Radioprotective effect of amifostine on cells from cancer prone patients and healthy individuals studied by the G₂ and PCC assays

References

• BARIA, K., WARREN, C., EDEN, 0. B., ROBERTS, S. A., WEST, C. M. and Scar'', D., 2002, Chromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition. International Journal of Radiation Biology, 78, 341–346.
   Google Scholar
• BARIA, K., WARREN, C., ROBERTS, S. A., WEST, C. M. and SCOTT', D., 2001, Chromosomal radiosensitivity as a marker of predisposition to common cancers. British Journal of Cancer, 6, 892–896.
   Google Scholar
• BORGMANN, K., ROPER, B., EL-AWADY, R., BRACKROCK, S., BIGALKE, M., DORK, T., ALBERTI, W., DIKOMEY, E. and DAHM-DAPHI, J., 2002, Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiotherapy and Oncology, 64, 141–152.
   Google Scholar
• CAPIZZI, R. L., 1996, The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine (Ethyol). European Journal of Cancer, 32A(Suppl.), S5—S16.
   Google Scholar
• CAPIZZI, R. L., 1999, The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine. Seminars in Oncology, 26(2 Suppl. 7), 3–21.
   PubMedGoogle Scholar
• CASTIGLIONE, F., DALLA MOLA, A. and PORCILE, G., 1999, Protection of normal tissues from radiation and cytotoxic therapy: the development of amifostine. Tumorigenesis, 85, 85–91.
   Google Scholar
• COCO-MARTIN, J. M. and BEGG, A. C., 1997, Detection of radiation-induced chromosome aberrations using fluorescence in situ hybridization in drug-induced premature chromosome condensations of tumour cell lines with different radiosensitivities. International Journal of Radiation Biology, 71, 265–273.
   Google Scholar
• DURANTE, M., FURUSAWA, Y. and GOTOH, E., 1998, A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. International Journal of Radiation Biology, 74, 457–462.
   PubMed Web of Science ®Google Scholar
• GOTOH, E., KAWATA, T. and DURANTE, M., 1999, Chromatid break rejoining and exchange aberration formation following y-ray exposure: analysis in G2 human fibroblasts by chemically induced premature chromosome condensation. International Journal of Radiation Biology, 75, 1129–1135.
   PubMed Web of Science ®Google Scholar
• GRDINA, D. J., MURLEY, J. S. and KATAOKA, Y., 2002b, Radioprotectants: current status and new directions. Oncology, Suppl. 2, 2–10.
   Google Scholar
• GRDINA, D. J., MURLEY, J. S., KATAOKA, Y. and EPPERLY, W., 2002a, Relationships between cytoprotection and mutation prevention by VVR-1065. Military Medicine, 167(2 Suppl), 51–53.
   PubMedGoogle Scholar
• GRDINA, D. J. and NAGY, B., 1986, The effect of 24(amino-propyl)amino] ethanethiol(WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells. British Journal of Cancer, 54, 933–941.
   PubMed Web of Science ®Google Scholar
• GRDINA, D. J. and SIGDESTADT, C. P., 1989, Radiation protectors; the unexpected benefits. Drug Metabolism Reviews, 20, 13–42.
   PubMed Web of Science ®Google Scholar
• GRIGGS, J. J., 1998, Reducing the toxicity of anticancer therapy: new strategies. Leukemia Research, 22\(Suppl. 1), S27–33.
   Google Scholar
• HOSPERS, G. A., EISENHAUER, E. A. and DE VRIES, E. G., 1999, The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects. British Journal of Cancer, 80, 629–638.
   PubMed Web of Science ®Google Scholar
• KATAOKA, Y., PERRIN, J.5 HUNTER, N., MILLAS, L. and GRDINAD, J., 1996, Antimutagenic effects of amifostine: clinical implications. Seminars in Oncology, 23 (Suppl. 8), 53–57.
   PubMedGoogle Scholar
• LINDEGAARD, J. C. and GRAu, C., 2000, Has the outlook improved for Amifostine as a clinical radioprotector? Radiotherapy and Oncology, 57, 113–118.
   Google Scholar
• L-LEEIELD, L. G., JOINER, E. E., COLYER, S. P., SALLAM, F. and FROME, E. L., 1993, Concentration-dependent protection against X-ray-induced chromosome aberrations in human lymphocytes by the WR-1065. Radiation Research, 133, 88–93.
   Google Scholar
• MARZATICO, F., PORTA, C., MORONI, M., BERTORELLI, L., BORASIO, E., FINOTII, N., PANSARASA, 0. and CASTAGNA, L., 2000, In vitro antioxidant properties of amifostine (VVR-2721, Ethyol). Cancer Chemotherapy and Pharmacology, 45, 172–176.
   Google Scholar
• NORTH, S., EL-GHLSSASSI, F., PLUQUET, 0., VERHAEGH, G. and HAINAUT, P., 2000, The cytoprotective aminothiol WR1065 activates p21 waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene, 24, 1206–1214.
   Google Scholar
• PANTELIAS, G. E., 1986, Radiation-induced cytogenetic damage in relation to changes in interphase chromosome conformation. Radiation Research, 105, 341–350.
   PubMed Web of Science ®Google Scholar
• PANTELIAS, G. E. and MarmE, H. D., 1983, A simple method for premature chromosome condensation induction in primary human and rodent cells using polyethylene glycol. Somatic Cell Genetics, 9, 533–547.
   PubMedGoogle Scholar
• PANTELIAS, G. E. and MannE, H. D., 1985, Direct analysis of radiation-induced chromosome fragments and rings in unstimulated human peripheral blood lymphocytes by means of the premature chromosome condensation technique. Mutation Research, 149, 67–72.
   Google Scholar
• PETERS, G. J. and VAN DER VIJGH, W. J. F., 1995, Protection of normal tissue from cytotoxic effects of chemotherapy and radiation by amifostine (WR-27-21): Preclinical aspects. European Journal of Cancer, 31A\(Suppl. 1), Sl—S7.
   Google Scholar
• SANFORD, K. K., PARSHAD, R., GaNTr, R. E., TARO, R. E., JONES, G. M. and PRICE, F. M., 1989, Factors affecting and significance of G2 chromatin radiosensitivity and predisposition to cancer. International Journal of Radiation Biology, 55, 963–968.
   PubMed Web of Science ®Google Scholar
• SANTINI, V. and Grms, F. J., 1999, The potential of amifostine: from cytoprotectant to therapeutic agent. Haematologica, 84, 1035–1042.
   PubMed Web of Science ®Google Scholar
• SCHWARTZ, J. L., GIOVANAZZI, S. M., KARRISON, T., JONES, C. and GRDINA, D. J., 1988, 2-[(Aminopropyl)amino] ethanethiol-mediated reductions in 60Co gamma-ray and fission-spectrum neutron-induced chromosome damage in V79 cells. Radiation Research, 113, 145–154.
   PubMed Web of Science ®Google Scholar
• Scurr, D., SPREADBOROUGH, A. R., ROBERTS, L. A. and MOORE, C. J., 1996, Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition. Radiation Research, 145, 3–16.
   PubMedGoogle Scholar
• SHAW, L. M., BONNER, H. and LIEBERMAN, R., 1996, Pharmacokinetic profile of amifostine. Seminars in Oncology, 23(4 Suppl. 8), 18–22.
   PubMedGoogle Scholar
• SHEN, H., CHEN, Z. J., ZILFOU, J. T., HOPPER, E., MURPHY, M. and TEW, K. D., 2001, Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. Journal of Pharmacology and Experimental Therapeutics, 297, 1067–1073.
   PubMed Web of Science ®Google Scholar
• SHIGEMATSU, N., SCHWARTZ, J. L. and GRDINA, D. J., 1994, Protection against radiation-induced mutagenesis at the HPRT locus by spermine and N,N-(diothiodi-2,1- ethanediy1),bis-1,3-propanecliamine(VVR-33278).Mutagenesis, 9, 355-360. Smowx, G. D., FAHEY, R. C., CALABRO-JONES, P. M. and AGUILERA, J. A., 1988, Radioprotection of cells in culture by VVR-2721 and derivatives: form of the drug responsible for protection. Cancer Research, 48, 3641–3647.
   Google Scholar
• TERZOUDI, G. I., JUNG, T., HAIN, J., VROUVAS, J., MARGARITIS, 1(.5 DONTA-BAKOYIANNI, C., MAKROPOULOS, V., ANGELAKIS, PH. and PANTELIAS, G. E., 2000, Increased G2 chromosomal radiosensitivity in cancer patients: the role of cdkl / cyclinB activity level in the mechanisms involved. International Journal of Radiation Biology, 76, 607–616.
   Google Scholar
• TERZOUDI, G. I. and PANTELIAS, G. E., 1997, Conversion of DNA damage in response to cell cycle regulation of chromatin condensation after irradiation. Mutagenesis, 12, 271–276.
   PubMed Web of Science ®Google Scholar
• WOLFF, S. and ARUTYUNYAN, R., 1979, The apparent decrease in thiotepa induced chromosome aberrations in human lymphocytes caused by an effect of VVR2721 on the cell cycle as found by the definitely determined division method. Environmental Mutagenesis, 1, 5–13.
   PubMedGoogle Scholar
• XINBO, C., PANTELIAS, G. E., OKAYASU, R., CHEONG, N. G. E. and Luaus, G., 1993, Mitosis-promoting factor activity of inducer mitotic cells may affect radiation yield of interphase chromosome breaks in the premature chromosome condensation assay. Cancer Research, 53, 5592–5596.
   Google Scholar