Molecular nature of mutations induced by irradiation with repeated low doses of X‐rays in spleen, liver, brain and testis of lacZ‐transgenic mice

References

• BAO, C.-Y., MA, A.-H., EVANS, H. H., HORNG, M. F., MENCL, J., Hui, T. E. and SEDWICK, W. D., 1995, Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by a- and X-radiation in human lymphoblastoid cells. Mutation Research, 326, 1–15.
   PubMed Web of Science ®Google Scholar
• BIELAS, J. H. and HEDDLE, J. A., 2000, Proliferation is necessary for both repair and mutation in transgenic mouse cells. Proceedings of the National Academic of Sciences, USA, 97, 11391–11396.
   PubMed Web of Science ®Google Scholar
• Corussi, N., VAN LEEUWEN, X. and LOHIVIAN, P. H. M., 1998, Similar mutational spectra in the HPRT gene of human and hamster cell lines after exposure to either low dose rate or high dose rate X-rays. Mutation Research, 401, 89–97.
   PubMed Web of Science ®Google Scholar
• ESSERS, J., VAN STEEG, H., DE WIT, J., SWAGEMAKERS, S. M. A., VERMEU, M., HOEIJMAKERS, J. H. J. and KANAAR, R., 2000, Homologous and non-homologous recombination differentially affect DNA damage repair in mice. EMBO Journal, 19, 1703–1710.
   Google Scholar
• FURUNO-FUKUSIII, I., TATSUMI, K., TAKAHAGI, M. and TACHEBAN AA., 1996, Quantitative and qualitative effect of y-ray dose-rate on mutagenesis in human lymphoblastoid cells. International Journal of Radiation Biology, 70, 209–217.
   PubMed Web of Science ®Google Scholar
• FUSCOE, J. C., ZIMMERMAN, L. J., FEKETA, A., SETZER, R. W. and RossrrER, B. J., 1992, Analysis of X-ray-induced HPRT mutations in CHO cells: insertion and deletions. Mutation Research, 269, 171–183.
   PubMedGoogle Scholar
• KIMURA, H., Htuucm, H., IYEHARA-OGAWA, H. and KATO, T., 1993, Sequence analysis of X-ray-induced mutations occurring in a cDNA of the human hprt gene integrated into mammalian chromosomal DNA. Radiation Research, 134, 202–208.
   Google Scholar
• LEACH, E. G., GUNTHER, E. J., YEASKY, T. M., GIBSON, L. H., YANG-FENG, T. L. and GLAZER, P. M., 1996, Frequent spontaneous deletions at a shuttle vector locus in transgenic mice. Mutagenesis, 11, 49–56.
   Google Scholar
• MASUMURA, K., KUNIYA, K., KUROBE, T., FUKUOKA, M., YATAGAI, F. and Nomm, T., 2002, Heavy-ion-induced mutations in the gpt delta transgenic mouse: comparison of mutation spectra induced by heavy-ion, X-ray, and y-ray radiation. Environmental and Molecular Mutagenesis, 40, 207–215.
   PubMed Web of Science ®Google Scholar
• NAKAMURA, S., IKEHATA, H., KOMURA, J., HOSOI, Y., INouE, H., GONDO, Y., YAMAMOTO, K., IcurvlAsA, Y. and ONO, T., 2000, Radiation-induced mutations in the spleen and brain of lacZ transgenic mice. International Journal of Radiation Biology, 76, 431–440.
   PubMed Web of Science ®Google Scholar
• NARAYANAN, L., FRrrzELL, J. A., BAKER, S. M., LISKAY, R. M. and GLAZER, P. M., 1997, Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proceedings of the National Academic of Sciences, USA, 94, 3122–3127.
   PubMed Web of Science ®Google Scholar
• NELSON, S. L., GIVER, C. R. and GROSOVSKY, A. J., 1994, Spectrum of X-ray-induced mutations in the human hprt gene. Carcinogenesis, 15, 495–502.
   PubMed Web of Science ®Google Scholar
• NELSON, S. L., Pius, K. K. and GROSOVSKY, A. J., 1996, Ionizing radiation signature mutations in human cell mutants induced by low-dose exposures. Mutagenesis, 11, 275–279.
   PubMed Web of Science ®Google Scholar
• NORM', T., SUZUKI, M., MASUMURA, K., YAMADA, M., MATSUI, K., UEDA, 0., SUZUKI, H., KATOH, M., IKEDA, H. and SOFUNI, T., 1999, Spi— selection: An efficient method to detect y-ray-induced deletions in transgenic mice. Environmental and Molecular Mutagenesis, 34, 9–15.
   Google Scholar
• ONO, T., IKEHATA, H., Hosoi, Y., SHUNG, B.-K., KuiusurrA, A., WANG, X., YAMAMOTO, K., Suzum, T. and SOFUNI, T., 1997, X-ray- and ultraviolet-radiation-induced mutations in Mutac' mouse. Radiation Research, 148, 123–128.
   Google Scholar
• ONO, T., IKEHATA, H., NAKAMURA, S., SAITO, Y., Hosoi, Y., TAKAI, Y., YAMADA, S., ONODERA, J. and YAMAMOTO, K., 2000, Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old /ac-transgenic mouse. Mutation Research, 447, 165–177.
   PubMed Web of Science ®Google Scholar
• ONO, T., IKEHATA, H., NAKAMURA, S., SAITO, Y., KOMURA, J., Hosoi, Y. and YAMAMOTO, K., 1999, Molecular nature of mutations induced by a high dose of X-rays in spleen, liver and brain of the lac-transgenic mouse. Environmental and Molecular Mutagenesis, 34, 97–105.
   PubMed Web of Science ®Google Scholar
• ONO, T., UEHARA, Y., SArro, Y. and IKEHATA, H., 2002, Mutation theory of aging, assessed in transgenic mice and knockout mice. Mechanisms of Ageing and Development, 123, 1543–1552.
   PubMed Web of Science ®Google Scholar
• PARK, M. S., HANKS, T., JABERABOANSARI, A. and CHEN, D. J., 1995, Molecular analysis of gamma-ray-induced muta-tions at the hprt locus in primary human skin fibroblasts by multiplex polymerase chain reaction. Radiation Research, 141, 11–18.
   PubMed Web of Science ®Google Scholar
• PHILLIPS, E. N., X1A, F., KELSEY, K. T. and LIBER, H. L., 1995, Spectra of spontaneous and X-ray-induced mutations at the hprt locus in related human lymphoblast cell lines that express wild-type or mutant p53. Radiation Research, 143, 255–262.
   Google Scholar
• RIGAUD, 0. and MousrAccm, E., 1996, Raclioaclaptation for gene mutation and the possible molecular mechanisms of the adaptive response. Mutation Research, 358, 127–134.
   Google Scholar
• ROTHKAMM, K., KUHNE, M., JEGGO, P. A. and LOBRICH, M., 2001, Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Research, 61, 3886–3893.
   PubMed Web of Science ®Google Scholar
• SASAKI, M. S., 1995, On the reaction kinetics of the raclioaclaptive response in cultured mouse cells. International Journal of Radiation Biology, 68, 281–291.
   PubMed Web of Science ®Google Scholar
• SCHWARTZ, J. L., JORDAN, R., SUN, J., MA, H. and Hsu, A. W., 2000, Dose-dependent changes in the spectrum of muta-tions induced by ionizing radiation. Radiation Research, 153, 312–317.
   PubMed Web of Science ®Google Scholar
• SHAO, C., YIN, M., DG, L., STAMBROOK, P. J., DOETSCHMAN, T. D. and TISCHFIELD, J. A., 2002, Loss of heterozygosity and point mutation at Aprt locus in T cells and fibroblasts of Pms2-1— mice. Oncogene, 21, 2840–2845.
   PubMed Web of Science ®Google Scholar
• STERNBERG, N., TIEMEIER, D. and ENQUIST, L., 1977, In vivo packaging of a A Dam vector containing EcoRI DNA fragments of Eschefichia coli and phage Pl. Gene, 1, 255–280.
   PubMed Web of Science ®Google Scholar
• VUG, J. and Dou.P, M. E. T., 2002, Large genome rearrangements as a primary cause of aging. Mechanisms of Ageing and Development, 123, 907–915.
   Google Scholar
• YAMADA, Y., PARK, M. S., OKINAKA, R. T. and CH, D. J., 1996, Molecular analysis and comparison of radiation-induced large deletions of the hprt locus in primary human skin fibroblasts. Radiation Research, 145, 481–490.
   PubMed Web of Science ®Google Scholar
• YATAGAI, F., KUROBE, T., Nonmii, T., MASUMURA, K., TSUKADA, T., YAMAGUCHI, H., KAskt-Euucm, K. and Fuxumsm, N., 2002, Heavy-ion-induced mutations in the gpt delta transgenic mouse: effect of p53 gene knockout. Environmental and Molecular Mutagenesis, 40, 216–225.
   Google Scholar
• Zuou, P. K., Liu, X. Y., SUN, W. Z., ZHANG, Y. P. and WET, K., 1993, Cultured mouse SR-1 cells exposed to low dose of y-rays become less susceptible to the induction of mutagenesis by radiation as well as bleomycin. Mutagenesis, 8, 109–111.
   PubMed Web of Science ®Google Scholar