Ntg1 and Ntg2 proteins as 5‐formyluracil‐DNA glycosylases/AP lyases in Saccharomyces cerevisiae

References

• ALSETH, I., EIDE, L., PIROVANO, M., ROGNES, T., SEEBERG, E. and BjoaAs, M., 1999, The Saccharonzyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg 1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Molecular and Cellular Biology, 19, 3779–3783.
   PubMed Web of Science ®Google Scholar
• AMES, B. N., SIIIGENAGA, M. K. and HAGEN, T. M., 1993, Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences, USA, 90, 7915–7922.
   PubMed Web of Science ®Google Scholar
• ANENSEN, H., PROVAN, F., LIAN, A. T., REINERTSEN, S.-H. H. S., UENO, Y., MATSUDA, A., SEEBERG, E. and BJELLAND, S., 2001, Mutations induced by 5-formy1-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine. Mutation Research, 476, 99–107.
   Google Scholar
• AUGERI, L., TjF, Y. M., BARTON, A. B. and DOETSCH, P. W., 1997, Puri-fication, characterization, gene cloning, and expression of Saccharomyces cerevisiae redoxyendonuclease, a homolog of Escherichia coli endonuclease III. Biochemistry, 36, 721–729.
   PubMed Web of Science ®Google Scholar
• BECKMAN, K. B. and AMES, B. N., 1998, The free radical theory of aging !natures. Physiological Reviews, 78, 547–581.
   PubMed Web of Science ®Google Scholar
• BJELLAND, S., ANENSEN, H., KNIEVELSRUD, I. and SEEBERG, E., 2001, Cellular effects of 5-formyluracil in DNA. Mutation Research, 486, 147–154.
   PubMed Web of Science ®Google Scholar
• BJELLAND, S., BnumAND, N. K., BENNECHE, T., VOLDEN, G. and SEEBERG, E., 1994, DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli. Journal of Biological Chemistry, 269, 30489–30495.
   PubMed Web of Science ®Google Scholar
• BRUNER, S. D., NASH, H. M., LANE, W. S. and VERDINE, G. L., 1998, Repair of oxidatively damaged guanine in Sacchar-omyces cerevisiae by an alternative pathway. Current Biology, 8, 393–403.
   PubMed Web of Science ®Google Scholar
• CADET, J., DELATOUR, T., DOUKI, T., GASPARUTIO, D., POUGET, J. P., RAVANAT, J. L. and SAUVAIGO, S., 1999, Hydroxyl radicals and DNA base damage. Mutation Research, 424, 9–21.
   PubMed Web of Science ®Google Scholar
• DAVID, S. S. and Wnnams, S. D., 1998, Chemistry of glycosy-lases and endonucleases involved in base-excision repair. Chemical Reviews, 98, 1221–1262.
   PubMed Web of Science ®Google Scholar
• DEMPLE, B. and HARRISON, L., 1994, Repair of oxidative damage to DNA: enzymology and biology. Annual Review of Biochemistry, 63, 915–948.
   PubMed Web of Science ®Google Scholar
• DIANOV, G. L., THYBO, T., DIANOVA, I. I., LIPINSKI, L. J. and BOHR, V. A., 2000, Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts. Journal of Biological Chemistry, 275, 11809–11813.
   PubMedGoogle Scholar
• DOUKI, T., DELATOUR, T., PAGANON, F. and CADET, J., 1996, Measurement of oxidative damage at pyrimicline bases in gamma-irradiated DNA. Chemical Research in Toxicology, 9, 1145–1151.
   PubMed Web of Science ®Google Scholar
• EIDE, L., BjoaAs, M., PIROVANO, M., ALSETH, I., BERDAL, K. G. and SEEBERG, E., 1996, Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Eschefichia coli. Proceedings of the National Academy of Sciences, USA, 93, 10735–10740.
   PubMed Web of Science ®Google Scholar
• EISEN, J. A. and HANAWALT, P. C., 1999, A phylogenomic study of DNA repair genes, proteins, and processes. Mutation Research, 435, 171–213.
   PubMed Web of Science ®Google Scholar
• FUJIKAWA, K., Kamwa, H. and KASAI, H., 1998, The mutations induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP, in Escherichia coli. Nucleic Acids Research, 26, 4582–4587.
   PubMed Web of Science ®Google Scholar
• GELLON, L., BARBEY, R., AUFFRET VAN DER KEMP, P., THOMAS, D. and BorrEux, S., 2001, Synergism between base excision repair, mediated by the DNA glycosylases Ntgl and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae. Molecular Genetics and Genomics, 265, 1087–1096.
   Google Scholar
• GIRARD, P. M., GUIBOURT, N. and BorrEux, S., 1997, The Oggl protein of Saccharomyces cerevisiae: a 7,8-clihydro-8-oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity. Nucleic Acids Research, 25, 3204–3211.
   PubMed Web of Science ®Google Scholar
• HAZRA, T. K., Izumi, T., BOLDOGH, I., IminoFF, B., Kow, Y. W., JARUGA, P., DIZDALOGLU, M. and MITRA, S., 2002, Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proceedings of the National Academy of Sciences, USA, 99, 3523–3528.
   PubMed Web of Science ®Google Scholar
• HAZRA, T. K., Izumi, T., MAIDT, L., FLOYD, R. A. and MITRA, S., 1998, The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation. Nucleic Acids Research, 26, 5116–5122.
   PubMed Web of Science ®Google Scholar
• HILBERT, T. P., CHAUNG, W., BOORSTEIN, R. J., CUNNINGHAM, R. P. and TEEBOR, G. W., 1997, Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III. Journal of Biological Chemistry, 272, 6733–6740.
   PubMed Web of Science ®Google Scholar
• IKEDA, S., BISWAS, T., ROY, R., Izumi, T., BOLDOGH, I., KUROSKY, A., SARKER, A. H., SEKI, S. and MrnzA, S., 1998, Puri-fication and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue. Journal of Biological Chemistry, 273, 21585–21593.
   PubMedGoogle Scholar
• KAMIYA, H., MURATA-KAMIYA, N., KARIN°, N., UENO, Y., MATSUDA, A. and KASAI, H., 2002, Induction of T -> G and T -> A transversions by 5-formyluracil in mammalian cells. Mutation Research, 513, 213–232.
   Google Scholar
• KAspa, H., IrDA, A., YAMAIZUMI, Z., NISHIMURA, S. and TANOOKA, H, 1990,5-Formyldeoxyuricline: a new type of DNA damage induced by ionizing radiation and its mutagenicity to Salmonella strain TA102. Mutation Research, 243, 249–253.
   PubMedGoogle Scholar
• KLUNGLAND, A., PAULSEN, R., ROLSETH, V., YAMADA, Y., UENO, Y., WILK, P., MATSUDA, A., SEEBERG, E. and BJELLAND, S., 2001, 5-Formyluracil and its nucleoside derivatives confer toxi-city and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism. Toxicology Letters, 119, 71–78.
   PubMed Web of Science ®Google Scholar
• LEVY, D. D. and TEEBOR, G. W., 1991, Site directed substitution of 5-hydroxymethyluracil for thymine in replicating 4a-1 74am3 DNA via synthesis of 5-hydroxymethy1-2'-deoxyuricline-5'-triphosphate. Nucleic Acids Research, 19, 3337–3343.
   PubMed Web of Science ®Google Scholar
• MARNETT, L. J., 2000, Oxyradicals and DNA damage. Carcinogenesis, 21, 361–370.
   PubMed Web of Science ®Google Scholar
• MCCULLOUGH, A. K., DODSON, M. L. and LLOYD, R. S., 1999, Initiation of base excision repair: glycosylase mechanisms and structure. Annual Review of Biochemistry, 68, 255–285.
   PubMed Web of Science ®Google Scholar
• MILLER, J. H., 1972, Experiments in Molecular Genetics (New York: Cold Spring Harbor Laboratories Press).
   Google Scholar
• MIYABE, I.5 ZHANG, Q,-M., Kr\ro, K., SUGIYAMA, H., Two, M., YASUI, A. and YONEI, S., 2002, Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein. Nucleic Acids Research, 30, 3443–3448.
   Google Scholar
• MIYABE, I., ZHANG, Q,-M., SUGIYAMA, H., KINO, K. and YONEI, S., 2001, Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli. International Journal of Radiation Biology, 77, 53–58.
   Google Scholar
• MoL, C. D., PARIKH, S. S., PUTNAM C, D., Lo, T. P. and TAINER, J. A., 1999, DNA repair mechanisms for the recognition and removal of damaged DNA bases. Annual Reviews of Biophysics and Biomolecular Structure, 28, 101–128.
   PubMedGoogle Scholar
• NASH, H. M., BRUNER, S. D., SCHaRER, 0. D., KAWATE, T., ADDONA, T. A., SPOONER, E., LANE, W. S. and VERDINE, G. L., 1996, Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Current Biology, 6, 968–980.
   Google Scholar
• RABOW, L. E. and Kow, Y. W., 1997, Mechanism of action of base release by Escherichia coli Fpg protein: role of lysine 155 in catalysis. Biochemistry, 36, 5084–5096.
   PubMedGoogle Scholar
• SENTURKER, S., AUFFRET VAN DER KEMP, P., You, H. J.5 DOETSCH, P. W., DIZDAROGLU, M. and BorrEux, S., 1998, Substrate specificities of the ntg 1 and ntg2 proteins of Sciccharomyces cerevisiae for oxidized DNA bases are not identical. Nucleic Acids Research, 26, 5270–5276.
   Google Scholar
• SIDORK1NA, 0. M. and LAVAL, J., 1998, Role of lysine-57 in the catalytic activities of Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg protein). Nucleic Acids Research, 26, 5351–5357.
   Google Scholar
• SUGIYAMA, H., MATSUDA, S., ZHANG, Q,-M., YONEI, S. and SAITO, I., 1996, New synthetic method of 5-formyluracil-containing oligonucleotides and their melting behavior. Tetrahedron Letters, 37, 9067–9070.
   Google Scholar
• SWANSON, B. L., MOREY, N. J., DOETSCH, P. W. and JINKS-ROBERTSON, S., 1999, Overlapping specificities of base excision repair, nucleotide excision repair, recom-bination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. Molecular and Cellular Biology, 19, 2929–2935.
   Google Scholar
• TEEBOR, G. W., BOORSTEIN, R. J. and CADET, J., 1988, The reparability of oxidative free radical mediated damage to DNA: a review. International Journal of Radiation Biology, 54, 131–150.
   PubMed Web of Science ®Google Scholar
• TOFIGH, S. and FRENKEL, K., 1989, Effect of metals on nucleoside hydroperoxide, a product of ionizing radiation in DNA. Free Radicals in Biology and Medicine, 7, 131–143.
   PubMed Web of Science ®Google Scholar
• WAGNER, J. R., VAN LIER, J. E.5 DECARROZ, C., BERGER, M. and CADET, J., 1990, Photodynamic methods for oxy radical-induced DNA damage. Methods in Enzymology, 186, 502–511.
   Google Scholar
• WALLACE, S. S., 1997, Oxidative damage of DNA and its repair. In J. Scandalios (ed.), Oxidative Stress and the Molecular Biology of Antioxidant Defenses (New York: Cold Spring Harbor Laboratories Press), pp. 49–90.
   Google Scholar
• WARNER, H. R., 1994, Superoxide dismutase, aging and degene-rative disease. Free Radicals in Biology and Medicine, 17, 249–258.
   PubMed Web of Science ®Google Scholar
• You, H. J., SWANSON, R. L. and DOETSCH, P. W., 1998, Saccharomyces cerevisiae possesses two functional homo-logues of Escherichia coli endonuclease III. Biochemistry, 37, 6033–6040.
   PubMedGoogle Scholar
• ZHANG, Q.-M., 2001, Role of the Escherichia coli and human DNA glycosylases that remove 5-formyluracil from DNA in the prevention of mutations. Journal of Radiation Research, 42, 11–19.
   PubMedGoogle Scholar
• ZHANG, Q.-M., FUJIMOTO, J. and YONEI, S., 1995, Enzymatic release of 5-formyluracil by mammalian liver extracts from DNA irradiated with ionizing radiation. International Journal of Radiation Biology, 68, 603–607.
   PubMed Web of Science ®Google Scholar
• ZHANG, Q.-M., MIYABE, I., MATSUMOTO, Y., Kr\ro, K., SUGIYAMA, H. and YONEI, S., 2000, Identification of repair enzymes for 5-formyluracil in DNA. Nth, Nei and MutM proteins of Escherichia coli. Journal of Biological Chemistry, 275, 35471–35477.
   PubMed Web of Science ®Google Scholar
• ZHANG, Q,-M., SUGIYAMA, H., MIYABE, I., MATSUDA, S., KINTO, K., SArro, I. and YONEI, S., 1999, Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil-and 5-hydroxymethyluracil-containing oligonucleotides. International Journal of Radiation Biology, 75, 59–65.
   Google Scholar
• ZHANG, Q,-M., SUGIYAMA, H., MIYABE, I., MATSUDA, S., SAITO, I. and YONEI, S., 1997, Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA. Nucleic Acids Research, 25, 3969–3973.
   Google Scholar