, 5, 2884–2890.
   Google Scholar
• ANG, K. K., MASON, K. A., ME, R. E. and Mr[As, L., 2002, Epidermal growth factor receptor (EGFR) and its inhibition in radiotherapy. In H. D. Kogelnik, P. Lukas and F. Secllmayer (eds), Progress in Radiation-Oncology, vol. 7 (Bologna: Monduzzi), pp. 557–567.
   Google Scholar
• BALABAN, N., Mom, J., SHANNON, M., DG, L., MURPHY, E. and GOLDKORN, T., 1996, The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. Biochimica et Biophysica Acta, 1314, 147–156.
   PubMed Web of Science ®Google Scholar
• BAUMANN, M., DUBOIS, W. and SUIT, H. D., 1990, Response of human squamous cell carcinoma xenografts of different sizes to irradiation: relationship of clonogenic cells, cellular radiation sensitivity in vivo, and tumor rescuing units. Radiation Research, 123, 325–330.
   PubMed Web of Science ®Google Scholar
• BAUMANN, M., LIERTZ, C., BAISCH, H., WIEGEL, T., LORENZEN," and ARPS, H., 1994, Impact of overall treatment time of fractionated irradiation on local control of human FaDu squamous cell carcinoma in nude mice. Radiotherapy and Oncology, 32, 137–143.
   Google Scholar
• BAUMANN, M., PETERSEN, C., EICHELER, W., HESSEL, F., KRAUSE, M., THAMES, H. D. and ZIPS, D., 2002, Mechanisms of repopulation in experimental squamous cell carcinoma. In H. D. Kogelnik, P. Lukas and F. Secllmayer (eds), Progress inRadiation-Oncology, vol. 7 (Bologna: Monduzzi),pp. 417–422.
   Google Scholar
• BEGG, A. C., 1987, Principles and practices of the tumour growth delay assay. In R. F. Kallman (ed.), Rodent Tumor Models in Experimental Cancer Therapy (New York: Pergamon), pp. 114–121.
   Google Scholar
• BIANCO, C., BIANCO, R., TORTORA, G., DAMIANO, V., GUERRIERI, P., MONTEMAGGI, P., MENDELSOHN, J., DE PLACID°, S., BIANCO, A. R. and CIARDIELLO, F., 2000, Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide. Clinical Cancer Research, 6, 4343–4350.
   Google Scholar
• BONNER, I A., RAISCH, K. P., TRUMMELL, H. Q, ROBERT, F., MEREDITH, R. F., SPENCER, S. A., BUCHSBAUM, D. J., SALEH, M. N., STACKHOUSE, M. A., LOBUGLIO, A. F., PETERS, G. E., CARROLL, W. R. and WAKSAL, H. W., 2000, Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. Journal of Clinical Oncology, 18, 475–535.
   Web of Science ®Google Scholar
• BOWERS, G., REARDON, D., HEWITT, T., DENT, P., MIKKELSEN, R. B., VALERIE, K., LAMMERING, G., AMIR, C. and SCHMIDT-ULLRICH, R. K., 2001, The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. Oncogene, 20, 1388–1397.
   Google Scholar
• CIARDIELLO, F. and TORTORA, G., 2001, A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clinical Cancer Research, 7, 2958–2970.
   PubMed Web of Science ®Google Scholar
• CONTESSA, J. N., HAMPTON, J., LAMMER1NG, G., M1KKELSEN, R. B., DENT, P., VALEIUE, K. and ScHmiur-UmucH, R. K., 2002, Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene, 21, 4032–4041.
   Google Scholar
• DITTRICH, C., GREIM, G., BORNER, M., WEIGANG-KOHLER, K., HUISMAN, H., AMELSBERG, A., EHRET, A., WANDERS, J., HANAUSKE, A. and FUMOLEAU, P., 2002, Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. European Journal of Cancer, 38, 1072–1080.
   Google Scholar
• EDWARDS, A. W. F., 1992, Likelihood, revd edn (Baltimore: Johns Hopkins University Press).
   Google Scholar
• EGEBLAD, M., MORTENSEN, 0. H., VANKEMPEN, L. C. and JAATTELA, M., 2001, BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells. Biochemical and Biophysical Research Communications, 281, 25–31.
   Google Scholar
• EICHELER, W., ZIPS, D., DORFLER, A., GRENMAN, R. and BAUMANN, M., 2002, Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection. Journal of Histochemistry and Cytochemistry, 50, 197–204.
   PubMed Web of Science ®Google Scholar
• FOWLER, J. F., 1991, Rapid repopulation in radiotherapy: a debate on mechanism. The phantom of tumor treatment continually rapid proliferation unmasked. Radiotherapy and Oncology, 22, 156–158.
   Google Scholar
• GRANA, T. M., RUSYN, E. V., Zuou, H., SARTOR, C. I. and Cox, A. D., 2002, Ras mediates raclioresistance through both phosphatidylinositol 3-kinase-dependent and raf-dependent but mitogen-activated protein kinase/ extracellular signal-regulated kinase kinase-independent signaling pathways. Cancer Research, 62, 4142–4150.
   PubMed Web of Science ®Google Scholar
• GRAND'S, J. R., MELHEM, M. F., GOODING, W. E., DAY, R., HOLST, V. A., WAGENER, M. M., DRENNING, S. D. and TWEARDY, D. J., 1998, Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. Journal of the National Cancer Institute, 90, 824–832.
   Google Scholar
• GuPTA, A. K., MCKENNA, W. G., WEBER, C. N., FELDMAN, M. D., GOLDSMITH," D., MICK, R., MACHTAY, M., ROSENTHAL, D. I., BAKANAUSKAS, V. J., CERNIGLIA, G. J., BERNHARD, E. J., WEBER, R. S. and MUSCHEL, R. J., 2002, Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clinical Cancer Research, 8, 885–892.
   Google Scholar
• HARAIU, P. M. and HUANG, S. M., 2001a, Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation. International Journal of Radiation Oncology Biology Physics, 49, 427–433.
   PubMed Web of Science ®Google Scholar
• HARARI, P. M. and HUANG, S. M., 2001b, Radiation response modification following molecular inhibition of epidermal growth factor receptor signaling. Seminars in Radiation Oncology, 11, 281–289.
   PubMed Web of Science ®Google Scholar
• HESSEL, F., PETERSEN, C., ZIPS, D., KRAUSE, M. D. P., THAMES, H. D. and BAUMANN, M., 2003, Impact of increased cell loss on repopulation rate during fractionated irradiation in human FaDu squamous cell carcinoma growing in nude mice. International Journal of Radiation Biology, 79, 479–486.
   Google Scholar
• HUANG, S. M. and HARARI, P. M., 2000, Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clinical Cancer Research, 6, 2166–2174.
   PubMed Web of Science ®Google Scholar
• HUANG, S. M., BOCK, J. M. and HARARI, P. M., 1999, Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and racliosensitivity in squamous cell carcinomas of the head and neck. Cancer Research, 59, 1935–1940.
   PubMed Web of Science ®Google Scholar
• HUANG, S. M., Li, J., ARMSTRONG, E. A. and HARARI, P. M., 2002, Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Research, 62, 4300–4306.
   PubMed Web of Science ®Google Scholar
• KLIJN, J. G., BERNS, P. M., Scumrrz, P. I. and FoEKENs, J. A., 1992, The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocrine Reviews, 13, 3–17.
   PubMed Web of Science ®Google Scholar
• LAMMERING, G., HEWIT, T. H., HAWKINS, W. T., CONTESSA, J. N., REARDON, D. B., UN, P. S., VALERIE, K., DENT, P., MIKKELSEN, R. B. and ScummT-Umucll, R. K., 2001a, Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. Journal of the National Cancer Institute, 93, 921–929.
   Google Scholar
• LAMMERING, G., LIN, P. S., CONTESSA, J. N., HAMPTON, J. L., VALERIE, K. and SCHMIDT-ULLRICH, R. K., 2001b, Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells. International Journal of Radiation Oncology Biology Physics, 51, 775–784.
   Google Scholar
• LEITH, J. T., HARIUGAN, P., PADFIELD, G., FAULKNER, L. and MICHELSON, S., 1991, Modification of the growth rates and hypoxic fractions of xenografted A431 tumors by sialoadenectomy or exogenously supplied epidermal growth factor. Cancer Research, 51, 4111–4113.
   PubMed Web of Science ®Google Scholar
• MENDELSOHN, J., 1997, Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy. Clinical Cancer Research, 3, 2703–2707.
   PubMed Web of Science ®Google Scholar
• MENDELSOHN, J. and FAN, Z., 1997, Epidermal growth factor receptor family and chemosensitization. Journal of the National Cancer Institute, 89, 341–343.
   PubMed Web of Science ®Google Scholar
• MENDONCA, M. S., RODRIGUEZ, A. and ALPEN, E. L., 1990, Differential repair of potentially lethal damage in exponentially growing and quiescent 9L cells. Radiation Research, 122, 38–43.
   PubMed Web of Science ®Google Scholar
• MIIAS, L., MASON, K., HUNTER, N., PETERSEN, S., YAMAKAWA, M., ANG, K., MENDELSOHN, J. and FAN, Z., 2000, In vivo enhancement of tumor raclioresponse by C225 antiepidermal growth factor receptor antibody. Clinical Cancer Research, 6, 701–708.
   PubMed Web of Science ®Google Scholar
• MOTOYAMA, A. B., HyNEs, N. E. and LANE, H. A., 2002, The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides. Cancer Research, 62, 3151–3158.
   PubMed Web of Science ®Google Scholar
• NASU, S., ANG, K. K., FAN, Z. and MILAS, L., 2001, C225 antiepidermal growth factor receptor antibody enhances tumor racliocurability. International Journal of Radiation Oncology Biology Physics, 51, 474–477.
   PubMed Web of Science ®Google Scholar
• NUUEN, B., BOUMA, N., HENRAR, R. E. C., BRAUNS, U., BETTE, P., BOULT, A. and BEIJNEN, J. H., 2000, In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS. International Journal of Pharmaceutics, 194, 261–267.
   Google Scholar
• PETERSEN, C., EICHELER, W., BAISCH, H., ZIPS, D. and BAUMANN, M., 1999, Impact of preirradiation of the tumour bed on cell production rate and cell loss of human FaDu squamous cell carcinoma growing in nude mice. International Journal of Radiation Biology, 75, 1293–1297.
   PubMed Web of Science ®Google Scholar
• PETERSEN, C., ZIPS, D., KRAUSE, M., SCHONE, K., EICHELER, W., HOINKIS, C., THAMES, H. D. and BAUMANN, M., 2001, Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation. International Journal of Radiation Oncology Biology Physics, 51, 483–493.
   PubMed Web of Science ®Google Scholar
• REITER, J. L., THREADGILL, D. W., ELEY, G. D., STRUNK, K. E., DANIELSEN, A. J., SINCLAIR, C. S., PEARSALL, R. S., GREEN, P. J., YEE, D., LAMPLAND, A. L., BALASUBRAMANIAM, S., CROSSLEY, T. D., MAGNUSON, T. R., JAMES, C. D. and MAIHLE, N. J., 2001, Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms. Genomics, 71, 1–20.
   PubMed Web of Science ®Google Scholar
• SACHS, L., 1992, Angewandte Statistik, 7th edn (Berlin: Springer).
   Google Scholar
• SALEH, M. N., RAISCH, K. P., STACKHOUSE, M. A., GRIZZLE, W. E., BONNER, A., MAYO, M. S., Kim, H. G., MEREDITH, R. F., WHEELER, R. H. and BUCHSBAUM, D. J., 1999, Combined modality therapy of A431 human epidermoid cancer using anti-EGFr antibody C225 and radiation. Cancer Biotherapy and Radiopharmaceuticals, 14, 451–463.
   PubMed Web of Science ®Google Scholar
• SCHMIDT-ULLRICH, R. K., CONTESSA". N., DENT, P., MIKKELSEN, R. B., VALEIUE, K., REARDON, D. B., BOWERS, G. and LIN, P. S., 1999, Molecular mechanisms of radiation-induced accelerated repopulation. Radiation Oncology Investigations, 7, 321–330.
   Google Scholar
• SCHMIDT-ULLRICH, R. K., DENT, P., GRANT, S., MIKKELSEN, R. B. and VALERIE, K., 2000, Signal transduction and cellular radiation responses. Radiation Research, 153, 245–257.
   Google Scholar
• SCHMIDT-ULLRICH, R. K., MIKKELSEN, R. B., DENT, P., TODD, D. G., VALERIE, K., KAVANAGH, B. D., CONTESSA, J. N., ROARER, W. K. and CHEN, P. B., 1997, Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene, 15, 1191–1197.
   Google Scholar
• SCHMIDT-ULLRICH, R. K., VALEIUE, K., FOGLEMAN, P. B. and WALTERS, J., 1996, Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells. Radiation Research, 145, 81–85.
   Google Scholar
• SHERIDAN, M. T., O'DWYER, T., SEYMOUR, C. B. and MOTHERSILL, C. E., 1997, Potential indicators of racliosensitivity in squamous cell carcinoma of the head and neck. Radiation Oncology Investigations, 5, 180–186.
   Google Scholar
• SINCLAIR, W. K., 1968, Cyclic X-ray responses in mammalian cells in vitro. Radiation Research, 33, 620–643.
   PubMed Web of Science ®Google Scholar
• STEEL, G. G., 1977, Growth Iiinetks of Tumours: Cell Population nineties in Relation to the Growth and Treatment of Cancer (Oxford: Clarendon).
   Google Scholar
• WALKER, A. M. and Sun, H. D., 1983, Assessment of local tumor control using censored tumor response data. International Journal of Radiation Oncology Biology Physics, 9, 383–836.
   PubMed Web of Science ®Google Scholar
• WILLIAMS, K. J., TELFER, B. A., STRATFORD, I. J. and WEDGE, S. R., 2002, ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model. British Journal of Cancer, 86, 1157–1161.
   PubMed Web of Science ®Google Scholar
• WOLLMAN, R., YAHALOM, J., MANY, R., PINT°, J. and Fuxs, Z., 1994, Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro. International Journal of Radiation Oncology Biology Physics, 30, 91–98.
   Google Scholar
• YARDEN, Y. and Suwxowsiu, M. X., 2001, Untangling the ErbB signalling network. Nature Reviews Molecular Cell Biology, 2, 127–137.
   PubMed Web of Science ®Google Scholar
• ZIETMAN, A. L., Sun, H. D., RAMSAY, J. R., SILOBRCIC, V. and SEDLACEK, R. S., 1988, Quantitative studies on the transplantability of murine and human tumors into the brain and subcutaneous tissues of NCr/Sed nude mice. Cancer Research, 48, 6510–6516.
   PubMed Web of Science ®Google Scholar
• ZIPS, D., EICHELER, W., BRUCHNER, K., JACKISCH, T., GEYER, P., PETERSEN, C., VAN DER KOGEL, A. J. and BAUMANN, M., 2001, Impact of the tumour bed effect on micro-environment, radiobiological hypoxia and the outcome of fractionated radiotherapy of human FaDu squamous-cell carcinoma growing in the nude mouse. International Journal of Radiation Biology, 77, 1185–1193.
   PubMed Web of Science ®Google Scholar