26
Views
11
CrossRef citations to date
0
Altmetric
Article

‘In‐field’ and ‘out‐of‐field’ functional impairment during subacute and chronic phases of experimental radiation enteropathy in the rat

, , , &
Pages 437-450 | Received 30 Sep 2002, Accepted 08 May 2003, Published online: 03 Jul 2009

References

  • ASFAHA, S., CAMERON, J. B., WALLACE, J. L. and MACNAUGHTON, W. K., 1999, Prolonged colonic epithelial hypo-responsiveness after colitis: role of inducible nitric oxide synthase. American Journal of Physiology, 276, G703—G710.
  • BARABANOVA, A. E. and GUSKOVA, A. K., 1990, Acute radiation disease in Chernobyl accident victims. In R. C. Ricks and S. A. Fry (eds), The Medical Basis for Radiation Accident Preparedness (New York: Elsevier), pp. 79–86.
  • BEAR, A. R., CHEESEMAN, C. I. and THOMSON, A. B., 1987, The assessment of recovery of the intestine after acute radiation injury. Radiation Research, 109, 319–329.
  • BECCIOLINI, A., 1987, Relative sensitivities of the small and large intestine. Advances in Radiation Biology, 12, 83–128.
  • BELL, C. J., GALL, D. G. and WALLACE, J. L., 1995, Disruption of colonic electrolyte transport in experimental colitis. American Journal of Physiology, 268, G622—G630.
  • BERTHRONG, M. and FAJARDO, L. F., 1981, Radiation injury in surgical pathology. Part II. Alimentary tract. American Journal of Surgical Pathology, 5, 153–176.
  • Cur, N., MADSEN, K. L., FRIEND, D. R., STEVENSON, B. R. and FEDORAK, R. N., 1996, Increased permeability occurs in rat ileum following induction of pancolitis. Digestive Diseases and Sciences, 41, 405–411.
  • DUBLINEAU, I., KSAS, B., AIGUEPERSE, J., GOURMELON, P. and GRIFFrrlls, N. M., 1998, In vivo alterations of fluid and electrolyte fluxes in rat colon by gamma irradiation. Digestive Disease and Sciences, 43, 652–662.
  • FRANcOIS, A., AIGUEPERSE, J., GOURMELON, P., MACNAUGHTON, W. K. and GRIFFITHS, N. M., 1998, Exposure to ionizing radiation modifies neurally-evoked electrolyte transport and some inflammatory responses in rat colon in vitro. International Journal of Radiation Biology, 73, 93–101.
  • FRANçOIS, A., KsAs, B., AIGUEPERSE, J. and GRIFFITHS, N. M., 2002, The recovery of the neurally-evoked secretory response of rat colonic mucosa after irradiation is independent of mast cells. Radiation Research, 157, 266–274.
  • FRANçOIS, A., KsAs, B., GOURMELON, P. and GRIFFITHS, N. M., 2000, Changes in 5-HT-mediated pathways in radiation-induced attenuation and recovery of ion transport in rat colon. American Journal of Physiology, 278, G75—G82.
  • GERACI, J. P., JACKSON, K. L. and MAIUANO, M. S., 1985, The intestinal radiation syndrome: sepsis and endotoxin. Radiation Research, 101, 442–450.
  • GERACI, J. P., JACKSON, K. L. and MAIUANO, M. S., 1987, Fluid and sodium loss in whole-body-irradiated rats. Radiation Research, 111, 518–532.
  • Grrs, J. and GERBER, G. B., 1973, Electrolyte loss, the main cause of death from the gastrointestinal syndrome? Radiation Research, 55, 18–28.
  • GRASSIN, P., 1986, Occlusion aiguë du gréle. In J. J. Bernier (ed.), Gastro-entérologie (Paris: Flammarion Medecine Sciences), pp. 533–540.
  • GUNTER-SMITH, P. J., 1986, Gamma irradiation affects active electrolyte transport by rabbit ileum: basal Na and Cl transport. American Journal of Physiology, 250, G540—G545.
  • GUNTER-SMITH, P. J., 1987, Effects of ionizing radiation on gastrointestinal physiology. In J. J. Conklin and R. L. Walker (eds), Militag Radiobiology (Orlando: Academic Press), pp. 135–152.
  • GuNTER-Smrru, P. J., 1989, Gamma radiation affects active electrolyte transport by rabbit ileum. II. Correlation of alanine and theophylline response with morphology. Radiation Research, 117, 419–432.
  • HARARI, Y., KESTER, D., TRAVIS, E., WALLACE, J. and CASTRO, G., 1994, Intestinal anaphylaxis: radiation-induced suppres-sion. American Journal of Physiology, 267, G709—G715.
  • HARIUS, M. S. and KENNEDY, J. G., 1988, Relationship between distension and absorption in rat intestine. II. Effects of volume and flow rate transport. Gastroenterology, 94, 1172–1179.
  • HARRIS, M. S., KENNEDY, J. G., SIEGESMUND, K. A. and YORDE, D. E., 1988, Relationship between distention and absorp-tion in rat intestine. I. Effect of luminal volume on the morphology of the absorbing surface. Gastroenterology, 94, 1164–1171.
  • HAUERJENSEN, M., 1997, Increased transforming growth factor beta immunoreactivity is independently associated with chronic injury in both consequential and primary radiation enteropathy. International Journal of Radiation Oncology, Biology and Physics, 39, 187–195.
  • HAUERJENSEN, M., POUIAKOS, L. and OSBORNE, J. W., 1988, Effects of accelerated fractionation on radiation injury of the small intestine: a new rat model. International Journal of Radiation Oncology, Biology and Physics, 14, 1205–1212.
  • HAUERJENSEN, M., RICHTER, K. K., WANG, J., ABE, E., SUNG, C. C. and HARDIN, J. W., 1998, Changes in transforming growth factor betal gene expression and immuno-reactivity levels during development of chronic radiation enteropathy. Radiation Research, 150, 673–680.
  • HAUERJENSEN, M., SAUER, T., DEVIK, F. and NYGAARD, K., 1983, Late changes following single dose roentgen irradiation of rat small intestine. Acta Radiologica Oncologica, 22, 299–303.
  • HAUERJENSEN, M., THEUS, J. W., BRADLEY, J. D., BAKER, M. L. and LANGBERG, C. W., 1995, Localized subclinical radiation enteropathy prolongs intestinal transit time. An experimental study in a rat model. Radiation Oncology Investigation, 3, 157–166.
  • HUBEI, K. A., 1978, The effect of electrical field stimulation and tetrodotoxin on ion transport by the isolated rabbit ileum. Journal of Clinical Investigation, 62, 1039–1047.
  • HUBEI, K. A. and RENQUIST, K. S., 1990, Ion transport in normal and inflamed human jejunum in vitro: changes with electrical field stimulation and theophylline. Digestive Diseases and Sciences, 35, 815–820.
  • HUSEBYE, E., HAUERJENSEN, M., KJORSTAD, K. and SKAR, V., 1994, Severe late radiation enteropathy is characterized by impaired motility of proximal small intestine. Digestive Diseases and Sciences, 39, 2341–2349.
  • JACOBSON, K., MCHUGH, K. and COLLINS, S. M., 1995, Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat. Gastroenterology, 109, 718–722.
  • KROESEN, A. J., STOCKMANN, M., RANSCO, C., SCHULZKE, J. D., ERMA:NA, M. and BUHR, H. J., 2002, Impairment of epithelial transport but not barrier function in idiopathic pouchitis after ulcerative colitis. Gut, 50, 821–826.
  • KUCHARZIK, T., WALSH, S. V., CHEN, J., PARKOS, C. A. and NUSRAT, A., 2001, Neutrophil transmigration in inflam-matory bowel disease is associated with differential expression of epithelial intercellular junction proteins. American Journal of Pathology, 159, 2001–2009.
  • LANGBERG, C. W., SAUER, T., REITAN, J. B. and HAUERJENSEN, M., 1992, Tolerance of rat small intestine to localized single dose and fractionated irradiation. Acta Oncologica, 31, 781–787.
  • LATELLA, G., VERNIA, P., VISCIDO, A., FRIERI, G., CADAU, G., Como, A., Cossu, A., TOMEI, E. and CAPRILLI, R., 2002, GI distension in severe ulcerative colitis. American Journal of Gastroenterology, 97, 1169–1175.
  • LEBRUN, F., FRANcOIS, A., VERGNET, M., LEBARONJACOBS, L., GOURMELON, P. and GRIFFITHS, N. M., 1998, Ionizing radiation stimulates muscarinic regulation of rat intestinal mucosal function. American Journal of Physiology, 175, G1333—G1340.
  • MACNAUGHTON, W. K., 2000, Review article: new insights into the pathogenesis of radiation-induced intestinal dysfunction. Alimentary Pharmacology and Therapeutics, 14, 523–528.
  • MACNAUGHTON, W. K., LEACH, K. E., PRUD'HOMME-LALONDE, L. and HARDING, R. K., 1997, Exposure to ionizing radiation increases responsiveness to neural secretory stimuli in the ferret jejunum in vitro. International Journal of Radiation Biology, 72, 219–226.
  • MACNAUGHTON, W. K., LEACH, K. E., PRUD'HOMME-LALONDE, L., Ho, W. and SHARKEY, K. A., 1994, Ionizing radiation reduces neurally-evoked electrolyte transport in rat ileum through a mast cell-dependent mechanism. Gastroenterology, 106, 324–335.
  • MOTHERSILL, C. and SEYmouR, C., 2001, Radiation-induced bystander effects: past history and future directions. Radiation Research, 155, 759–767.
  • MOULDER," E., 2002, Report on an interagency workshop on the racliobiology of nuclear terrorism: molecular and cellular biology of moderate dose (1–10 Sv) radiation and potential mechanisms of radiation protection (Bethesda, Maryland, December 17–18,2001), Radiation Research, 158, 118–124.
  • NEU GARD, P., Bojo, L. and CASSUTO, J., 1995, Importance of vasoactive intestinal peptide and somatostatin for fluid losses in small-bowel obstruction. Scandinavian Journal of Gastroenterology, 30, 464469.
  • NEU GARD, P. and CASSUTO, J., 1993, Inflammation as a major cause of fluid losses in small bowel obstruction. Scandinavian Journal of Gastroenterology, 28, 1035–1041.
  • Nov, J. M., ComNs, J. T., DONOWITZ, M., FARMAN, J., SHEAHAN, D. J. and SPIRO, H. M., 1979, Effects of radiation on the human gastrointestinal tract. Journal of Clinical Gastroenterology, 1, 9–39.
  • NUSRAT, A., TURNER, J. R. and MADARA, J. L., 2000, Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. American Journal of Physiology, 279, G851—G857.
  • PANTZAR, N., EKSTROM, Q. and WESTROM, B. R., 1994, Mechanisms of increased intestinal riCr] EDTA absorption during experimental colitis in the rat. Digestive Diseases and Sciences, 39, 2327–2333.
  • PARIS, F., FUKS, Z., KANG, A., CAPODIECI, P., JUAN, G., EFILEITER, D., HAmovrrz-FREromAN, A., CORDON-CARDO, C. and KOLESNICK, R., 2001, Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science, 293, 293–297.
  • PHILLIPS, T. E., PHILLIPS, T. L. and NEUTRA, M. R., 1987, macromolecules can pass through occluding junctions of rat ileal epithelium during cholinergic stimulation. Cell Tissue Research, 247, 547–554.
  • PORVAZNIK, M., 1979, Tight junction disruption and recovery after sublethal gamma irradiation. Radiation Research, 78, 233–250.
  • POTTEN, C. S. and HENDRY, J. H., 1995, Clonal regeneration studies. In C. S. Potten and J. H. Hendry (eds), Radiation and Gut (Amsterdam: Elsevier), pp. 45–59.
  • POTTEN, C. S., Ow, G. and ROBERTS, S. A., 1990, The temporal and spatial changes in cell proliferation within the irradiated crypts of the murine small intestine. International Journal of Radiation Biology, 57, 185–199.
  • QUASTLER, H., 1956, The nature of intestinal radiation death. Radiation Research, 4, 303–320.
  • RUBIO, C. A. and JALNAS, M., 1996, Dose—time dependent histological changes following irradiation of the small intestine of rats. Digestive diseases and Sciences, 41, 392–401.
  • SANDLE, G. I., HIGGS, N., CROWE, P., MARSH, M. N., VENKATESAN, S. and PETERS, T. J., 1990, Cellular basis for defective electrolyte transport in inflamed human colon. Gastroenterology, 99, 97–105.
  • ScHmirrz, H., BARMEYER, C., FROMM, M., RUNKEL, N., Foss, H. D., BENTZEL, C. J., RIECKEN, E. 0. and ScHurzKE, J. D., 1999, Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology, 116, 301–309.
  • SCHOFIELD, P. F., HOLDEN, D. and CAR, N. D., 1983, Bowel disease after radiotherapy. Journal of the Royal Society of Medicine, 76, 463–466.
  • STELZNER, M., SOMASUNDARAM, S. and KHAKBERDIEV, T., 2001, Systemic effects of acute terminal ileitis on uninflamed gut aggravate bile acid malabsorption. Journal of Surgical Research, 99, 359–364.
  • SUNDARAM, U. and WEST, A. B., 1997, Effect of chronic inflammation on electrolyte transport in rabbit ileal villus and crypt cells. American Journal of Physiology, 272, G732—G741.
  • THOMSON, A. B. R., CHEESEMAN, C. I. and WALKER, K., 1984, Effect of external abdominal irradiation on the dimensions and characteristics of the barriers to passive transport in the rat intestine. Lipids, 19, 405–418.
  • TORNQVIST, A., FORSGREN, A., FALDT, K., JIBORN, H. and ZEDERFELDT, B., 1991, Bacterial load and inflammatory reaction in the bowel wall after colonic obstruction. An experimental study in rats. European Journal of Surgery, 157, 539–542.
  • VRIESENDORP, H. M., VIGNEULLE, R. M., KITTO, G., PELKY, T., TAYLOR, P. and Smrrx, J., 1992, Survival after total body irradiation: effects of irradiation of exteriorized small intestine. Radiotherapy and Oncology, 23, 160–169.
  • WACHSMANN, F. and DREXLER, G., 1968, Graphs and Tables for Use in Radiology (Berlin: Springer).
  • YEOH, E. K. and HoRowrrz, M., 1987, Radiation enteritis. Surgery Gynecology and Obstetrics, 9, 165–173.
  • ZSEBOK, Z. and PETRANYI, G., 1964, Changes in electrolyte balance in the GI syndrome. Acta Radiologica, 2, 377–383.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.