Less G₂ arrest in irradiated cells of breast cancer patients than in female controls: a contribution to their enhanced chromosomal radiosensitivity?

References

• BAEYENS, A., THIERENS, H., CLAES, K., POPPE, B., MESSIAEN, L., DE RIDDER, L. and Vii, A., 2002, Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. British Journal of Cancer, 87, 1379–1385.
   PubMed Web of Science ®Google Scholar
• BARIA, K., WARREN, C., ROBERTS, S. A., WEST, C. M. and SCOTT, D., 2001, Chromosomal radiosensitivity as a marker of predisposition to common cancers? British Journal of Cancer, 84, 892–896.
   Google Scholar
• BRADLEY,J. and Xu, X., 1996, Diet, age, and the immune system. Nutrition Reviews, 54, 543–550.
   Google Scholar
• BRYANT, P. E., 1998, The signal model: a possible explanation for the conversion of DNA double-strand breaks into chromatid breaks. International Journal of Radiation Biology, 73, 243–251.
   PubMed Web of Science ®Google Scholar
• FERNANDEZ, L. A., MAC SWEEN, J. M. and LANGLEY, G. R., 1976, Lymphocyte responses to phytohaemagglutinin: age-related effects. Immunology, 31, 583–587.
   PubMedGoogle Scholar
• GANGULY, B. B., 1993, Cell division, chromosome damage and micronucleus formation in peripheral lymphocytes of healthy donors: related to donor's age. Mutation Research, 295, 135–148.
   PubMedGoogle Scholar
• GHOSH, B. B., YALUKDER, G. and SHARM AA., 1988, Variation in human karyotype in short term cultured lymphocytes. Cell and Chromosome Research, 11, 7–12.
   Google Scholar
• KELLER, S. E., IoAcurvi, H. L., PEARSE, T. and SWETT', B. A., 1976, Decreased T-lymphocytes in patients with mammary cancer. American Journal of Clinical Pathology, 65, 445–449.
   Google Scholar
• MATSUOKA, S., HUANG, M. and ELT YDGE, S. J., 1998, Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science, 282, 1893–1897.
   PubMed Web of Science ®Google Scholar
• MEIJERs-HEuBouR, H. et al., 2002, Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nature Genetics, 31, 55–59.
   Google Scholar
• O'CoNNETJ, M. J., WALWORTH, N. C. and CARR, A. M., 2000, The G2 DNA-damage checkpoint. Trends in Cell Biology, 10, 296–303.
   Google Scholar
• PRETAZZOLI, V., SALONE, B., Bosi, A. and OLIVIER', G., 2000, Variability of G2 checkpoint sensitivity to low doses of X-rays: correlation with G2 chromatid aberrations but not with an adaptive response. Mutagenesis, 15, 531–535.
   Google Scholar
• RARY, J. M., BENDER, M. A. and KELLY, T. E., 1974, The cytogenetic status of ataxia telangiectasia. Cancer, 32, 70–73.
   Google Scholar
• RICHES, A. C., BRYANT, P. E., STEEL, C. M., GLEIG, A., ROBERTSON, A. J.5 PREECE, P. E. and THOMPSON, A. M., 2001, Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. British Journal of Cancer, 85, 1157–1161.
   Google Scholar
• ROBERTS, S. A., SPREADBOROUGH, A. R., BULMAN, B., BARBER," B. P., EVANS, D. G. R. and SCOTT, D., 1999, Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer. American Journal of Human Genetics, 65, 784–794.
   Google Scholar
• ROTMAN, G. and Sumou, Y., 1999, ATM: a mediator of multiple responses to genotoxic stress. Oncogene, 18, 6135–6144.
   PubMedGoogle Scholar
• ScoiT, D., 2000, Chromosomal radiosensitivity, cancer predisposition and response to therapy. Strahlentherapie und Onkologie, 176, 229–234.
   PubMedGoogle Scholar
• SCOTT', D., BARBER, J. B. P., SPREADBOROUGH, A. R., BURRILL, W. and ROBERTS, S. A., 1999, Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. International Journal of Radiation Biology, 75, 1–10.
   PubMed Web of Science ®Google Scholar
• SCOTT', D., SPREADBOROUGH, A., LEVINE, E. and ROBERTS, S. A" 1994a, Genetic predisposition in breast cancer. Lancet, 344, 444.
   PubMedGoogle Scholar
• ScoiT, D., SPREADBOROUGH, A. R. and ROBERTS, S. A., 1994b, Radiation-induced G2 delay and spontaneous chromo-some aberrations in ataxia-telangiectasia homozygotes and heterozygotes. International Journal of Radiation Biology, 66, S157—S163.
   Google Scholar
• Scarr, D. and ZAM PETITBOSSELER, F., 1980, The relationship between cell killing, chromosome aberrations, spindle defects and mitotic delay in mouse lymphoma cells of differential sensitivity to X-rays. International Journal of Radiation Biology, 37, 33–47.
   Google Scholar
• ScoiT, D. and ZAM PETTI-BOSSET YR, F., 1982, Cell cycle dependence of mitotic delay in X-irradiated normal and ataxia-telangiectasia fibroblasts. International Journal of Radiation Biology, 42, 679–683.
   Google Scholar
• TAYLOR, A. M. R., 1978, Unrepaired DNA strand breaks in irradiated ataxia-telangiectasia lymphocytes suggested from cytogenetic observations. Mutation Research, 50, 407–418.
   PubMed Web of Science ®Google Scholar
• TERZOUDI, G. I. and PANTELIAS, G. E., 1997, Conversion of DNA damage into chromosome damage in response to cell cycle regulation of chromatin condensation after irradiation. Mutagenesis, 12, 271–276.
   PubMed Web of Science ®Google Scholar
• WurrrAKER, M. G., REES, K. and CLARK, C. G., 1971, Reduced lymphocyte transformation in breast cancer. Lancet, i, 892–893.
   Google Scholar
• ZAM PETITBOSSELER, F. and Scurr, D., 1981, Cell death, chro-mosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation. International Journal of Radiation Biology, 39, 547–558.
   Google Scholar