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Article

Bowman–Birk protease inhibitor activates DNA‐dependent protein kinase and reduces formation of radiation‐induced dicentric chromosomes

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Pages 801-808 | Received 28 Jan 2003, Accepted 29 Jul 2003, Published online: 03 Jul 2009

References

  • ACHANTA, G., PELICAN°, H., FENG, L., PLuNKETT, W. and HUANG, P., 2001, Interaction of p.53 and DNA-Pk in response to nucleoside analogues: potential role as a sensor complex for DNA-damage. Cancer Research, 61, 8723–8729.
  • AKYUZ, N., BOEHDEN, G. S., SUSSE, S., RIMEK, A., PREUSS, U., SCHEIDMANN, K. H. and WIESMULLER, L., 2002, DNA Substrate dependence of p53-mediated regulation of double-strand break repair. Molecular and Cellular Biology, 22, 6306–6317.
  • ARIUMI, Y., MASUTANI, M., COPELAND, T. D., M1M01U, T., SUG1MURA, T., SHIMOTOHNO, K., UEDA, K., HATANAKA, M. and NODA, M., 1999, suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. Oncogene, 18, 4616–4625.
  • BIEDERMANN, K. A., SUN, J., GI_Amu, A. J., TOSTO, L. M. and BROWN, M. J., 1991, Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proceedings of the National Academy of Sciences, USA, 88, 1394–1397.
  • BRUSH, G. S., ANDERSON, C. W. and KELLY, T. J., 1994, The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proceedings of the National Academy of Sciences, USA, 91, 12520–12524.
  • CHEN, C. Y., OL1NER, J. D., ZHAN, (1).„ FORNACE, A. J., JR., VOGELSTE1N, B. and KASTAN, M. B., 1994, Interactions between p.53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proceedings of the National Academy of Sciences, USA, 91, 2684–2688.
  • DEFAzio, L. G., STANSEL, R. M., GRIFFITH, J. D. and CHU, G., 2002, Synapsis of DNA ends by DNA-dependent protein kinase. EMBO Journal, 21, 3192–3200.
  • DrrrmANN, K. H., DIKOMEY, E., MAYER, C. and RODEMANN, H. P., 2000, The Bowman—Birk protease inhibitor enhances clonogenic cell survival of ionising radiation-treated nucleotide excision repair-competent cells but not of Xeroderma pigmentosum cells. International Journal of Radiation Biology, 76, 223–229.
  • DITTMANN, K. H., GUVEN, N., MAYER, C., OHNESEIT, P., ZELL, R., BEGG, A. C. and RODEMANN, H. P., 1998a, The presence of wild-type p53 is necessary for the raclioprotective effect of the Bowman—Birk proteinase inhibitor in vitro. Radiation Research, 150, 648–655.
  • DrrrmANN, K. H., GUVEN, N., MAYER, C. and RODEMANN, H. P., 1998b, The radioprotective effect of BBI is associated with the activation of DNA-repair relevant genes. International Journal of Radiation Biology, 74, 225–230.
  • DrrrmANN, K. H., KNAUS-DITTMANN, D., MAYER, C. and RODEMANN, H. P., 2001, Bowman-Birk proteinase inhibitor mediated radioprotection against UV-irradiation is TP53 dependent and associated with stimulation of nucleotide excision repair. Radiation and Environmental Biophysics, 40, 163–167.
  • DrrrmANN, K. H., LOFFLER, H., BAMBERG, M. and RODEMANN, H. P., 1995, Bowman—Birk proteinase inhibitor modulates racliosensitivity and radiation-induced differentiation of human fibroblasts in culture. Radiotherapy and Oncology, 34, 137–143.
  • EVANS, J. W., Liu, X. F., KIRCHGESSNER, C. U. and BROWN, J. M., 1996, Induction and repair of chromosome aberrations in scid cells measured by premature chromosome condensation. Radiation Research, 145, 39–46.
  • FRASCA, D., BARATTINI, P., Toccm, G., GUIDI, L., PIERELLI, L. and DORIO, G., 2001, Role of DNA-dependent protein kinase in recognition of radiation-induced DNA-damage in human peripheral blood mononuclear cells. International Immunology, 13, 791–797.
  • GAO, Y., FERGUSON, D. 0., MANIS, J. P., SEKIGUCHI, J., FRANK, K. M., CHOUDHURI, J., HORNER, J., DEPINHO, R. A. and ALT, F. W., 2000, Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability, and development. Nature, 404, 897–900.
  • Hsu, H. L., YANNONE, S. M. and CHEN, D., 2002, Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair, 1, 225–235.
  • JEGGO, P., 1998, Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiation Research, 150(Suppl.), 580—S91.
  • KENNEDY, A. R., 1994, Prevention of carcinogenesis by protease inhibitor. Cancer Research, 52, 1999–2005.
  • KENNEDY, A. R., RADNER, B. S. and NAGASAWA, H., 1984, Protease inhibitors reduce the frequency of spontaneous chromosome abnormalities in cells from patients with Bloom syndrome. Proceedings of the National Academy of Sciences, USA, 81, 1827–1830.
  • KHANNA, K. K. and JACKSON, S., 2001, DNA double-strand breaks: signalling, repair and the cancer connection. Nature Genetics, 27, 247–254.
  • KOLIN-GERRESHEIM, J. and BAUCHINGER, M., 1981, Dependence of the frequency of harlequin-stained cells on BrdU concentration in human lymphocyte cultures. Mutation Research, 91, 251–254.
  • LIN, Y., LuKAcsovicH, T. and WALDMAN, A. S., 1999, Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes. Molecular and Cellular Biology, 19, 8353–8360.
  • MANNA, S. K. and AGGARWAL, B. B., 2000, All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factor-kappaB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene, 19, 2110–2119.
  • MORGAN, W. F., CORCORAN, J., HARTMANN, A., KAPLAN, M. I., Dmou, M. I. and PONNAIYA, B., 1998, DNA double-strand breaks, chromosomal rearrangements, and genomic instability. Mutation Research, 404, 125–128.
  • MOROZOV, V. E., FALZON, M., ANDERSON, C. W. and RUFF, E. L., 1994, DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. Journal of Biological Chemistry, 269, 16 684–16 688.
  • NIMURA, Y., IsmAn., S. M., KURIMAS, A., CHEN, D. J. and STEVENS, C. W., 2002, DNA-PK and ATM are required for radiation-enhanced integration. Radiation Research, 157, 562–567.
  • ODERSKY, A., PANYUTIN, I. V., PANYMIN, I. G., SCHUNCK, C., FELDMANN, E., GOEDECKE, W., NEUMANN, R. D., OBE, G. and PFEIFFER, P., 2002, Repair of sequence-specific 1251-induced double-strand breaks by nonhomologous DNA end joining in mammalian cell-free extracts. Journal of Biological Chemistry, 277, 11 756–11 764.
  • OLIVE, P. L., 1998, The role of DNA single and double-strand breaks in cell killing by ionising radiation. Radiation Research, 150, 542—S51.
  • PFEIFFER, P., GOEDECKE, W. and OBE, G., 2000, Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis, 15, 289–302. RIBALLO, E., CRITCHLOW, S. E., TEO, S. H., DOHERTY, A. J.,
  • PRIESTLEY, A., BROUGHTON, B., KYSELA, B., BEAMISH, H., PLOWMAN, N., ARLETT, C. F., LEHMANN, A. R., JACKSON, S. P. and JEGGO, P. A., 1999, Identification of a defect in DNA-ligase IV in a radiosensitive leukemia patient. Current Biology, 9, 699–702.
  • RICH, T., ALLEN, R. I. and WYLLIE, A. H., 2000, Defying death after DNA damage. Nature, 407, 777–783.
  • ROTHKAMM, K., KIIIINE, M., JEGGO, P. A. and LOBRICH, M., 2001, Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Research, 61, 3886–3886.
  • SHAO, R. G., GAO, C. X., ZHANG, H., KOHN, K. W., WOLD, M. S. and PoivEvHER, Y., 1999, Replication-mediated DNA damage by camptothecin induces phosphoryla-tion of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO Journal, 18, 1397–406.
  • VAN GENT, D. C., HOEUMM(ERS, J. H. and KANAAR, R., 2001, Chromosomal stability and the DNA double-stranded break connection. Nature Reviews Genetics, 2, 196–206.
  • VIRSIK, R. P. and HARDER, D., 1980, Recovery kinetics of radiation-induced chromosome aberrations in human GO lymphocytes. Radiation and Environmental Biophysics, 18, 221–238.
  • WANG, S., GUO, M., OUYANG, H., Li, X., CORDON-CARDO, C., KURIMASA, A., CHEN, D. J., FuKs, Z., LING, C. C. and Li, G. C., 2000, The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proceedings of the National Academy of Sciences, USA, 97, 1584–1588.
  • Woo, R. A., McLuRE, K. G., LEES-MILLER, S. P., RANCOURT, D. E. and LEE, P. W. K., 1998, DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature, 394, 700–704.
  • YAVUZER, U., SMITH, G. C., BLISS, T., WERNER, D. and JACKSON, S. P., 1998, DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes and Development, 12, 2188–2199.

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